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Molecular Cancer Therapeutics, ISSN 1535-7163, 10/2003, Volume 2, Issue 10, pp. 971 - 984
Histone deacetylase inhibitors induce hyperacetylation of the amino-terminal lysine residues of the core nucleosomal histones, which results in chromatin... 
SIGNAL-TRANSDUCTION | ACUTE-LEUKEMIA CELLS | ONCOLOGY | ACETYLATION | RESISTANCE | RECEPTOR | RAF-1 | MONOCLONAL-ANTIBODY | OVARIAN-CANCER | TAXOL-INDUCED APOPTOSIS | HSP90 FUNCTION | Chromatin - metabolism | Phosphorylation | Taxoids - pharmacology | Coloring Agents - pharmacology | Annexin A5 - pharmacology | Humans | Epothilones - pharmacology | Multienzyme Complexes - metabolism | Deoxycytidine - pharmacology | Proteasome Endopeptidase Complex | Dose-Response Relationship, Drug | Antibodies, Monoclonal, Humanized | Sepharose - pharmacology | Cysteine Endopeptidases - metabolism | Flow Cytometry | Cyclins - metabolism | Time Factors | Antimetabolites, Antineoplastic - pharmacology | Antineoplastic Agents - pharmacology | Hydroxamic Acids - pharmacology | Detergents - pharmacology | Receptor, ErbB-2 - biosynthesis | Cyclin-Dependent Kinase Inhibitor p21 | Antibodies, Monoclonal - pharmacology | Down-Regulation | Enzyme Inhibitors - pharmacology | Tetrazolium Salts - pharmacology | Reverse Transcriptase Polymerase Chain Reaction | Breast Neoplasms - drug therapy | Blotting, Western | Precipitin Tests | Blotting, Northern | Cell Line, Tumor | Histone Deacetylase Inhibitors | Thiazoles - pharmacology | Antineoplastic Agents, Phytogenic - pharmacology | Deoxycytidine - analogs & derivatives | Microscopy, Fluorescence | Trastuzumab | Apoptosis
Journal Article
Journal Article
Oncogene, ISSN 0950-9232, 04/1999, Volume 18, Issue 13, pp. 2241 - 2251
Previous studies have demonstrated a synergistic interaction between rhuMAb HER2 and the cytotoxic drug cisplatin in human breast and ovarian cancer cells. To... 
Chemotherapy | Breast cancer | Synergy | Multiple drug effects analysis | HER-2/neu (c-erbB-2) | HER2/NEU-OVEREXPRESSING METASTATIC BREAST | synergy | GROWTH-FACTOR-RECEPTOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | ANTINEOPLASTIC AGENTS | breast cancer | MONOCLONAL-ANTIBODY | OVARIAN-CANCER | SALIVARY-GLAND | chemotherapy | ENDOMETRIAL CANCER | CELL BIOLOGY | C-ERBB-2 PROTEIN | ONCOLOGY | multiple drug effects analysis | TUMOR NECROSIS FACTOR | GENETICS & HEREDITY | GENE-PRODUCT | Recombinant Proteins - therapeutic use | Doxorubicin - therapeutic use | Adenocarcinoma - pathology | Receptor, ErbB-2 - genetics | Humans | Neoplasm Proteins - immunology | Antibodies, Monoclonal - therapeutic use | Neoplasm Proteins - antagonists & inhibitors | Antineoplastic Agents - therapeutic use | Vinblastine - therapeutic use | Topoisomerase II Inhibitors | Antimetabolites, Antineoplastic - pharmacology | Receptor, ErbB-2 - antagonists & inhibitors | Receptor, ErbB-2 - immunology | Phosphorylation - drug effects | Neoplasm Proteins - genetics | Receptor, ErbB-2 - biosynthesis | Antibodies, Monoclonal - pharmacology | Etoposide - pharmacology | Combined Modality Therapy | Adenocarcinoma - drug therapy | Breast Neoplasms - drug therapy | Antineoplastic Agents, Alkylating - therapeutic use | Drug Synergism | Antimetabolites, Antineoplastic - therapeutic use | Adenocarcinoma - therapy | Antibiotics, Antineoplastic - therapeutic use | Mice, Nude | Cyclophosphamide - pharmacology | Immunization, Passive | Fluorouracil - pharmacology | Mice | Cell Cycle - drug effects | Trastuzumab | Neoplasm Transplantation | Paclitaxel - pharmacology | Antibiotics, Antineoplastic - pharmacology | Antineoplastic Agents, Alkylating - pharmacology | Transplantation, Heterologous | Fluorouracil - antagonists & inhibitors | Cyclophosphamide - therapeutic use | Breast Neoplasms - therapy | Antibodies, Monoclonal, Humanized | Fluorouracil - therapeutic use | Protein Processing, Post-Translational - drug effects | Female | Antineoplastic Agents - pharmacology | Thiotepa - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Neoplasm Proteins - biosynthesis | Etoposide - therapeutic use | Treatment Outcome | Cisplatin - pharmacology | Recombinant Proteins - pharmacology | Paclitaxel - therapeutic use | Neoplasms, Hormone-Dependent - therapy | Animals | Breast Neoplasms - pathology | Neoplasms, Hormone-Dependent - pathology | Vinblastine - pharmacology | Neoplasms, Hormone-Dependent - drug therapy | Doxorubicin - pharmacology | Drug Screening Assays, Antitumor
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 12/2001, Volume 276, Issue 50, pp. 47107 - 47115
Journal Article
American Journal of Respiratory Cell and Molecular Biology, ISSN 1044-1549, 07/2011, Volume 45, Issue 1, pp. 111 - 119
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 02/2012, Volume 11, Issue 2, pp. 427 - 438
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2008, Volume 105, Issue 49, pp. 19306 - 19311
Journal Article
International Journal of Cancer, ISSN 0020-7136, 08/2008, Volume 123, Issue 3, pp. 552 - 560
Genistein is a phytoestrogen that has been reported to suppress the AKT signaling pathway in several malignancies. However, the molecular mechanism of... 
genistein | prostate cancer | tumor suppressor gene | Prostate cancer | Genistein | Tumor suppressor gene | APOPTOSIS | METHYLATION | PROTEIN-KINASE | TRANSCRIPTION | SIRT1 | FACULTATIVE HETEROCHROMATIN | CYLD | ONCOLOGY | SIGNALING PATHWAY | NF-KAPPA-B | EXPRESSION | PTEN Phosphohydrolase - drug effects | Prostatic Neoplasms - metabolism | Deubiquitinating Enzyme CYLD | CpG Islands - drug effects | Humans | Male | NF-kappa B - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Genes, Tumor Suppressor - drug effects | Genes, p53 - drug effects | Prostatic Neoplasms - genetics | Chromatin Immunoprecipitation | Forkhead Transcription Factors - metabolism | Sirtuin 1 | Antimetabolites, Antineoplastic - pharmacology | Electrophoretic Mobility Shift Assay | Gene Expression Regulation, Neoplastic - drug effects | Chromones - pharmacology | Anticarcinogenic Agents - pharmacology | Hydroxamic Acids - pharmacology | Phytoestrogens - pharmacology | Prostatic Neoplasms - drug therapy | PTEN Phosphohydrolase - genetics | Tumor Suppressor Proteins - metabolism | Enzyme Inhibitors - pharmacology | Morpholines - pharmacology | PTEN Phosphohydrolase - metabolism | Azacitidine - analogs & derivatives | Down-Regulation - drug effects | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Histones - drug effects | Gene Expression Regulation - drug effects | Up-Regulation - drug effects | Azacitidine - pharmacology | Acetylation - drug effects | Methylation - drug effects | Genistein - pharmacology | Cell Line, Tumor | Protein Kinase Inhibitors - pharmacology | Histones - metabolism | Forkhead Box Protein O3 | Sirtuins - metabolism | NF-kappa B - drug effects | Index Medicus
Journal Article
Cancer Chemotherapy and Pharmacology, ISSN 0344-5704, 3/2009, Volume 63, Issue 4, pp. 691 - 701
Cannabinoids (CBs) have been found to exert antiproliferative effects upon a variety of cancer cells, including colorectal carcinoma cells. However, little is... 
