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Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 07/2017, Volume 37, Issue 11, pp. 2102 - 2102
OBJECTIVE—The role of TGF-β (transforming growth factor-β) signaling in abdominal aortic aneurysm (AAA) formation is controversial. Others reported that... 
aneurysm | smooth muscle | SERVICES TASK-FORCE | ATHEROSCLEROSIS | RECEPTOR | mice | macrophages | TGF-beta | DISRUPTION | angiotensin II | ANEURYSM MOUSE MODEL | PERIPHERAL VASCULAR DISEASE | aorta | SMOOTH-MUSCLE-CELLS | APOE(-/-) MICE | HEMATOLOGY | E-DEFICIENT MICE | PROMOTES | PROGRESSION | Protein-Serine-Threonine Kinases - deficiency | Tunica Media - pathology | Aortic Aneurysm, Abdominal - chemically induced | Receptors, Transforming Growth Factor beta - genetics | Aortic Aneurysm, Abdominal - prevention & control | Muscle, Smooth, Vascular - metabolism | Transforming Growth Factor beta1 - antagonists & inhibitors | Transforming Growth Factor beta2 - metabolism | Aortic Aneurysm, Thoracic - prevention & control | Transforming Growth Factor beta1 - metabolism | Male | Aortic Aneurysm, Thoracic - chemically induced | Transforming Growth Factor beta3 - metabolism | Aorta, Abdominal - drug effects | Aortic Aneurysm, Abdominal - metabolism | Adventitia - metabolism | Receptor, Transforming Growth Factor-beta Type II | Aortic Aneurysm, Thoracic - pathology | Tunica Media - metabolism | Transforming Growth Factor beta - antagonists & inhibitors | Female | Aorta, Abdominal - pathology | Aorta, Thoracic - drug effects | Vascular Remodeling - drug effects | Angiotensin II | Aorta, Abdominal - metabolism | Dilatation, Pathologic | Aorta, Thoracic - pathology | Aortic Aneurysm, Abdominal - pathology | Disease Models, Animal | Muscle, Smooth, Vascular - drug effects | Severity of Illness Index | Genetic Predisposition to Disease | Mice, Inbred C57BL | Protein-Serine-Threonine Kinases - genetics | Aorta, Thoracic - metabolism | Transforming Growth Factor beta3 - antagonists & inhibitors | Mice, Knockout | Antibodies - pharmacology | Muscle, Smooth, Vascular - pathology | Phenotype | Animals | Signal Transduction - drug effects | Aortic Aneurysm, Thoracic - metabolism | Transforming Growth Factor beta2 - antagonists & inhibitors | Adventitia - pathology | Transforming Growth Factor beta - metabolism | Receptors, Transforming Growth Factor beta - deficiency | Index Medicus | growth factor | Animal Models of Human Disease | Vascular Disease | Genetically Altered and Transgenic Models | Aortic Dissection | genetically altered mice
Journal Article
Diabetes, ISSN 0012-1797, 08/2018, Volume 67, Issue 8, pp. 1549 - 1560
Obesity increases the risk of vascular diseases, including aortic aneurysm (AA). Perivascular adipose tissue (PVAT) surrounding arteries are altered during... 
PATHOGENESIS | CELLS | GROWTH-FACTOR-BETA | HOMEOSTASIS | INFLAMMATION | ENDOCRINOLOGY & METABOLISM | CARDIOVASCULAR-DISEASE | WEIGHT-LOSS | FAT | RECEPTOR | MICE | Drug Implants | Aortic Aneurysm, Abdominal - diagnostic imaging | Male | Aorta, Abdominal - drug effects | Aortic Aneurysm, Abdominal - metabolism | Adventitia - metabolism | Aorta, Abdominal - diagnostic imaging | Platelet-Derived Growth Factor - agonists | Lymphokines - antagonists & inhibitors | Lymphokines - metabolism | Obesity - etiology | Angiotensin II - adverse effects | Recombinant Proteins - chemistry | Mice, Transgenic | Obesity - physiopathology | Adventitia - drug effects | Intra-Abdominal Fat - metabolism | Obesity - pathology | Subcutaneous Fat, Abdominal - pathology | Survival Analysis | Benzimidazoles - pharmacology | Adventitia - pathology | Mice | Aortic Aneurysm, Abdominal - etiology | Angiotensin II - administration & dosage | Adventitia - immunology | Diet, High-Fat - adverse effects | Platelet-Derived Growth Factor - genetics | Quinolines - pharmacology | Lymphokines - genetics | Mice, Mutant Strains | Inflammation Mediators - metabolism | Subcutaneous Fat, Abdominal - immunology | Intra-Abdominal Fat - drug effects | Aorta, Abdominal - pathology | Aorta, Abdominal - metabolism | Aortic Aneurysm, Abdominal - pathology | Intra-Abdominal Fat - immunology | Recombinant Proteins - metabolism | Cells, Cultured | Organ Specificity | Obesity - metabolism | Gene Expression Regulation - drug effects | Subcutaneous Fat, Abdominal - drug effects | Platelet-Derived Growth Factor - metabolism | Animals | Lymphokines - agonists | Intra-Abdominal Fat - pathology | Subcutaneous Fat, Abdominal - metabolism | Platelet-Derived Growth Factor - antagonists & inhibitors | Obesity | Complications and side effects | Wound healing | Research | Abdominal aneurysm | Risk factors | Animal models | Adipose tissue | Platelet-derived growth factor | Cytokines | Pathogenesis | Migration | Transgenic mice | Aneurysm | Aneurysms | Inflammation | Gene expression | Arteries | High fat diet | Vascular diseases | Leptin | Angiotensin | Fibroblasts | Aorta | Angiotensin II | Index Medicus | Abridged Index Medicus
