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1. Full Text Timing of initiation of antiretroviral therapy in AIDS-free HIV-1-infected patients: a collaborative analysis of 18 HIV cohort studies
by Sterne, Jonathan A. C and May, Margaret and Costagliola, Dominique and de Wolf, Frank and Phillips, Anew N and Harris, Ross and Funk, Michele Jönsson and Geskus, Ronald B and Gill, John and Dabis, François and Miró, Jose M and Justice, Amy C and Ledergerber, Bruno and Fätkenheuer, Gerd and Hogg, Robert S and D'Arminio Monforte, Antonella and Saag, Michael and Smith, Colette and Staszewski, Schlomo and Egger, Matthias and Cole, Stephen R and Brodt, Hans Reinhard and Casabona, Jordi and Chêne, Geneviève and Costagliola, Dominque and del Amo, Julia and Guest, Jodie and Hogg, Robert and Justice, Amy and Kitahata, Mari and Lampe, Fiona and Mocroft, Amanda and Reiss, Peter and Start Consortium and When To Start Consortium
Lancet, The, ISSN 0140-6736, 2009, Volume 373, Issue 9672, pp. 1352 - 1363
Summary Background The CD4 cell count at which combination antiretroviral therapy should be started is a central, unresolved issue in the care of... 
Internal Medicine | MEDICINE, GENERAL & INTERNAL | BASE-LINE | CD4 CELL COUNTS | VIROLOGICAL TREATMENT FAILURE | BLIND CONTROLLED-TRIAL | PROTEASE-INHIBITOR | SOCIETY-USA PANEL | INFECTED PATIENTS | HUMAN-IMMUNODEFICIENCY-VIRUS | T-LYMPHOCYTE COUNTS | DISEASE PROGRESSION | HIV-1 | Drug Administration Schedule | Humans | Middle Aged | Kaplan-Meier Estimate | Proportional Hazards Models | Europe - epidemiology | Male | Treatment Outcome | CD4 Lymphocyte Count | Disease Progression | Patient Selection | Antiretroviral Therapy, Highly Active - standards | Time Factors | Sensitivity and Specificity | Adult | Female | HIV Infections - drug therapy | HIV Infections - mortality | HIV Infections - transmission | North America - epidemiology | Antiretroviral Therapy, Highly Active - methods | Cohort Studies | Practice Guidelines as Topic | Antiviral agents | CD4 lymphocytes | Dosage and administration | Research | Drug therapy | Health aspects | HIV infection | Studies | Antiretroviral drugs | Human immunodeficiency virus--HIV | Mortality | Fast track
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2. Full Text A quantitative basis for antiretroviral therapy for HIV-1 infection
by Jilek, Benjamin L and Zarr, Melissa and Sampah, Maame E and Rabi, S. Alireza and Bullen, Cynthia K and Lai, Jun and Shen, Lin and Siliciano, Robert F
Nature Medicine, ISSN 1078-8956, 03/2012, Volume 18, Issue 3, pp. 446 - 451
Highly active antiretroviral therapy (HAART)(1-3) has dramatically decreased mortality from HIV-1 infection(4) and is a major achievement of modern medicine.... 
MEDICINE, RESEARCH & EXPERIMENTAL | CONTROLLED-TRIAL | IMMUNODEFICIENCY-VIRUS-INFECTION | COMBINATION THERAPY | BIOCHEMISTRY & MOLECULAR BIOLOGY | RESPONSE CURVE SLOPE | CELL BIOLOGY | LAMIVUDINE | VIRAL DYNAMICS | ZIDOVUDINE | INHIBITOR | TREATMENT-NAIVE PATIENTS | DYNAMICS IN-VIVO | Anti-Retroviral Agents - therapeutic use | HIV-1 - pathogenicity | Anti-Retroviral Agents - pharmacokinetics | CD4-Positive T-Lymphocytes - cytology | Humans | Anti-Retroviral Agents - standards | Algorithms | Antiretroviral Therapy, Highly Active - standards | Virus Replication | HIV Infections - drug therapy | Antiretroviral Therapy, Highly Active - methods | CD4-Positive T-Lymphocytes - virology | Drug Combinations | Drug Therapy, Combination - standards | Highly active antiretroviral therapy | Research | Drug therapy | HIV infection | Health aspects | Patient outcomes | Antiretroviral drugs | Pharmacology | Computational mathematics | Human immunodeficiency virus--HIV
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3. Full Text The parametric g‐formula to estimate the effect of highly active antiretroviral therapy on incident AIDS or death
by Westreich, Daniel and Cole, Stephen R and Young, Jessica G and Palella, Frank and Tien, Phyllis C and Kingsley, Lawrence and Gange, Stephen J and Hernán, Miguel A
Statistics in Medicine, ISSN 0277-6715, 08/2012, Volume 31, Issue 18, pp. 2000 - 2009
The parametric g‐formula can be used to contrast the distribution of potential outcomes under arbitrary treatment regimes. Like g‐estimation of structural... 
