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Journal of Controlled Release, ISSN 0168-3659, 06/2015, Volume 207, pp. 18 - 30
Exosomes are naturally occurring nanosized vesicles that have attracted considerable attention as drug delivery vehicles in the past few years. Exosomes are... 
Oxidative stress | Neuroinflammation | Parkinson's disease | Catalase | Exosomes | Blood–brain barrier | Blood-brain barrier | ALZHEIMERS-DISEASE | REPEATED INJECTIONS | MACROPHAGE DELIVERY | MEDIATED TRANSFER | BLOOD-BRAIN-BARRIER | BIOLOGICAL BARRIERS | CHEMISTRY, MULTIDISCIPLINARY | IN-VITRO | PEGYLATED LIPOSOMES | PHARMACOLOGY & PHARMACY | SUPEROXIDE-DISMUTASE | Antioxidants - chemistry | Antioxidants - metabolism | Oxidopamine | Anti-Inflammatory Agents - metabolism | PC12 Cells | Neuroprotective Agents - metabolism | Drug Carriers | Brain - metabolism | Nanoparticles | Parkinsonian Disorders - metabolism | Parkinsonian Disorders - drug therapy | Antiparkinson Agents - chemistry | Anti-Inflammatory Agents - administration & dosage | Female | Neurons - metabolism | Neuroprotective Agents - administration & dosage | Nanomedicine | Disease Models, Animal | Neuroprotective Agents - chemistry | Mice, Inbred C57BL | Solubility | Rats | Technology, Pharmaceutical - methods | Parkinsonian Disorders - chemically induced | Administration, Intranasal | Chemistry, Pharmaceutical | Brain - drug effects | Catalase - metabolism | Catalase - administration & dosage | Animals | Anti-Inflammatory Agents - chemistry | Antioxidants - administration & dosage | RAW 264.7 Cells | Antiparkinson Agents - administration & dosage | Mice | Kinetics | Oxidative Stress - drug effects | Antiparkinson Agents - metabolism | Catalase - chemistry | Drugs | Drug delivery systems | Proteases | Analysis | Antiparkinsonian agents | Vehicles
Journal Article
Journal Article
Progress in Neurobiology, ISSN 0301-0082, 2007, Volume 81, Issue 1, pp. 29 - 44
Parkinson's disease (PD) affects one in every 100 persons above the age of 65 years, making it the second most common neurodegenerative disease after... 
Current therapies | PD vaccine | Parkinson's disease (PD) | Drug delivery | Levodopa | Neuroprotective agents | Non-pharmacological treatments | Cell transplantation | Nicotine | nicotine | OXIDATIVE DAMAGE | neuroprotective | MAO-B INHIBITOR | drug delivery | ALPHA-SYNUCLEIN | DOPAMINERGIC-NEURONS | SUBSTANTIA-NIGRA | NEUROSCIENCES | current therapies | agents | cell transplantation | MOTOR FLUCTUATIONS | LEVODOPA-INDUCED DYSKINESIA | NEUROTROPHIC FACTOR GDNF | levodopa | non-pharmacological treatments | L-DOPA | DEEP BRAIN-STIMULATION | Neuroprotective Agents - therapeutic use | Parkinson Disease - therapy | Genetic Therapy | Nicotine - therapeutic use | Humans | Vaccination | Dopamine Agonists - therapeutic use | Parkinson Disease - drug therapy | Antiparkinson Agents - therapeutic use | Stem Cell Transplantation | Fetal Tissue Transplantation | Parkinsonian Disorders - drug therapy | Deep Brain Stimulation | Anti-Inflammatory Agents - therapeutic use | Cholinergic Antagonists - therapeutic use | Iron Chelating Agents - therapeutic use | Brain Tissue Transplantation | Vitamins - therapeutic use | Antiparkinson Agents - adverse effects | Enzyme Inhibitors - therapeutic use | Parkinson Disease - surgery | Antioxidants - therapeutic use | Animals | Globus Pallidus - surgery | Parkinsonian Disorders - prevention & control | Antiparkinson Agents - classification | Nanotechnology | Drug therapy | Parkinson's disease
Journal Article
Drugs, ISSN 0012-6667, 2015, Volume 75, Issue 5, pp. 487 - 501
This narrative review reports on the pharmacological and pharmacokinetic properties of rotigotine, a non-ergolinic D-3/D-2/D-1 dopamine receptor agonist... 
