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Journal Article
Nature, ISSN 0028-0836, 08/2010, Volume 466, Issue 7309, pp. 935 - 940
Despite the success of genomics in identifying new essential bacterial genes, there is a lack of sustainable leads in antibacterial drug discovery to address... 
BREAKAGE-REUNION DOMAIN | B-PROTEIN | BAD BUGS | MECHANISM | COLI DNA GYRASE | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | FUSION PROTEIN | INFECTIOUS-DISEASES-SOCIETY | CLEAVAGE | Staphylococcus aureus - enzymology | Crystallography, X-Ray | Structure-Activity Relationship | Quinolines - pharmacology | Quinolones - chemistry | Anti-Bacterial Agents - chemistry | Topoisomerase II Inhibitors | Apoenzymes - metabolism | DNA, Superhelical - chemistry | Drug Design | Binding Sites | Ciprofloxacin - metabolism | Drug Resistance | Catalytic Domain | Escherichia coli - enzymology | DNA Gyrase - chemistry | Quinolines - chemistry | Quinolones - metabolism | Models, Molecular | Anti-Bacterial Agents - metabolism | DNA - metabolism | Quinolines - metabolism | DNA Gyrase - metabolism | DNA - chemistry | Manganese - metabolism | Apoenzymes - chemistry | Ciprofloxacin - chemistry | Aspartic Acid - metabolism | Protein Conformation | Anti-Bacterial Agents - pharmacology | DNA, Superhelical - metabolism | Arginine - metabolism | DNA Cleavage | Antimitotic agents | Enzymes | Drug resistance in microorganisms | Topoisomerases | DNA | Genes | Research | Properties | Antineoplastic agents | Antibacterial agents | Staphylococcus aureus | Bacteria | Mutation | E coli | Deoxyribonucleic acid--DNA | Streptococcus infections | Index Medicus
Journal Article
Journal Article
Journal Article
Science, ISSN 0036-8075, 5/2009, Volume 324, Issue 5928, pp. 787 - 790
Metastatic prostate cancer is treated with drugs that antagonize androgen action, but most patients progress to a more aggressive form of the disease called... 
COS cells | Androgens | Cell lines | Agonists | Oncology | Reports | Androgen antagonists | Prostate cancer | Heterologous transplantation | Tumors | Vehicles | NONSTEROIDAL ANTIANDROGENS | STRUCTURAL BASIS | AFFINITY | MULTIDISCIPLINARY SCIENCES | ANDROGEN-RECEPTOR | RESISTANCE | ANTAGONISM | LIGAND | MODEL | BICALUTAMIDE | Transcription, Genetic - drug effects | Nitriles - pharmacology | Phenylthiohydantoin - therapeutic use | Humans | Receptors, Androgen - metabolism | Biological Availability | Male | Antineoplastic Agents - therapeutic use | Tosyl Compounds - pharmacology | Antineoplastic Agents - metabolism | Cell Nucleus - metabolism | Receptors, Androgen - chemistry | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Prostatic Neoplasms - drug therapy | Androgen Antagonists - pharmacokinetics | Phenylthiohydantoin - pharmacology | Nitriles - metabolism | Prostatic Neoplasms - pathology | Androgen Antagonists - metabolism | Androgen Antagonists - pharmacology | Anilides - metabolism | DNA - metabolism | Phenylthiohydantoin - analogs & derivatives | Xenograft Model Antitumor Assays | Animals | Receptors, Androgen - genetics | Anilides - pharmacology | Tosyl Compounds - metabolism | Androgen Antagonists - therapeutic use | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Phenylthiohydantoin - metabolism | Drug Screening Assays, Antitumor | Phenylthiohydantoin - pharmacokinetics | Care and treatment | Antiandrogens | Dosage and administration | Drug therapy | Methods | Cancer | Chemotherapy | Pharmacology | Binding sites | Index Medicus
Journal Article
Blood, ISSN 0006-4971, 11/2012, Volume 120, Issue 23, pp. 4621 - 4634
The nuclear export protein XPO1 is overexpressed in cancer, leading to the cytoplasmic mislocalization of multiple tumor suppressor proteins. Existing... 
