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Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 01/2015, Volume 35, Issue 1, pp. 127 - 136
OBJECTIVE—Abdominal aortic aneurysm (AAA) is considered a chronic inflammatory disease; however, the molecular basis underlying the sterile inflammatory... 
macrophages | Cytokines | inflammation | oxidative stress | APOPTOSIS | CASPASE-1 | CHRONIC GRANULOMATOUS-DISEASE | ATHEROSCLEROSIS | PERIPHERAL VASCULAR DISEASE | cytokines | HEMATOLOGY | E-DEFICIENT MICE | Aortic Aneurysm, Abdominal - chemically induced | Aortic Aneurysm, Abdominal - prevention & control | Inflammasomes - metabolism | Reactive Oxygen Species - metabolism | Aortic Aneurysm, Abdominal - immunology | Oxidative Stress | NLR Family, Pyrin Domain-Containing 3 Protein | Humans | Male | Mitochondria - immunology | Aortic Aneurysm, Abdominal - metabolism | Time Factors | Apoptosis Regulatory Proteins - deficiency | Interleukin-1beta - metabolism | Inflammation Mediators - metabolism | Apoptosis Regulatory Proteins - genetics | Female | Apolipoproteins E | Aorta, Abdominal - pathology | Angiotensin II | Aorta, Abdominal - metabolism | Aortic Aneurysm, Abdominal - pathology | Macrophages - immunology | Disease Models, Animal | Signal Transduction | Mice, Inbred C57BL | Cells, Cultured | Mitochondria - metabolism | Inflammasomes - genetics | Macrophage Activation | Mice, Knockout | Aorta, Abdominal - immunology | Carrier Proteins - genetics | Macrophages - metabolism | Animals | Carrier Proteins - metabolism | Caspase 1 - genetics | CARD Signaling Adaptor Proteins | Inflammasomes - immunology | Caspase 1 - deficiency | Fibrosis | Aged
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 07/2017, Volume 37, Issue 11, pp. 2102 - 2102
OBJECTIVE—The role of TGF-β (transforming growth factor-β) signaling in abdominal aortic aneurysm (AAA) formation is controversial. Others reported that... 
aneurysm | smooth muscle | SERVICES TASK-FORCE | ATHEROSCLEROSIS | RECEPTOR | mice | macrophages | TGF-beta | DISRUPTION | angiotensin II | ANEURYSM MOUSE MODEL | PERIPHERAL VASCULAR DISEASE | aorta | SMOOTH-MUSCLE-CELLS | APOE(-/-) MICE | HEMATOLOGY | E-DEFICIENT MICE | PROMOTES | PROGRESSION | Protein-Serine-Threonine Kinases - deficiency | Tunica Media - pathology | Aortic Aneurysm, Abdominal - chemically induced | Receptors, Transforming Growth Factor beta - genetics | Aortic Aneurysm, Abdominal - prevention & control | Muscle, Smooth, Vascular - metabolism | Transforming Growth Factor beta1 - antagonists & inhibitors | Transforming Growth Factor beta2 - metabolism | Aortic Aneurysm, Thoracic - prevention & control | Transforming Growth Factor beta1 - metabolism | Male | Aortic Aneurysm, Thoracic - chemically induced | Transforming Growth Factor beta3 - metabolism | Aorta, Abdominal - drug effects | Aortic Aneurysm, Abdominal - metabolism | Adventitia - metabolism | Receptor, Transforming Growth Factor-beta Type II | Aortic Aneurysm, Thoracic - pathology | Tunica Media - metabolism | Transforming Growth Factor beta - antagonists & inhibitors | Female | Aorta, Abdominal - pathology | Aorta, Thoracic - drug effects | Vascular Remodeling - drug effects | Angiotensin II | Aorta, Abdominal - metabolism | Dilatation, Pathologic | Aorta, Thoracic - pathology | Aortic Aneurysm, Abdominal - pathology | Disease Models, Animal | Muscle, Smooth, Vascular - drug effects | Severity of Illness Index | Genetic Predisposition to Disease | Mice, Inbred C57BL | Protein-Serine-Threonine Kinases - genetics | Aorta, Thoracic - metabolism | Transforming Growth Factor beta3 - antagonists & inhibitors | Mice, Knockout | Antibodies - pharmacology | Muscle, Smooth, Vascular - pathology | Phenotype | Animals | Signal Transduction - drug effects | Aortic Aneurysm, Thoracic - metabolism | Transforming Growth Factor beta2 - antagonists & inhibitors | Adventitia - pathology | Transforming Growth Factor beta - metabolism | Receptors, Transforming Growth Factor beta - deficiency | growth factor | Animal Models of Human Disease | Vascular Disease | Genetically Altered and Transgenic Models | Aortic Dissection | genetically altered mice
Journal Article
Hypertension, ISSN 0194-911X, 09/2017, Volume 70, Issue 5, pp. 959 - 963
Journal Article
Atherosclerosis, ISSN 0021-9150, 2011, Volume 217, Issue 2, pp. 350 - 357
Abstract Objective We sought to examine the effect of resveratrol (3,4′,5-trihydroxy-trans-stilbene), a plant-derived polyphenolic compound, on the development... 
