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Current Medicinal Chemistry, ISSN 0929-8673, 2011, Volume 18, Issue 25, pp. 3871 - 3888
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 08/2005, Volume 94, Issue 3, pp. 819 - 827
Minocycline is neuroprotective in animal models of a number of acute CNS injuries and neurodegenerative diseases. While anti‐inflammatory and anti‐apoptotic... 
neurodegenerative diseases | lipid peroxidation assay | deoxyribose degradation assay | radical scavenging assay | tetracyclines | mixed neuronal cultures | Deoxyribose degradation assay | Mixed neuronal cultures | Radical scavenging assay | Neurodegenerative diseases | Tetracyclines | Lipid peroxidation assay | CEREBELLAR GRANULE NEURONS | BIOCHEMISTRY & MOLECULAR BIOLOGY | NEUROTOXICITY | NEUROSCIENCES | neuroclegenerative diseases | CELL-DEATH | IN-VITRO | CORTICAL-NEURONS | MOUSE MODEL | DISEASE | SPINAL-CORD-INJURY | CYTOCHROME-C RELEASE | Free Radical Scavengers - pharmacology | L-Lactate Dehydrogenase - metabolism | Embryo, Mammalian | Minocycline - pharmacology | Antipyrine - pharmacology | Minocycline - chemistry | Oxidative Stress - physiology | Cerebral Cortex - cytology | Deoxyribose - metabolism | Dose-Response Relationship, Drug | Drug Interactions | Neuroprotective Agents - pharmacology | Antipyrine - analogs & derivatives | Chromans - pharmacology | Lipid Peroxidation - drug effects | Inhibitory Concentration 50 | Cell Death - drug effects | Neurons - drug effects | Glutamic Acid - pharmacology | Cells, Cultured | Phenethylamines - metabolism | Rats | Antioxidants - pharmacology | Rats, Sprague-Dawley | Sulfonic Acids - metabolism | Animals | Free Radicals - pharmacology | Oxidative Stress - drug effects | Dizocilpine Maleate - pharmacology | Benzothiazoles | Vitamin E - pharmacology | Antioxidants | Oxidation | Antibiotics | Neurons | Stress
Journal Article
Anti-Cancer Drugs, ISSN 0959-4973, 02/2008, Volume 19, Issue 2, pp. 115 - 124
Journal Article
Cell Death and Differentiation, ISSN 1350-9047, 04/2007, Volume 14, Issue 4, pp. 775 - 784
Nine-day-old harlequin (Hq) mice carrying the hypomorphic apoptosis-inducing factor (AIF)(Hq) mutation expressed 60% less AIF, 18% less respiratory chain... 
CALPAIN | RAT | BIOCHEMISTRY & MOLECULAR BIOLOGY | MITOCHONDRIA | FREE-RADICAL SCAVENGER | edaravone | caspase inhibitor | MECHANISMS | harlequin | DEVELOPING BRAIN | DAMAGE | CELL-DEATH | CELL BIOLOGY | CASPASE-3 ACTIVATION | CYCLOSPORINE-A | free radical | oxidative stress | Free Radical Scavengers - pharmacology | Neurons - pathology | Oxidative Stress | Apoptosis - drug effects | Antipyrine - pharmacology | Apoptosis Inducing Factor - deficiency | Male | Hypoxia-Ischemia, Brain - pathology | Hypoxia-Ischemia, Brain - genetics | Quinolines - pharmacology | Caspases - metabolism | Antipyrine - analogs & derivatives | Amino Acid Chloromethyl Ketones - pharmacology | Mice, Mutant Strains | Female | Neurons - metabolism | Neurons - drug effects | Hypoxia-Ischemia, Brain - metabolism | Apoptosis Inducing Factor - metabolism | Animals, Newborn | Cytochromes c - metabolism | Necrosis - metabolism | Mitochondria - metabolism | Caspase Inhibitors | Animals | Mice | Necrosis - genetics | Antipyrine/analogs & derivatives/pharmacology | Hypoxia-Ischemia | Neurosciences | Free Radical Scavengers/pharmacology | Apoptosis Inducing Factor/deficiency/metabolism | Mitochondria/metabolism | Caspases/antagonists & inhibitors/metabolism | Necrosis/genetics/metabolism | Fysiologi | Apoptosis/drug effects | Brain/genetics/metabolism/pathology | Cytochromes c/metabolism | Quinolines/pharmacology | Newborn | Neurons/drug effects/metabolism/pathology | Mutant Strains | Physiology | Amino Acid Chloromethyl Ketones/pharmacology | Neurovetenskaper
Journal Article
Journal Article
Drug Design, Development and Therapy, ISSN 1177-8881, 06/2015, Volume 9, pp. 3377 - 3391
To develop novel anti-ischemic stroke agents with better therapeutic efficacy and bioavailability, we designed and synthesized a series of... 
