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Cancer Research, ISSN 0008-5472, 08/2017, Volume 77, Issue 15, pp. 4102 - 4115
IDH1-mutant gliomas are dependent upon the canonical coenzyme NAD(+) for survival. It is known that PARP activation consumes NAD(+) during base excision repair... 
GLIOMA-CELLS | IDH2 MUTATIONS | GLIOBLASTOMA | REPAIR | INHIBITION | ONCOLOGY | GENOMIC ANALYSIS | PHENOTYPE | RESISTANCE | MSH6 MUTATIONS | DEHYDROGENASE | Humans | Enzyme Inhibitors - pharmacology | Antineoplastic Agents, Alkylating - pharmacology | Isocitrate Dehydrogenase - genetics | Random Allocation | Mice, SCID | Nicotinamide Phosphoribosyltransferase - antagonists & inhibitors | Glioma - metabolism | Glioma - genetics | NAD | Xenograft Model Antitumor Assays | Animals | Piperidines - pharmacology | Dacarbazine - pharmacology | Dacarbazine - analogs & derivatives | Cell Line, Tumor | Female | Mice | Stress, Physiological - drug effects | Mutation | Acrylamides - pharmacology | NADPH | Toxicity | DNA damage | Genotoxicity | Methyltransferase | Cytotoxicity | Biosynthesis | Activation | DNA repair | Cancer therapies | Base excision repair | Alkylation | Anticancer properties | Pathways | Metabolites | Mismatch repair | Xenografts | Biocompatibility | Phosphoribosyltransferase | Repair | Damage | Deoxyribonucleic acid--DNA | Methylguanine | Poly(ADP-ribose) polymerase | Durability | Metabolism | Chemotherapy | Depletion | Inhibitors | Nicotinamide phosphoribosyltransferase | Cell lines | Metabolic pathways | Nicotinamide | Temozolomide | Cancer | Index Medicus | IDH1 mutation | PARP | NAMPT inhibitor | Glioblastoma
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2014, Volume 111, Issue 1, pp. 409 - 414
Journal Article
Nature, ISSN 0028-0836, 11/2015, Volume 527, Issue 7579, pp. 472 - 476
The role of epithelial-to-mesenchymal transition (EMT) in metastasis is a longstanding source of debate, largely owing to an inability to monitor transient and... 
CANCER-CELLS | STEM-CELLS | THERAPY | MULTIDISCIPLINARY SCIENCES | RESISTANCE | INDUCTION | MODEL | MIR-200 FAMILY | EXPRESSION | BREAST | PLASTICITY | Lung Neoplasms - drug therapy | Apoptosis - drug effects | Antineoplastic Agents, Alkylating - pharmacology | Epithelial-Mesenchymal Transition - drug effects | Lung Neoplasms - pathology | Male | Epithelial-Mesenchymal Transition - genetics | Cyclophosphamide - therapeutic use | Mammary Neoplasms, Experimental - genetics | Cell Tracking | Lung Neoplasms - secondary | Neoplasm Metastasis - drug therapy | Mammary Neoplasms, Experimental - pathology | Female | Disease Models, Animal | Mammary Neoplasms, Experimental - drug therapy | Lung Neoplasms - genetics | Reproducibility of Results | Disease Progression | Antineoplastic Agents, Alkylating - therapeutic use | Cell Lineage | Neoplasm Metastasis - genetics | Drug Resistance, Neoplasm - genetics | Animals | Neoplasm Metastasis - pathology | Cyclophosphamide - pharmacology | Cell Proliferation - drug effects | Mice | MicroRNAs - genetics | Drug Resistance, Neoplasm - drug effects | Development and progression | Metastasis | Drug resistance | Cell differentiation | Health aspects | Lung cancer | Chemotherapy | Analysis | Stem cells | Cancer | Studies | Genotype & phenotype | Transgenic animals | Rodents | Morphology | Fibroblasts | Breast cancer | Cancer therapies | Tumors | Index Medicus
Journal Article
Journal Article
Journal Article
Cell Stem Cell, ISSN 1934-5909, 03/2009, Volume 4, Issue 3, pp. 226 - 235
In normal brain, the side population (SP) phenotype is generated by ABC transporter activity and identifies stem cell and endothelial cell subpopulations by... 
