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Antimicrobial agents and chemotherapy, ISSN 1098-6596, 2017, Volume 61, Issue 3
Journal Article
Journal Article
Journal of antimicrobial chemotherapy, ISSN 0305-7453, 2012, Volume 67, Issue 11, pp. 2576 - 2597
Journal Article
Journal Article
Journal Article
The Lancet infectious diseases, ISSN 1473-3099, 2017, Volume 17, Issue 6, pp. 626 - 635
.... We investigated the safety, tolerability, and pharmacokinetics of DSM265, and tested its antimalarial activity... 
Infectious Disease | VIVAX MALARIA | CLEARANCE | INFECTIOUS DISEASES | MULTICENTER | COMBINATION THERAPY | QUANTITATIVE PCR | RESISTANCE | INFECTION | PIPERAQUINE | PLASMODIUM-FALCIPARUM MALARIA | FERROQUINE | Malaria, Falciparum - drug therapy | Triazoles - administration & dosage | Antimalarials - pharmacokinetics | Double-Blind Method | Pyrimidines - administration & dosage | Humans | Middle Aged | Half-Life | Antimalarials - therapeutic use | New Zealand | Plasmodium falciparum | Mefloquine - therapeutic use | Antimalarials - administration & dosage | Enzyme Inhibitors - pharmacokinetics | Pyrimidines - therapeutic use | Enzyme Inhibitors - chemistry | Adolescent | Pyrimidines - pharmacokinetics | Adult | Oxidoreductases Acting on CH-CH Group Donors | Triazoles - pharmacokinetics | Australia | Triazoles - therapeutic use | Drugs | Physiological aspects | Enzymes | Pyrimidines | Safety and security measures | Clinical trials | Malaria | Dehydrogenases | Plasmodia | Erythrocytes | Selectivity | Biochemistry | Drug resistance | Drug development | Dosage | Incidence | Food industry | New combinations | Inhibition | Pharmaceutical industry | Drug dosages | Active control | Public health | Half life | Atovaquone | Mortality | Immunodeficiency | Parasite resistance | Bioavailability | Studies | Polymerase chain reaction | Chemotherapy | Disease transmission | Inhibitors | Cytochrome bc1 | Human beings | Antimalarial agents | Minimum inhibitory concentration | Added value | Antiprotozoal agents | Dihydroorotate dehydrogenase | Bednets | Animal models | Chloroquine | Artemisinin | Infections | Biosynthesis | Spacecraft components | Mathematical models | Gametocytes | Safety | Effectiveness | Pharmacology | Antimalarial activity | Strategy
Journal Article
Journal Article
eLife, ISSN 2050-084X, 05/2016, Volume 5, Issue 2016
There is an urgent requirement for safe, oral and cost-effective drugs for the treatment of visceral leishmaniasis (VL). We report that delamanid (OPC-67683),... 
MYCOBACTERIUM-TUBERCULOSIS | IN-VITRO | DISEASES | HUMAN AFRICAN TRYPANOSOMIASIS | DONOVANI | BIOLOGY | RESISTANCE | NITRO DRUGS | PLASMA-PROTEIN BINDING | ANTITUBERCULOSIS DRUG | DISCOVERY | Leishmaniasis, Visceral - blood | Antiprotozoal Agents - blood | Parasitic Sensitivity Tests | Nitroimidazoles - blood | Antiprotozoal Agents - pharmacokinetics | Drug Dosage Calculations | Biotransformation | Oxazoles - blood | Female | Hormesis | Leishmaniasis, Visceral - parasitology | Nitroimidazoles - pharmacokinetics | Disease Models, Animal | Nitroimidazoles - pharmacology | Drug Administration Schedule | Administration, Oral | Leishmania donovani - drug effects | Antitubercular Agents - pharmacology | Oxazoles - pharmacokinetics | Leishmania donovani - pathogenicity | Treatment Outcome | Drug Repositioning | Antiprotozoal Agents - pharmacology | Leishmaniasis, Visceral - pathology | Leishmania donovani - growth & development | Leishmaniasis, Visceral - drug therapy | Antitubercular Agents - blood | Animals | Antitubercular Agents - pharmacokinetics | Mice | Mice, Inbred BALB C | Oxazoles - pharmacology | Kala-azar | Antitubercular agents | Dosage and administration | Drug therapy | Laboratories | Multidrug resistance | Nitroreductase | Clinical trials | Infections | Parasites | Leishmaniasis | Drug resistance | Metabolism | Tropical diseases | Tuberculosis | Visceral leishmaniasis | Parasitic diseases | Software | Life sciences | Drug dosages
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 05/2017, Volume 60, Issue 10, pp. 4212 - 4233
Journal Article
Journal Article
Journal Article