Cannabinoids | Biomedicine | 5-Fluorouracil | Polyunsaturated fatty acids | Colorectal cancer | Cancer Research | Oncology | Cytotoxicity | Pharmacology/Toxicology | MOLECULAR CHARACTERIZATION | ACTIVATION | TUMOR ANGIOGENESIS | CERAMIDE | CANCER | ONCOLOGY | VANILLOID RECEPTORS | NITRIC-OXIDE | PHARMACOLOGY & PHARMACY | ARACHIDONYLETHANOLAMIDE ANANDAMIDE | ADENYLATE-CYCLASE | EXPRESSION | Adenocarcinoma - pathology | Oxidative Stress | Cannabinoid Receptor Antagonists | Colonic Neoplasms - drug therapy | Humans | Nitric Oxide Synthase - antagonists & inhibitors | Colonic Neoplasms - metabolism | Receptors, Cannabinoid - metabolism | Adenocarcinoma - metabolism | Neuroprotective Agents - pharmacology | Piperidines - pharmacology | Dronabinol - analogs & derivatives | Antimetabolites, Antineoplastic - pharmacology | Tumor Cells, Cultured | Dronabinol - pharmacology | Drug Therapy, Combination | Cyclic AMP - metabolism | Pyrazoles - pharmacology | Thymidine - metabolism | NG-Nitroarginine Methyl Ester - pharmacology | Cell Survival - drug effects | Enzyme Inhibitors - pharmacology | Fatty Acids, Unsaturated - pharmacology | Antioxidants - pharmacology | Adenocarcinoma - drug therapy | Cannabinoids - pharmacology | Drug Synergism | Colonic Neoplasms - pathology | Cell Proliferation - drug effects | Fluorouracil - pharmacology | Neurosciences | Care and treatment | Carcinoma | Fluorescence | Arachidonic acid | Glycine | Unsaturated fatty acids | Analysis | Nitric oxide | Phenols | Omega-3 fatty acids | Fluorouracil | Cancer | Index Medicus | Basic Medicine | toxikologi | Medical and Health Sciences | Medicin och hälsovetenskap | biokemisk farmakologi | Toxicology | Medicinska och farmaceutiska grundvetenskaper | Farmakologi och toxikologi | Pharmacology and Toxicology
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2012, Volume 109, Issue 19, pp. 7338 - 7343
Chromosomal loci jiggle in place between segregation events in prokaryotic cells and during interphase in eukaryotic nuclei. This motion seems random and is... 
