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The American Journal of Human Genetics, ISSN 0002-9297, 08/2013, Volume 93, Issue 2, pp. 398 - 404
Journal Article
Arteriosclerosis, thrombosis, and vascular biology, ISSN 1079-5642, 04/2015, Volume 35, Issue 4, pp. 888 - 898
Objective-Aortic aneurysm, focal dilation of the aorta, results from impaired integrity of aortic extracellular matrix (ECM). Matrix metalloproteinases (MMPs)... 
aortic aneurysm, thoracic | matrix metalloproteinase 2 | ACTIVATION | TGF-BETA | CONVERTING ENZYME-INHIBITORS | ANGIOTENSIN RECEPTOR BLOCKERS | aortic aneurysm | GROWTH-FACTOR-BETA | GENE | MARFAN-SYNDROME | TISSUE INHIBITOR | DOXYCYCLINE | PERIPHERAL VASCULAR DISEASE | EXTRACELLULAR-MATRIX | HEMATOLOGY | thoracic | Aortic Aneurysm, Thoracic - genetics | Vascular Remodeling | Aortic Aneurysm, Thoracic - prevention & control | Myocytes, Smooth Muscle - pathology | Male | Smad3 Protein - metabolism | Aortic Aneurysm, Thoracic - chemically induced | RNA, Messenger - metabolism | Muscle, Smooth, Vascular - diagnostic imaging | Aortic Aneurysm, Thoracic - diagnosis | Ultrasonography | Collagen - genetics | Angiotensin II | Dilatation, Pathologic | Aorta, Thoracic - pathology | Disease Models, Animal | Elastin - metabolism | Calcium Chloride | Signal Transduction | Aortic Aneurysm, Thoracic - enzymology | Matrix Metalloproteinase 2 - metabolism | Myocytes, Smooth Muscle - enzymology | Mice, Inbred C57BL | Cells, Cultured | Smad2 Protein - metabolism | Genotype | Aorta, Thoracic - enzymology | Collagen - metabolism | Matrix Metalloproteinase 2 - genetics | Muscle, Smooth, Vascular - pathology | Phenotype | Animals | Elastin - genetics | Matrix Metalloproteinase 2 - deficiency | Muscle, Smooth, Vascular - enzymology | Transforming Growth Factor beta - metabolism | Aorta, Thoracic - diagnostic imaging
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 04/2017, Volume 37, Issue 4, pp. 694 - 706
OBJECTIVE—Increasing evidence suggests that contractile dysfunction in smooth muscle cells (SMCs) plays a critical role in aortic biomechanical dysfunction and... 
Caspase 1 | Glyburide | Inflammasomes | Contractile proteins | Proteolysis | Aortic aneurysm | OXIDATIVE STRESS | ACTIVATION | glyburide | inflammasomes | FOCUS | INJURY | caspase 1 | DELETION | aortic aneurysm | PERIPHERAL VASCULAR DISEASE | MICE | MUTATIONS | ISCHEMIA-REPERFUSION | HEMATOLOGY | proteolysis | contractile proteins | Aneurysm, Dissecting - genetics | Aortic Aneurysm, Abdominal - prevention & control | Inflammasomes - metabolism | Humans | Middle Aged | Caspase 1 - metabolism | Male | Mice, 129 Strain | Aorta, Abdominal - drug effects | Aneurysm, Dissecting - physiopathology | Glyburide - pharmacology | Inflammasomes - antagonists & inhibitors | Myocytes, Smooth Muscle - drug effects | Aneurysm, Dissecting - prevention & control | Disease Models, Animal | Muscle, Smooth, Vascular - drug effects | Genetic Predisposition to Disease | Myocytes, Smooth Muscle - enzymology | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Vasoconstriction - drug effects | Aortic Aneurysm, Thoracic - physiopathology | Mice, Knockout | Aorta, Thoracic - enzymology | Biomechanical Phenomena | Phenotype | Aortic Aneurysm, Abdominal - enzymology | Aortic Aneurysm, Abdominal - physiopathology | Caspase 1 - deficiency | Muscle, Smooth, Vascular - enzymology | Aortic Aneurysm, Thoracic - genetics | Aortic Aneurysm, Thoracic - prevention & control | Myocytes, Smooth Muscle - pathology | Muscle, Smooth, Vascular - physiopathology | NLR Family, Pyrin Domain-Containing 3 Protein - genetics | Aneurysm, Dissecting - enzymology | Muscle Proteins - metabolism | Female | Aorta, Abdominal - pathology | Aorta, Thoracic - drug effects | Angiotensin II | Aorta, Abdominal - physiopathology | Aorta, Thoracic - pathology | Aortic Aneurysm, Thoracic - enzymology | Mice, Inbred C57BL | Cells, Cultured | Aortic Aneurysm, Abdominal - genetics | Aorta, Thoracic - physiopathology | Aorta, Abdominal - enzymology | Inflammasomes - genetics | NLR Family, Pyrin Domain-Containing 3 Protein - deficiency | Muscle, Smooth, Vascular - pathology | Animals | Caspase 1 - genetics | Aged | aneurysm | cardiovascular diseases | contractility | vessels
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 09/2017, Volume 37, Issue 9, pp. 1657 - 1666
OBJECTIVE—Elastin deficiency because of heterozygous loss of an ELN allele in Williams syndrome causes obstructive aortopathy characterized by medial... 
