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Marine drugs, ISSN 1660-3397, 2011, Volume 9, Issue 7, pp. 1273 - 1292
Marine algae contain various bromophenols that have been shown to possess a variety of biological activities, including antioxidant, antimicrobial, anticancer,... 
Marine algae | Bromophenols | Bioactivity | CHEMISTRY, MEDICINAL | FEEDING-DETERRENT | POLYBROMINATED DIPHENYL ETHERS | RED ALGA | marine algae | DIBENZO-P-DIOXINS | SYMPHYOCLADIA-LATIUSCULA | IN-VITRO | bioactivity | ANTIMICROBIAL ACTIVITIES | POLYSIPHONIA-URCEOLATA | ANTIVIRAL ACTIVITY | FLAME RETARDANTS | bromophenols | Hydrocarbons, Brominated - metabolism | Phenols - isolation & purification | Anti-Infective Agents - isolation & purification | Antioxidants - chemistry | Anti-Infective Agents - metabolism | Hydrocarbons, Brominated - isolation & purification | Hypoglycemic Agents - metabolism | Anti-Infective Agents - pharmacology | Antioxidants - metabolism | Biological Products - pharmacology | Chlorophyta - metabolism | Hydrocarbons, Brominated - pharmacology | Antineoplastic Agents - metabolism | Antineoplastic Agents - isolation & purification | Anti-Infective Agents - chemistry | Antineoplastic Agents - pharmacology | Hydrocarbons, Brominated - chemistry | Phytotherapy | Phenols - pharmacology | Phaeophyta - metabolism | Rhodophyta - chemistry | Hypoglycemic Agents - chemistry | Antioxidants - pharmacology | Phenols - metabolism | Antineoplastic Agents - chemistry | Phaeophyta - chemistry | Hypoglycemic Agents - pharmacology | Rhodophyta - metabolism | Chlorophyta - chemistry | Hypoglycemic Agents - isolation & purification | Biological Products - chemistry | Antioxidants - isolation & purification | Biological Products - metabolism | Phenols - chemistry
Journal Article
Marine drugs, ISSN 1660-3397, 09/2018, Volume 16, Issue 9, p. 319
The mangrove ecosystem is considered as an attractive biodiversity hotspot that is intensively studied in the hope of discovering new useful chemical... 
Endophytes | Mangrove microorganisms | Bioactive natural products | Drug leads | CHEMISTRY, MEDICINAL | NATURAL-PRODUCT DISCOVERY | drug leads | CELL-CYCLE ARREST | endophytes | INDOLE-DITERPENES | ENDOPHYTIC FUNGUS | IN-VITRO | bioactive natural products | mangrove microorganisms | BACTERIAL DIVERSITY | A-C | MCF-7 CELLS | HETEROLOGOUS EXPRESSION | PENICILLIUM-BROCAE MA-231 | Glycoside Hydrolase Inhibitors - metabolism | Glycoside Hydrolase Inhibitors - isolation & purification | Plants - microbiology | Antiviral Agents - metabolism | Biodiversity | Fungi - metabolism | Endophytes - metabolism | Wetlands | Antineoplastic Agents - metabolism | Antineoplastic Agents - isolation & purification | Antifungal Agents - metabolism | Antineoplastic Agents - pharmacology | Biological Factors - metabolism | Biological Factors - isolation & purification | Receptor-Like Protein Tyrosine Phosphatases, Class 5 - antagonists & inhibitors | Antifungal Agents - pharmacology | Antiviral Agents - pharmacology | Bacteria - metabolism | Soil Microbiology | Anti-Bacterial Agents - metabolism | Anti-Bacterial Agents - isolation & purification | Glycoside Hydrolase Inhibitors - pharmacology | Drug Discovery | Antifungal Agents - isolation & purification | Anti-Bacterial Agents - pharmacology | Antiviral Agents - isolation & purification | Biological Factors - pharmacology | Fungicides | Ecosystems | Cytotoxicity | Genomes | Biology | Phosphatase | Ecosystem biology | Fungi | Proteins | Microorganisms | Secondary metabolites | Metabolites | Bioactive compounds | Bacteria | Physiology | Ecological distribution | Tyrosine | Antiviral agents | Plants (botany) | Mangrove swamps | Mangroves | Glucosidase | Lead compounds | Biological activity | Salinity | Studies | Organic chemistry | Soils | Chemistry | Soil microorganisms | Ecological niches | Natural products | Morphology | Niches | Protein-tyrosine-phosphatase | Cancer
Journal Article
Journal of virology, ISSN 0022-538X, 2016, Volume 90, Issue 21, pp. 9683 - 9692
RNA viruses present an extraordinary threat to human health, given their sudden and unpredictable appearance, the potential for rapid spread among the human... 