PLASMA-LEVELS | SAFETY | DOUBLE-BLIND | PHARMACOLOGY & PHARMACY | TOXICOLOGY | PLACEBO-CONTROLLED TRIAL | QUALITY-OF-LIFE | CLINICAL-FEATURES | OPEN-LABEL EXTENSION | LONG-TERM TREATMENT | DOPAMINE AGONIST ROTIGOTINE | PATCH | Thiophenes - therapeutic use | Restless Legs Syndrome - epidemiology | Thiophenes - adverse effects | Humans | Dopamine Agonists - therapeutic use | Tetrahydronaphthalenes - therapeutic use | Dopamine Agonists - adverse effects | Parkinson Disease - drug therapy | Thiophenes - administration & dosage | Tetrahydronaphthalenes - adverse effects | Restless Legs Syndrome - metabolism | Antiparkinson Agents - therapeutic use | Restless Legs Syndrome - drug therapy | Drug Interactions | Tetrahydronaphthalenes - administration & dosage | Parkinson Disease - epidemiology | Anti-Dyskinesia Agents - administration & dosage | Parkinson Disease - metabolism | Comorbidity | Dopamine Agonists - pharmacokinetics | Tetrahydronaphthalenes - pharmacokinetics | Evidence-Based Medicine | Antiparkinson Agents - adverse effects | Transdermal Patch - adverse effects | Antiparkinson Agents - pharmacokinetics | Anti-Dyskinesia Agents - therapeutic use | Thiophenes - pharmacokinetics | Animals | Anti-Dyskinesia Agents - adverse effects | Dopamine Agonists - administration & dosage | Antiparkinson Agents - administration & dosage | Anti-Dyskinesia Agents - pharmacokinetics | Practice Guidelines as Topic
Journal Article
Science, ISSN 0036-8075, 11/2007, Volume 318, Issue 5854, pp. 1309 - 1312
Deep brain stimulation (DBS) of the subthalamic nucleus markedly improves the motor symptoms of Parkinson's disease, but causes cognitive side effects such as... 
Neurology | Basal ganglia | Health outcomes | Deep brain stimulation | Parkinson disease | Medications | Thalamus | Reports | Lesions | Behavioral neuroscience | Modeling | CHOICE | SUBTHALAMIC NUCLEUS | REACTION-TIME | OPTIMAL DECISION-MAKING | BASAL GANGLIA | MULTIDISCIPLINARY SCIENCES | DISEASE | DOPAMINE | HIGH-FREQUENCY STIMULATION | COGNITIVE CONTROL | SELECTION | Parkinson Disease - therapy | Impulsive Behavior - etiology | Humans | Middle Aged | Male | Reaction Time | Deep Brain Stimulation - adverse effects | Dopamine Agents - therapeutic use | Antiparkinson Agents - therapeutic use | Dopamine Agents - adverse effects | Learning | Levodopa - administration & dosage | Conflict (Psychology) | Female | Dopamine Agents - administration & dosage | Neural Networks (Computer) | Decision Making | Levodopa - therapeutic use | Reinforcement (Psychology) | Parkinson Disease - physiopathology | Parkinson Disease - psychology | Antiparkinson Agents - adverse effects | Basal Ganglia - physiology | Subthalamic Nucleus - physiology | Levodopa - adverse effects | Aged | Antiparkinson Agents - administration & dosage | Models, Neurological | Parkinsonism | Psychological aspects | Physiological aspects | Brain stimulation | Impulse | Health aspects | Brain | Side effects | Cognition & reasoning | Medical treatment | Parkinsons disease | Drug therapy
Journal Article
Clinical Therapeutics, ISSN 0149-2918, 2007, Volume 29, Issue 9, pp. 1825 - 1849
Abstract Background: Inhibitors of monoamine oxidase (MAO) with selectivity and specificity for MAO type B (MAO-B) prolong the duration of action of both... 
