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Life sciences (1973), ISSN 0024-3205, 2005, Volume 78, Issue 5, pp. 442 - 453
.... Historically marine natural products have largely been explored as anticancer agents. The indole alkaloids are a class of marine natural products that show unique promise in the development of new drug leads... 
Indole alkaloids | Bioactive marine natural products | New drug leads | MISCELLANEOUS MECHANISMS | MEDICINE, RESEARCH & EXPERIMENTAL | indole alkaloids | BETA-CARBOLINES | BIS-INDOLE | NERVOUS SYSTEMS | ANTIVIRAL ACTIVITIES | new drug leads | SPONGE | TUNICATE | EUDISTOMINS | PHARMACOLOGY & PHARMACY | ANTIFUNGAL | DEEP-WATER | bioactive marine natural products | Anti-Infective Agents - isolation & purification | Serotonin Agents - isolation & purification | Anti-Infective Agents - pharmacology | Humans | Parasitic Diseases - drug therapy | Neoplasms - prevention & control | Neuroprotective Agents - pharmacology | Antineoplastic Agents - isolation & purification | Anti-Infective Agents - chemistry | Enzyme Inhibitors - chemistry | Antiparasitic Agents - isolation & purification | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Alkaloids - pharmacology | Neuroprotective Agents - chemistry | Enzyme Inhibitors - pharmacology | Nervous System Diseases - drug therapy | Antineoplastic Agents - chemistry | Enzyme Inhibitors - isolation & purification | Neoplasms - drug therapy | Biological Products - chemistry | Nervous System Diseases - prevention & control | Animals | Serotonin Agents - chemistry | Serotonin Agents - pharmacology | Neuroprotective Agents - isolation & purification | Antiparasitic Agents - pharmacology | Alkaloids - therapeutic use | Indoles - therapeutic use | Indoles - chemistry | Alkaloids - chemistry | Antiparasitic Agents - chemistry | Antimitotic agents | Alkaloids | Care and treatment | Antineoplastic agents | Cancer
Journal Article
Journal Article
Cancer Chemotherapy and Pharmacology, ISSN 0344-5704, 8/2011, Volume 68, Issue 2, pp. 445 - 455
The natural flavonoid fisetin was recently identified as a lead compound that stabilizes endothelial cell microtubules. In this study, we investigated the... 
Fisetin | Lewis lung carcinoma | Angiogenesis | Antitumour activity | Cyclophosphamide | Medicine & Public Health | Cancer Research | Oncology | Cytotoxicity | EA·hy 926 endothelial cells | Pharmacology/Toxicology | Flavonoid | EA•hy 926 endothelial cells | APOPTOSIS | ANTIINFLAMMATORY ACTIVITY | CELL-CYCLE ARREST | PROLIFERATION | FLUOROURACIL | CANCER | IN-VITRO | ONCOLOGY | ENDOTHELIAL-CELLS | PHARMACOLOGY & PHARMACY | EA.hy 926 endothelial cells | INHIBITORS | NIH 3T3 Cells | Cyclophosphamide - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Tubulin Modulators - pharmacology | Humans | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Antineoplastic Agents, Alkylating - pharmacology | Flavonoids - adverse effects | Antineoplastic Agents, Alkylating - administration & dosage | Cyclophosphamide - adverse effects | Cyclophosphamide - therapeutic use | Flavonoids - therapeutic use | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Angiogenesis Inhibitors - administration & dosage | Antineoplastic Agents, Phytogenic - administration & dosage | Angiogenesis Inhibitors - therapeutic use | Flavonoids - administration & dosage | Tubulin Modulators - administration & dosage | Female | Flavonoids - pharmacology | Antineoplastic Agents, Phytogenic - therapeutic use | Angiogenesis Inhibitors - adverse effects | Antineoplastic Agents, Phytogenic - adverse effects | Cell Line | Cell Survival - drug effects | Tubulin Modulators - adverse effects | Mice, Inbred C57BL | Angiogenesis Inhibitors - pharmacology | Tubulin Modulators - therapeutic use | Carcinoma, Lewis Lung - drug therapy | Antineoplastic Agents, Alkylating - therapeutic use | Cell Movement - drug effects | Animals | Tumor Burden - drug effects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Endothelial Cells - cytology | Neovascularization, Pathologic - drug therapy | Cyclophosphamide - pharmacology | Carcinoma, Lewis Lung - pathology | Cell Proliferation - drug effects | Mice | Antineoplastic Agents, Alkylating - adverse effects | Antineoplastic Agents, Phytogenic - pharmacology | Cell Cycle - drug effects | Endothelial Cells - drug effects | Antimitotic agents | Flavonoids | Flavones | Lung cancer | Bioflavonoids | Accountants | Drug therapy, Combination | Universities and colleges | Antineoplastic agents | Endothelium | Tumors | Index Medicus | cytology | Antineoplastic Agents, Phytogenic | pathology | Cell Proliferation | Endothelial Cells | Tubulin Modulators | Neovascularization, Pathologic | fisetin | administration & dosage | pharmacology | flavonoid | Carcinoma, Lewis Lung | Antineoplastic Agents, Alkylating | cytotoxicity | drug therapy | Cell Survival | angiogenesis | Antineoplastic Combined Chemotherapy Protocols | drug effects | Tumor Burden | Angiogenesis Inhibitors | EA.hy 926 | Cell Cycle | antitumour activity | adverse effects | therapeutic use | Cell Movement
Journal Article
Journal Article