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1. Oligonucleotides
Oligonucleotides, ISSN 1545-4576
Antisense peptides | Antisense nucleic acids
Journal
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2. Delivery strategies for antisense oligonucleotide therapeutics
by Akhtar, Saghir
1995, 1, ISBN 0849347785, 305
Drugs | Antisense nucleic acids | Dosage forms | Therapeutic use | Oligonucleotides | Pharmacology | Biopharmaceutics | Drug Design & Development
Book
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3. Full Text Cellular uptake and trafficking of antisense oligonucleotides
by Crooke, Stanley T and Wang, Shiyu and Vickers, Timothy A and Shen, Wen and Liang, Xue-Hai
Nature biotechnology, ISSN 1087-0156, 03/2017, Volume 35, Issue 3, pp. 230 - 237
Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | Animals | Oligonucleotides, Antisense - genetics | Humans | Oligonucleotides, Antisense - pharmacokinetics | Oligonucleotides, Antisense - therapeutic use | Cell Membrane - metabolism | Structure-Activity Relationship | Subcellular Fractions - metabolism | Genetic Therapy - methods | Health aspects | Oligonucleotides | Cellular biology | Gene expression | Ribonucleic acid--RNA | Gene therapy | Index Medicus
Journal Article
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4. Full Text Anti-microRNA-21 oligonucleotides prevent Alport nephropathy progression by stimulating metabolic pathways
by Gomez, Ivan G and MacKenna, Deidre A and Johnson, Bryce G and Kaimal, Vivek and Roach, Allie M and Ren, Shuyu and Nakagawa, Naoki and Xin, Cuiyan and Newitt, Rick and Pandya, Shweta and Xia, Tai-He and Liu, Xueqing and Borza, Dorin-Bogdan and Grafals, Monica and Shankland, Stuart J and Himmelfarb, Jonathan and Portilla, Didier and Liu, Shiguang and Chau, B. Nelson and Duffield, Jeremy S
The Journal of clinical investigation, ISSN 0021-9738, 01/2015, Volume 125, Issue 1, pp. 141 - 156
Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Up-Regulation | Nephritis, Hereditary - pathology | Reactive Oxygen Species - metabolism | Kidney - pathology | Transcriptome | MicroRNAs - metabolism | Mice, 129 Strain | Fibrosis - metabolism | Autoantigens - genetics | Nephritis, Hereditary - therapy | Disease Progression | Kidney - metabolism | Metabolic Networks and Pathways - genetics | Animals | Nephritis, Hereditary - metabolism | Collagen Type IV - deficiency | Oligoribonucleotides, Antisense - genetics | Collagen Type IV - genetics | MicroRNAs - genetics | MicroRNA | Oligonucleotides | Physiological aspects | Development and progression | Alport's syndrome | Genetic aspects | Research | Studies | Mutation | Rodents | Chronic illnesses | Index Medicus | Abridged Index Medicus
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5. Molecular Mechanisms of Antisense Oligonucleotides
by Crooke, Stanley T
Nucleic acid therapeutics, ISSN 2159-3337, 04/2017, Volume 27, Issue 2, pp. 70 - 77
RNase H | RNA | mechanisms | DNA | antisense | oligonucleotide | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Chemistry, Medicinal | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Nucleic Acid Hybridization | Membrane Glycoproteins - metabolism | Humans | RNA, Messenger - genetics | Gene Expression Regulation | Oligonucleotides, Antisense - metabolism | Eukaryotic Cells - metabolism | RNA, Messenger - metabolism | Membrane Glycoproteins - genetics | Receptors, Complement - metabolism | Oligonucleotides, Antisense - genetics | Biological Transport | RNA, Messenger - antagonists & inhibitors | Receptors, Complement - genetics | Cell Membrane - metabolism | Eukaryotic Cells - cytology | Kinetics | Ribonuclease H - genetics | Ribonuclease H - metabolism | Ribonucleic acid--RNA | Biochemistry | Pharmaceutical sciences | Index Medicus
Journal Article
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6. Full Text Antisense oligonucleotides for neurodegeneration
by Leavitt, Blair R and Tabrizi, Sarah J
Science (American Association for the Advancement of Science), ISSN 0036-8075, 03/2020, Volume 367, Issue 6485, pp. 1428 - 1429
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Huntington Disease - therapy | RNA Interference | Humans | Oligonucleotides, Antisense - therapeutic use | Gene Expression Regulation | Neurodegenerative Diseases - therapy | RNA Precursors - genetics | Clinical Trials as Topic | Huntingtin Protein - genetics | RNA, Messenger | Huntingtons disease | Parkinson's disease | Neurodegenerative diseases | Pathogenesis | Medical treatment | Central nervous system | Oligonucleotides | Clinical trials | Amyotrophic lateral sclerosis | Antisense oligonucleotides | Ribonucleic acid--RNA | Huntington's disease | Gene expression | Regulatory approval | Spinal muscular atrophy | Diseases | Mutants | Atrophy | Proteins | Motor neuron diseases | Neurodegeneration | Alzheimers disease | Alzheimer's disease | Movement disorders | Index Medicus
