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Journal of Cellular Physiology, ISSN 0021-9541, 01/2020, Volume 235, Issue 1, pp. 31 - 64
Cytotoxic small‐molecule drugs have a major influence on the fate of antibody–drug conjugates (ADCs). An ideal cytotoxic agent should be highly potent, remain... 
warheads | calicheamicin | payloads | maytansine | auristatin | antibody–drug Conjugate (ADC) | cytotoxic small molecules | Viral antibodies | Antimitotic agents | Architecture | Antibodies | Antineoplastic agents | Health aspects | Biopharmaceutics | Drugs | Conjugates | Tumor cells | Internalization | Clinical trials | Cytotoxicity | Drug development | Payloads
Journal Article
BMC Cancer, ISSN 1471-2407, 03/2019, Volume 19, Issue 1, pp. 255 - 11
Journal Article
Journal Article
Drug Delivery, ISSN 1071-7544, 01/2019, Volume 26, Issue 1, pp. 34 - 44
The addition of temozolomide (TMZ) to radiotherapy (RT) improves survival of patients with glioblastoma (GBM). However, TMZ + RT causes excess toxicity in... 
TMZ | radiosensitized polyprodrug | synergetic therapy | Glioma | angiopep-2 | TUMOR HYPOXIA | DRUG-DELIVERY | CANCER | ADJUVANT TEMOZOLOMIDE | GLIOBLASTOMA | HIGH-DOSE METRONIDAZOLE | GAMMA-H2AX | PHARMACOLOGY & PHARMACY | RADIOTHERAPY PLUS CONCOMITANT | SIRNA | ELDERLY-PATIENTS | Prodrugs - administration & dosage | Antineoplastic Agents, Alkylating - chemical synthesis | Nanoparticles - chemistry | Polylactic Acid-Polyglycolic Acid Copolymer - administration & dosage | Humans | Male | Prodrugs - chemistry | Antineoplastic Agents, Alkylating - administration & dosage | Peptides - administration & dosage | Prodrugs - metabolism | Glioma - metabolism | Peptides - chemical synthesis | Peptides - metabolism | Radiation-Sensitizing Agents - administration & dosage | Nanoparticles - metabolism | Glioma - therapy | Radiation-Sensitizing Agents - chemical synthesis | Polylactic Acid-Polyglycolic Acid Copolymer - chemical synthesis | Xenograft Model Antitumor Assays - methods | Polylactic Acid-Polyglycolic Acid Copolymer - metabolism | Temozolomide - chemical synthesis | Mice, Inbred ICR | Temozolomide - metabolism | Animals | Mice, Nude | Temozolomide - administration & dosage | Radiation-Sensitizing Agents - metabolism | Radiotherapy - methods | Cell Line, Tumor | Combined Modality Therapy - methods | Mice | Nanoparticles - administration & dosage | Drug Delivery Systems - methods | Antineoplastic Agents, Alkylating - metabolism
Journal Article
CANCER CELL INTERNATIONAL, ISSN 1475-2867, 08/2019, Volume 19, Issue 1, pp. 207 - 20
Cancer is one of the leading causes of death around the world and although the different clinical approaches have helped to increase survival rates, incidence... 
OXIDATIVE STRESS | Natural compounds | Multi-target agents | TOPOISOMERASE-II INHIBITION | CELL-CYCLE ARREST | ENDOPLASMIC-RETICULUM STRESS | ANTITUMOR-ACTIVITY | BETA-LAPACHONE | Chemotherapy | IN-VITRO | ONCOLOGY | Cancer drug discovery | Naphthoquinones | 1,4-NAPHTHOQUINONE DERIVATIVES | PYRANONAPHTHOQUINONE DERIVATIVES | ASSAY INTERFERENCE COMPOUNDS
Journal Article
Journal Article