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Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 07/2017, Volume 37, Issue 11, pp. 2102 - 2102
OBJECTIVE—The role of TGF-β (transforming growth factor-β) signaling in abdominal aortic aneurysm (AAA) formation is controversial. Others reported that... 
aneurysm | smooth muscle | SERVICES TASK-FORCE | ATHEROSCLEROSIS | RECEPTOR | mice | macrophages | TGF-beta | DISRUPTION | angiotensin II | ANEURYSM MOUSE MODEL | PERIPHERAL VASCULAR DISEASE | aorta | SMOOTH-MUSCLE-CELLS | APOE(-/-) MICE | HEMATOLOGY | E-DEFICIENT MICE | PROMOTES | PROGRESSION | Protein-Serine-Threonine Kinases - deficiency | Tunica Media - pathology | Aortic Aneurysm, Abdominal - chemically induced | Receptors, Transforming Growth Factor beta - genetics | Aortic Aneurysm, Abdominal - prevention & control | Muscle, Smooth, Vascular - metabolism | Transforming Growth Factor beta1 - antagonists & inhibitors | Transforming Growth Factor beta2 - metabolism | Aortic Aneurysm, Thoracic - prevention & control | Transforming Growth Factor beta1 - metabolism | Male | Aortic Aneurysm, Thoracic - chemically induced | Transforming Growth Factor beta3 - metabolism | Aorta, Abdominal - drug effects | Aortic Aneurysm, Abdominal - metabolism | Adventitia - metabolism | Receptor, Transforming Growth Factor-beta Type II | Aortic Aneurysm, Thoracic - pathology | Tunica Media - metabolism | Transforming Growth Factor beta - antagonists & inhibitors | Female | Aorta, Abdominal - pathology | Aorta, Thoracic - drug effects | Vascular Remodeling - drug effects | Angiotensin II | Aorta, Abdominal - metabolism | Dilatation, Pathologic | Aorta, Thoracic - pathology | Aortic Aneurysm, Abdominal - pathology | Disease Models, Animal | Muscle, Smooth, Vascular - drug effects | Severity of Illness Index | Genetic Predisposition to Disease | Mice, Inbred C57BL | Protein-Serine-Threonine Kinases - genetics | Aorta, Thoracic - metabolism | Transforming Growth Factor beta3 - antagonists & inhibitors | Mice, Knockout | Antibodies - pharmacology | Muscle, Smooth, Vascular - pathology | Phenotype | Animals | Signal Transduction - drug effects | Aortic Aneurysm, Thoracic - metabolism | Transforming Growth Factor beta2 - antagonists & inhibitors | Adventitia - pathology | Transforming Growth Factor beta - metabolism | Receptors, Transforming Growth Factor beta - deficiency | growth factor | Animal Models of Human Disease | Vascular Disease | Genetically Altered and Transgenic Models | Aortic Dissection | genetically altered mice
Journal Article
CIRCULATION, ISSN 0009-7322, 04/2010, Volume 121, Issue 13, pp. E266 - E369
Journal Article
JACC (Journal of the American College of Cardiology), ISSN 0735-1097, 2014, Volume 64, Issue 16, pp. 1725 - 1739
Journal Article
Hypertension, ISSN 0194-911X, 01/2019, Volume 73, Issue 1, pp. 190 - 196
Women with thoracic aortic aneurysms (TAAs) have higher risk of acute aortic syndromes and death than men. We have shown that TAA growth is accelerated in... 
AUGMENTATION INDEX | WALL COMPLIANCE | vascular stiffness | NATURAL-HISTORY | PREDICTION | sex characteristics | MECHANICS | DISSECTION | ARTERIAL STIFFNESS | pulse wave analysis | RUPTURE | GENDER | PERIPHERAL VASCULAR DISEASE | aorta | humans | EXPRESSION
Journal Article
Circulation Research, ISSN 0009-7330, 04/2015, Volume 116, Issue 8, pp. 1448 - 1461
Thoracic aortic diseases that involve progressive enlargement, acute dissection, or rupture are influenced by the hemodynamic loads and mechanical properties... 
