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Arteriosclerosis, thrombosis, and vascular biology, ISSN 1524-4636, 09/2017, Volume 37, Issue 9, pp. 1657 - 1666
.... We investigated the effects of mTOR inhibition in Eln-null mice partially rescued by human ELN that manifest a less severe arterial phenotype and survive long term... 
collagen | everolimus | aorta | elastin | mice | Peripheral Vascular Disease | Life Sciences & Biomedicine | Hematology | Cardiovascular System & Cardiology | Science & Technology | Phosphorylation | Mechanotransduction, Cellular - drug effects | TOR Serine-Threonine Kinases - metabolism | Humans | Mechanistic Target of Rapamycin Complex 2 | Muscle, Smooth, Vascular - physiopathology | Mechanistic Target of Rapamycin Complex 1 | TOR Serine-Threonine Kinases - antagonists & inhibitors | Multiprotein Complexes - metabolism | Time Factors | Williams Syndrome - physiopathology | Aortic Diseases - enzymology | Aorta, Thoracic - drug effects | Elastin - deficiency | Williams Syndrome - enzymology | Focal Adhesion Kinase 1 - metabolism | Aorta, Thoracic - pathology | Aortic Diseases - pathology | Muscle, Smooth, Vascular - drug effects | Genetic Predisposition to Disease | Everolimus - pharmacology | Imatinib Mesylate - pharmacology | Mice, Inbred C57BL | Williams Syndrome - drug therapy | Aorta, Thoracic - physiopathology | Sirolimus - pharmacology | Mice, Knockout | Aorta, Thoracic - enzymology | Collagen - metabolism | Aortic Diseases - drug therapy | Aortic Diseases - physiopathology | Muscle, Smooth, Vascular - pathology | Phenotype | Animals | Elastin - genetics | Vascular Stiffness - drug effects | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Muscle, Smooth, Vascular - enzymology | Williams Syndrome - pathology | Index Medicus | smooth muscle cell | Animal models of human disease | Cardiovascular Pharmacology | mechanistic target of rapamycin | Other Vascular biology
Journal Article
The Journal of thoracic and cardiovascular surgery, ISSN 0022-5223, 2010, Volume 140, Issue 2, pp. 305 - 312.e2
Objective Losartan potassium (INN losartan), an antihypertensive drug, has been shown to prevent thoracic aortic aneurysm in Marfan syndrome through the inhibition of transforming growth factor β... 
Cardiothoracic Surgery | MMP | thoracic aortic aneurysm | TAA | metalloproteinase | tissue inhibitor of metalloproteinase | transforming growth factor β | TGF-β | TIMP | Cardiac & Cardiovascular Systems | Respiratory System | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Surgery | Science & Technology | Aortic Aneurysm, Thoracic - genetics | Phosphorylation | Aortic Aneurysm, Thoracic - prevention & control | Marfan Syndrome - physiopathology | Aortic Aneurysm, Thoracic - drug therapy | Secondary Prevention - methods | Doxycycline - administration & dosage | Matrix Metalloproteinase 9 - metabolism | Marfan Syndrome - drug therapy | Aortic Aneurysm, Thoracic - pathology | Time Factors | Mice, Mutant Strains | Protease Inhibitors - administration & dosage | Marfan Syndrome - complications | Aorta, Thoracic - drug effects | Drug Therapy, Combination | Microfilament Proteins - genetics | Aorta, Thoracic - pathology | Angiotensin II Type 1 Receptor Blockers - administration & dosage | Disease Models, Animal | Fibrillin-1 | Matrix Metalloproteinase 2 - metabolism | Mice, Inbred C57BL | Smad2 Protein - metabolism | Aorta, Thoracic - metabolism | Fibrillins | Aorta, Thoracic - physiopathology | Vasoconstriction - drug effects | Aortic Aneurysm, Thoracic - physiopathology | Marfan Syndrome - genetics | Drug Synergism | Elastic Tissue - pathology | Animals | Marfan Syndrome - pathology | Mice | Losartan - administration & dosage | Vasodilation - drug effects | Transforming Growth Factor beta - metabolism | Prevention | Aortic aneurysms | Transforming growth factors | Losartan | Marfan syndrome | Doxycycline | Index Medicus | Abridged Index Medicus
Journal Article
PloS one, ISSN 1932-6203, 07/2017, Volume 12, Issue 7, pp. e0179908 - e0179908
.... This study was to investigate the effect of pyrrolidine dithiocarbamate (PDTC) on impairment of endothelium-dependent vasodilatation in diabetic rats and its potential mechanism... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Amidohydrolases - metabolism | Diabetes Mellitus, Experimental - drug therapy | Diabetes Mellitus, Experimental - enzymology | Humans | Endothelium, Vascular - physiopathology | Rats | Thiocarbamates - therapeutic use | Endothelium, Vascular - drug effects | Aorta, Thoracic - physiopathology | Arginine - analogs & derivatives | Pyrrolidines - pharmacology | Pyrrolidines - therapeutic use | Animals | Thiocarbamates - pharmacology | HEK293 Cells | Aorta, Thoracic - drug effects | Oxidative Stress - drug effects | Vasodilation - drug effects | Blood Glucose - metabolism | Diabetes Mellitus, Experimental - metabolism | Nitric Oxide - metabolism | Arginine - metabolism | Diabetes Mellitus, Experimental - physiopathology | Enzymes | Physiological aspects | Development and progression | Hydrolases | Genetic aspects | Research | Cardiovascular diseases | Risk factors | Endothelium | Drinking water | Streptozocin | Impairment | DDAH2 gene | Glucose | Blood | Vasodilation | Antioxidants | Transfection | Restoration | Rodents | Aorta | Inhibition | Pyrrolidine | Pharmaceutical sciences | Dimethylargininase | Hypertension | Medical research | Preservation | Complications | Diabetes mellitus | Thorax | Metabolism | Nitric-oxide synthase | Studies | Nitric oxide | Venom | Coronary vessels | Acetylcholine | Diabetes | Pyrrolidine dithiocarbamate | Cancer | Index Medicus
Journal Article
Journal Article