3-dihydro-1H-isoindol-1-ones | Stroke | Platelet aggregation | 3-alkyl-2 | Ischemia/reperfusion | Middle cerebral artery occlusion | CHEMISTRY, MEDICINAL | RAT | FOCAL CEREBRAL-ISCHEMIA | INJURY | MECHANISMS | stroke | ANTIPLATELET | NEUROPROTECTION | platelet aggregation | PROTECTS | ischemia/reperfusion | 3-alkyl-2,3-dihydro-1H-isoindol-1-ones | 3-N-BUTYLPHTHALIDE | PHARMACOLOGY & PHARMACY | RADICALS | middle cerebral artery occlusion | BRAIN | Infarction, Middle Cerebral Artery - physiopathology | Infarction, Middle Cerebral Artery - prevention & control | Thrombosis - chemically induced | Antipyrine - pharmacology | Benzofurans - pharmacology | Biological Availability | Male | Benzofurans - blood | Structure-Activity Relationship | Reperfusion Injury - blood | Benzofurans - pharmacokinetics | Brain - metabolism | Tissue Distribution | Neuroprotective Agents - pharmacology | Antipyrine - analogs & derivatives | Neuroprotective Agents - pharmacokinetics | Infarction, Middle Cerebral Artery - psychology | Platelet Aggregation Inhibitors - pharmacology | Behavior, Animal - drug effects | Molecular Structure | Platelet Aggregation - drug effects | Thrombosis - blood | Thrombosis - prevention & control | Isoindoles - pharmacology | Disease Models, Animal | Cell Line | Isoindoles - pharmacokinetics | Reperfusion Injury - pathology | Brain - physiopathology | Isoindoles - blood | Benzofurans - chemical synthesis | Isoindoles - chemical synthesis | Antioxidants - pharmacology | Infarction, Middle Cerebral Artery - pathology | Reperfusion Injury - psychology | Rats, Sprague-Dawley | Infarction, Middle Cerebral Artery - blood | Brain - drug effects | Fibrinolytic Agents - pharmacology | Neuroprotective Agents - blood | Neuroprotective Agents - chemical synthesis | Animals | Reperfusion Injury - prevention & control | Reperfusion Injury - physiopathology | Brain - pathology | Mice | Carrageenan | Oxidative Stress - drug effects | Stroke (Disease) | Prevention | Drugs | Pharmacology, Experimental | Structure-activity relationship (Pharmacology) | Anticoagulants (Medicine) | Research | Structure-activity relationships | Testing | Occlusion | Brain | Oxidative stress | Reactive oxygen species | Nuclear magnetic resonance--NMR | Toxicity | Cytotoxicity | Strokes | Arachidonic acid | Drug development | Antioxidants | Reperfusion | Ischemia | Blood platelets | Aqueous solutions | Cerebral blood flow | Attenuation | Adenosine | Aspirin | Free radicals | Cell survival | Scavenging | Adenosine diphosphate | Pharmacology | Bioavailability | FDA approval | Metabolism | Nitrogen | Gene expression | Chemical compounds | Chromatography | Nitric oxide | Laboratory animals | Veins & arteries
Journal Article
Biological and Pharmaceutical Bulletin, ISSN 0918-6158, 2018, Volume 41, Issue 4, pp. 555 - 563
Journal Article
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 2006, Volume 40, Issue 4, pp. 632 - 640
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 06/2009, Volume 329, Issue 3, pp. 865 - 874
Edaravone, a potent free radical scavenger, is clinically used for the treatment of cerebral infarction in Japan. Here, we examined the effects of edaravone on... 
