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Cancer Chemotherapy and Pharmacology, ISSN 0344-5704, 8/2011, Volume 68, Issue 2, pp. 445 - 455
The natural flavonoid fisetin was recently identified as a lead compound that stabilizes endothelial cell microtubules. In this study, we investigated the... 
Fisetin | Lewis lung carcinoma | Angiogenesis | Antitumour activity | Cyclophosphamide | Medicine & Public Health | Cancer Research | Oncology | Cytotoxicity | EA·hy 926 endothelial cells | Pharmacology/Toxicology | Flavonoid | EA•hy 926 endothelial cells | APOPTOSIS | ANTIINFLAMMATORY ACTIVITY | CELL-CYCLE ARREST | PROLIFERATION | FLUOROURACIL | CANCER | IN-VITRO | ONCOLOGY | ENDOTHELIAL-CELLS | PHARMACOLOGY & PHARMACY | EA.hy 926 endothelial cells | INHIBITORS | NIH 3T3 Cells | Cyclophosphamide - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Tubulin Modulators - pharmacology | Humans | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Antineoplastic Agents, Alkylating - pharmacology | Flavonoids - adverse effects | Antineoplastic Agents, Alkylating - administration & dosage | Cyclophosphamide - adverse effects | Cyclophosphamide - therapeutic use | Flavonoids - therapeutic use | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Angiogenesis Inhibitors - administration & dosage | Antineoplastic Agents, Phytogenic - administration & dosage | Angiogenesis Inhibitors - therapeutic use | Flavonoids - administration & dosage | Tubulin Modulators - administration & dosage | Female | Flavonoids - pharmacology | Antineoplastic Agents, Phytogenic - therapeutic use | Angiogenesis Inhibitors - adverse effects | Antineoplastic Agents, Phytogenic - adverse effects | Cell Line | Cell Survival - drug effects | Tubulin Modulators - adverse effects | Mice, Inbred C57BL | Angiogenesis Inhibitors - pharmacology | Tubulin Modulators - therapeutic use | Carcinoma, Lewis Lung - drug therapy | Antineoplastic Agents, Alkylating - therapeutic use | Cell Movement - drug effects | Animals | Tumor Burden - drug effects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Endothelial Cells - cytology | Neovascularization, Pathologic - drug therapy | Cyclophosphamide - pharmacology | Carcinoma, Lewis Lung - pathology | Cell Proliferation - drug effects | Mice | Antineoplastic Agents, Alkylating - adverse effects | Antineoplastic Agents, Phytogenic - pharmacology | Cell Cycle - drug effects | Endothelial Cells - drug effects | Antimitotic agents | Flavonoids | Flavones | Lung cancer | Bioflavonoids | Accountants | Drug therapy, Combination | Universities and colleges | Antineoplastic agents | Endothelium | Tumors | Index Medicus | cytology | Antineoplastic Agents, Phytogenic | pathology | Cell Proliferation | Endothelial Cells | Tubulin Modulators | Neovascularization, Pathologic | fisetin | administration & dosage | pharmacology | flavonoid | Carcinoma, Lewis Lung | Antineoplastic Agents, Alkylating | cytotoxicity | drug therapy | Cell Survival | angiogenesis | Antineoplastic Combined Chemotherapy Protocols | drug effects | Tumor Burden | Angiogenesis Inhibitors | EA.hy 926 | Cell Cycle | antitumour activity | adverse effects | therapeutic use | Cell Movement
Journal Article
International journal of molecular sciences, ISSN 1422-0067, 2015, Volume 16, Issue 7, pp. 15625 - 15658
Annona muricata is a member of the Annonaceae family and is a fruit tree with a long history of traditional use. A. muricata, also known as soursop, graviola... 