Internal Medicine | Medical Education | rasagiline | Parkinson's disease | propargylamine | neuroprotection | monoamine oxidase | selegiline | CONTROLLED-TRIAL | SEROTONIN SYNDROME | MAO-B INHIBITOR | MPTP-INDUCED NEUROTOXICITY | MOTOR FLUCTUATIONS | MITOCHONDRIAL PERMEABILITY TRANSITION | IN-VIVO | DOUBLE-BLIND | PHARMACOLOGY & PHARMACY | L-DEPRENYL | NEUROBLASTOMA SH-SY5Y CELLS | rasagilme | Indans - adverse effects | Neuroprotective Agents - therapeutic use | Antiparkinson Agents - pharmacology | Humans | Selegiline - pharmacology | Parkinson Disease - drug therapy | Indans - therapeutic use | Monoamine Oxidase Inhibitors - administration & dosage | Antiparkinson Agents - therapeutic use | Drug Interactions | Neuroprotective Agents - pharmacology | Indans - administration & dosage | Neuroprotective Agents - adverse effects | Drug Therapy, Combination | Neuroprotective Agents - administration & dosage | Selegiline - therapeutic use | Monoamine Oxidase Inhibitors - therapeutic use | Monoamine Oxidase Inhibitors - pharmacology | Selegiline - adverse effects | Monoamine Oxidase Inhibitors - adverse effects | Food-Drug Interactions | Antiparkinson Agents - adverse effects | Selegiline - administration & dosage | Antiparkinson Agents - administration & dosage | Indans - pharmacology | Oxidases | Medical colleges | Drug therapy | Analysis
Journal Article
Nutrition, ISSN 0899-9007, 2012, Volume 28, Issue 11, pp. 1081 - 1088
Abstract Ginkgo Biloba extract 761 (EGb 761) is a patented and well-defined mixture of active compounds extracted from Ginkgo biloba leaves. This extract... 
Gastroenterology and Hepatology | Neuroprotection | Dopamine | Natural extract | Antioxidant | Recovery | OXIDATIVE STRESS | SUBSTANTIA-NIGRA NEURONS | LIPID-PEROXIDATION | STANDARDIZED EXTRACT | EGB761 PROTECTS | DOPAMINERGIC NEUROTOXICITY | NUTRITION & DIETETICS | SUPEROXIDE-DISMUTASE ACTIVITY | MONOAMINE-OXIDASE ACTIVITY | IN-VIVO | MOUSE CORPUS STRIATUM | Neuroprotective Agents - therapeutic use | Plant Extracts - chemistry | Antioxidants - chemistry | Oxidative Stress | Mesencephalon - metabolism | Humans | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Dietary Supplements - analysis | Antiparkinson Agents - therapeutic use | Dopaminergic Neurons - metabolism | Antiparkinson Agents - chemistry | Parkinson Disease - metabolism | Dietary Supplements - adverse effects | Neuroprotective Agents - adverse effects | Phytotherapy | Parkinson Disease - diet therapy | Disease Models, Animal | Neuroprotective Agents - chemistry | Antiparkinson Agents - adverse effects | Antioxidants - therapeutic use | Parkinson Disease - prevention & control | Animals | Anti-Inflammatory Agents, Non-Steroidal - adverse effects | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Antioxidants - adverse effects | Plant Extracts - therapeutic use | Apoptosis | Plant Extracts - adverse effects | Drugs | Antioxidants | Parkinson's disease | Neurons | Analysis | Medicine, Botanic | Medicine, Herbal | Health aspects | Isoflavones | Studies | Oxidative stress | Chinese medicine | Neurotoxicity | Free radicals | Acids | Neurodegeneration | Rodents | Dementia | Index Medicus
Journal Article
Annals of Neurology, ISSN 0364-5134, 07/2010, Volume 68, Issue 1, pp. 18 - 27
Journal Article