Cardiovascular | Neoangiogenesis | Oxidative stress | Extracellular matrix | Inflammation | Abdominal aortic aneurysm | CELLS | ACTIVATION | ANGIOGENESIS | TRANSCRIPTION | COMPOUND | FACTOR-KAPPA-B | ANGIOTENSIN-II | INHIBITION | TRANS-RESVERATROL | PERIPHERAL VASCULAR DISEASE | E-DEFICIENT MICE | Inflammation - chemically induced | Neovascularization, Physiologic - drug effects | Aortic Aneurysm, Abdominal - chemically induced | Phosphorylation | Aortic Aneurysm, Abdominal - prevention & control | Reactive Oxygen Species - metabolism | Aortic Aneurysm, Abdominal - immunology | Extracellular Matrix - metabolism | Stilbenes - pharmacology | Aorta, Abdominal - drug effects | Aortic Aneurysm, Abdominal - metabolism | Inflammation - metabolism | Matrix Metalloproteinase 9 - metabolism | Inflammation Mediators - metabolism | Aorta, Abdominal - pathology | Aorta, Abdominal - metabolism | Aortic Aneurysm, Abdominal - pathology | Macrophages - immunology | Disease Models, Animal | Calcium Chloride | Anti-Inflammatory Agents - pharmacology | Matrix Metalloproteinase 2 - metabolism | Mice, Inbred C57BL | Angiogenesis Inhibitors - pharmacology | Inflammation - immunology | Antioxidants - pharmacology | Aorta, Abdominal - immunology | Animals | Transcription Factor RelA - metabolism | Aortic Aneurysm, Abdominal - physiopathology | Macrophages - drug effects | Inflammation - prevention & control | Mice | Oxidative Stress - drug effects | Inflammation - physiopathology | Prevention | Medical colleges | Atherosclerosis | Resveratrol | Neovascularization | Abdominal aneurysm
Journal Article
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 09/2017, Volume 37, Issue 11, pp. 2161 - 2170
OBJECTIVE—Abdominal aortic aneurysm (AAA) is an increasingly prevalent and ultimately fatal disease with no effective pharmacological treatment. Because matrix... 
microRNAs | Inflammation | Matrix metalloproteinase 9 | Bone marrow cells | Aortic aneurysm, abdominal | bone marrow cells | aortic aneurysm, abdominal | ATHEROSCLEROSIS | MODEL | HDL | INHIBITION | inflammation | matrix metalloproteinase 9 | MONOCYTE-CHEMOATTRACTANT PROTEIN-1 | DENSITY-LIPOPROTEIN | CHOLESTEROL EFFLUX | DISEASE | PERIPHERAL VASCULAR DISEASE | MICE | HEMATOLOGY | EXPRESSION | Aortic Aneurysm, Abdominal - chemically induced | Vascular Remodeling | Aortic Aneurysm, Abdominal - prevention & control | Apolipoproteins E - deficiency | Muscle, Smooth, Vascular - metabolism | Humans | Macrophages, Peritoneal - pathology | Myocytes, Smooth Muscle - pathology | JNK Mitogen-Activated Protein Kinases - metabolism | Male | MicroRNAs - metabolism | Aortitis - chemically induced | Aortitis - prevention & control | Aortic Aneurysm, Abdominal - metabolism | Matrix Metalloproteinase 9 - metabolism | Transfection | Time Factors | Bone Marrow Transplantation | Inflammation Mediators - metabolism | Female | Chemokine CCL2 - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | Aorta, Abdominal - pathology | Angiotensin II | Aorta, Abdominal - metabolism | Dilatation, Pathologic | Myocytes, Smooth Muscle - metabolism | Disease Models, Animal | Cell Line | Calcium Chloride | Genetic Predisposition to Disease | Signal Transduction | Mice, Inbred C57BL | Aortitis - genetics | Aortic Aneurysm, Abdominal - genetics | Mice, Knockout | Aortitis - metabolism | Muscle, Smooth, Vascular - pathology | Phenotype | Animals | Apolipoproteins E - genetics | Cholesterol, HDL - blood | MicroRNAs - genetics | Macrophages, Peritoneal - metabolism
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 06/2012, Volume 32, Issue 6, pp. 1400 - 1409
OBJECTIVE—Recently, we reported that angiopoietin-like protein 2 (Angptl2) functions in various chronic inflammatory diseases. In the present study, we asked... 