Acetogenins | Bioactive compounds | Natural products | Annonaceae | Fruit tree | Annona muricata | Biological activity | CYTOTOXIC ACTIVITIES | ATYPICAL PARKINSONISM | biological activity | BIOCHEMISTRY & MOLECULAR BIOLOGY | HERBAL MEDICINE | annonaceae | acetogenins | CHEMISTRY, MULTIDISCIPLINARY | STRUCTURE ELUCIDATION | INSECTICIDAL ACTIVITY | natural products | AQUEOUS LEAF EXTRACT | fruit tree | MONO-TETRAHYDROFURAN RING | MITOCHONDRIAL COMPLEX-I | bioactive compounds | GAMMA-LACTONE | SEED EXTRACTS | Anti-Infective Agents - isolation & purification | Antioxidants - chemistry | Oils, Volatile - chemistry | Apoptosis - drug effects | Anti-Infective Agents - pharmacology | Oils, Volatile - pharmacology | Acetogenins - chemistry | Central Nervous System Agents - isolation & purification | Anti-Infective Agents - chemistry | Anti-Inflammatory Agents - isolation & purification | Acetogenins - isolation & purification | Acetogenins - pharmacology | Central Nervous System Agents - chemistry | Anti-Inflammatory Agents - pharmacology | Antineoplastic Agents, Phytogenic - chemistry | Hypoglycemic Agents - chemistry | Antioxidants - pharmacology | Oils, Volatile - isolation & purification | Hypoglycemic Agents - pharmacology | Antineoplastic Agents, Phytogenic - toxicity | Hypoglycemic Agents - isolation & purification | Anti-Inflammatory Agents - chemistry | Antioxidants - isolation & purification | Annona - chemistry | Central Nervous System Agents - pharmacology | Central Nervous System - drug effects | Annona - metabolism | Antineoplastic Agents, Phytogenic - isolation & purification | Herbal medicine | Trees | Ethnomedicine
Journal Article
Mini-Reviews in Medicinal Chemistry, ISSN 1389-5575, 2016, Volume 16, Issue 2, pp. 113 - 141
The coumarin (benzopyran-2-one, or chromen-2-one) ring system, present in many natural products, displays diverse pharmacological properties. It has attracted... 
Antimicrobial | Pharmacological properties | Anticonvulsant | Anticancer | Antioxidant | Anti-inflammatory | Coumarin | MAO inhibitory | ANTIOXIDANT ACTIVITY | antimicrobial | antioxidant | 3-ARYLCOUMARINS SYNTHESIS | ANTIINFLAMMATORY ACTIVITY | CHEMISTRY, MEDICINAL | anticonvulsant | coumarin | INHIBITORY-ACTIVITY | pharmacological properties | ANTICONVULSANT AGENTS | IN-VITRO | anti-inflammatory | BIOLOGICAL EVALUATION | DERIVATIVES | HYBRIDS | Anti-HIV Agents - pharmacology | Antitubercular Agents - chemical synthesis | Antitubercular Agents - chemistry | Anti-Infective Agents - pharmacology | Humans | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Coumarins - chemistry | Monoamine Oxidase Inhibitors - chemical synthesis | Anti-HIV Agents - chemical synthesis | Anticonvulsants - pharmacology | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Anti-Infective Agents - chemistry | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Monoamine Oxidase Inhibitors - pharmacology | Antineoplastic Agents, Phytogenic - chemical synthesis | Anticonvulsants - chemical synthesis | Antitubercular Agents - pharmacology | Antineoplastic Agents, Phytogenic - chemistry | Anti-Infective Agents - chemical synthesis | Coumarins - pharmacology | Anti-HIV Agents - chemistry | Animals | Anticonvulsants - chemistry | Coumarins - chemical synthesis | Monoamine Oxidase Inhibitors - chemistry | Antineoplastic Agents, Phytogenic - pharmacology
Journal Article
Mini-Reviews in Medicinal Chemistry, ISSN 1389-5575, 2013, Volume 13, Issue 2, pp. 163 - 193
Objective: Piper has been used for long timelike condiment and food, but also in traditional medicine around of the world. This work resumes the available and... 
