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Journal Article
Molecules, ISSN 1420-3049, 11/2017, Volume 22, Issue 11, p. 1881
Journal Article
Journal of Hepatology, ISSN 0168-8278, 2011, Volume 55, Issue 1, pp. 192 - 206
Journal Article
Journal Article
PLoS Pathogens, ISSN 1553-7366, 07/2012, Volume 8, Issue 7, p. 22
Hepatitis C virus (HCV) infects over 170 million people worldwide and is the leading cause of chronic liver diseases, including cirrhosis, liver failure, and... 
WILD-TYPE | TELAPREVIR | RAPID VIRAL RESPONSE | ENZYMATIC-ACTIVITIES | PRECLINICAL PROFILE | MICROBIOLOGY | DISCOVERY | INTERFERON | REPLICATION | VIROLOGY | ANTIVIRAL EFFICACY | BOCEPREVIR | PARASITOLOGY | Hepatitis C - drug therapy | Proline - metabolism | Humans | Hepacivirus - genetics | Structure-Activity Relationship | Antiviral Agents - metabolism | Protease Inhibitors - pharmacology | Indoles - metabolism | Viral Nonstructural Proteins - chemistry | Antiviral Agents - chemistry | Lactams - pharmacology | Proline - pharmacology | Indoles - pharmacology | Protease Inhibitors - therapeutic use | Oligopeptides - chemistry | Hepacivirus - drug effects | Protein Structure, Tertiary | Antiviral Agents - pharmacology | Proline - analogs & derivatives | Sulfonamides - chemistry | Models, Molecular | Protease Inhibitors - chemistry | Protease Inhibitors - metabolism | Oligopeptides - metabolism | Sulfonamides - pharmacology | Lactams - metabolism | Proline - chemistry | Drug Resistance, Viral - genetics | Hepatitis C - virology | Sulfonamides - metabolism | Oligopeptides - pharmacology | Viral Nonstructural Proteins - antagonists & inhibitors | Indoles - chemistry | Lactams - chemistry | Virus diseases | Viral drug resistance | Research | Protease inhibitors | Properties | Observations | Hepatitis | Liver cancer | Liver diseases | Ligands | Genetic diversity | Drug resistance | Pharmaceutical industry | Cancer therapies | Viral infections
Journal Article
Nature, ISSN 0028-0836, 07/2016, Volume 535, Issue 7610, pp. 169 - 172
Ebola viruses (EBOVs) are responsible for repeated outbreaks of fatal infections, including the recent deadly epidemic in West Africa. There are currently no... 
SYSTEM | NIEMANN-PICK C1 | ENTRY | CHOLESTEROL | SMALL-MOLECULE INHIBITORS | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | ANTIBODY | RECEPTOR | INFECTION | HIV-1 VIRION FUSION | Temperature | Humans | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Antiviral Agents - metabolism | Endosomes - metabolism | Protein Subunits - metabolism | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Ebolavirus - drug effects | Ibuprofen - chemistry | Antiviral Agents - chemistry | Endosomes - drug effects | Viral Envelope Proteins - metabolism | Conserved Sequence | Marburgvirus - chemistry | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Binding Sites | Membrane Fusion - drug effects | Toremifene - metabolism | Toremifene - pharmacology | Cell Line | Antiviral Agents - pharmacology | Ibuprofen - pharmacology | Models, Molecular | Protein Structure, Quaternary - drug effects | Ibuprofen - metabolism | Virus Attachment - drug effects | Ebolavirus - chemistry | Viral Envelope Proteins - antagonists & inhibitors | Protein Stability - drug effects | Viral Envelope Proteins - chemistry | Hydrophobic and Hydrophilic Interactions | Protein Binding | Ligands | Protein Subunits - chemistry | Toremifene - chemistry | Ebola virus | Glycoproteins | Host-virus relationships | Observations | Health aspects | Drug interactions | Drug therapy | Binding sites | Viral infections | Crystal structure
Journal Article
Acs chemical biology, ISSN 1554-8929, 06/2015, Volume 10, Issue 6, pp. 1362 - 1375
Peptide-based drug discovery has experienced a significant upturn within the past decade since the introduction of chemical modifications and :unnatural amino... 
ALPHA-HELICAL PEPTIDES | CLOSING OLEFIN METATHESIS | FACTOR-RECEPTOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | EPIDERMAL-GROWTH-FACTOR | ACUTE LYMPHOBLASTIC-LEUKEMIA | PROTEIN-PROTEIN INTERACTIONS | CELL-PENETRATING PEPTIDES | HYDROGEN-BOND SURROGATE | C-TERMINAL-DOMAIN | HIV-1 INTEGRASE INHIBITORS | Hepatitis C - drug therapy | Antineoplastic Agents - chemical synthesis | Humans | Malaria, Falciparum - pathology | Receptors, Cell Surface - antagonists & inhibitors | Neoplasms - chemistry | Peptides - chemical synthesis | HIV Infections - pathology | Neoplasms - genetics | Antiviral Agents - chemistry | Antineoplastic Agents - pharmacology | Antimalarials - chemical synthesis | Protein Structure, Tertiary | Malaria, Falciparum - drug therapy | Antiviral Agents - pharmacology | Peptides - chemistry | Protein Structure, Secondary | Signal Transduction | HIV Infections - virology | Gene Expression Regulation | Receptors, Cell Surface - agonists | Models, Molecular | Receptors, Cell Surface - metabolism | Antineoplastic Agents - chemistry | Drug Discovery | Antimalarials - pharmacology | Neoplasms - drug therapy | Peptides - pharmacology | Malaria, Falciparum - parasitology | Antimalarials - chemistry | Hepatitis C - virology | Antiviral Agents - chemical synthesis | HIV Infections - drug therapy | Hepatitis C - pathology | Neoplasms - pathology | Receptors, Cell Surface - genetics
Journal Article