HIV/AIDS | confounding | Monte Carlo methods | cohort study | g‐formula | Confounding | Cohort study | G-formula | MORTALITY | SURVIVAL | MEDICINE, RESEARCH & EXPERIMENTAL | CONTROLLED-TRIAL | MEDICAL INFORMATICS | CAUSAL INFERENCE | MARGINAL STRUCTURAL MODELS | AIDS | STATISTICS & PROBABILITY | TIME | G-COMPUTATION | FAILURE | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | HIV | DYNAMIC TREATMENT REGIMES | MATHEMATICAL & COMPUTATIONAL BIOLOGY | g-formula | Data Interpretation, Statistical | Prospective Studies | Humans | Acquired Immunodeficiency Syndrome - prevention & control | Male | CD4 Lymphocyte Count | Models, Statistical | Viral Load | HIV Infections - immunology | Antiretroviral Therapy, Highly Active - standards | Female | HIV Infections - drug therapy | Cohort Studies | Highly active antiretroviral therapy | Antiviral agents | Analysis | AIDS (Disease)
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4. Full Text Switch to maraviroc with darunavir/r, both QD, in patients with suppressed HIV-1 was well tolerated but virologically inferior to standard antiretroviral therapy: 48-Week results of a randomized trial
by Rossetti, Barbara and Gagliardini, Roberta and Meini, Genny and Sterrantino, Gaetana and Colangeli, Vincenzo and Re, Maria Carla and Latini, Alessandra and Colafigli, Manuela and Vignale, Francesca and Rusconi, Stefano and Micheli, Valeria and Biagio, Antonio Di and Orofino, Giancarlo and Ghisetti, Valeria and Fantauzzi, Alessandra and Vullo, Vincenzo and Grima, Pierfrancesco and Francisci, Daniela and Mastroianni, Claudio and Antinori, Andrea and Trezzi, Michele and Lisi, Lucia and Navarra, Pierluigi and Canovari, Benedetta and D’Arminio Monforte, Antonella and Lamonica, Silvia and D’Avino, Alessandro and Zazzi, Maurizio and Giambenedetto, Simona Di and De Luca, Andrea and GUSTA Trial Study Grp and for GUSTA trial study group
PLoS ONE, ISSN 1932-6203, 11/2017, Volume 12, Issue 11, p. e0187393
Objectives Primary study outcome was absence of treatment failure (virological failure, VF, or treatment interruption) per protocol at week 48. Methods... 
