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Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 01/2015, Volume 35, Issue 1, pp. 155 - 162
OBJECTIVE—Low-density lipoprotein receptor–related protein 1 (LRP1), a multifunctional protein involved in endocytosis and cell signaling pathways, leads to... 
mouse | aortic aneurysm | Angiotensin II | LRP1 protein | SYSTEM | LRP1 protein, mouse | TISSUE GROWTH-FACTOR | angiotensin II | ATHEROSCLEROSIS | PERIPHERAL VASCULAR DISEASE | VASCULAR WALL | LRP | HEMATOLOGY | EXPRESSION | DEFICIENCY | Aortic Aneurysm, Abdominal - chemically induced | Aortic Aneurysm - metabolism | Muscle, Smooth, Vascular - metabolism | Aneurysm - chemically induced | Myocytes, Smooth Muscle - pathology | Male | Aneurysm - physiopathology | RNA, Messenger - metabolism | Muscle, Smooth, Vascular - physiopathology | Aortic Aneurysm, Abdominal - metabolism | Aortic Aneurysm - chemically induced | Arterial Pressure | Tumor Suppressor Proteins - deficiency | Gene Deletion | Tumor Suppressor Proteins - genetics | Receptors, LDL - deficiency | Aorta, Abdominal - pathology | Aortic Aneurysm - pathology | Mesenteric Artery, Superior - pathology | Aorta, Abdominal - metabolism | Dilatation, Pathologic | Myocytes, Smooth Muscle - metabolism | Aneurysm - metabolism | Aortic Aneurysm, Abdominal - pathology | Disease Models, Animal | Elastin - metabolism | Receptors, LDL - genetics | Matrix Metalloproteinase 2 - metabolism | Aortic Aneurysm - physiopathology | Cells, Cultured | Aortic Aneurysm, Abdominal - genetics | Urokinase-Type Plasminogen Activator - genetics | Aneurysm - pathology | Aneurysm - genetics | Mice, Knockout | Matrix Metalloproteinase 2 - genetics | Macrophages - metabolism | Muscle, Smooth, Vascular - pathology | Animals | Mesenteric Artery, Superior - metabolism | Urokinase-Type Plasminogen Activator - metabolism | Ligands | Norepinephrine | Aortic Aneurysm - genetics | Index Medicus
Journal Article
Journal Article
Circulation, ISSN 0009-7322, 10/2012, Volume 126, Issue 18, pp. 2220 - 2226
Background-Girls and women with Turner syndrome are at risk for aortic dissection and rupture. However, the size of the aorta and the clinical characteristics... 
Turner syndrome | aneurysm | aorta | WOMEN | INTERVENTIONS | CARDIAC & CARDIOVASCULAR SYSTEMS | DISEASE | RISK | PERIPHERAL VASCULAR DISEASE | COMPLICATIONS | DILATATION | SOCIETY | Aneurysm, Dissecting - epidemiology | Aortic Valve - abnormalities | Anthropometry | Humans | Middle Aged | Hypertension - drug therapy | Aortic Aneurysm - etiology | Young Adult | Heart Defects, Congenital - genetics | Postoperative Complications - genetics | Ultrasonography | Abnormalities, Multiple - epidemiology | Turner Syndrome - complications | Adult | Cardiac Surgical Procedures - statistics & numerical data | Female | Registries | Surveys and Questionnaires | Retrospective Studies | Aortic Aneurysm - pathology | Hypertension - epidemiology | Aneurysm, Dissecting - prevention & control | Abnormalities, Multiple - genetics | Aneurysm, Dissecting - etiology | Aortic Aneurysm - prevention & control | Aorta - diagnostic imaging | Aortic Valve - diagnostic imaging | Aortic Aneurysm - epidemiology | Risk Factors | Postoperative Complications - epidemiology | Aneurysm, Dissecting - pathology | Aorta - pathology | Pregnancy | Aortic Coarctation - surgery | Adolescent | Pregnancy Complications - genetics | Heart Defects, Congenital - epidemiology | Aortic Aneurysm - classification | Aortic Coarctation - genetics | Aortic Coarctation - epidemiology | Aneurysm, Dissecting - classification | Turner Syndrome - pathology | Dissecting aneurysm | Complications and side effects | Cardiovascular diseases | Risk factors | Index Medicus | Abridged Index Medicus
Journal Article
Science, ISSN 0036-8075, 4/2011, Volume 332, Issue 6027, pp. 358 - 361
Transforming growth factor—β (TGFβ) signaling drives aneurysm progression in multiple disorders, including Marfan syndrome (MFS), and therapies that inhibit... 