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7. Full Text Splice-switching antisense oligonucleotides as therapeutic drugs
by Havens, Mallory A and Hastings, Michelle L
Nucleic acids research, ISSN 0305-1048, 08/2016, Volume 44, Issue 14, pp. 6549 - 6563
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Genetic Therapy | Gene Expression | Animals | Humans | Oligonucleotides, Antisense - therapeutic use | RNA Splicing - genetics | Clinical Trials as Topic | Index Medicus | Survey and Summary
Journal Article
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8. The effects of 2'-o-methoxyethyl oligonucleotides on renal function in humans
by Crooke, Stanley T and Baker, Brenda F and Pham, Nguyen C and Hughes, Steven G and Kwoh, T. Jesse and Cai, Danlin and Tsimikas, Sotirios and Geary, Richard S and Bhanot, Sanjay
Nucleic acid therapeutics, ISSN 2159-3337, 02/2018, Volume 28, Issue 1, pp. 10 - 22
kidney | clinical trials | humans | safety | antisense | oligonucleotide | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Chemistry, Medicinal | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Hyperlipidemias - genetics | Receptors, Glucocorticoid - antagonists & inhibitors | Diabetes Mellitus - genetics | Humans | Middle Aged | Oligonucleotides, Antisense - metabolism | Male | Receptors, Glucocorticoid - metabolism | Obesity - genetics | Apolipoproteins - antagonists & inhibitors | Factor XI - antagonists & inhibitors | Clinical Trials, Phase III as Topic | Apolipoproteins - genetics | Oligonucleotides, Antisense - therapeutic use | Protein Tyrosine Phosphatases, Non-Receptor - genetics | Patient Safety | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Adult | Female | Hyperlipidemias - physiopathology | Hyperlipidemias - therapy | Thrombosis - therapy | Factor XI - genetics | Thrombosis - physiopathology | Glomerular Filtration Rate | Hyperlipidemias - metabolism | Apolipoproteins - metabolism | Diabetes Mellitus - metabolism | Obesity - physiopathology | Receptor Protein-Tyrosine Kinases - metabolism | Obesity - metabolism | Randomized Controlled Trials as Topic | Thrombosis - metabolism | Oligonucleotides, Antisense - genetics | Receptor Protein-Tyrosine Kinases - genetics | Diabetes Mellitus - physiopathology | Diabetes Mellitus - therapy | Protein Tyrosine Phosphatases, Non-Receptor - metabolism | Obesity - therapy | Receptors, Glucocorticoid - genetics | Creatinine - blood | Thrombosis - genetics | Factor XI - metabolism | Clinical Trials, Phase II as Topic | Protein Tyrosine Phosphatases, Non-Receptor - antagonists & inhibitors | Urine | Creatinine | Medical research | Renal function | Diabetes mellitus | Oligonucleotides | Clinical trials | Data processing | Antisense oligonucleotides | Dosage | Apolipoproteins | Patients | Clinical outcomes | Glomerular filtration rate | Incidence | Studies | Lipoproteins | Randomization | Metabolites | Diabetes | Kidney diseases | Drug dosages | Pharmaceuticals
Journal Article
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9. Full Text Antisense oligonucleotides in therapy for neurodegenerative disorders
by Evers, Melvin M and Toonen, Lodewijk J.A and van Roon-Mom, Willeke M.C
Advanced drug delivery reviews, ISSN 0169-409X, 06/2015, Volume 87, pp. 90 - 103
Genetic therapies | Allele-specific reduction | Splicing modulation | Blood brain barrier | Translational blockage | Neurodegenerative disorders | RNase H-mediated degradation | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Gene Targeting | Alternative Splicing - genetics | Humans | Oligonucleotides, Antisense - pharmacokinetics | Oligonucleotides, Antisense - chemistry | Neurodegenerative Diseases - genetics | Structure-Activity Relationship | Neurodegenerative Diseases - drug therapy | Blood-Brain Barrier - metabolism | Drug Delivery Systems | Alternative Splicing - drug effects | Animals | Oligonucleotides, Antisense - therapeutic use | Oligonucleotides, Antisense - administration & dosage | Drugs | Care and treatment | Nervous system diseases | Multiple sclerosis | Drug delivery systems | Peptides | RNA | Glycogen | Neurons | Creutzfeldt-Jakob disease | Amyloid beta-protein | Development and progression | Superoxide | Ribonuclease | Glutamate | Vehicles | Prevention | Synthesis | Huntington's chorea | Prions | Single nucleotide polymorphisms | Index Medicus
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