TRIPLE TREATMENT | MAINTENANCE | EFFICACY | RITONAVIR PLUS LAMIVUDINE | MULTIDISCIPLINARY SCIENCES | REGIMEN | OPEN-LABEL | COMBINATION | TREATMENT-NAIVE PATIENTS | DUAL TREATMENT | ONCE-DAILY MARAVIROC | Triazoles - administration & dosage | Triazoles - adverse effects | Ritonavir - administration & dosage | HIV-1 - drug effects | Anti-HIV Agents - adverse effects | HIV Infections - virology | Humans | Middle Aged | Antiretroviral Therapy, Highly Active - adverse effects | Male | Treatment Outcome | Cyclohexanes - administration & dosage | Anti-HIV Agents - administration & dosage | Drug Therapy, Combination - adverse effects | Antiretroviral Therapy, Highly Active - standards | Darunavir - administration & dosage | Adult | Female | HIV Infections - drug therapy | Cyclohexanes - adverse effects | Darunavir - adverse effects | Viral Load - drug effects | Complications and side effects | Maraviroc | Darunavir | Dosage and administration | Research | Drug therapy | HIV infection | Tropism | Therapy | Biotechnology | Femur | Laboratories | Ritonavir | Viruses | Drug resistance | Tropical diseases | Randomization | Antiretroviral agents | Human immunodeficiency virus--HIV | Failure | Public health | Antiretroviral drugs | CCR5 protein | Dermatology | Ribonucleic acid--RNA | Patients | Antiretroviral therapy | Virology | Infectious diseases | Hospitals | Bone mineral density | RNA | Ribonucleic acid | HIV | Human immunodeficiency virus
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5. Full Text Patient retention in antiretroviral therapy programs in sub-Saharan Africa: A systematic review
by Rosen, Sydney and Fox, Matthew P and Gill, Christopher J
PLoS Medicine, ISSN 1549-1277, 10/2007, Volume 4, Issue 10, pp. 1691 - 1701
Background Long-term retention of patients in Africa's rapidly expanding antiretroviral therapy (ART) programs for HIV/AIDS is essential for these programs'... 
SOUTH-AFRICA | MEDICINE, GENERAL & INTERNAL | RAPID SCALE-UP | PRIVATE-SECTOR | TREATMENT SERVICE | FOLLOW-UP | RURAL DISTRICT | HIV-1-INFECTED PATIENTS | INCOME COUNTRIES | CELL COUNT | ADHERENCE | Severity of Illness Index | Drug Administration Schedule | Risk Assessment | Humans | Africa South of the Sahara | Male | Acquired Immunodeficiency Syndrome - drug therapy | Patient Compliance - statistics & numerical data | Dose-Response Relationship, Drug | Treatment Refusal - statistics & numerical data | Antiretroviral Therapy, Highly Active - standards | Anti-Retroviral Agents - administration & dosage | HIV Infections - diagnosis | Survival Analysis | Acquired Immunodeficiency Syndrome - mortality | Acquired Immunodeficiency Syndrome - diagnosis | Female | HIV Infections - drug therapy | HIV Infections - mortality | Developing Countries | Antiretroviral Therapy, Highly Active - trends | Care and treatment | Wellness programs | Analysis | Mortality | Research | HIV infection | Health aspects | Risk factors | International health | Infectious Diseases | AIDS | Public Health and Epidemiology | Medicine in Developing Countries | HIV Infection
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6. Full Text Treatment for Adult HIV Infection: 2006 Recommendations of the International AIDS Society–USA Panel
by Hammer, Scott M and Saag, Michael S and Schechter, Mauro and Montaner, Julio S. G and Schooley, Robert T and Jacobsen, Donna M and Thompson, Melanie A and Carpenter, Charles C. J and Fischl, Margaret A and Gazzard, Brian G and Gatell, Jose M and Hirsch, Martin S and Katzenstein, David A and Richman, Douglas D and Vella, Stefano and Yeni, Patrick G and Volberding, Paul A and International AIDS Society-USA panel
JAMA, ISSN 0098-7484, 08/2006, Volume 296, Issue 7, pp. 827 - 843
CONTEXT Guidelines for antiretroviral therapy are important for clinicians worldwide given the complexity of the field and the varied clinical situations in... 