ANTICANCER ACTIVITY | APOPTOSIS | TRANSPORT | PROTEIN | MECHANISM | RITUXIMAB | DRUG-RESISTANCE | CELL-SURVIVAL | CRM1 | HEMATOLOGY | EXPRESSION | Triazoles - chemistry | Humans | Crystallography, X-Ray | Immunoblotting | Leukemia, Lymphocytic, Chronic, B-Cell - genetics | Antineoplastic Agents - metabolism | RNA Interference | T-Lymphocytes - metabolism | Acrylates - metabolism | T-Lymphocytes - drug effects | Acrylates - pharmacology | Receptors, Cytoplasmic and Nuclear - chemistry | Interleukin-10 - metabolism | Antineoplastic Agents - pharmacology | Molecular Structure | Interleukin-6 - metabolism | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | Cell Survival - drug effects | Acrylates - chemistry | Karyopherins - chemistry | Cells, Cultured | Models, Molecular | Mice, Transgenic | Proto-Oncogene Proteins - genetics | Receptors, Cytoplasmic and Nuclear - genetics | Antineoplastic Agents - chemistry | Mice, SCID | Reverse Transcriptase Polymerase Chain Reaction | Triazoles - pharmacology | Microscopy, Confocal | Triazoles - metabolism | Animals | Karyopherins - metabolism | Active Transport, Cell Nucleus - drug effects | Leukemia, Lymphocytic, Chronic, B-Cell - metabolism | Cell Line, Tumor | Karyopherins - genetics | Protein Binding | Mice | Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy | Receptors, Cytoplasmic and Nuclear - metabolism | Index Medicus | Abridged Index Medicus | Lymphoid Neoplasia
Journal Article
ACS Nano, ISSN 1936-0851, 12/2017, Volume 11, Issue 12, pp. 12134 - 12144
Journal Article
Journal Article
Journal of Photochemistry & Photobiology, B: Biology, ISSN 1011-1344, 09/2016, Volume 162, pp. 298 - 308
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2012, Volume 109, Issue 30, pp. 11987 - 11992
Monofunctional platinum(II) complexes of general formula cis-[Pt(NH₃)₂(N-heterocycle)Cl]Cl bind DNA at a single site, inducing little distortion in the double... 
Cell culture techniques | HT29 cells | Reactivity | Platinum | DNA | Cell lines | Antineoplastics | Ligands | Kinetics | Adducts | X-ray crystallography | Metals in medicine | Cancer therapy | DNA damage | Transcription inhibition | cancer therapy | RESPONSES | COMPLEX | CISPLATIN | MULTIDISCIPLINARY SCIENCES | KINETIC CONTROL | metals in medicine | ADDUCTS | CIS-DIAMMINEDICHLOROPLATINUM(II) | transcription inhibition | Phenanthridines - chemistry | Crystallography, X-Ray | Drug Discovery - methods | Platinum Compounds - chemistry | Platinum Compounds - pharmacokinetics | Phenanthridines - pharmacology | Organoplatinum Compounds - pharmacology | Antineoplastic Agents - metabolism | Luciferases | Organoplatinum Compounds - metabolism | Organoplatinum Compounds - pharmacokinetics | Inhibitory Concentration 50 | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Deoxyguanine Nucleotides - metabolism | Molecular Structure | Gene Expression Regulation, Neoplastic - drug effects | Organoplatinum Compounds - chemistry | Phenanthridines - pharmacokinetics | Models, Molecular | DNA - metabolism | Antineoplastic Agents - chemistry | Genetic Vectors | Phenanthridines - metabolism | Platinum Compounds - pharmacology | Platinum Compounds - metabolism | Antimitotic agents | Composition | Platinum compounds | Physiological aspects | Genetic aspects | DNA binding proteins | Research | Antineoplastic agents | Health aspects | Pharmaceutical chemistry | Chemistry | RNA polymerase | Chemical compounds | Deoxyribonucleic acid--DNA | Binding sites | Pharmaceuticals | Index Medicus | Biological Sciences | Physical Sciences
Journal Article
Journal Article