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Journal Article
Cell Stem Cell, ISSN 1934-5909, 03/2009, Volume 4, Issue 3, pp. 226 - 235
In normal brain, the side population (SP) phenotype is generated by ABC transporter activity and identifies stem cell and endothelial cell subpopulations by... 
STEMCELL | SURVIVAL | TRANSPORTER | PLASMA | DISTINCT | MULTIDRUG-RESISTANCE | EXPRESSION | TEMOZOLOMIDE | CELL & TISSUE ENGINEERING | CELL BIOLOGY | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Neoplastic Stem Cells - drug effects | Humans | Antineoplastic Agents, Alkylating - pharmacology | Drug Resistance, Neoplasm | Phosphatidylinositol 3-Kinases - metabolism | Neoplasm Proteins - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Glioma - metabolism | Brain - metabolism | Neoplastic Stem Cells - metabolism | Dacarbazine - pharmacology | Glioma - pathology | Dacarbazine - analogs & derivatives | ATP-Binding Cassette Transporters - metabolism | Neoplastic Stem Cells - pathology | Antineoplastic Agents - pharmacology | Chromones - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | PTEN Phosphohydrolase - genetics | Cells, Cultured | Dacarbazine - metabolism | Enzyme Inhibitors - pharmacology | Glioma - chemically induced | Morpholines - pharmacology | PTEN Phosphohydrolase - metabolism | Platelet-Derived Growth Factor - pharmacology | Blood-Brain Barrier - metabolism | Animals | Mice, Nude | Brain - pathology | Mice | Mitoxantrone - pharmacology | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Antineoplastic Agents, Alkylating - metabolism | Index Medicus | PTEN | Akt | Glioma | Side Population | ABCG2
Journal Article
Lancet Oncology, The, ISSN 1470-2045, 2008, Volume 9, Issue 5, pp. 453 - 461
Summary Since the introduction of chemoradiotherapy with temozolomide as the new standard of care for patients with glioblastoma, there has been an increasing... 
Hematology, Oncology and Palliative Medicine | POSITRON-EMISSION-TOMOGRAPHY | MAGNETIC-RESONANCE-SPECTROSCOPY | WHOLE-BRAIN IRRADIATION | STEREOTACTIC RADIOSURGERY | ONCOLOGY | GLIOBLASTOMA-MULTIFORME | CENTRAL-NERVOUS-SYSTEM | HYPERFRACTIONATED RADIATION-THERAPY | IONIZING-RADIATION | CEREBRAL RADIONECROSIS | ENDOTHELIAL GROWTH-FACTOR | Apoptosis - drug effects | Apoptosis - radiation effects | Dacarbazine - therapeutic use | Humans | Brain Neoplasms - pathology | DNA Repair Enzymes - genetics | Gene Expression Regulation, Neoplastic | Vascular Endothelial Growth Factor A - metabolism | Glioma - radiotherapy | Necrosis | Patient Selection | Diagnostic Imaging - methods | Glioma - genetics | Neoplasm Recurrence, Local - pathology | Chemotherapy, Adjuvant - adverse effects | Radiotherapy, Adjuvant - adverse effects | Glioma - pathology | Tumor Suppressor Proteins - genetics | DNA Repair Enzymes - metabolism | Dacarbazine - analogs & derivatives | Brain Neoplasms - radiotherapy | Radiation Injuries - therapy | Acute Disease | Brain Neoplasms - enzymology | Diagnosis, Differential | Tumor Suppressor Proteins - metabolism | Glioma - enzymology | Brain Edema - etiology | DNA Modification Methylases - metabolism | Risk Assessment | Brain Edema - pathology | Dacarbazine - metabolism | Brain Neoplasms - genetics | Endothelial Cells - radiation effects | Treatment Outcome | Brain Edema - therapy | Brain Neoplasms - drug therapy | Disease Progression | Radiation Injuries - etiology | Gene Expression Regulation, Enzymologic | Magnetic Resonance Imaging | DNA Modification Methylases - genetics | Radiation Injuries - pathology | Antineoplastic Agents, Alkylating - adverse effects | Endothelial Cells - pathology | Glioma - drug therapy | Antineoplastic Agents, Alkylating - metabolism | Endothelial Cells - drug effects | Development and progression | Chemotherapy | Permeability | Gliomas | Cancer | Index Medicus
Journal Article
Journal Article
International Journal of Pharmaceutics, ISSN 0378-5173, 07/2018, Volume 545, Issue 1-2, pp. 84 - 92
Journal Article
Journal Article
Biochemistry, ISSN 0006-2960, 02/2017, Volume 56, Issue 6, pp. 805 - 808
The biosynthesis of the azabicyclic ring system of the azinomycin family of antitumor agents represents the “crown jewel” of the pathway and is a complex... 
