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Circulation Research, ISSN 0009-7330, 04/2015, Volume 116, Issue 8, pp. 1448 - 1461
Thoracic aortic diseases that involve progressive enlargement, acute dissection, or rupture are influenced by the hemodynamic loads and mechanical properties of the wall... 
Elastic fibers | Actomyosin | Marfan syndrome | Focal adhesion | focal adhesion | LIGHT-CHAIN KINASE | ASCENDING AORTA | DEVELOPING MOUSE AORTA | CARDIAC & CARDIOVASCULAR SYSTEMS | ANGIOTENSIN-II | GROWTH-FACTOR-BETA | actomyosin | MARFAN-SYNDROME | ARTERIAL-WALL | elastic fibers | PERIPHERAL VASCULAR DISEASE | SMOOTH-MUSCLE-CELLS | EXTRACELLULAR-MATRIX | HEMATOLOGY | EHLERS-DANLOS-SYNDROME | Aneurysm, Dissecting - genetics | Aortic Aneurysm, Thoracic - genetics | Humans | Stress, Mechanical | Aortic Rupture - metabolism | Aneurysm, Dissecting - physiopathology | Aortic Aneurysm, Thoracic - pathology | Aorta, Thoracic - pathology | Extracellular Matrix Proteins - metabolism | Aortic Rupture - physiopathology | Genetic Predisposition to Disease | Aneurysm, Dissecting - metabolism | Extracellular Matrix Proteins - genetics | Aorta, Thoracic - metabolism | Aortic Rupture - pathology | Aneurysm, Dissecting - pathology | Aneurysm, Dissecting - therapy | Aorta, Thoracic - physiopathology | Aortic Aneurysm, Thoracic - physiopathology | Disease Progression | Mechanotransduction, Cellular | Biomechanical Phenomena | Phenotype | Animals | Aortic Aneurysm, Thoracic - metabolism | Aortic Aneurysm, Thoracic - therapy | Aortic Rupture - genetics | Aortic Rupture - therapy | Hemodynamics | familial thoracic aortic aneurysms and dissections | mechanosensing
Journal Article
American journal of human genetics, ISSN 0002-9297, 2013, Volume 93, Issue 2, pp. 398 - 404
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 04/2017, Volume 37, Issue 4, pp. 694 - 706
.... APPROACH AND RESULTS—We observed significant SMC contractile protein degradation in aortas from patients with sporadic thoracic AAD... 
Caspase 1 | Glyburide | Inflammasomes | Contractile proteins | Proteolysis | Aortic aneurysm | OXIDATIVE STRESS | ACTIVATION | glyburide | inflammasomes | FOCUS | INJURY | caspase 1 | DELETION | aortic aneurysm | PERIPHERAL VASCULAR DISEASE | MICE | MUTATIONS | ISCHEMIA-REPERFUSION | HEMATOLOGY | proteolysis | contractile proteins | Aneurysm, Dissecting - genetics | Aortic Aneurysm, Abdominal - prevention & control | Inflammasomes - metabolism | Humans | Middle Aged | Caspase 1 - metabolism | Male | Mice, 129 Strain | Aorta, Abdominal - drug effects | Aneurysm, Dissecting - physiopathology | Glyburide - pharmacology | Inflammasomes - antagonists & inhibitors | Myocytes, Smooth Muscle - drug effects | Aneurysm, Dissecting - prevention & control | Disease Models, Animal | Muscle, Smooth, Vascular - drug effects | Genetic Predisposition to Disease | Myocytes, Smooth Muscle - enzymology | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Vasoconstriction - drug effects | Aortic Aneurysm, Thoracic - physiopathology | Mice, Knockout | Aorta, Thoracic - enzymology | Biomechanical Phenomena | Phenotype | Aortic Aneurysm, Abdominal - enzymology | Aortic Aneurysm, Abdominal - physiopathology | Caspase 1 - deficiency | Muscle, Smooth, Vascular - enzymology | Aortic Aneurysm, Thoracic - genetics | Aortic Aneurysm, Thoracic - prevention & control | Myocytes, Smooth Muscle - pathology | Muscle, Smooth, Vascular - physiopathology | NLR Family, Pyrin Domain-Containing 3 Protein - genetics | Aneurysm, Dissecting - enzymology | Muscle Proteins - metabolism | Female | Aorta, Abdominal - pathology | Aorta, Thoracic - drug effects | Angiotensin II | Aorta, Abdominal - physiopathology | Aorta, Thoracic - pathology | Aortic Aneurysm, Thoracic - enzymology | Mice, Inbred C57BL | Cells, Cultured | Aortic Aneurysm, Abdominal - genetics | Aorta, Thoracic - physiopathology | Aorta, Abdominal - enzymology | Inflammasomes - genetics | NLR Family, Pyrin Domain-Containing 3 Protein - deficiency | Muscle, Smooth, Vascular - pathology | Animals | Caspase 1 - genetics | Aged | aneurysm | cardiovascular diseases | contractility | vessels
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