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Antimicrobial agents and chemotherapy, ISSN 1098-6596, 10/2018, Volume 62, Issue 11
.... A population pharmacokinetic (POP PK) analysis was conducted with tafenoquine exposure data obtained following oral administration from 6 clinical studies in phase 1 through phase 3 with a nonlinear mixed effects modeling approach... 
Tafenoquine | Antimalarial | Population pharmacokinetics | 8-aminoquinoline | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Microbiology | Science & Technology
Journal Article
British journal of clinical pharmacology, ISSN 0306-5251, 04/2015, Volume 79, Issue 4, pp. 636 - 649
Journal Article
Journal Article
The Lancet infectious diseases, ISSN 1473-3099, 06/2017, Volume 17, Issue 6, pp. 626 - 635
.... We investigated the safety, tolerability, and pharmacokinetics of DSM265, and tested its antimalarial activity... 
Infectious Disease | Life Sciences & Biomedicine | Infectious Diseases | Science & Technology | Malaria, Falciparum - drug therapy | Triazoles - administration & dosage | Antimalarials - pharmacokinetics | Double-Blind Method | Pyrimidines - administration & dosage | Humans | Middle Aged | Half-Life | Antimalarials - therapeutic use | New Zealand | Plasmodium falciparum | Mefloquine - therapeutic use | Antimalarials - administration & dosage | Enzyme Inhibitors - pharmacokinetics | Pyrimidines - therapeutic use | Enzyme Inhibitors - chemistry | Adolescent | Pyrimidines - pharmacokinetics | Adult | Oxidoreductases Acting on CH-CH Group Donors | Triazoles - pharmacokinetics | Australia | Triazoles - therapeutic use | Drugs | Physiological aspects | Enzymes | Pyrimidines | Safety and security measures | Clinical trials | Malaria | Dehydrogenases | Plasmodia | Erythrocytes | Selectivity | Biochemistry | Drug resistance | Drug development | Dosage | Incidence | Food industry | New combinations | Inhibition | Pharmaceutical industry | Drug dosages | Active control | Public health | Half life | Atovaquone | Mortality | Immunodeficiency | Parasite resistance | Bioavailability | Studies | Polymerase chain reaction | Chemotherapy | Disease transmission | Inhibitors | Cytochrome bc1 | Human beings | Antimalarial agents | Minimum inhibitory concentration | Added value | Antiprotozoal agents | Dihydroorotate dehydrogenase | Bednets | Animal models | Chloroquine | Artemisinin | Infections | Biosynthesis | Spacecraft components | Mathematical models | Gametocytes | Safety | Effectiveness | Pharmacology | Antimalarial activity | Strategy | Index Medicus
Journal Article
PLoS medicine, ISSN 1549-1676, 06/2018, Volume 15, Issue 6, pp. e1002579 - e1002579
.... The aim of this study was to investigate the pharmacokinetic and pharmacodynamic properties of lumefantrine and the pharmacokinetic properties of its metabolite, desbutyl-lumefantrine, in order... 
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Ethanolamines - pharmacology | Fluorenes - pharmacokinetics | Malaria, Falciparum - drug therapy | Antimalarials - pharmacokinetics | Models, Chemical | Humans | Child, Preschool | Infant | Male | Antimalarials - therapeutic use | Fluorenes - pharmacology | Artemether, Lumefantrine Drug Combination - pharmacology | Antimalarials - pharmacology | Dose-Response Relationship, Drug | Pregnancy | Ethanolamines - pharmacokinetics | Artemether, Lumefantrine Drug Combination - pharmacokinetics | Ethanolamines - metabolism | Female | Artemether, Lumefantrine Drug Combination - therapeutic use | Fluorenes - metabolism | Infant, Newborn | Plasmodium falciparum | Medical research | Usage | Plasma physics | Metabolites | Malaria | Pregnant women | Medicine, Experimental | Drug therapy | Development and progression | Care and treatment | Health aspects | Health care | Schedules | Tablets | Systematic review | Epidemiology | Maternal & child health | Search engines | Children | Pretreatment | Drug dosages | Age | Dihydroartemisinin | Vector-borne diseases | Computer simulation | Exposure | Pharmacology | Bioavailability | Patients | Computer programs | Medicine | Scientific papers | Hospitals | Womens health | Pharmacy | Artemether | Adults | Index Medicus | Life Sciences | Santé publique et épidémiologie | randomized-trial | clinical-response | benflumetol | Klinisk medicin | plasmodium-falciparum malaria | therapeutic response | efficacy | population pharmacokinetics | sulfadoxine-pyrimethamine | Clinical Medicine | ugandan children | uncomplicated malaria | Farmakologi och toxikologi | Pharmacology and Toxicology
Journal Article