Pharmacological actions | Piperaceae | Complementary medicine | Phytochemical constituents | Piper | OXIDATIVE STRESS | CHEMISTRY, MEDICINAL | LIPID-PEROXIDATION | ALZHEIMERS-DISEASE | LARVICIDAL ACTIVITY | LUNG CARCINOGENESIS | ORAL SUPPLEMENTATION | B16F-10 MELANOMA-CELLS | IN-VITRO | pharmacological actions | complementary medicine | HEALTHY-VOLUNTEERS | phytochemical constituents | CYTOTOXIC PYRIDONE ALKALOIDS | Anti-Infective Agents - toxicity | Central Nervous System Agents - therapeutic use | Plant Extracts - chemistry | Plant Extracts - toxicity | Antioxidants - chemistry | Obesity - drug therapy | Plant Extracts - pharmacology | Anti-Infective Agents - pharmacology | Cardiovascular Diseases - drug therapy | Humans | Platelet Aggregation Inhibitors - toxicity | Anti-Obesity Agents - therapeutic use | Anti-Obesity Agents - toxicity | Anti-Infective Agents - chemistry | Anti-Inflammatory Agents - therapeutic use | Platelet Aggregation Inhibitors - pharmacology | Antineoplastic Agents, Phytogenic - therapeutic use | Platelet Aggregation Inhibitors - therapeutic use | Alkaloids - toxicity | Alkaloids - pharmacology | Central Nervous System Agents - chemistry | Anti-Inflammatory Agents - pharmacology | Anti-Inflammatory Agents - toxicity | Anti-Infective Agents - therapeutic use | Antineoplastic Agents, Phytogenic - chemistry | Cardiovascular Agents - toxicity | Antioxidants - pharmacology | Cognition Disorders - drug therapy | Piper - chemistry | Cardiovascular Agents - pharmacology | Neoplasms - drug therapy | Antineoplastic Agents, Phytogenic - toxicity | Antioxidants - toxicity | Cardiovascular Agents - therapeutic use | Anti-Obesity Agents - chemistry | Antioxidants - therapeutic use | Animals | Anti-Inflammatory Agents - chemistry | Central Nervous System Agents - pharmacology | Platelet Aggregation Inhibitors - chemistry | Alkaloids - therapeutic use | Antineoplastic Agents, Phytogenic - pharmacology | Anti-Obesity Agents - pharmacology | Plant Extracts - therapeutic use | Alkaloids - chemistry | Central Nervous System Agents - toxicity | Cardiovascular Agents - chemistry
Journal Article
Current Medicinal Chemistry, ISSN 0929-8673, 09/2011, Volume 18, Issue 25, pp. 3825 - 3852
The chemistry of chromones is very well known. This system is widely used in organic chemistry as an intermediate compound for the synthesis of numerous... 
Mast cell stabilizers | Benzopyran-4-ones | Occurrence | Biological activity | Chromones | STELLERA-CHAMAEJASME L | CHEMISTRY, MEDICINAL | biological activity | mast cell stabilizers | BIOCHEMISTRY & MOLECULAR BIOLOGY | benzopyran-4-ones | DNA-BINDING PROPERTIES | occurrence | CONCENTRATING HORMONE-RECEPTOR-1 ANTAGONISTS | ANTI-HIV AGENTS | BENZOYL HYDRAZONE | ALDOSE REDUCTASE INHIBITORS | CHEMICAL-CONSTITUENTS | ANTIBACTERIAL ACTIVITY | LN(III) COMPLEXES | PHARMACOLOGY & PHARMACY | POTENTIAL ANTIINFLAMMATORY AGENTS | Plant Extracts - chemistry | Anti-Infective Agents - isolation & purification | Antioxidants - chemistry | Plant Extracts - pharmacology | Anti-Infective Agents - pharmacology | Humans | Anti-Infective Agents - chemistry | Enzyme Inhibitors - chemistry | Anti-Inflammatory Agents - therapeutic use | Anti-Inflammatory Agents - isolation & purification | Plants - chemistry | Antineoplastic Agents, Phytogenic - therapeutic use | Chromones - pharmacology | Chromones - therapeutic use | Anti-Inflammatory Agents - pharmacology | Enzyme Inhibitors - pharmacology | Anti-Infective Agents - therapeutic use | Antineoplastic Agents, Phytogenic - chemistry | Plant Extracts - isolation & purification | Antioxidants - pharmacology | Enzyme Inhibitors - therapeutic use | Enzyme Inhibitors - isolation & purification | Neoplasms - drug therapy | Chromones - chemistry | Antioxidants - therapeutic use | Animals | Anti-Inflammatory Agents - chemistry | Antioxidants - isolation & purification | Chromones - isolation & purification | Antineoplastic Agents, Phytogenic - pharmacology | Plant Extracts - therapeutic use | Antineoplastic Agents, Phytogenic - isolation & purification
Journal Article
Journal Article
Journal Article
Carbohydrate Polymers, ISSN 0144-8617, 11/2016, Volume 153, pp. 663 - 678
•This review presented naturally occurring polysaccharides from tea materials (TPS).•Main methods for extraction and purification were... 
