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Mini reviews in medicinal chemistry, ISSN 1389-5575, 2016, Volume 16, Issue 2, pp. 113 - 141
The coumarin (benzopyran-2-one, or chromen-2-one) ring system, present in many natural products, displays diverse pharmacological properties. It has attracted... 
Antimicrobial | Pharmacological properties | Anticonvulsant | Anticancer | Antioxidant | Anti-inflammatory | Coumarin | MAO inhibitory | ANTIOXIDANT ACTIVITY | antimicrobial | antioxidant | 3-ARYLCOUMARINS SYNTHESIS | ANTIINFLAMMATORY ACTIVITY | CHEMISTRY, MEDICINAL | anticonvulsant | coumarin | INHIBITORY-ACTIVITY | pharmacological properties | ANTICONVULSANT AGENTS | IN-VITRO | anti-inflammatory | BIOLOGICAL EVALUATION | DERIVATIVES | HYBRIDS | Anti-HIV Agents - pharmacology | Antitubercular Agents - chemical synthesis | Antitubercular Agents - chemistry | Anti-Infective Agents - pharmacology | Humans | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Coumarins - chemistry | Monoamine Oxidase Inhibitors - chemical synthesis | Anti-HIV Agents - chemical synthesis | Anticonvulsants - pharmacology | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Anti-Infective Agents - chemistry | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Monoamine Oxidase Inhibitors - pharmacology | Antineoplastic Agents, Phytogenic - chemical synthesis | Anticonvulsants - chemical synthesis | Antitubercular Agents - pharmacology | Antineoplastic Agents, Phytogenic - chemistry | Anti-Infective Agents - chemical synthesis | Coumarins - pharmacology | Anti-HIV Agents - chemistry | Animals | Anticonvulsants - chemistry | Coumarins - chemical synthesis | Monoamine Oxidase Inhibitors - chemistry | Antineoplastic Agents, Phytogenic - pharmacology
Journal Article
Journal Article
Current pharmaceutical design, ISSN 1381-6128, 04/2008, Volume 14, Issue 10, pp. 1001 - 1047
Amidoximes are compounds bearing both a hydroxyimino and an amino group at the same carbon atom which makes them versatile building blocks for the synthesis of various heterocycles... 
Amidines | Biological activities | Prodrugs | Amidoximes | NO donors | amidines | DIRECT THROMBIN INHIBITOR | SOLID-PHASE SYNTHESIS | NITRIC-OXIDE SYNTHASE | STRAND DNA OLIGOMERS | HUMAN LIVER-MICROSOMES | prodrugs | METABOLIC N-HYDROXYLATION | biological activities | amidoximes | PHARMACOLOGY & PHARMACY | SMOOTH-MUSCLE-CELLS | CARINII PNEUMONIA ACTIVITY | HYDROXY-L-ARGININE | FACTOR XA INHIBITOR | Antihypertensive Agents - pharmacology | Nitric Oxide Donors - chemistry | Antioxidants - chemistry | Anti-Arrhythmia Agents - pharmacology | Anti-Infective Agents - pharmacology | Antineoplastic Agents - chemical synthesis | Humans | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Prodrugs - chemistry | Anti-Allergic Agents - pharmacology | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Platelet Aggregation Inhibitors - chemical synthesis | Anti-Allergic Agents - chemical synthesis | Anti-Infective Agents - chemistry | Anti-Allergic Agents - chemistry | Platelet Aggregation Inhibitors - pharmacology | Antineoplastic Agents - pharmacology | Nitric Oxide Donors - pharmacology | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Central Nervous System Agents - chemistry | Pesticides - chemical synthesis | Anti-Arrhythmia Agents - chemistry | Antihypertensive Agents - chemical synthesis | Antioxidants - chemical synthesis | Antioxidants - pharmacology | Oximes - chemical synthesis | Antineoplastic Agents - chemistry | Anti-Infective Agents - chemical synthesis | Oximes - chemistry | Antihypertensive Agents - chemistry | Anti-Arrhythmia Agents - chemical synthesis | Central Nervous System Agents - pharmacology | Platelet Aggregation Inhibitors - chemistry | Oximes - pharmacology | Pesticides - chemistry | Prodrugs - chemical synthesis | Nitric Oxide Donors - chemical synthesis | Central Nervous System Agents - chemical synthesis | Prodrugs - pharmacology | Pesticides - pharmacology
Journal Article
Drug discovery today, ISSN 1359-6446, 2015, Volume 20, Issue 5, pp. 595 - 601
Journal Article
Current medicinal chemistry, ISSN 0929-8673, 07/2007, Volume 14, Issue 17, pp. 1829 - 1852
Journal Article
European journal of medicinal chemistry, ISSN 0223-5234, 2015, Volume 89, pp. 743 - 816
The biological activity of Mannich bases, a structurally heterogeneous class of chemical compounds that are generated from various substrates through the introduction of an aminomethyl function... 