BRAIN INFARCTION | ARTERY OCCLUSION | INDUCED APOPTOSIS | ACUTE ISCHEMIC-STROKE | PHARMACOLOGY & PHARMACY | HMGB1 | MCI-186 | ACTIVATED PROTEIN-KINASES | END-PRODUCTS RAGE | PC12 CELLS | STRESS | Free Radical Scavengers - pharmacology | Neuroprotective Agents - therapeutic use | Cerebral Infarction - drug therapy | Cell Hypoxia - physiology | Nitriles - pharmacology | Rats, Wistar | Apoptosis - drug effects | Antipyrine - pharmacology | Oxidative Stress - physiology | Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors | Cytoplasm - metabolism | Male | Extracellular Signal-Regulated MAP Kinases - metabolism | PC12 Cells | Cell Nucleus - metabolism | Cerebral Infarction - metabolism | Neuroprotective Agents - pharmacology | Antipyrine - analogs & derivatives | HMGB1 Protein - metabolism | Cerebrum - metabolism | Free Radical Scavengers - therapeutic use | Neurons - metabolism | Neurons - drug effects | Cerebrum - pathology | Cerebral Infarction - pathology | Antipyrine - therapeutic use | Butadienes - pharmacology | Cell Hypoxia - drug effects | Cytochromes c - metabolism | Enzyme Inhibitors - pharmacology | Hydrogen Peroxide - pharmacology | Rats | S100 Proteins - metabolism | Glucose - deficiency | Animals | Active Transport, Cell Nucleus - drug effects | Oxidative Stress - drug effects | Cytoplasm - drug effects | HMGB1 Protein - blood
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 01/2009, Volume 29, Issue 4, pp. 1017 - 1033
Journal Article
Journal of Neuroscience Research, ISSN 0360-4012, 03/2009, Volume 87, Issue 4, pp. 991 - 1001
5‐Lipoxygenase (5‐LOX) is a key enzyme catalyzing arachidonic acid to form leukotrienes. We have reported that ischemic‐like injury activates 5‐LOX in PC12... 
ischemia‐reperfusion | PC12 cells | 5‐lipoxygenase | reactive oxygen species | Ischemia-reperfusion | Reactive oxygen species | 5-lipoxygenase | PHOSPHORYLATION | FOCAL CEREBRAL-ISCHEMIA | INJURY | MAP-KINASES | ischemia-reperfusion | NEUROSCIENCES | LEUKOTRIENE SYNTHESIS | CAFFEIC ACID | INFLAMMATION | INHIBITOR | EXPRESSION | BRAIN | Hydroxyurea - analogs & derivatives | Hydroxyurea - pharmacology | Reactive Oxygen Species - metabolism | Arachidonate 5-Lipoxygenase - genetics | Antipyrine - pharmacology | Oxidative Stress - physiology | Reactive Oxygen Species - pharmacology | Caffeic Acids - pharmacology | PC12 Cells | MAP Kinase Signaling System | Cell Hypoxia | Transfection | Antipyrine - analogs & derivatives | Indoles - pharmacology | p38 Mitogen-Activated Protein Kinases - metabolism | Phosphorylation - drug effects | Lipoxygenase Inhibitors | Arachidonate 5-Lipoxygenase - metabolism | Carrier Proteins - antagonists & inhibitors | Enzyme Inhibitors - pharmacology | Hydrogen Peroxide - pharmacology | Rats | Imidazoles - pharmacology | Antioxidants - pharmacology | Leukotrienes - metabolism | Animals | Membrane Proteins - antagonists & inhibitors | 5-Lipoxygenase-Activating Proteins | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Glucose - metabolism | Pyridines - pharmacology | Enzyme Activation
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2011, Volume 286, Issue 15, pp. 13382 - 13392
Journal Article