collagen | everolimus | aorta | elastin | mice | ACTIVATION | STENOSIS | INTEGRIN | MUSCLE | CELL-PROLIFERATION | KINASE INHIBITOR | ADHESION | ARTERIAL STIFFNESS | GROWTH | WILLIAMS-BEUREN-SYNDROME | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | Phosphorylation | Mechanotransduction, Cellular - drug effects | TOR Serine-Threonine Kinases - metabolism | Humans | Mechanistic Target of Rapamycin Complex 2 | Muscle, Smooth, Vascular - physiopathology | Mechanistic Target of Rapamycin Complex 1 | TOR Serine-Threonine Kinases - antagonists & inhibitors | Multiprotein Complexes - metabolism | Time Factors | Williams Syndrome - physiopathology | Aortic Diseases - enzymology | Aorta, Thoracic - drug effects | Elastin - deficiency | Williams Syndrome - enzymology | Focal Adhesion Kinase 1 - metabolism | Aorta, Thoracic - pathology | Aortic Diseases - pathology | Muscle, Smooth, Vascular - drug effects | Genetic Predisposition to Disease | Everolimus - pharmacology | Imatinib Mesylate - pharmacology | Mice, Inbred C57BL | Williams Syndrome - drug therapy | Aorta, Thoracic - physiopathology | Sirolimus - pharmacology | Mice, Knockout | Aorta, Thoracic - enzymology | Collagen - metabolism | Aortic Diseases - drug therapy | Aortic Diseases - physiopathology | Muscle, Smooth, Vascular - pathology | Phenotype | Animals | Elastin - genetics | Vascular Stiffness - drug effects | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Muscle, Smooth, Vascular - enzymology | Williams Syndrome - pathology | Index Medicus | smooth muscle cell | Animal models of human disease | Cardiovascular Pharmacology | mechanistic target of rapamycin | Other Vascular biology
Journal Article
Circulation Research, ISSN 0009-7330, 02/2013, Volume 112, Issue 4, pp. 618 - 632
RATIONALE:Aortic aneurysm and dissection (AAD) are major diseases of the adult aorta caused by progressive medial degeneration of the aortic wall. Although the... 
forkhead box protein O1 | tissue inhibitor of metalloproteinase-1 | AKT | matrix metalloproteinase-9 | aortic aneurysm and dissection | PHOSPHATIDYLINOSITOL 3-KINASE/AKT | APOPTOSIS | SIGNALING PATHWAYS | ACTIVATION | CARDIAC & CARDIOVASCULAR SYSTEMS | MICE LACKING | MATRIX METALLOPROTEINASES | INSULIN-RESISTANCE | IN-VIVO | ENDOTHELIAL-CELLS | PERIPHERAL VASCULAR DISEASE | MUSCLE-CELL-PROLIFERATION | HEMATOLOGY | Phosphorylation | Tissue Inhibitor of Metalloproteinase-1 - biosynthesis | Apoptosis - drug effects | Aortic Aneurysm, Thoracic - prevention & control | Humans | Middle Aged | Proto-Oncogene Proteins c-akt - deficiency | Aortitis - enzymology | Aortitis - chemically induced | Case-Control Studies | Proto-Oncogene Proteins c-akt - genetics | Aneurysm, Dissecting - enzymology | Forkhead Transcription Factors - metabolism | Matrix Metalloproteinase 9 - genetics | Forkhead Transcription Factors - antagonists & inhibitors | Angiotensin II - toxicity | Aortitis - pathology | Myocytes, Smooth Muscle - drug effects | Aneurysm, Dissecting - prevention & control | Aneurysm, Dissecting - etiology | Aorta, Thoracic - pathology | Promoter Regions, Genetic | Angiotensin II - pharmacology | Cells, Cultured - drug effects | Matrix Metalloproteinase 9 - biosynthesis | Aortic Aneurysm, Thoracic - enzymology | Myocytes, Smooth Muscle - enzymology | Mice, Inbred C57BL | Aortitis - genetics | Enzyme Induction | Proto-Oncogene Proteins c-akt - physiology | Aortic Aneurysm, Thoracic - etiology | Cells, Cultured - enzymology | Mice, Knockout | Aorta, Thoracic - enzymology | Elastic Tissue - pathology | Tissue Inhibitor of Metalloproteinase-1 - genetics | Animals | Protein Binding | Aged | Forkhead Box Protein O1 | Mice | Protein Processing, Post-Translational | Aortic aneurysm and dissection | TIMP-1 | MMP-9 | FOXO1
Journal Article
Kidney International, ISSN 0085-2538, 10/2015, Volume 88, Issue 4, pp. 711 - 721
Vascular calcification (VC) is a major risk factor for cardiovascular mortality in chronic renal failure (CRF) patients, but the pathogenesis remains partially... 