DOMAIN | NAPHTHOATE | CARZINOPHILIN | MECHANISM | POLYKETIDE SYNTHASE | THIOESTERASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | THERMUS-THERMOPHILUS | SEQUENCE SELECTIVITY | Azabicyclo Compounds - pharmacology | Phosphotransferases (Carboxyl Group Acceptor) - genetics | Antibiotics, Antineoplastic - pharmacology | Substrate Specificity | Antineoplastic Agents, Alkylating - pharmacology | Phosphotransferases (Carboxyl Group Acceptor) - metabolism | Amino-Acid N-Acetyltransferase - metabolism | Azabicyclo Compounds - chemistry | Azabicyclo Compounds - metabolism | Pyrrolidines - pharmacology | Streptomyces - metabolism | Peptides - metabolism | Antibiotics, Antineoplastic - chemistry | Drug Design | Pyrrolidines - metabolism | Molecular Structure | Acetylation | Dipeptides - metabolism | Antineoplastic Agents, Alkylating - chemistry | Naphthalenes - metabolism | Naphthalenes - chemistry | Recombinant Proteins - metabolism | Biocatalysis | Peptides - chemistry | Dipeptides - pharmacology | Bacterial Proteins - genetics | Amino-Acid N-Acetyltransferase - genetics | Aldehyde Oxidoreductases - genetics | Dipeptides - chemistry | Gene Knockout Techniques | Pyrrolidines - chemistry | Acetyl Coenzyme A - metabolism | Aldehyde Oxidoreductases - metabolism | Naphthalenes - pharmacology | Peptides - pharmacology | Bacterial Proteins - metabolism | Streptomyces - enzymology | Glutamic Acid - metabolism | Mutation | Antibiotics, Antineoplastic - metabolism | Antineoplastic Agents, Alkylating - metabolism | Usage | Biosynthesis | Research | Chemical properties | Pyrrole | Antineoplastic antibiotics
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 09/2016, Volume 116, pp. 176 - 187
The clinical stage anti-cancer agent PR-104 has potential utility as a cytotoxic prodrug for exogenous bacterial nitroreductases expressed from replicating... 
Hypoxia | Aldo-keto reductase 1C3 | Prodrug | Oxidoreductase | Alkylation | CB1954 | ANTITUMOR-ACTIVITY | BYSTANDER | ESCHERICHIA-COLI NITROREDUCTASE | PHASE-I TRIAL | KETO REDUCTASE 1C3 | PHARMACOLOGY & PHARMACY | GENE-THERAPY | PRE-PRODRUG | LINKING AGENT PR-104 | Humans | Benzamides - metabolism | Mesylates - metabolism | Prodrugs - chemistry | 3-Hydroxysteroid Dehydrogenases - antagonists & inhibitors | Colorectal Neoplasms - drug therapy | 3-Hydroxysteroid Dehydrogenases - metabolism | Antineoplastic Agents, Alkylating - chemistry | Hydroxyprostaglandin Dehydrogenases - chemistry | Carcinoma - drug therapy | Specific Pathogen-Free Organisms | Organophosphonates - therapeutic use | HCT116 Cells | Enzyme Inhibitors - pharmacology | Mesylates - therapeutic use | Models, Molecular | Recombinant Proteins - chemistry | Random Allocation | Antineoplastic Agents, Alkylating - therapeutic use | Hydroxyprostaglandin Dehydrogenases - antagonists & inhibitors | Nitroreductases - metabolism | Aldo-Keto Reductase Family 1 Member C3 | Mice, Nude | Survival Analysis | 3-Hydroxysteroid Dehydrogenases - chemistry | Molecular Docking Simulation | 3-Hydroxysteroid Dehydrogenases - genetics | Nitroreductases - genetics | Organophosphonates - metabolism | Substrate Specificity | Antineoplastic Agents, Alkylating - pharmacology | Hydroxyprostaglandin Dehydrogenases - metabolism | Prodrugs - metabolism | Benzamides - therapeutic use | Drug Design | Activation, Metabolic - drug effects | Benzamides - pharmacology | Carcinoma - pathology | Colorectal Neoplasms - metabolism | Benzamides - chemistry | Recombinant Proteins - metabolism | Escherichia coli Proteins - metabolism | Mesylates - chemistry | Hydroxyprostaglandin Dehydrogenases - genetics | Xenograft Model Antitumor Assays | Organophosphonates - pharmacology | Animals | Tumor Burden - drug effects | Mesylates - pharmacology | Organophosphonates - chemistry | Escherichia coli Proteins - genetics | Cell Proliferation - drug effects | Prodrugs - therapeutic use | Carcinoma - metabolism | Colorectal Neoplasms - pathology | Prodrugs - pharmacology | Antineoplastic Agents, Alkylating - metabolism | Drug Resistance, Neoplasm - drug effects | Enzymes | Biopharmaceutics
Journal Article