DRUG | EFLORNITHINE | REPLICATION | VIROLOGY | ALPHA-DIFLUOROMETHYLORNITHINE | DEPLETION | INFECTION | TRANSLATION | MAMMALIAN-CELLS | RESPIRATORY SYNDROME CORONAVIRUS | SPERMIDINE | Zika Virus Infection - drug therapy | Acetyltransferases - metabolism | Ebolavirus - metabolism | Chikungunya virus - metabolism | Humans | Eflornithine - pharmacology | Ebolavirus - drug effects | Zika Virus Infection - virology | Disease Outbreaks | RNA Viruses - drug effects | Hemorrhagic Fever, Ebola - virology | Hemorrhagic Fever, Ebola - drug therapy | Spermine - analogs & derivatives | Cell Line | Virus Replication - drug effects | Antiviral Agents - pharmacology | Mice, Inbred C57BL | Chikungunya Fever - drug therapy | Zika Virus - drug effects | Chikungunya Fever - virology | Polyamines - metabolism | Chikungunya virus - drug effects | Animals | Spermine - pharmacology | Mice | Spermine/analogs & derivatives | Virus Replication/drug effects | Hemorrhagic Fever, Ebola/virology | Life Sciences | Zika Virus/drug effects | Immunology | Chikungunya virus/metabolism | Chikungunya Fever/drug therapy | Zika Virus Infection/drug therapy | Ebolavirus/drug effects | Acetyltransferases/metabolism | Chikungunya virus/drug effects | Eflornithine/pharmacology | Spermine/pharmacology | Polyamines/metabolism | Chikungunya Fever/virology | Hemorrhagic Fever, Ebola/drug therapy | Virology | Microbiology and Parasitology | Zika Virus Infection/virology | Ebolavirus/metabolism | Antiviral Agents/pharmacology | RNA Viruses/drug effects
Journal Article
PloS one, ISSN 1932-6203, 2009, Volume 4, Issue 6, pp. e6093 - e6093
The persistence of transcriptionally silent but replication-competent HIV-1 reservoirs in Highly Active Anti-Retroviral Therapy (HAART)-treated infected... 
TRANSCRIPTIONAL ACTIVATION | LONG TERMINAL REPEAT | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | VALPROIC ACID | HUMAN-IMMUNODEFICIENCY-VIRUS | NF-KAPPA-B | BROMODOMAIN PROTEIN BRD4 | HISTONE DEACETYLASE | T-CELLS | P-TEFB | Anti-HIV Agents - pharmacology | HIV-1 - metabolism | NF-KappaB Inhibitor alpha | NF-kappa B - antagonists & inhibitors | Humans | Middle Aged | Enzyme Inhibitors - pharmacology | Nucleosomes - metabolism | Cytoplasm - metabolism | I-kappa B Proteins - metabolism | Virus Latency - drug effects | Drug Synergism | Monocytes - virology | Cell Nucleus - metabolism | CD8-Positive T-Lymphocytes - metabolism | Phorbol Esters - pharmacology | Adult | HIV Infections - drug therapy | HIV-1 - enzymology | Aged | Highly active antiretroviral therapy | Antiviral agents | Control | Physiological aspects | Genetic research | Genetic transcription | T cells | HIV (Viruses) | Health aspects | Therapy | Oxidative stress | Histone deacetylase | Transcription | Laboratories | CD8 antigen | Leukocytes (mononuclear) | Viruses | Lymphocytes T | Infections | Activation | Remodeling | DNA-directed RNA polymerase | Synergism | Recruitment | Long terminal repeat | Cell growth | Transfection | Acquired immune deficiency syndrome--AIDS | Lymphocytes | Human immunodeficiency virus--HIV | Peripheral blood mononuclear cells | Elongation | Deoxyribonucleic acid--DNA | NF-κB protein | Latent infection | Gene expression | Ribonucleic acid--RNA | Patients | Virology | CD4 antigen | Monocytes | Inhibitors | Replication | Reservoirs | Combined treatment | RNA polymerase II | Index Medicus | HIV Infections | HIV-1 | Enzyme Inhibitors | Virus Latency | I-kappa B Proteins | Anti-HIV Agents | CD8-Positive T-Lymphocytes | Life Sciences | Microbiology and Parasitology | NF-kappa B | Nucleosomes | Phorbol Esters | Cell Nucleus | Cytoplasm | RNA | Acquired immune deficiency syndrome | Deoxyribonucleic acid | Ribonucleic acid | AIDS | HIV | DNA | Human immunodeficiency virus
Journal Article
Nature (London), ISSN 1476-4687, 2016, Volume 535, Issue 7610, pp. 169 - 172
Ebola viruses (EBOVs) are responsible for repeated outbreaks of fatal infections, including the recent deadly epidemic in West Africa. There are currently no... 