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 05/2019, Volume 380, Issue 19, pp. e35 - e35
Journal Article
Science Translational Medicine, ISSN 1946-6234, 02/2012, Volume 4, Issue 122, pp. 122ra22 - 122ra22
Journal Article
Cardiovascular Research, ISSN 0008-6363, 08/2017, Volume 113, Issue 10, pp. 1230 - 1242
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 09/2017, Volume 37, Issue 11, pp. 2171 - 2181
OBJECTIVE—Current experimental models of abdominal aortic aneurysm (AAA) do not accurately reproduce the major features of human AAA. We hypothesized that... 
Models | Animals | Humans | Aneurysm | Immune system | aneurysm | models | MANAGEMENT | RECEPTOR | II-INFUSED MICE | MURINE MODEL | DISRUPTION | DISSECTION | ELASTASE | DEFICIENT | immune system | PERIPHERAL VASCULAR DISEASE | animals | HEMATOLOGY | humans | Antibodies, Monoclonal - toxicity | Aortic Aneurysm, Abdominal - chemically induced | Thrombosis - chemically induced | Aortic Aneurysm, Abdominal - immunology | Extracellular Matrix - metabolism | Male | Aortic Rupture - metabolism | Aortic Rupture - immunology | Apolipoproteins E - metabolism | Aorta, Abdominal - drug effects | Aortic Aneurysm, Abdominal - metabolism | Chemotaxis, Leukocyte - drug effects | Interleukin-1beta - metabolism | Synchrotrons | Ultrasonography | Transforming Growth Factor beta - antagonists & inhibitors | Aorta, Abdominal - pathology | Vascular Remodeling - drug effects | Aorta, Abdominal - metabolism | Dilatation, Pathologic | Wound Healing - drug effects | Aortic Aneurysm, Abdominal - pathology | Disease Models, Animal | Transforming Growth Factor beta - immunology | Extracellular Matrix - drug effects | Mice, Inbred C57BL | Aortic Rupture - pathology | Disease Progression | Mice, Knockout | Aorta, Abdominal - immunology | Thrombosis - pathology | Thrombosis - metabolism | Apolipoproteins E - genetics | Pancreatic Elastase | Aortic Rupture - chemically induced | Kinetics | Extracellular Matrix - pathology | Transforming Growth Factor beta - metabolism | Index Medicus
Journal Article
Circulation, ISSN 0009-7322, 06/2015, Volume 131, Issue 24, pp. 2104 - 2113
Background-Data are limited on the presence, distribution, and extent of subclinical atherosclerosis in middle-aged populations. Methods and Results-The PESA... 
Population | Epidemiology | Risk assessment | Atherosclerosis | Ultrasonography | Multidetector computed tomography | atherosclerosis | YOUNG-ADULTS | risk assessment | DESIGN | CARDIAC & CARDIOVASCULAR SYSTEMS | EVENTS | ultrasonography | RISK | PLAQUE | population | epidemiology | multidetector computed tomography | CARDIOVASCULAR-DISEASE | PERIPHERAL VASCULAR DISEASE | HEALTH | CORONARY-HEART-DISEASE | ARTERY CALCIUM | ASSOCIATION | Aortic Diseases - diagnostic imaging | Femoral Artery - pathology | Iliac Artery - pathology | Plaque, Atherosclerotic - diagnostic imaging | Prevalence | Prospective Studies | Age Factors | Follow-Up Studies | Ankle Brachial Index | Humans | Middle Aged | Calcinosis - diagnostic imaging | Male | Plaque, Atherosclerotic - epidemiology | Asymptomatic Diseases | Atherosclerosis - epidemiology | Aorta, Abdominal - diagnostic imaging | Atherosclerosis - diagnostic imaging | Carotid Artery Diseases - diagnostic imaging | Carotid Artery Diseases - pathology | Coronary Artery Disease - pathology | Adult | Female | Aorta, Abdominal - pathology | Aortic Diseases - pathology | Multidetector Computed Tomography | Atherosclerosis - pathology | Aortic Diseases - epidemiology | Comorbidity | Risk Factors | Carotid Artery Diseases - epidemiology | Disease Progression | Calcinosis - epidemiology | Coronary Angiography | Coronary Artery Disease - diagnostic imaging | Femoral Artery - diagnostic imaging | Iliac Artery - diagnostic imaging | Spain - epidemiology | Coronary Artery Disease - epidemiology | Aortography | Calcinosis - pathology | Index Medicus | Abridged Index Medicus
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 01/2015, Volume 35, Issue 1, pp. 127 - 136
OBJECTIVE—Abdominal aortic aneurysm (AAA) is considered a chronic inflammatory disease; however, the molecular basis underlying the sterile inflammatory... 
