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European Journal of Medicinal Chemistry, ISSN 0223-5234, 2011, Volume 46, Issue 8, pp. 3179 - 3189
This review summarizes recent medicinal chemistry investigations and in search for new phenothiazines of promising biological activities. New phenothiazine... 
Multi-drug resistance | Antifungal | Antibacterial | Azaphenothiazines | Anticancer | Phenothiazines | CHEMISTRY, MEDICINAL | MUSTARD TYPE PHENOTHIAZINES | SULFONE DERIVATIVES | ANTITUMOR-ACTIVITY | ANTICANCER ACTIVITY | ANTIMICROBIAL ACTIVITIES | RIBOFURANOSIDES | N-ACYLPHENOTHIAZINES | ANTITUBERCULAR ACTIVITY | INHIBITORS | MULTIDRUG-RESISTANCE | Analgesics - pharmacology | Drug Resistance, Multiple | Humans | Bacteria - drug effects | Cell Membrane Permeability | Trypanocidal Agents - chemistry | Antifungal Agents - chemistry | Structure-Activity Relationship | Anticonvulsants - pharmacology | Antiviral Agents - chemistry | Phenothiazines - pharmacology | Anti-Bacterial Agents - chemistry | Antineoplastic Agents - pharmacology | Immunosuppressive Agents - pharmacology | Antifungal Agents - pharmacology | Rabbits | Antiviral Agents - pharmacology | Anti-Inflammatory Agents - pharmacology | Solubility | Rats | Viruses - drug effects | Antineoplastic Agents - chemistry | Antimalarials - pharmacology | Animals | Anti-Inflammatory Agents - chemistry | Antipsychotic Agents - chemistry | Phenothiazines - chemistry | Trypanocidal Agents - pharmacology | Analgesics - chemistry | Anticonvulsants - chemistry | Antimalarials - chemistry | Hydrophobic and Hydrophilic Interactions | Anti-Bacterial Agents - pharmacology | Mice | Antipsychotic Agents - pharmacology | Immunosuppressive Agents - chemistry
Journal Article
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 09/2017, Volume 138, pp. 774 - 806
Journal Article
Journal Article
Journal Article
Neuropsychopharmacology, ISSN 0893-133X, 09/2008, Volume 33, Issue 10, pp. 2303 - 2312
Quetiapine is an atypical antipsychotic drug that is also US FDA approved for treating bipolar depression, albeit by an unknown mechanism. To discover the... 
Antidepressant | N-Desalkylquetiapine | Norepinephrine reuptake inhibitor | Antipsychotic | Quetiapine | PSYCHIATRY | antidepressant | BIPOLAR-II DEPRESSION | quetiapine | SCHIZOPHRENIA | CLINICAL PHARMACOKINETICS | NEUROSCIENCES | ATYPICAL ANTIPSYCHOTIC-DRUGS | norepinephrine reuptake inhibitor | DOUBLE-BLIND | PHARMACOLOGY & PHARMACY | antipsychotic | MICE | SEROTONIN | INDUCED WEIGHT-GAIN | RECEPTORS | BLOCKADE | Brain Chemistry - drug effects | Serotonin 5-HT1 Receptor Agonists | Cricetulus | Humans | Depressive Disorder - drug therapy | Male | Antidepressive Agents - metabolism | Serotonin Receptor Agonists - pharmacology | Dose-Response Relationship, Drug | Adrenergic Uptake Inhibitors - chemistry | Dibenzothiazepines - chemistry | Antidepressive Agents - chemistry | Dibenzothiazepines - metabolism | Female | Antidepressive Agents - pharmacology | Drug Evaluation, Preclinical | Receptor, Serotonin, 5-HT1A - metabolism | CHO Cells | Disease Models, Animal | Cell Line | Cricetinae | Dibenzothiazepines - pharmacology | Mice, Inbred C57BL | Quetiapine Fumarate | Rats | Depressive Disorder - metabolism | Brain Chemistry - physiology | Mice, Knockout | Animals | Antipsychotic Agents - chemistry | Depressive Disorder - physiopathology | Vesicular Monoamine Transport Proteins - genetics | Adrenergic Uptake Inhibitors - pharmacology | Antipsychotic Agents - metabolism | Mice | Antipsychotic Agents - pharmacology
Journal Article
Journal Article
Nature, ISSN 0028-0836, 03/2018, Volume 555, Issue 7695, pp. 269 - 273
Dopamine is a neurotransmitter that has been implicated in processes as diverse as reward, addiction, control of coordinated movement, metabolism and hormonal... 
LIGANDS | CLONING | CRYSTAL-STRUCTURE | PHARMACOLOGY | MULTIDISCIPLINARY SCIENCES | CHARGES | RHODOPSIN | MODEL | BETA-ADRENERGIC RECEPTOR | DISCOVERY | AGONIST | Receptors, Dopamine D4 - chemistry | Humans | Receptors, Dopamine D3 - chemistry | Receptors, Dopamine D3 - metabolism | Mutant Proteins - genetics | Models, Molecular | Crystallography, X-Ray | Mutant Proteins - metabolism | Risperidone - chemistry | Receptors, Dopamine D2 - metabolism | Receptors, Dopamine D2 - genetics | Antipsychotic Agents - chemistry | Mutant Proteins - chemistry | Drug Design | Hydrophobic and Hydrophilic Interactions | Receptors, Dopamine D2 - chemistry | Antipsychotic Agents - metabolism | Ligands | Receptors, Dopamine D4 - metabolism | Risperidone - metabolism | Kinetics | Mutation | Binding Sites | Pharmacology, Experimental | Drug interactions | Physiological aspects | Research | Risperidone | Structure | Dopamine receptors | Drugs | Attention deficit disorder | Neuroleptics | Parkinson's disease | Molecular structure | Mental disorders | Parkinsons disease | Schizophrenia | Mental depression | Proteins | Psychotropic drugs | Receptors | Vomiting | Reinforcement | Dopamine D2 receptors | Movement disorders | Crystal structure | Dopamine | Neurodegenerative diseases | Secretion | Attention deficit hyperactivity disorder | Nausea | Metabolism | Side effects | Addiction | Structure-function relationships
Journal Article