Extraction | Bioactivity | Future perspectives | Purification | Structure | Tea polysaccharide | PU-ERH TEA | DIABETIC MICE | POLYMER SCIENCE | CHEMICAL-CHARACTERIZATION | CHEMISTRY, ORGANIC | OOLONG TEA | VITRO ANTIOXIDANT ACTIVITY | ACIDIC POLYSACCHARIDE | CAMELLIA-SINENSIS FLOWER | ZIYANG GREEN TEA | ACTIVITY IN-VITRO | CHEMISTRY, APPLIED | WATER-SOLUBLE POLYSACCHARIDE | Camellia sinensis - chemistry | Plant Extracts - chemistry | Anti-Infective Agents - isolation & purification | Adjuvants, Immunologic - pharmacology | Antioxidants - chemistry | Plant Extracts - pharmacology | Anti-Infective Agents - pharmacology | Humans | Adjuvants, Immunologic - chemistry | Polysaccharides - isolation & purification | Anti-Infective Agents - chemistry | Polysaccharides - chemistry | Adjuvants, Immunologic - isolation & purification | Antineoplastic Agents, Phytogenic - chemistry | Plant Extracts - isolation & purification | Hypoglycemic Agents - chemistry | Antioxidants - pharmacology | Anti-Obesity Agents - isolation & purification | Polysaccharides - pharmacology | Hypoglycemic Agents - pharmacology | Hypoglycemic Agents - isolation & purification | Anti-Obesity Agents - chemistry | Animals | Antioxidants - isolation & purification | Chemical Fractionation | Antineoplastic Agents, Phytogenic - pharmacology | Anti-Obesity Agents - pharmacology | Tea - chemistry | Antineoplastic Agents, Phytogenic - isolation & purification | Polysaccharides | Polyphenols | Yuan (China) | Functional foods
Journal Article
Journal Article
Current Medicinal Chemistry, ISSN 0929-8673, 2005, Volume 12, Issue 6, pp. 657 - 666
Betulinic acid is a naturally occurring pentacyclic triterpenoid and has been shown to exhibit a variety of biological activities including inhibition of human... 
Antimalarial | Anticancer mechanism | Anti-HIV derivatives | Biotransformation | Anti-HIV mechanism | Anticancer derivates | Antiinflammatory | Betulinic acid | ANTI-AIDS AGENTS | anti-HIV mechanism | ACTIVATION | CHEMISTRY, MEDICINAL | HIV ACTIVITY | TRITERPENOIDS | BIOCHEMISTRY & MOLECULAR BIOLOGY | STEM BARK | ENVELOPE GLYCOPROTEIN | anti-HIV derivatives | betulinic acid | antimalarial | HUMAN-IMMUNODEFICIENCY-VIRUS | anticancer mechanism | biotransformation | TYPE-1 ENVELOPE | anticancer derivatives | PHARMACOLOGY & PHARMACY | antiinflammatory | INHIBITORS | CONSTITUENTS | Anti-HIV Agents - pharmacology | Antineoplastic Agents, Phytogenic - chemical synthesis | Triterpenes - pharmacology | Anti-Inflammatory Agents - pharmacology | Humans | Molecular Conformation | Antineoplastic Agents, Phytogenic - chemistry | Structure-Activity Relationship | Anti-HIV Agents - chemical synthesis | Antimalarials - pharmacology | Anti-Bacterial Agents - chemical synthesis | Anti-HIV Agents - chemistry | Triterpenes - chemistry | Animals | Anti-Inflammatory Agents - chemistry | Triterpenes - chemical synthesis | Anti-Bacterial Agents - chemistry | Antimalarials - chemistry | Anti-Bacterial Agents - pharmacology | Anti-Inflammatory Agents - chemical synthesis | Antineoplastic Agents, Phytogenic - pharmacology | Antimalarials - chemical synthesis
Journal Article
Marine drugs, ISSN 1660-3397, 2015, Volume 13, Issue 4, pp. 2327 - 2346
.... Most of the chemotherapeutic agents used in cancer treatment are designed to target common deregulated mechanisms within cancer cells... 