STEMCELL | CANCER-CELLS | SURVIVAL | GLIOBLASTOMA | TRANSPORTER | IN-VIVO | DISTINCT | DRUG-RESISTANCE | MULTIDRUG-RESISTANCE | EXPRESSION | TEMOZOLOMIDE | CELL & TISSUE ENGINEERING | CELL BIOLOGY | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Neoplastic Stem Cells - drug effects | Humans | Antineoplastic Agents, Alkylating - pharmacology | Drug Resistance, Neoplasm | Phosphatidylinositol 3-Kinases - metabolism | Neoplasm Proteins - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Glioma - metabolism | Brain - metabolism | Neoplastic Stem Cells - metabolism | Dacarbazine - pharmacology | Glioma - pathology | Dacarbazine - analogs & derivatives | ATP-Binding Cassette Transporters - metabolism | Neoplastic Stem Cells - pathology | Antineoplastic Agents - pharmacology | Chromones - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | PTEN Phosphohydrolase - genetics | Cells, Cultured | Dacarbazine - metabolism | Enzyme Inhibitors - pharmacology | Glioma - chemically induced | Morpholines - pharmacology | PTEN Phosphohydrolase - metabolism | Platelet-Derived Growth Factor - pharmacology | Blood-Brain Barrier - metabolism | Animals | Mice, Nude | Brain - pathology | Mice | Mitoxantrone - pharmacology | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Antineoplastic Agents, Alkylating - metabolism | Index Medicus | PTEN | Akt | Glioma | Side Population | ABCG2
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2011, Volume 6, Issue 11, pp. e27183 - e27183
First line chemotherapeutics for brain tumors (malignant gliomas) are alkylating agents such as temozolomide and nimustine. Despite growing knowledge of how... 
APOPTOSIS | GLIOBLASTOMA | METHYLTRANSFERASE | O-6-METHYLGUANINE | MGMT | BIOLOGY | DOUBLE-STRAND BREAKS | MISMATCH REPAIR | HOMOLOGOUS RECOMBINATION | DNA-DAMAGE TOLERANCE | TEMOZOLOMIDE | Apoptosis - drug effects | Humans | Brain Neoplasms - pathology | BRCA2 Protein - drug effects | Morpholines - pharmacology | Antineoplastic Agents, Alkylating - pharmacology | Homologous Recombination | Brain Neoplasms - drug therapy | Antineoplastic Agents, Alkylating - therapeutic use | Flow Cytometry | Rad51 Recombinase - drug effects | Base Sequence | Glioma - pathology | Cell Line, Tumor | Protein Kinase Inhibitors - pharmacology | RNA, Small Interfering | DNA Damage | Chromones - pharmacology | Glioma - drug therapy | Microscopy, Fluorescence | Antimitotic agents | Ionizing radiation | Prognosis | RNA | Gliomas | Brain tumors | Genetic aspects | Drug therapy | Antineoplastic agents | Health aspects | Apoptosis | Cancer | Brain | Homologous recombination | Brain cancer | Nervous system | ADP | Cancer therapies | Alkylation | Proteins | Toxicology | Antitumor agents | Inhibition | Deoxyribonucleic acid--DNA | Sensitizing | RNA-mediated interference | Alkylating agents | Gene expression | Patients | Chemotherapy | Phytochemicals | Inhibitors | Ribonucleic acids | Non-homologous end joining | DNA methyltransferase | Temozolomide | Drugs | DNA damage | Homology | Malignancy | DNA repair | O6-methylguanine-DNA methyltransferase | Glioma cells | DNA methylation | BRCA2 protein | Killing | Methylguanine | Cloning | Poly(ADP-ribose) polymerase | I.R. radiation | siRNA | Breast cancer | DNA-dependent protein kinase | Cell death | Strategy | Protein expression | Prostate cancer | Tumors | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 2006, Volume 41, Issue 11, pp. 1301 - 1309
The aim of this research was to examine chemical and biological properties of the products ( – / – , – , – ) of the reaction of methyl chromone-3-carboxylate (... 
Alkylating properties | Phosphorohydrazine | Chromone | Antitumor activity | Antibacterial activity | Tautomerism | Coumarin | antibacterial activity | CHEMISTRY, MEDICINAL | 3-AMINOFLAVONE | coumarin | CIS-DDP | chromone | HYDROGEN-BONDS | tautomerism | phosphorohydrazine | CHROMONE-3-CARBOXYLIC ESTERS | antitumor activity | alkylating properties | CIS-PT(II) COMPLEX | A549 CELLS | X-RAY | AGENTS | TRANSITION-METAL CHEMISTRY | MAIN-GROUP HYDRAZIDES | Antineoplastic Agents, Alkylating - chemical synthesis | Gram-Positive Bacteria - drug effects | Antineoplastic Agents, Alkylating - pharmacology | Coumarins - chemistry | Male | Microbial Sensitivity Tests | Anti-Bacterial Agents - chemistry | Mice, Inbred DBA | Antineoplastic Agents, Alkylating - chemistry | Chromones - pharmacology | Leukemia L1210 - drug therapy | Magnetic Resonance Spectroscopy | Hydrazones - chemical synthesis | Hydrazones - chemistry | Leukemia P388 - drug therapy | Hydrazones - pharmacology | Anti-Bacterial Agents - chemical synthesis | Chromones - chemistry | Coumarins - pharmacology | Gram-Negative Bacteria - drug effects | Animals | Coumarins - chemical synthesis | Anti-Bacterial Agents - pharmacology | Mice | Mice, Inbred BALB C | Chromones - chemical synthesis | Integrated logistic support | Pyridine | Analysis | Leukemia | Dimethyl sulfoxide | Nuclear magnetic resonance spectroscopy | Methotrexate | Enols | Antibacterial agents | Index Medicus
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 12/2016, Volume 15, Issue 12, pp. 3000 - 3014
Journal Article