Angiopoietin-like protein 2 | Matrix metalloproteinase | Chronic inflammation | Abdominal aortic aneurysm | Macrophage | CELLS | RISK-FACTORS | macrophage | RANDOMIZED CONTROLLED-TRIAL | abdominal aortic aneurysm | angiopoietin-like protein 2 | PATHOGENESIS | INHIBITION | INFLAMMATION | GROWTH | METALLOPROTEINASE-9 | SURVEILLANCE | matrix metalloproteinase | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | NF-KAPPA-B | chronic inflammation | Immunohistochemistry | Aortic Aneurysm, Abdominal - chemically induced | Aortic Aneurysm, Abdominal - prevention & control | Aortic Aneurysm, Abdominal - immunology | Humans | Extracellular Matrix - metabolism | Male | Aortic Aneurysm, Abdominal - metabolism | Matrix Metalloproteinase 9 - metabolism | Angiopoietin-like Proteins | Matrix Metalloproteinase 9 - genetics | Bone Marrow Transplantation | Inflammation Mediators - metabolism | Aorta, Abdominal - pathology | Aorta, Abdominal - metabolism | Cytokines - genetics | Aortic Aneurysm, Abdominal - pathology | Macrophages - immunology | Disease Models, Animal | Angiopoietins - metabolism | Calcium Chloride | Cytokines - metabolism | Macrophages - pathology | Mice, Inbred C57BL | Gene Expression Regulation | Angiopoietins - deficiency | Genotype | Aortic Aneurysm, Abdominal - genetics | Mice, Knockout | Aorta, Abdominal - immunology | Macrophages - metabolism | Phenotype | Animals | Mice | Angiopoietins - genetics
Journal Article
Journal Article
Circulation, ISSN 0009-7322, 12/2017, Volume 136, Issue 23, pp. 2271 - 2283
BACKGROUND:Abnormal amino acid metabolism is associated with vascular disease. However, the causative link between dysregulated tryptophan metabolism and... 
indoleamine-pyrrole 2,3-dioxygenase | angiotensin II | matrix metallopeptidases | tryptophan | aortic aneurysm, abdominal | 3-hydroxyanthranilic acid | OXIDATIVE STRESS | CARDIAC & CARDIOVASCULAR SYSTEMS | KYNURENINE PATHWAY | INDOLEAMINE 2,3-DIOXYGENASE | T-CELL | FAMILIAL HYPERTRYPTOPHANEMIA | DEGRADE INSOLUBLE ELASTIN | PERIPHERAL VASCULAR DISEASE | SMOOTH-MUSCLE-CELLS | CHRONIC KIDNEY-DISEASE | CARDIOVASCULAR RISK | HYPERCHOLESTEROLEMIC MICE | Indoleamine-Pyrrole 2,3,-Dioxygenase - genetics | Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism | Aortic Aneurysm, Abdominal - chemically induced | Hydrolases - genetics | Aortic Aneurysm, Abdominal - prevention & control | Muscle, Smooth, Vascular - metabolism | Humans | Myocytes, Smooth Muscle - pathology | NF-kappa B - metabolism | Interferon-gamma - metabolism | Tryptophan - metabolism | Aortic Aneurysm, Abdominal - metabolism | Elastic Tissue - metabolism | Time Factors | Bone Marrow Transplantation | Aorta, Abdominal - pathology | Angiotensin II | Aorta, Abdominal - metabolism | Dilatation, Pathologic | Myocytes, Smooth Muscle - metabolism | Aortic Aneurysm, Abdominal - pathology | Disease Models, Animal | Hydrolases - metabolism | Matrix Metalloproteinase 2 - metabolism | Cells, Cultured | Genotype | 3-Hydroxyanthranilic Acid - metabolism | Mice, Knockout, ApoE | Elastic Tissue - pathology | Muscle, Smooth, Vascular - pathology | Phenotype | Animals | matrix metallopeptidase | Abdominal aortic aneurysm
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 2016, Volume 213, Issue 11, pp. 2473 - 2488
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 02/2018, Volume 38, Issue 4, pp. 843 - 853
Journal Article
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 07/2014, Volume 34, Issue 7, pp. 1412 - 1421
Journal Article