Transcriptional regulatory elements | Echocardiography | Aortic diseases | Root growth | REPORTS | Placebos | Aneurysms | Aorta | Mice | Aortic aneurysm | Marfan syndrome | PATHOGENESIS | CELLS | ACTIVATION | VALSALVA | MULTIDISCIPLINARY SCIENCES | N-TERMINAL KINASE | MOUSE MODEL | NOONANS-SYNDROME | RECEPTOR | MUTATIONS | INHIBITOR | Diphenylamine - pharmacology | Aortic Aneurysm - metabolism | Mitogen-Activated Protein Kinase 8 - antagonists & inhibitors | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Anthracenes - therapeutic use | MAP Kinase Signaling System | Diphenylamine - analogs & derivatives | Marfan Syndrome - drug therapy | Smad4 Protein - genetics | Transforming Growth Factor beta - antagonists & inhibitors | Aortic Aneurysm - pathology | Aortic Aneurysm - prevention & control | Disease Models, Animal | Transforming Growth Factor beta - immunology | Diphenylamine - therapeutic use | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Mitogen-Activated Protein Kinase 8 - metabolism | Aortic Aneurysm - physiopathology | Losartan - pharmacology | Smad2 Protein - metabolism | Sulfonamides - pharmacology | Anthracenes - pharmacology | Disease Progression | Aorta - pathology | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Sulfonamides - therapeutic use | Protein Kinase Inhibitors - therapeutic use | Losartan - therapeutic use | Marfan Syndrome - metabolism | Marfan Syndrome - pathology | Protein Kinase Inhibitors - pharmacology | Smad4 Protein - deficiency | Enzyme Activation | Transforming Growth Factor beta - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism | Index Medicus | Therapy | Progressions | Pathways | Strategy | Activation | Inhibition | Kinases
Journal Article
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 12/2009, Volume 119, Issue 12, pp. 3637 - 3651
Journal Article
Journal Article
Science, ISSN 0036-8075, 4/2011, Volume 332, Issue 6027, pp. 361 - 365
Angiotensin II (AngII) mediates progression of aortic aneurysm, but the relative contribution of its type 1 (AT1) and type 2 (AT2) receptors remains unknown.... 
Connective tissues | Receptors | Root growth | Medical treatment | REPORTS | Aneurysms | Placebos | Aorta | Mice | Aortic aneurysm | Marfan syndrome | PATHOGENESIS | ACTIVATION | MECHANISM | MULTIDISCIPLINARY SCIENCES | MARFAN-SYNDROME | MOUSE MODEL | GROWTH | SMOOTH-MUSCLE-CELLS | BLOCKADE | CONTRIBUTES | EXPRESSION | Aortic Aneurysm - metabolism | Angiotensin II Type 1 Receptor Blockers - therapeutic use | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Aortic Rupture - metabolism | Angiotensin II Type 1 Receptor Blockers - pharmacology | Enalapril - therapeutic use | MAP Kinase Signaling System | Marfan Syndrome - drug therapy | Angiotensin-Converting Enzyme Inhibitors - therapeutic use | Aortic Rupture - prevention & control | Angiotensin-Converting Enzyme Inhibitors - pharmacology | Aortic Aneurysm - pathology | Aortic Aneurysm - prevention & control | Disease Models, Animal | Receptor, Angiotensin, Type 2 - genetics | Angiotensin II - metabolism | Signal Transduction | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Losartan - pharmacology | Aortic Rupture - pathology | Disease Progression | Mice, Knockout | Animals | Enalapril - pharmacology | Receptor, Angiotensin, Type 2 - metabolism | Mitogen-Activated Protein Kinase 3 - metabolism | Aortic Aneurysm - drug therapy | Losartan - therapeutic use | Marfan Syndrome - metabolism | Marfan Syndrome - pathology | Transforming Growth Factor beta - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism | Aortic aneurysms | Development and progression | Genetic aspects | Health aspects | Angiotensin | Signal transduction | Peptides | Cellular biology | Coronary vessels | Rodents | Index Medicus | Progressions | Inhibitors | Blocking | Attenuation | Kinases
Journal Article
Circulation Research, ISSN 0009-7330, 01/2012, Volume 110, Issue 2, pp. 312 - 324
RATIONALE:Marfan syndrome (MFS) is a systemic connective tissue disorder notable for the development of aortic root aneurysms and the subsequent... 
aneurysm | apoptosis | microRNA | extracellular matrix | Marfan syndrome | FIBROSIS | KAPPA-B ACTIVATION | CARDIAC & CARDIOVASCULAR SYSTEMS | AORTIC-ANEURYSM | KINASE | FAILURE | MICRORNA EXPRESSION SIGNATURE | INFLAMMATION | METALLOPROTEINASE SECRETION | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | REVEALS | Up-Regulation | Age Factors | Aortic Aneurysm - metabolism | Male | MicroRNAs - metabolism | NF-kappa B - metabolism | Aorta - metabolism | Angiotensin II Type 1 Receptor Blockers - pharmacology | Marfan Syndrome - therapy | Female | Marfan Syndrome - complications | Microfilament Proteins - metabolism | Aortic Aneurysm - pathology | Microfilament Proteins - genetics | Real-Time Polymerase Chain Reaction | Aortic Aneurysm - prevention & control | Disease Models, Animal | Elastin - metabolism | Fibrillin-1 | Matrix Metalloproteinase 2 - metabolism | Mice, Inbred C57BL | Cells, Cultured | Losartan - pharmacology | Fibrillins | Mice, Transgenic | Reverse Transcriptase Polymerase Chain Reaction | Marfan Syndrome - genetics | Apoptosis Regulatory Proteins - metabolism | Aorta - pathology | Animals | Elastin - genetics | Marfan Syndrome - metabolism | Marfan Syndrome - pathology | Oligonucleotides, Antisense - administration & dosage | Mice | MicroRNAs - genetics | Aortic Aneurysm - genetics | Transforming Growth Factor beta - metabolism | Apoptosis | Genetic Therapy - methods | Index Medicus
Journal Article