Synergy | Fucoidan | Apoptosis | Cancer | BREAST-CANCER | ANTICANCER ACTIVITY | IN-VITRO | CHEMISTRY, MEDICINAL | INDUCED APOPTOSIS | UNDARIA-PINNATIFIDA | CLADOSIPHON-OKAMURANUS | TOXICOLOGICAL EVALUATION | WEIGHT FUCOIDAN | BRONCHOPULMONARY CARCINOMA LINE | BROWN ALGA | Neoplasms - metabolism | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Drugs, Investigational - adverse effects | Drugs, Investigational - pharmacology | Apoptosis - drug effects | Humans | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Drugs, Investigational - therapeutic use | Functional Food - analysis | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Angiogenesis Inhibitors - administration & dosage | Antineoplastic Agents, Phytogenic - administration & dosage | Neoplasm Metastasis - prevention & control | Angiogenesis Inhibitors - therapeutic use | Polysaccharides - administration & dosage | Antineoplastic Agents, Phytogenic - therapeutic use | Drug Evaluation, Preclinical | Angiogenesis Inhibitors - adverse effects | Antineoplastic Agents, Phytogenic - adverse effects | Polysaccharides - therapeutic use | Polysaccharides - adverse effects | Angiogenesis Inhibitors - pharmacology | Cell Transformation, Neoplastic - metabolism | Phaeophyta - chemistry | Polysaccharides - pharmacology | Neoplasms - drug therapy | Animals | MAP Kinase Signaling System - drug effects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Models, Biological | Drugs, Investigational - administration & dosage | Cell Transformation, Neoplastic - drug effects | Antineoplastic Agents, Phytogenic - pharmacology | Neoplasms - pathology | Seaweed - chemistry | apoptosis | cancer | synergy | fucoidan
Journal Article
International journal of molecular sciences, ISSN 1422-0067, 2016, Volume 17, Issue 4, pp. 589 - 589
.... This review aimed to present an up-to-date and comprehensive analysis of the phytochemistry and pharmacology of the three Fagopyrum buckwheats... 
Fagopyrum | Pharmacology | Phytochemistry | Buckwheat | ANTIOXIDANT ACTIVITY | PROTEIN | TARTARY BUCKWHEAT | MOLECULAR-STRUCTURE | PHENOLIC-COMPOUNDS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, MULTIDISCIPLINARY | IN-VITRO | buckwheat | TATARICUM | pharmacology | ESCULENTUM-MOENCH | GALLSTONE FORMATION | LOWERS PLASMA-CHOLESTEROL | phytochemistry | Antioxidants - chemistry | Protective Agents - chemistry | Anti-Allergic Agents - pharmacology | Protective Agents - pharmacology | Anti-Allergic Agents - isolation & purification | Anti-Bacterial Agents - chemistry | Anti-Allergic Agents - chemistry | Anti-Inflammatory Agents - isolation & purification | Phytochemicals - chemistry | Fagopyrum - chemistry | Anti-Inflammatory Agents - pharmacology | Fatigue - drug therapy | Antineoplastic Agents, Phytogenic - chemistry | Hypoglycemic Agents - chemistry | Protective Agents - isolation & purification | Anti-Bacterial Agents - isolation & purification | Antioxidants - pharmacology | Hypoglycemic Agents - pharmacology | Phytochemicals - isolation & purification | Hypoglycemic Agents - isolation & purification | Anti-Inflammatory Agents - chemistry | Antioxidants - isolation & purification | Anti-Bacterial Agents - pharmacology | Antineoplastic Agents, Phytogenic - pharmacology | Phytochemicals - pharmacology | Antineoplastic Agents, Phytogenic - isolation & purification
Journal Article