inorganic phosphate | aging | vascular smooth muscle cell | chronic renal failure | LIFE-SPAN | STEM-CELLS | ACTIVATION | PROTEIN | OSTEOBLASTIC DIFFERENTIATION | MUSCLE-CELL CALCIFICATION | PHOSPHATE | UROLOGY & NEPHROLOGY | CHRONIC KIDNEY-DISEASE | EXPRESSION | CHRONIC-RENAL-FAILURE | Muscle, Smooth, Vascular - metabolism | TOR Serine-Threonine Kinases - metabolism | Humans | Vascular Calcification - genetics | Glucuronidase - metabolism | Myocytes, Smooth Muscle - pathology | Aorta, Abdominal - drug effects | Glucuronidase - deficiency | TOR Serine-Threonine Kinases - antagonists & inhibitors | TOR Serine-Threonine Kinases - genetics | Transfection | RNA Interference | Time Factors | Kidney Failure, Chronic - pathology | Tumor Suppressor Proteins - genetics | Aortic Diseases - prevention & control | Vascular Calcification - enzymology | Aortic Diseases - enzymology | Aorta, Abdominal - pathology | Aorta, Thoracic - drug effects | Kidney Failure, Chronic - enzymology | Myocytes, Smooth Muscle - drug effects | Myocytes, Smooth Muscle - metabolism | Aorta, Thoracic - pathology | Aortic Diseases - pathology | Disease Models, Animal | Muscle, Smooth, Vascular - drug effects | Genetic Predisposition to Disease | Tumor Suppressor Proteins - metabolism | Kidney Failure, Chronic - drug therapy | Mice, Inbred C57BL | Osteogenesis - drug effects | Cells, Cultured | Gene Expression Regulation | Vascular Calcification - prevention & control | Vascular Calcification - pathology | Aorta, Abdominal - enzymology | Sirolimus - pharmacology | Mice, Knockout | Aorta, Thoracic - enzymology | Aortic Diseases - genetics | Phenotype | Animals | Glucuronidase - genetics | Signal Transduction - drug effects | Protein Kinase Inhibitors - pharmacology | Muscle, Smooth, Vascular - enzymology
Journal Article
Journal of Vascular Surgery, ISSN 0741-5214, 2016, Volume 66, Issue 5, pp. 1543 - 1552
Abstract Background Hypertension (HTN), which is a major risk factor for cardiovascular morbidity and mortality, can drive pathologic remodeling of the macro-... 
Surgery | METALLOPROTEINASE PROMOTER ACTIVATION | SURGERY | MATRIX METALLOPROTEINASES | ARTERIAL STIFFNESS | ATHEROSCLEROSIS | PERIPHERAL VASCULAR DISEASE | SMOOTH-MUSCLE-CELLS | VASCULAR-DISEASES | ANEURYSM FORMATION | KINASE ACTIVATION | ANGIOTENSIN | CARDIOVASCULAR RISK | Blood Pressure | Cathepsin L - genetics | Matrix Metalloproteinases - genetics | Vascular Remodeling | Cathepsin L - metabolism | RNA, Messenger - metabolism | Matrix Metalloproteinase 9 - metabolism | Matrix Metalloproteinase 9 - genetics | Hypertension - chemically induced | Aorta, Abdominal - pathology | Hypertension - enzymology | Angiotensin II | Aorta, Abdominal - physiopathology | Aorta, Thoracic - pathology | Disease Models, Animal | Matrix Metalloproteinase 2 - metabolism | RNA, Messenger - genetics | Aorta, Thoracic - physiopathology | Matrix Metalloproteinase 14 - metabolism | Aorta, Abdominal - enzymology | Hypertension - pathology | Hypertension - physiopathology | Gene Expression Regulation, Enzymologic | Aorta, Thoracic - enzymology | Matrix Metalloproteinase 2 - genetics | Cathepsin K - genetics | Animals | Cathepsin K - metabolism | Cathepsins - genetics | Cathepsins - metabolism | Matrix Metalloproteinase 14 - genetics | Matrix Metalloproteinases - metabolism | Hypertension | Cathepsins | Medical colleges | Health aspects | Mortality | Index Medicus
Journal Article
Journal of Vascular Surgery, ISSN 0741-5214, 2008, Volume 47, Issue 1, pp. 166 - 172
Objectives Thoracic aneurysms are the main cardiovascular complication of Marfan syndrome (MFS) resulting in premature death. MFS has been associated with... 