MEDICINE, GENERAL & INTERNAL | TENOFOVIR DISOPROXIL FUMARATE | HEPATITIS-C VIRUS | COMBINATION THERAPY | ACTIVE ANTIRETROVIRAL THERAPY | EARLY VIROLOGICAL FAILURE | INITIAL TREATMENT | HIV-1-INFECTED PATIENTS | DRUG-RESISTANCE | HUMAN-IMMUNODEFICIENCY-VIRUS | DISEASE PROGRESSION | Humans | Drug Resistance, Viral | Tuberculosis - complications | Male | HIV - drug effects | Viral Load | Hepatitis B - complications | Pregnancy | HIV Infections - immunology | Antiretroviral Therapy, Highly Active - standards | HIV Infections - complications | Pregnancy Complications, Infectious - drug therapy | Adult | Female | HIV - genetics | HIV Infections - drug therapy | Hepatitis C - complications | Drug Monitoring | Antiviral agents | Care and treatment | AIDS treatment | HIV infection | Health aspects | Standards
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7. Full Text Antiretroviral Treatment of Adult HIV Infection: 2008 Recommendations of the International AIDS Society–USA Panel
by Hammer, Scott M and Eron, Joseph J and Reiss, Peter and Schooley, Robert T and Thompson, Melanie A and Walmsley, Sharon and Cahn, Pedro and Fischl, Margaret A and Gatell, Jose M and Hirsch, Martin S and Jacobsen, Donna M and Montaner, Julio S. G and Richman, Douglas D and Yeni, Patrick G and Volberding, Paul A and International AIDS Society-USA
JAMA, ISSN 0098-7484, 08/2008, Volume 300, Issue 5, pp. 555 - 570
CONTEXT The availability of new antiretroviral drugs and formulations, including drugs in new classes, and recent data on treatment choices for... 
MEDICINE, GENERAL & INTERNAL | TENOFOVIR DISOPROXIL FUMARATE | CD4 CELL COUNTS | REVERSE-TRANSCRIPTASE INHIBITORS | EXPERIENCED HIV-1-INFECTED PATIENTS | RANDOMIZED CONTROLLED-TRIAL | PLACEBO-CONTROLLED TRIAL | HUMAN-IMMUNODEFICIENCY-VIRUS | D-A-D | CHRONIC KIDNEY-DISEASE | TREATMENT-NAIVE PATIENTS | AIDS-Related Opportunistic Infections | HIV-1 - pathogenicity | AIDS-Associated Nephropathy | Risk Assessment | Comorbidity | Humans | Monitoring, Immunologic | Male | CD4 Lymphocyte Count | Pregnancy Complications, Infectious | AIDS Serodiagnosis - standards | Drug Resistance, Multiple, Viral | Evidence-Based Medicine | Viral Load | Anti-HIV Agents - administration & dosage | Pregnancy | Antiretroviral Therapy, Highly Active - standards | HIV Infections - diagnosis | Treatment Failure | Adult | Female | HIV Infections - drug therapy | Drug Monitoring | Antiviral agents | Medical care | Drug therapy | HIV infection | Health aspects | Risk factors | Quality management | Antiretroviral drugs | Medical treatment | Human immunodeficiency virus--HIV | Guidelines
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8. Full Text Adherence to Antiretroviral Therapy for Pediatric HIV Infection: A Qualitative Systematic Review With Recommendations for Research and Clinical Management
by Simoni, Jane M and Montgomery, Arianna and Martin, Erin and New, Michelle and Demas, Penelope A and Rana, Sohail
Pediatrics, ISSN 0031-4005, 06/2007, Volume 119, Issue 6, pp. e1371 - e1383
Although nonadherence to prescribed therapies is widespread, it is particularly problematic with highly active antiretroviral therapy for HIV infection. This... 
Adherence | HIV/AIDS | Interventions | Compliance | Pediatric | VIRAL LOAD | TRIALS | adherence | HUMAN-IMMUNODEFICIENCY-VIRUS | PROTEASE INHIBITORS | pediatric | CHILDREN | interventions | compliance | ADOLESCENTS | SELF-REPORT | PEDIATRICS | MEDICATION ADHERENCE | BEHAVIORAL SKILLS MODEL | POSITIVE MEN | Antiretroviral Therapy, Highly Active - standards | HIV Infections - economics | Practice Guidelines as Topic - standards | HIV Infections - epidemiology | Humans | Antiretroviral Therapy, Highly Active - economics | Health Planning Guidelines | HIV Infections - drug therapy | Disease Management | Patient Compliance | Child | AIDS | HIV
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9. Full Text Hunger, waiting time and transport costs: Time to confront challenges to ART adherence in Africa
by Hardon, A. P and Akurut, D and Comoro, C and Ekezie, C and Irunde, H. F and Gerrits, T and Kglatwane, J and Kinsman, J and Kwasa, R and Maridadi, J and Moroka, T. M and Moyo, S and Nakiyemba, A and Nsimba, S and Ogenyi, R and Oyabba, T and Temu, F and Laing, R
AIDS Care, ISSN 0954-0121, 05/2007, Volume 19, Issue 5, pp. 658 - 665
Adherence levels in Africa have been found to be better than those in the US. However around one out of four ART users fail to achieve optimal adherence,... 