SYSTEM | NIEMANN-PICK C1 | ENTRY | CHOLESTEROL | SMALL-MOLECULE INHIBITORS | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | ANTIBODY | RECEPTOR | INFECTION | HIV-1 VIRION FUSION | Temperature | Humans | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Antiviral Agents - metabolism | Endosomes - metabolism | Protein Subunits - metabolism | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Ebolavirus - drug effects | Ibuprofen - chemistry | Antiviral Agents - chemistry | Endosomes - drug effects | Viral Envelope Proteins - metabolism | Conserved Sequence | Marburgvirus - chemistry | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Binding Sites | Membrane Fusion - drug effects | Toremifene - metabolism | Toremifene - pharmacology | Cell Line | Antiviral Agents - pharmacology | Ibuprofen - pharmacology | Models, Molecular | Protein Structure, Quaternary - drug effects | Ibuprofen - metabolism | Virus Attachment - drug effects | Ebolavirus - chemistry | Viral Envelope Proteins - antagonists & inhibitors | Protein Stability - drug effects | Viral Envelope Proteins - chemistry | Hydrophobic and Hydrophilic Interactions | Protein Binding | Ligands | Protein Subunits - chemistry | Toremifene - chemistry | Ebola virus | Glycoproteins | Host-virus relationships | Observations | Health aspects | Drug interactions | Drug therapy | Binding sites | Viral infections | Crystal structure
Journal Article
Journal Article
PloS one, ISSN 1932-6203, 2018, Volume 13, Issue 12, p. e0209615
...)-free direct-acting-antiviral-agents (DAAs) affects liver steatosis and atherogenic risk... 
HEPATOCELLULAR-CARCINOMA | OXIDATIVE STRESS | LIPID-METABOLISM | THERAPY | METABOLISM-ASSOCIATED GENES | CHOLESTEROL | MULTIDISCIPLINARY SCIENCES | DISEASE | HEPATITIS-C-VIRUS | DACLATASVIR | EXPRESSION | Liver - virology | Atherosclerosis - virology | Humans | Middle Aged | Dyslipidemias - virology | Hepatitis C, Chronic - virology | Hepacivirus - pathogenicity | Male | Hepatitis C, Chronic - complications | Fatty Liver - chemically induced | Atherosclerosis - epidemiology | Liver - drug effects | Adult | Female | Hepatitis C, Chronic - epidemiology | Hepacivirus - drug effects | Fatty Liver - metabolism | Fatty Liver - virology | Atherosclerosis - chemically induced | Liver - metabolism | Risk Factors | Hepatitis C, Chronic - drug therapy | Atherosclerosis - metabolism | Dyslipidemias - epidemiology | Ribavirin - adverse effects | Antiviral Agents - adverse effects | Dyslipidemias - chemically induced | Lipid Metabolism - drug effects | Cholesterol, LDL - metabolism | Dyslipidemias - metabolism | Aged | Sustained Virologic Response | Fatty Liver - epidemiology | Prevention | Complications and side effects | Antiviral agents | Interferon | Dosage and administration | Research | Hepatoma | Hepatitis C virus | Liver cirrhosis | Risk factors | Lipoproteins (low density) | Laboratories | Liver | Dyslipidemia | Viruses | Lipids | Cardiovascular disease | Infections | Proteins | Hepatitis | Liver cancer | Genotype & phenotype | Fatty liver | Hepatology | Atherosclerosis | Gastroenterology | Attenuation | Oxidation | Lipid metabolism | University graduates | Metabolism | Patients | Cholesterol | Steatosis | Medicine | Lipoproteins | Body mass | Biopsy | Arteriosclerosis | Diabetes | Hepatitis C
Journal Article
Materials Science and Engineering: C, ISSN 0928-4931, 2016, Volume 61, pp. 1002 - 1017
Small molecules that bind genomic DNA have proven that they can be effective anticancer, antibiotic and antiviral therapeutic agents that affect the well-being of millions of people worldwide. Drug... 
Drug discovery | DNA hybridization | Drug–DNA interaction | DNA damage | Electrochemical DNA biosensor | Pharmacogenomics | Drug-DNA interaction | MATERIALS SCIENCE, BIOMATERIALS | MITOMYCIN-C | ANTICANCER DRUG | SITU ELECTROCHEMICAL EVALUATION | CARBON NANOTUBES | NUCLEIC-ACIDS | BREAST-CANCER | SURFACE-CONFINED DNA | ANTITUMOR DRUG | CYCLIC VOLTAMMETRY | ACTINOMYCIN-D | Anti-Bacterial Agents - analysis | Pharmacogenetics | Electrochemical Techniques | Alkylating Agents - pharmacology | Humans | Anti-Bacterial Agents - metabolism | Antineoplastic Agents - analysis | Intercalating Agents - pharmacology | DNA - metabolism | DNA Cleavage - drug effects | Alkylating Agents - metabolism | DNA - chemistry | Intercalating Agents - metabolism | Pharmaceutical Preparations - metabolism | DNA - analysis | Biosensing Techniques | Pharmaceutical Preparations - chemistry | Alkylating Agents - analysis | Nanostructures - chemistry | Anti-Bacterial Agents - pharmacology | Antineoplastic Agents - pharmacology | Intercalating Agents - analysis | Pharmaceutical Preparations - analysis | Antiviral agents | Usage | DNA replication | Drug interactions | DNA | Genetic research | Electrochemistry | Electric properties | Drugs | Deoxyribonucleic acid | Strands | Materials science | Nanostructure | Cognition | Biosensors | Binding sites
Journal Article