Viscosity | Azides | Enzymes | Yeasts | Sodium | Cell walls | DNA | Genetic loci | Prokaryotic cells | Cytoplasm | Nonthermal fluctuations | Intracellular transport | Active diffusion | Macromolecular motion | COMPLEX FLUIDS | PEPTIDOGLYCAN BIOSYNTHESIS | active diffusion | MULTIDISCIPLINARY SCIENCES | ESCHERICHIA-COLI | macromolecular motion | VISCOELASTIC MODULI | SACCHAROMYCES-CEREVISIAE | LOW-TEMPERATURE | intracellular transport | nonthermal fluctuations | MYOSIN I | DIFFUSION | CELL | RNA-POLYMERASE | Temperature | Chromosomes, Bacterial - genetics | Nucleic Acid Synthesis Inhibitors - pharmacology | Uncoupling Agents - pharmacology | Saccharomyces cerevisiae - genetics | Escherichia coli - drug effects | Saccharomyces cerevisiae - drug effects | Microscopy, Video | Genetic Loci | Time-Lapse Imaging | Saccharomyces cerevisiae - metabolism | Chromosomes, Bacterial - metabolism | Chromosomes, Fungal - metabolism | Adenosine Triphosphate - metabolism | Deoxyglucose - pharmacology | Escherichia coli - metabolism | Diffusion | Antimetabolites - pharmacology | Motion | Enzyme Inhibitors - pharmacology | Algorithms | Chromosomes, Fungal - genetics | Escherichia coli - genetics | 2,4-Dinitrophenol - pharmacology | Kinetics | Rifampin - pharmacology | Sodium Azide - pharmacology | Physiological aspects | Genetic aspects | Research | Chromosomes | Cells | Adenosine triphosphate | Biological Sciences
Journal Article
British Journal of Cancer, ISSN 0007-0920, 05/2002, Volume 86, Issue 10, pp. 1652 - 1657
Journal Article
Leukemia, ISSN 0887-6924, 2001, Volume 15, Issue 6, pp. 875 - 890
Nucleoside analogues (NA) are essential components of AML induction therapy (cytosine arabinoside), effective treatments of lymphoproliferative disorders... 
Nucleoside transporters | 5′-nucleotidase | Drug resistance | Nucleoside analogues | HUMAN CYTIDINE DEAMINASE | nucleoside transporters | COLONY-STIMULATING FACTOR | DOSE ARA-C | ACUTE MYELOGENOUS LEUKEMIA | MITOCHONDRIAL DEOXYGUANOSINE KINASE | 5'-nucleotidase | ACUTE MYELOID-LEUKEMIA | PROGRAMMED CELL-DEATH | P53 GENE MUTATION | ONCOLOGY | ACUTE LYMPHOBLASTIC-LEUKEMIA | nucleoside analogues | CHRONIC LYMPHOCYTIC-LEUKEMIA | drug resistance | HEMATOLOGY | Deoxycytidine - chemistry | Antimetabolites, Antineoplastic - pharmacokinetics | DNA Replication - drug effects | Neoplastic Stem Cells - drug effects | 2-Chloroadenosine - pharmacology | Humans | 2-Chloroadenosine - analogs & derivatives | Biological Transport | Dioxolanes - pharmacology | Antimetabolites, Antineoplastic - pharmacology | Cytosine - pharmacology | Acute Disease | DNA Repair - drug effects | Arabinonucleosides - pharmacology | Antimetabolites, Antineoplastic - chemistry | Remission Induction | Phosphotransferases (Alcohol Group Acceptor) - metabolism | Leukemia, Myeloid - drug therapy | Antimetabolites, Antineoplastic - therapeutic use | Cytarabine - chemistry | Cytidine Deaminase - metabolism | Hematopoietic Cell Growth Factors - pharmacology | Vidarabine - chemistry | Deoxycytidine - analogs & derivatives | Cytosine - analogs & derivatives | Deoxyadenosines - chemistry | Phosphorylation | Cytarabine - pharmacology | Nucleosides - pharmacokinetics | Deoxycytidine - pharmacology | Deoxycytidine Kinase - metabolism | 2-Chloroadenosine - chemistry | Nucleosides - pharmacology | Nucleosides - therapeutic use | Nucleosides - chemistry | Arabinonucleosides - chemistry | Vidarabine - analogs & derivatives | Cytosine - chemistry | Dioxolanes - chemistry | Vidarabine - pharmacology | Animals | Carrier Proteins - metabolism | Ribonucleotide Reductases - antagonists & inhibitors | Ribonucleotide Reductases - metabolism | Lymphoproliferative Disorders - drug therapy | DNA-Directed DNA Polymerase - metabolism | Deoxyadenosines - pharmacology | 5'-Nucleotidase - metabolism | Drug Resistance, Neoplasm - physiology
Journal Article