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The New England Journal of Medicine, ISSN 0028-4793, 08/2006, Volume 355, Issue 8, pp. 788 - 798
Journal Article
Nature genetics, ISSN 1061-4036, 2012, Volume 44, Issue 11, pp. 1249 - 1254
Journal Article
Nature Genetics, ISSN 1061-4036, 2008, Volume 40, Issue 2, pp. 217 - 224
Journal Article
Journal of the American College of Cardiology, ISSN 0735-1097, 2012, Volume 60, Issue 5, pp. 397 - 403
Objectives The purpose of this study was describe the cardiovascular phenotype of the aneurysms-osteoarthritis syndrome (AOS) and to provide clinical... 
Cardiovascular | Internal Medicine | aneurysm | aorta | genetics | SMAD3 | cerebrovascular disorders | FIBROSIS | CARDIAC & CARDIOVASCULAR SYSTEMS | TGF-BETA | CARDIOMYOPATHY | HEART-DISEASE | STIFFNESS | BICUSPID AORTIC-VALVE | MUTATIONS | MARFANS-SYNDROME | Aneurysm, Dissecting - genetics | Aortic Aneurysm, Thoracic - genetics | Aortic Aneurysm, Thoracic - diagnostic imaging | Humans | Middle Aged | Image Interpretation, Computer-Assisted | Male | Cardiovascular Diseases - genetics | Cause of Death | Osteoarthritis - mortality | Young Adult | Smad3 Protein - genetics | Cardiovascular Diseases - diagnostic imaging | Cardiovascular Diseases - mortality | Adult | Aortic Aneurysm, Thoracic - mortality | Female | Genomic Structural Variation - genetics | Aneurysm - diagnostic imaging | Imaging, Three-Dimensional | Peptide Fragments - genetics | Natriuretic Peptide, Brain - genetics | Vascular Stiffness - genetics | Osteoarthritis - diagnostic imaging | Osteoarthritis - genetics | Syndrome | Aneurysm - genetics | Cerebrovascular Disorders - mortality | Pregnancy | Phenotype | Adolescent | Cerebrovascular Disorders - diagnostic imaging | Chromosome Aberrations | Survival Analysis | Aneurysm, Dissecting - diagnostic imaging | Aged | Cerebrovascular Disorders - genetics | Aneurysm - mortality | Aortography | Genes, Dominant - genetics | Aneurysm, Dissecting - mortality | Cohort Studies | Medical colleges | Peptides | Atrial fibrillation | Aneurysms | Genetic aspects | Universities and colleges | Cardiology | Transforming growth factors | Marfan syndrome | Natriuretic peptides | Osteoarthritis | Medical genetics | Studies | Genotype & phenotype | Sinuses | Medical imaging | Mortality | Tomography | Arthritis | Dissection | Patients | Age | Abdomen
Journal Article
Nature Genetics, ISSN 1061-4036, 2011, Volume 43, Issue 2, pp. 121 - 126
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 01/2015, Volume 35, Issue 1, pp. 155 - 162
OBJECTIVE—Low-density lipoprotein receptor–related protein 1 (LRP1), a multifunctional protein involved in endocytosis and cell signaling pathways, leads to... 
mouse | aortic aneurysm | Angiotensin II | LRP1 protein | SYSTEM | LRP1 protein, mouse | TISSUE GROWTH-FACTOR | angiotensin II | ATHEROSCLEROSIS | PERIPHERAL VASCULAR DISEASE | VASCULAR WALL | LRP | HEMATOLOGY | EXPRESSION | DEFICIENCY | Aortic Aneurysm, Abdominal - chemically induced | Aortic Aneurysm - metabolism | Muscle, Smooth, Vascular - metabolism | Aneurysm - chemically induced | Myocytes, Smooth Muscle - pathology | Male | Aneurysm - physiopathology | RNA, Messenger - metabolism | Muscle, Smooth, Vascular - physiopathology | Aortic Aneurysm, Abdominal - metabolism | Aortic Aneurysm - chemically induced | Arterial Pressure | Tumor Suppressor Proteins - deficiency | Gene Deletion | Tumor Suppressor Proteins - genetics | Receptors, LDL - deficiency | Aorta, Abdominal - pathology | Aortic Aneurysm - pathology | Mesenteric Artery, Superior - pathology | Aorta, Abdominal - metabolism | Dilatation, Pathologic | Myocytes, Smooth Muscle - metabolism | Aneurysm - metabolism | Aortic Aneurysm, Abdominal - pathology | Disease Models, Animal | Elastin - metabolism | Receptors, LDL - genetics | Matrix Metalloproteinase 2 - metabolism | Aortic Aneurysm - physiopathology | Cells, Cultured | Aortic Aneurysm, Abdominal - genetics | Urokinase-Type Plasminogen Activator - genetics | Aneurysm - pathology | Aneurysm - genetics | Mice, Knockout | Matrix Metalloproteinase 2 - genetics | Macrophages - metabolism | Muscle, Smooth, Vascular - pathology | Animals | Mesenteric Artery, Superior - metabolism | Urokinase-Type Plasminogen Activator - metabolism | Ligands | Norepinephrine | Aortic Aneurysm - genetics
Journal Article
Nature Medicine, ISSN 1078-8956, 02/2017, Volume 23, Issue 2, pp. 200 - 212
Heritable thoracic aortic aneurysms and dissections (TAAD), including Marfan syndrome (MFS), currently lack a cure, and causative mutations have been... 
MEDICINE, RESEARCH & EXPERIMENTAL | INFLAMMATORY ANEURYSM | BIOCHEMISTRY & MOLECULAR BIOLOGY | THORACIC AORTA | ANGIOTENSIN-II | CELL BIOLOGY | SYNTHASE | DISINTEGRIN | IN-VIVO | DISSECTIONS | ANEURYSM FORMATION | EXPRESSION | PROGRESSION | Aneurysm, Dissecting - genetics | Aortic Aneurysm, Thoracic - genetics | Aortic Aneurysm - metabolism | ADAMTS1 Protein - genetics | Humans | Middle Aged | Immunoblotting | Male | Aorta - metabolism | Gene Knockdown Techniques | Nitric Oxide Synthase Type II - antagonists & inhibitors | Adult | Female | Fibrillin-1 - genetics | Real-Time Polymerase Chain Reaction | ADAMTS1 Protein - metabolism | Disease Models, Animal | NG-Nitroarginine Methyl Ester - pharmacology | Aneurysm, Dissecting - metabolism | Aorta - drug effects | Enzyme Inhibitors - pharmacology | Marfan Syndrome - genetics | Haploinsufficiency | Animals | Nitric Oxide Synthase Type II - genetics | Aortic Aneurysm, Thoracic - metabolism | Marfan Syndrome - metabolism | Aged | Mice | Aortic Aneurysm - genetics | Nitric Oxide - metabolism | Nitric Oxide Synthase Type II - metabolism | Blood circulation disorders | Molecular targeted therapy | Care and treatment | Proteases | Innovations | Development and progression | Genetic aspects | Oxidoreductases | Health aspects | Aneurysms | Cardiovascular disease | Genetic disorders | Rodents | Nitric oxide
Journal Article
Journal of medical genetics, ISSN 0022-2593, 2012, Volume 49, Issue 1, pp. 47 - 57
Journal Article