macrophages | Cytokines | inflammation | oxidative stress | APOPTOSIS | CASPASE-1 | CHRONIC GRANULOMATOUS-DISEASE | ATHEROSCLEROSIS | PERIPHERAL VASCULAR DISEASE | cytokines | HEMATOLOGY | E-DEFICIENT MICE | Aortic Aneurysm, Abdominal - chemically induced | Aortic Aneurysm, Abdominal - prevention & control | Inflammasomes - metabolism | Reactive Oxygen Species - metabolism | Aortic Aneurysm, Abdominal - immunology | Oxidative Stress | NLR Family, Pyrin Domain-Containing 3 Protein | Humans | Male | Mitochondria - immunology | Aortic Aneurysm, Abdominal - metabolism | Time Factors | Apoptosis Regulatory Proteins - deficiency | Interleukin-1beta - metabolism | Inflammation Mediators - metabolism | Apoptosis Regulatory Proteins - genetics | Female | Apolipoproteins E | Aorta, Abdominal - pathology | Angiotensin II | Aorta, Abdominal - metabolism | Aortic Aneurysm, Abdominal - pathology | Macrophages - immunology | Disease Models, Animal | Signal Transduction | Mice, Inbred C57BL | Cells, Cultured | Mitochondria - metabolism | Inflammasomes - genetics | Macrophage Activation | Mice, Knockout | Aorta, Abdominal - immunology | Carrier Proteins - genetics | Macrophages - metabolism | Animals | Carrier Proteins - metabolism | Caspase 1 - genetics | CARD Signaling Adaptor Proteins | Inflammasomes - immunology | Caspase 1 - deficiency | Fibrosis | Aged | Index Medicus
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 02/2013, Volume 33, Issue 2, pp. 294 - 304
OBJECTIVE—Abdominal aortic aneurysms (AAAs) are common, but their exact pathogenesis remains unknown and no specific medical therapies are available. We sought... 
aneurysm | vascular inflammation | animal model surgery | interleukin-1 receptor antagonist | aortic disease | RHEUMATOID-ARTHRITIS | MUSCLE PHENOTYPIC MODULATION | ANAKINRA | MODEL | RECEPTOR ANTAGONIST | PATHOPHYSIOLOGY | INFLAMMATION | DISEASE | PERIPHERAL VASCULAR DISEASE | IL-1-BETA | MICE | HEMATOLOGY | Aortic Aneurysm, Abdominal - chemically induced | Aortic Aneurysm, Abdominal - prevention & control | Humans | Receptors, Interleukin-1 - genetics | Male | Interleukin-1beta - genetics | RNA, Messenger - metabolism | Aorta, Abdominal - drug effects | Interleukin-1beta - deficiency | Aortic Aneurysm, Abdominal - metabolism | Dose-Response Relationship, Drug | Time Factors | Receptors, Interleukin-1 - deficiency | Aorta, Abdominal - pathology | Interleukin 1 Receptor Antagonist Protein - pharmacology | Aorta, Abdominal - metabolism | Dilatation, Pathologic | Neutrophils - metabolism | Aortic Aneurysm, Abdominal - pathology | Disease Models, Animal | Interleukin-1beta - antagonists & inhibitors | Neutrophils - pathology | Elastin - metabolism | Macrophages - pathology | Mice, Inbred C57BL | Neutrophils - drug effects | Gene Expression Regulation | Aortic Aneurysm, Abdominal - genetics | Mice, Knockout | Macrophages - metabolism | Animals | Signal Transduction - drug effects | Pancreatic Elastase | Macrophages - drug effects | Mice | Receptors, Interleukin-1 - antagonists & inhibitors | Index Medicus | Interleukin-1 Receptor Antagonist | Aortic disease | Vascular Inflammation | Animal model surgery | Aneurysm
Journal Article