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Angewandte Chemie International Edition, ISSN 1433-7851, 04/2016, Volume 55, Issue 17, pp. 5255 - 5258
The metabolic conversion of nucleoside analogues into their triphosphates often proceeds insufficiently. Rate‐limitations can be at the mono‐, but also at the... 
nucleoside analogues | biological activity | prodrugs | cell uptake | triphosphate | DIPHOSPHATE PRODRUGS | ACTIVATION | PURINE | PHOSPHORYLATION | CHEMISTRY, MULTIDISCIPLINARY | DELIVERY | NUCLEOTIDE | METABOLISM | PRONUCLEOTIDES | Anti-HIV Agents - pharmacology | Polyphosphates - pharmacology | Humans | Nucleosides - pharmacokinetics | Cell Membrane Permeability | Prodrugs - chemistry | HIV - drug effects | Prodrugs - metabolism | Swine | Thymine Nucleotides - metabolism | Nucleosides - pharmacology | Nucleosides - metabolism | Anti-HIV Agents - metabolism | CD4-Positive T-Lymphocytes - virology | Thymine Nucleotides - pharmacology | Cell Line | Nucleosides - chemistry | Esterases - metabolism | Thymine Nucleotides - chemical synthesis | Thymine Nucleotides - chemistry | Polyphosphates - metabolism | Anti-HIV Agents - chemistry | Animals | Prodrugs - pharmacokinetics | Anti-HIV Agents - pharmacokinetics | HIV Infections - drug therapy | Polyphosphates - pharmacokinetics | Prodrugs - pharmacology | Polyphosphates - chemistry | Phosphates | Nucleosides | Enzymes | Metabolites | Liver | Phosphonates | Protease inhibitors | Antiretroviral drugs | Drugs | Prodrugs | Series (mathematics) | Fluorescence | Lymphocytes T | Thymidine | Permeability | Derivatives | Chemical compounds | Conversion | Bearing | Polymerase chain reaction | Chemistry | Esterase | Phosphate | Antiviral activity | Nucleoside analogs
Journal Article
Cancer Research, ISSN 0008-5472, 04/2017, Volume 77, Issue 8, pp. 2102 - 2111
Journal Article
Israel Journal of Chemistry, ISSN 0021-2148, 06/2016, Volume 56, Issue 6-7, pp. 566 - 577
Journal Article
European Journal of Organic Chemistry, ISSN 1434-193X, 04/2014, Volume 2014, Issue 11, pp. 2201 - 2220
Journal Article
ChemMedChem, ISSN 1860-7179, 11/2018, Volume 13, Issue 21, pp. 2305 - 2316
Journal Article
AIDS (London, England), ISSN 0269-9370, 09/2015, Volume 29, Issue 14, pp. 1811 - 1820
Journal Article
PLoS ONE, ISSN 1932-6203, 2014, Volume 9, Issue 1, p. e85637
Nucleoside analogue reverse transcriptase inhibitor (NRTI), an integral component of highly active antiretroviral therapy (HAART), was widely used to inhibit... 
HIV/AIDS | REVERSE-TRANSCRIPTASE INHIBITORS | MULTIDISCIPLINARY SCIENCES | ACTIVE ANTIRETROVIRAL THERAPY | LACTIC-ACIDOSIS | TOXICITY | DYSFUNCTION | HYPERLACTATEMIA | CAPTURE | BRAIN | GENOME | DNA, Mitochondrial - metabolism | Liver - metabolism | Cells, Cultured | Didanosine - pharmacology | Zidovudine - pharmacology | Muscle, Skeletal - metabolism | Neurons - cytology | Mitochondria - metabolism | Mitochondria - drug effects | Cerebral Cortex - cytology | Cerebral Cortex - metabolism | Animals | Liver - drug effects | Muscle, Skeletal - drug effects | Stavudine - pharmacology | Lamivudine - pharmacology | Mice | Neurons - metabolism | Cerebral Cortex - drug effects | Neurons - drug effects | Antimetabolites - pharmacology | Highly active antiretroviral therapy | Antiviral agents | Brain | Neurons | Nucleosides | DNA polymerases | Mitochondrial DNA | RNA-directed DNA polymerase | Toxicity | Cardiomyopathy | Liver | Central nervous system | Stavudine | Glial cells | Polyneuropathy | Neuronal-glial interactions | Neurotoxicity | Blood-brain barrier | Acquired immune deficiency syndrome--AIDS | Clonal deletion | Antiretroviral agents | Animal tissues | Human immunodeficiency virus--HIV | Deletion | Lactic acidosis | Deoxyribonucleic acid--DNA | Antiretroviral drugs | Cortex | Muscles | Lamivudine | Exposure | Lipoatrophy | Didanosine | Acidosis | Zidovudine | Nucleoside analogs | Myopathy | Acquired immune deficiency syndrome | Deoxyribonucleic acid | AIDS | HIV | DNA | Human immunodeficiency virus
Journal Article
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 03/2013, Volume 57, Issue 3, pp. 1262 - 1269
Journal Article