Elastic fibers | Actomyosin | Marfan syndrome | Focal adhesion | focal adhesion | LIGHT-CHAIN KINASE | ASCENDING AORTA | DEVELOPING MOUSE AORTA | CARDIAC & CARDIOVASCULAR SYSTEMS | ANGIOTENSIN-II | GROWTH-FACTOR-BETA | actomyosin | MARFAN-SYNDROME | ARTERIAL-WALL | elastic fibers | PERIPHERAL VASCULAR DISEASE | SMOOTH-MUSCLE-CELLS | EXTRACELLULAR-MATRIX | HEMATOLOGY | EHLERS-DANLOS-SYNDROME | Aneurysm, Dissecting - genetics | Aortic Aneurysm, Thoracic - genetics | Humans | Stress, Mechanical | Aortic Rupture - metabolism | Aneurysm, Dissecting - physiopathology | Aortic Aneurysm, Thoracic - pathology | Aorta, Thoracic - pathology | Extracellular Matrix Proteins - metabolism | Aortic Rupture - physiopathology | Genetic Predisposition to Disease | Aneurysm, Dissecting - metabolism | Extracellular Matrix Proteins - genetics | Aorta, Thoracic - metabolism | Aortic Rupture - pathology | Aneurysm, Dissecting - pathology | Aneurysm, Dissecting - therapy | Aorta, Thoracic - physiopathology | Aortic Aneurysm, Thoracic - physiopathology | Disease Progression | Mechanotransduction, Cellular | Biomechanical Phenomena | Phenotype | Animals | Aortic Aneurysm, Thoracic - metabolism | Aortic Aneurysm, Thoracic - therapy | Aortic Rupture - genetics | Aortic Rupture - therapy | Hemodynamics | familial thoracic aortic aneurysms and dissections | mechanosensing
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 04/2015, Volume 35, Issue 4, pp. 911 - 917
Objective-Studies of mice with mild Marfan syndrome (MFS) have correlated the development of thoracic aortic aneurysm (TAA) with improper stimulation of... 
aortic aneurysm | receptor, angiotensin, type 1 | losartan | transforming growth factor β | Marfan syndrome | PATHOGENESIS | TGF-BETA | type 1 | transforming growth factor beta | MOUSE MODEL | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | receptor, angiotensin | Aortic Aneurysm, Thoracic - genetics | Phosphorylation | Aortic Aneurysm, Thoracic - prevention & control | Humans | Aortic Rupture - metabolism | Mice, 129 Strain | Angiotensin II Type 1 Receptor Blockers - pharmacology | Marfan Syndrome - drug therapy | Aortic Aneurysm, Thoracic - pathology | Time Factors | Mice, Mutant Strains | Aortic Rupture - prevention & control | Transforming Growth Factor beta - antagonists & inhibitors | Aorta, Thoracic - drug effects | Microfilament Proteins - genetics | Aorta, Thoracic - pathology | Disease Models, Animal | Transforming Growth Factor beta - immunology | Fibrillin-1 | Mice, Inbred C57BL | Losartan - pharmacology | Smad2 Protein - metabolism | Aorta, Thoracic - metabolism | Antibodies, Neutralizing - pharmacology | Aortic Rupture - pathology | Fibrillins | Disease Progression | Marfan Syndrome - genetics | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Signal Transduction - drug effects | Aortic Aneurysm, Thoracic - metabolism | Receptor, Angiotensin, Type 1 - metabolism | Aortic Rupture - genetics | Marfan Syndrome - metabolism | Marfan Syndrome - pathology | Mutation | Transforming Growth Factor beta - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism
Journal Article
Journal of Vascular Surgery, ISSN 0741-5214, 12/2018, Volume 68, Issue 6, pp. 3S - 13S
Journal Article
Arteriosclerosis, thrombosis, and vascular biology, ISSN 1079-5642, 04/2015, Volume 35, Issue 4, pp. 888 - 898
Objective-Aortic aneurysm, focal dilation of the aorta, results from impaired integrity of aortic extracellular matrix (ECM). Matrix metalloproteinases (MMPs)... 
aortic aneurysm, thoracic | matrix metalloproteinase 2 | ACTIVATION | TGF-BETA | CONVERTING ENZYME-INHIBITORS | ANGIOTENSIN RECEPTOR BLOCKERS | aortic aneurysm | GROWTH-FACTOR-BETA | GENE | MARFAN-SYNDROME | TISSUE INHIBITOR | DOXYCYCLINE | PERIPHERAL VASCULAR DISEASE | EXTRACELLULAR-MATRIX | HEMATOLOGY | thoracic | Aortic Aneurysm, Thoracic - genetics | Vascular Remodeling | Aortic Aneurysm, Thoracic - prevention & control | Myocytes, Smooth Muscle - pathology | Male | Smad3 Protein - metabolism | Aortic Aneurysm, Thoracic - chemically induced | RNA, Messenger - metabolism | Muscle, Smooth, Vascular - diagnostic imaging | Aortic Aneurysm, Thoracic - diagnosis | Ultrasonography | Collagen - genetics | Angiotensin II | Dilatation, Pathologic | Aorta, Thoracic - pathology | Disease Models, Animal | Elastin - metabolism | Calcium Chloride | Signal Transduction | Aortic Aneurysm, Thoracic - enzymology | Matrix Metalloproteinase 2 - metabolism | Myocytes, Smooth Muscle - enzymology | Mice, Inbred C57BL | Cells, Cultured | Smad2 Protein - metabolism | Genotype | Aorta, Thoracic - enzymology | Collagen - metabolism | Matrix Metalloproteinase 2 - genetics | Muscle, Smooth, Vascular - pathology | Phenotype | Animals | Elastin - genetics | Matrix Metalloproteinase 2 - deficiency | Muscle, Smooth, Vascular - enzymology | Transforming Growth Factor beta - metabolism | Aorta, Thoracic - diagnostic imaging
Journal Article