Aminomethylation | Drug design | Mannich bases | Structure–activity relationships | Biological activity | Structure-activity relationships | Structureeactivity relationships | CHEMISTRY, MEDICINAL | ANTIMICROBIAL ACTIVITY EVALUATION | ONE-POT SYNTHESIS | STATE ANALOG INHIBITORS | B VIRUS ACTIVITIES | ANTIMYCOBACTERIAL AGENTS ANALOGS | DOXORUBICIN-FORMALDEHYDE CONJUGATE | CORRESPONDING AZINE DERIVATIVES | REGIOSELECTIVE REACTION SYNTHESIS | MYCOBACTERIUM-TUBERCULOSIS ISOCITRATE | CYTOTOXIC ACTIVITY EVALUATION | Analgesics - pharmacology | Antioxidants - chemistry | Antineoplastic Agents - chemical synthesis | Humans | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Antifungal Agents - chemical synthesis | Antifungal Agents - chemistry | Anticonvulsants - pharmacology | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Mannich Bases - chemical synthesis | Analgesics - chemical synthesis | Antiviral Agents - chemistry | Anti-Bacterial Agents - chemistry | Drug Design | Mannich Bases - pharmacology | Antineoplastic Agents - pharmacology | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Antimalarials - chemical synthesis | Antifungal Agents - pharmacology | Antiviral Agents - pharmacology | Anticonvulsants - chemical synthesis | Antioxidants - chemical synthesis | Antioxidants - pharmacology | Antineoplastic Agents - chemistry | Chemistry, Pharmaceutical | Mannich Bases - chemistry | Antimalarials - pharmacology | Anti-Bacterial Agents - chemical synthesis | Animals | Analgesics - chemistry | Anticonvulsants - chemistry | Antimalarials - chemistry | Antiviral Agents - chemical synthesis | Anti-Bacterial Agents - pharmacology | Antioxidants | Antiviral agents | Enzymes | Mental illness | Bases (Chemistry)
Journal Article
Molecules (Basel, Switzerland), ISSN 1420-3049, 2016, Volume 21, Issue 3, p. 264
Nowadays, there are some molecules that have shown over the years a high capacity to act against relevant pathologies such as cardiovascular disease,... 
Lung diseases | Liver disorders | ROS | Curcumin | Bioavailability | Natural compound | Antioxidant | Cardiovascular diseases | Anti-inflammatory | Cancer | lung diseases | antioxidant | OXIDATIVE STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | natural compound | CHEMOPREVENTIVE AGENT CURCUMIN | cardiovascular diseases | ALLERGIC AIRWAY INFLAMMATION | INDUCED LIPID-PEROXIDATION | I CLINICAL-TRIAL | CHEMISTRY, MULTIDISCIPLINARY | HUMAN COLORECTAL-CANCER | TUMOR-NECROSIS-FACTOR | bioavailability | liver disorders | INDUCED PULMONARY-FIBROSIS | anti-inflammatory | cancer | GLUTATHIONE-S-TRANSFERASE | NF-KAPPA-B | curcumin | Neuroprotective Agents - therapeutic use | Cardiovascular Diseases - drug therapy | Humans | Biological Availability | Curcumin - chemical synthesis | Neurodegenerative Diseases - drug therapy | Cardiotonic Agents - therapeutic use | Cardiotonic Agents - chemical synthesis | Anti-Inflammatory Agents - therapeutic use | Anti-Inflammatory Agents - isolation & purification | Antineoplastic Agents, Phytogenic - therapeutic use | Antineoplastic Agents, Phytogenic - chemical synthesis | Curcumin - therapeutic use | Curcumin - isolation & purification | Inflammation | Antioxidants - chemical synthesis | Neoplasms - drug therapy | Antioxidants - therapeutic use | Neuroprotective Agents - chemical synthesis | Animals | Cardiotonic Agents - isolation & purification | Neuroprotective Agents - isolation & purification | Antioxidants - isolation & purification | Anti-Inflammatory Agents - chemical synthesis | Plants, Medicinal | Antineoplastic Agents, Phytogenic - isolation & purification | Curcuma - chemistry
Journal Article
Molecules (Basel, Switzerland), ISSN 1420-3049, 08/2016, Volume 21, Issue 8, p. 1054
.... There are different available methods for the synthesis of thiazine derivatives in the literature. In this review, we discuss available methods of thiazine preparation through green synthesis methods... 
Antibacterial activity | Green synthesis | Biologically active | Anticancer agents | Thiazine | antibacterial activity | ONE-POT SYNTHESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | green synthesis | 1,3-THIAZINE DERIVATIVES | CHEMISTRY, MULTIDISCIPLINARY | biologically active | anticancer agents | NEUTROPHIL RESPIRATORY BURST | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | BIOLOGICAL-ACTIVITY | CANNABINOID RECEPTOR AGONISTS | IMMUNODEFICIENCY VIRUS FIV | MICROWAVE-ASSISTED SYNTHESIS | ALDOSE REDUCTASE | ANTIMICROBIAL ACTIVITY | thiazine | Analgesics - pharmacology | Antineoplastic Agents - chemical synthesis | Humans | Antifungal Agents - chemical synthesis | Antifungal Agents - chemistry | Structure-Activity Relationship | Analgesics - chemical synthesis | Antiviral Agents - chemistry | Anti-Bacterial Agents - chemistry | Thiazines - pharmacology | Antineoplastic Agents - pharmacology | Molecular Structure | Antimalarials - chemical synthesis | Antifungal Agents - pharmacology | Green Chemistry Technology | Antiviral Agents - pharmacology | Anti-Inflammatory Agents - pharmacology | Antineoplastic Agents - chemistry | Thiazines - chemical synthesis | Thiazines - chemistry | Antimalarials - pharmacology | Anti-Bacterial Agents - chemical synthesis | Anti-Inflammatory Agents - chemistry | Analgesics - chemistry | Antimalarials - chemistry | Antiviral Agents - chemical synthesis | Anti-Bacterial Agents - pharmacology | Anti-Inflammatory Agents - chemical synthesis
Journal Article