international | refereed | SOUTH-AFRICA | PSYCHOLOGY, MULTIDISCIPLINARY | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | HIV-INFECTION | METAANALYSIS | RESOURCE-POOR SETTINGS | SUB-SAHARAN AFRICA | PROGRAMS | SOCIAL SCIENCES, BIOMEDICAL | ACTIVE ANTIRETROVIRAL THERAPY | HEALTH POLICY & SERVICES | EXPERIENCE | Costs and Cost Analysis | HIV Infections - economics | Transportation - statistics & numerical data | Humans | Health Services Needs and Demand - economics | Male | Hunger - ethnology | Health Services Accessibility - economics | Patient Compliance - ethnology | Antiretroviral Therapy, Highly Active - standards | Africa - ethnology | Antiretroviral Therapy, Highly Active - economics | Female | HIV Infections - drug therapy | Health Services Needs and Demand - standards | Patient Compliance - psychology | Health Services Accessibility - standards | Transportation - economics | Studies | Hunger | Drug resistance | Human immunodeficiency virus--HIV | Clinical outcomes
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10. Full Text Treatment for Adult HIV Infection: 2004 Recommendations of the International AIDS Society-USA Panel
by Yeni, Patrick G and Hammer, Scott M and Hirsch, Martin S and Saag, Michael S and Schechter, Mauro and Carpenter, Charles C. J and Fischl, Margaret A and Gatell, Jose M and Gazzard, Brian G and Jacobsen, Donna M and Katzenstein, David A and Montaner, Julio S. G and Richman, Douglas D and Schooley, Robert T and Thompson, Melanie A and Vella, Stefano and Volberding, Paul A
JAMA, ISSN 0098-7484, 07/2004, Volume 292, Issue 2, pp. 251 - 265
CONTEXT Substantial changes in the field of human immunodeficiency virus (HIV) treatment have occurred in the last 2 years, prompting revision of the... 
MEDICINE, GENERAL & INTERNAL | LOPINAVIR-RITONAVIR | PROGNOSTIC IMPORTANCE | STRUCTURED TREATMENT INTERRUPTION | COMBINATION THERAPY | ACTIVE ANTIRETROVIRAL THERAPY | IMMUNODEFICIENCY-VIRUS TYPE-1 | CD4(+) CELL COUNT | PROTEASE-INHIBITOR | INITIAL TREATMENT | SEQUENTIAL 3-DRUG REGIMENS | Antiretroviral Therapy, Highly Active - standards | Humans | Adult | Anti-HIV Agents - therapeutic use | HIV Infections - drug therapy | CD4 Lymphocyte Count | Viral Load
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11. Full Text A mechanistic theory to explain the efficacy of antiretroviral therapy
by Laskey, Sarah B and Siliciano, Robert F
Nature Reviews Microbiology, ISSN 1740-1526, 09/2014, Volume 12, Issue 11, pp. 772 - 780
In the early years of the AIDS epidemic, a diagnosis of HIV-1 infection was equivalent to a death sentence. The development of combination antiretroviral... 
CD4 CELL COUNTS | REPLICATION | HIV-1 DRUG-RESISTANCE | COMBINATION THERAPY | RESPONSE CURVE SLOPE | IMMUNODEFICIENCY-VIRUS TYPE-1 | DYNAMICS | MICROBIOLOGY | INFECTION | TREATMENT INTENSIFICATION | T-CELLS | Dose-Response Relationship, Drug | Drug Interactions | HIV-1 - physiology | Antiretroviral Therapy, Highly Active - standards | Models, Biological | HIV Infections - virology | Humans | Anti-HIV Agents - therapeutic use | HIV Infections - drug therapy | Treatment Outcome | Viremia - drug therapy | Highly active antiretroviral therapy | Models | Drug therapy, Combination | Drug therapy | Patient outcomes | AIDS (Disease)
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