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Science, ISSN 0036-8075, 5/2009, Volume 324, Issue 5928, pp. 801 - 804
New drugs are required to counter the tuberculosis (TB) pandemic. Here, we describe the synthesis and characterization of 1,3-benzothiazin-4-ones (BTZs), a new... 
Enzymes | Antibacterials | Tuberculosis | Mycobacterium tuberculosis | Cell walls | Antituberculars | Bacteria | Reports | Biochemistry | Enantiomers | Codons | IDENTIFICATION | MULTIDISCIPLINARY SCIENCES | CELL-WALL | Antitubercular Agents - chemical synthesis | Antitubercular Agents - chemistry | Thiazines - therapeutic use | Ethambutol - pharmacology | Drug Resistance, Bacterial | Molecular Sequence Data | Spiro Compounds - therapeutic use | Tuberculosis - microbiology | Mycobacterium tuberculosis - drug effects | Polysaccharides - biosynthesis | Microbial Sensitivity Tests | Racemases and Epimerases - metabolism | Enzyme Inhibitors - chemistry | Spiro Compounds - chemical synthesis | Tuberculosis - drug therapy | Arabinose - metabolism | Thiazines - pharmacology | Molecular Structure | Mycobacterium tuberculosis - metabolism | Spiro Compounds - chemistry | Antitubercular Agents - therapeutic use | Amino Acid Sequence | Genes, Bacterial | Antitubercular Agents - pharmacology | Enzyme Inhibitors - pharmacology | Racemases and Epimerases - antagonists & inhibitors | Enzyme Inhibitors - therapeutic use | Thiazines - chemical synthesis | Thiazines - chemistry | Mycobacterium - genetics | Mycobacterium - drug effects | Gene Expression Regulation, Bacterial - drug effects | Animals | Cell Wall - metabolism | Enzyme Inhibitors - cerebrospinal fluid | Mice | Mice, Inbred BALB C | Spiro Compounds - pharmacology | Mycobacterium tuberculosis - genetics | Antitubercular agents | Dosage and administration | Drug therapy | Genetics | Pharmacology | Chemical synthesis
Journal Article
Lancet Infectious Diseases, The, ISSN 1473-3099, 2013, Volume 13, Issue 1, pp. 27 - 35
Summary Background Intensified antibiotic treatment might improve the outcome of tuberculous meningitis. We assessed pharmacokinetics, safety, and survival... 
Infectious Disease | MYCOBACTERIUM-TUBERCULOSIS | ETHAMBUTOL | INFECTIOUS DISEASES | IN-VITRO | PHARMACOKINETICS | LEVOFLOXACIN | PULMONARY TUBERCULOSIS | INFECTION | DRUG-RESISTANCE | CEREBROSPINAL-FLUID | CIPROFLOXACIN | Fluoroquinolones | Aza Compounds - pharmacokinetics | Antitubercular Agents - adverse effects | Rifampin - pharmacokinetics | Antibiotics, Antitubercular - adverse effects | Follow-Up Studies | Humans | Middle Aged | Aza Compounds - adverse effects | Male | Quinolines - administration & dosage | Quinolines - pharmacokinetics | Young Adult | Drug Therapy, Combination - adverse effects | Rifampin - adverse effects | Adult | Female | Rifampin - administration & dosage | Antibiotics, Antitubercular - administration & dosage | Aza Compounds - administration & dosage | Anti-Infective Agents - adverse effects | Antibiotics, Antitubercular - pharmacokinetics | Tuberculosis, Meningeal - drug therapy | Drug Administration Schedule | Drug Therapy, Combination - methods | Anti-Infective Agents - administration & dosage | Antitubercular Agents - pharmacokinetics | Anti-Infective Agents - pharmacokinetics | Adolescent | Antitubercular Agents - administration & dosage | Tuberculosis, Meningeal - metabolism | Quinolines - adverse effects | Indonesia | Tuberculosis | Meningitis | Dosage and administration | Product development | Moxifloxacin | Universities and colleges | Rifampin | Index Medicus
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 12/2011, Volume 55, Issue 12, pp. 5485 - 5492
Journal Article
Science, ISSN 0036-8075, 1/2005, Volume 307, Issue 5707, pp. 223 - 227
The incidence of tuberculosis has been increasing substantially on a worldwide basis over the past decade, but no tuberculosis-specific drugs have been... 
Antibacterials | Mycobacterium tuberculosis | Lungs | Half lives | Antituberculars | Multidrug resistant tuberculosis | Infections | Dosage | Bacterial load | Pharmacokinetics | Research Article | ANTITUBERCULOSIS AGENTS | MULTIDISCIPLINARY SCIENCES | Antitubercular Agents - chemistry | Humans | Drug Resistance, Bacterial | Molecular Sequence Data | Male | Tuberculosis - microbiology | Mycobacterium tuberculosis - drug effects | Quinolines - pharmacology | Dose-Response Relationship, Drug | Microbial Sensitivity Tests | Quinolines - pharmacokinetics | Tuberculosis, Multidrug-Resistant - microbiology | Enzyme Inhibitors - chemistry | Tuberculosis - drug therapy | Bacterial Proton-Translocating ATPases - antagonists & inhibitors | Drug Evaluation, Preclinical | Drug Therapy, Combination | Mycobacterium smegmatis - enzymology | Antitubercular Agents - therapeutic use | Amino Acid Sequence | Mycobacterium smegmatis - growth & development | Bacterial Proton-Translocating ATPases - chemistry | Bacterial Proton-Translocating ATPases - metabolism | Quinolines - chemistry | Antitubercular Agents - pharmacology | Enzyme Inhibitors - pharmacology | Enzyme Inhibitors - therapeutic use | Point Mutation | Animals | Antitubercular Agents - pharmacokinetics | Mycobacterium tuberculosis - enzymology | Mycobacterium smegmatis - drug effects | Diarylquinolines | Mice | Protein Subunits - antagonists & inhibitors | Protein Subunits - chemistry | Quinolines - therapeutic use | Mycobacterium tuberculosis - growth & development | Tuberculosis, Multidrug-Resistant - drug therapy | Care and treatment | Usage | Tuberculosis | Respiratory agents | Research | Adenosine triphosphatase | Clinical trials | Drug resistance
Journal Article