Surgery | PATHOGENESIS | SURGERY | LOCALIZATION | INHIBITION | ABDOMINAL AORTIC-ANEURYSMS | GENE | GELATINASE-B | PERIPHERAL VASCULAR DISEASE | SMOOTH-MUSCLE-CELLS | MICE | MMP-9 | MATRIX METALLOPROTEINASE-2 EXPRESSION | Aortic Aneurysm, Thoracic - drug therapy | Elastic Tissue - metabolism | Protease Inhibitors - pharmacology | Matrix Metalloproteinase 9 - metabolism | Marfan Syndrome - drug therapy | Aortic Aneurysm, Thoracic - pathology | Time Factors | Mice, Mutant Strains | Aortic Rupture - prevention & control | Marfan Syndrome - complications | Microfilament Proteins - metabolism | Aorta, Thoracic - drug effects | Protease Inhibitors - therapeutic use | Microfilament Proteins - genetics | Aorta, Thoracic - pathology | Disease Models, Animal | Marfan Syndrome - enzymology | Fibrillin-1 | Aortic Rupture - etiology | Aortic Aneurysm, Thoracic - enzymology | Doxycycline - therapeutic use | Matrix Metalloproteinase 2 - metabolism | Mice, Inbred C57BL | Aortic Rupture - pathology | Fibrillins | Aortic Aneurysm, Thoracic - etiology | Disease Progression | Aorta, Thoracic - enzymology | Animals | Matrix Metalloproteinase Inhibitors | Doxycycline - pharmacology | Marfan Syndrome - pathology | Mice | Aortic Aneurysm, Thoracic - complications | Aortic Rupture - enzymology | Aneurysms | Marfan syndrome | Doxycycline | mouse | aortic aneurysm | doxycycline | matrix metalloproteinase 2, 9
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 06/2013, Volume 169, Issue 4, pp. 922 - 932
Background and Purpose Hydrogen sulfide (H2S) is a signalling molecule that belongs to the gasotransmitter family. Two major sources for endogenous enzymatic... 
DL‐propargylglycine | nitric oxide | hydrogen sulfide | cystathionine γ‐lyase | pyridoxal‐5′‐phosphate | cystathionine β‐synthase | aminooxyacetic acid | β‐cyano‐L‐alanine | cystathionine γ-lyase | DL-propargylglycine | cystathionine β-synthase | β-cyano-L-alanine | pyridoxal-5′-phosphate | Hydrogen Sulfide - metabolism | Glycine - analogs & derivatives | Cystathionine beta-Synthase - antagonists & inhibitors | Humans | Cystathionine gamma-Lyase - metabolism | Recombinant Fusion Proteins - metabolism | Alanine - analogs & derivatives | Glutathione Transferase - genetics | Alkynes - pharmacology | Aorta, Thoracic - drug effects | Cystathionine gamma-Lyase - genetics | Nitric Oxide Donors - pharmacology | Cystathionine beta-Synthase - genetics | Peptide Fragments - genetics | Alanine - pharmacology | Peptide Fragments - metabolism | Enzyme Inhibitors - pharmacology | Aorta, Thoracic - metabolism | Glutathione Transferase - metabolism | Rats | Cystathionine beta-Synthase - metabolism | Recombinant Fusion Proteins - chemistry | Glutathione Transferase - chemistry | Cystathionine gamma-Lyase - antagonists & inhibitors | Rats, Sprague-Dawley | Hydrogen Sulfide - analysis | Aorta, Thoracic - enzymology | Animals | Glycine - pharmacology | Kinetics | Vasodilation - drug effects | In Vitro Techniques | Nitric Oxide - metabolism | Research Papers
Journal Article