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Nature Genetics, ISSN 1061-4036, 2008, Volume 40, Issue 2, pp. 217 - 224
Journal Article
Journal of Thoracic and Cardiovascular Surgery, The, ISSN 0022-5223, 2017, Volume 153, Issue 4, pp. S65 - S71
Abstract Objective Bicuspid aortic valve (BAV) anatomy is associated with ascending aortic aneurysm in approximately 50% of individuals; it may also lead to... 
Cardiothoracic Surgery | root remodeling | aortic root replacement | bicuspid aortic valve | aortic valve repair | REPLACEMENT | SURGERY | CARDIAC & CARDIOVASCULAR SYSTEMS | RESPIRATORY SYSTEM | RECONSTRUCTION | CONFIGURATION | DILATATION | Recurrence | Vascular Remodeling | Aortic Valve - abnormalities | Humans | Middle Aged | Cardiac Valve Annuloplasty - mortality | Male | Heart Valve Diseases - surgery | Aortic Aneurysm - etiology | Aortic Valve - surgery | Young Adult | Aneurysm, Dissecting - physiopathology | Time Factors | Aneurysm, Dissecting - surgery | Heart Valve Diseases - complications | Aortic Valve Stenosis - etiology | Aged, 80 and over | Heart Valve Diseases - mortality | Adult | Female | Pericardium - transplantation | Aortic Valve Stenosis - surgery | Retrospective Studies | Aorta - physiopathology | Cardiac Valve Annuloplasty - adverse effects | Child | Dilatation, Pathologic | Aneurysm, Dissecting - etiology | Heart Valve Diseases - physiopathology | Reoperation | Hospital Mortality | Aortic Aneurysm - mortality | Risk Factors | Aortic Aneurysm - physiopathology | Aortic Valve Stenosis - physiopathology | Aortic Aneurysm - surgery | Aortic Valve - physiopathology | Aortic Valve Insufficiency - physiopathology | Heart Valve Prosthesis Implantation - mortality | Treatment Outcome | Aortic Valve Insufficiency - etiology | Heart Valve Prosthesis Implantation - adverse effects | Aorta - surgery | Adolescent | Aortic Valve Insufficiency - surgery | Aged | Aortic Valve Insufficiency - mortality | Aneurysm, Dissecting - mortality | Aneurysms | Heart valve diseases | Epidemiology | Medical informatics | Health aspects
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 12/2009, Volume 119, Issue 12, pp. 3637 - 3651
Journal Article
Journal of Thoracic and Cardiovascular Surgery, The, ISSN 0022-5223, 2013, Volume 145, Issue 2, pp. 385 - 390.e1
Background Few data exist on clinical/imaging characteristics, management, and outcomes of patients with type A acute dissection and mesenteric malperfusion.... 
Cardiothoracic Surgery | SURGERY | REPAIR | CARDIAC & CARDIOVASCULAR SYSTEMS | RESPIRATORY SYSTEM | IRAD | STRATEGIES | Aneurysm, Dissecting - diagnosis | Multivariate Analysis | Vascular Diseases - complications | Aortic Aneurysm - diagnosis | Humans | Middle Aged | Male | Ischemia - mortality | Postoperative Complications - mortality | North America | Vascular Diseases - mortality | Aneurysm, Dissecting - physiopathology | Time Factors | Vascular Surgical Procedures - mortality | Aneurysm, Dissecting - surgery | Ischemia - complications | Adult | Female | Registries | Odds Ratio | Acute Disease | Mesenteric Ischemia | Hospital Mortality | Risk Assessment | Aortic Aneurysm - mortality | Endovascular Procedures - adverse effects | Europe | Japan | Risk Factors | Aortic Aneurysm - physiopathology | Aortic Aneurysm - surgery | Logistic Models | Postoperative Complications - therapy | Treatment Outcome | Vascular Diseases - physiopathology | Endovascular Procedures - mortality | Ischemia - physiopathology | Chi-Square Distribution | Ischemia - diagnosis | Vascular Diseases - diagnosis | Aortic Aneurysm - complications | Vascular Surgical Procedures - adverse effects | Aneurysm, Dissecting - complications | Ischemia - surgery | Splanchnic Circulation | Aged | Vascular Diseases - surgery | Aneurysm, Dissecting - mortality | Medical colleges | Cardiology | Surgery | Medical genetics
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 01/2015, Volume 35, Issue 1, pp. 155 - 162
OBJECTIVE—Low-density lipoprotein receptor–related protein 1 (LRP1), a multifunctional protein involved in endocytosis and cell signaling pathways, leads to... 
mouse | aortic aneurysm | Angiotensin II | LRP1 protein | SYSTEM | LRP1 protein, mouse | TISSUE GROWTH-FACTOR | angiotensin II | ATHEROSCLEROSIS | PERIPHERAL VASCULAR DISEASE | VASCULAR WALL | LRP | HEMATOLOGY | EXPRESSION | DEFICIENCY | Aortic Aneurysm, Abdominal - chemically induced | Aortic Aneurysm - metabolism | Muscle, Smooth, Vascular - metabolism | Aneurysm - chemically induced | Myocytes, Smooth Muscle - pathology | Male | Aneurysm - physiopathology | RNA, Messenger - metabolism | Muscle, Smooth, Vascular - physiopathology | Aortic Aneurysm, Abdominal - metabolism | Aortic Aneurysm - chemically induced | Arterial Pressure | Tumor Suppressor Proteins - deficiency | Gene Deletion | Tumor Suppressor Proteins - genetics | Receptors, LDL - deficiency | Aorta, Abdominal - pathology | Aortic Aneurysm - pathology | Mesenteric Artery, Superior - pathology | Aorta, Abdominal - metabolism | Dilatation, Pathologic | Myocytes, Smooth Muscle - metabolism | Aneurysm - metabolism | Aortic Aneurysm, Abdominal - pathology | Disease Models, Animal | Elastin - metabolism | Receptors, LDL - genetics | Matrix Metalloproteinase 2 - metabolism | Aortic Aneurysm - physiopathology | Cells, Cultured | Aortic Aneurysm, Abdominal - genetics | Urokinase-Type Plasminogen Activator - genetics | Aneurysm - pathology | Aneurysm - genetics | Mice, Knockout | Matrix Metalloproteinase 2 - genetics | Macrophages - metabolism | Muscle, Smooth, Vascular - pathology | Animals | Mesenteric Artery, Superior - metabolism | Urokinase-Type Plasminogen Activator - metabolism | Ligands | Norepinephrine | Aortic Aneurysm - genetics
Journal Article
Circulation: Cardiovascular Imaging, ISSN 1941-9651, 07/2013, Volume 6, Issue 4, pp. 499 - 507
Background Ascending aortic dilation is important in bicuspid aortic valve (BAV) disease, with increased risk of aortic dissection. We used cardiovascular MR... 
Aorta | Cardiac MRI | Wall shear stress | Vascular function | Bicuspid aortic valve | vascular function | WALL SHEAR-STRESS | CARDIAC & CARDIOVASCULAR SYSTEMS | cardiac MRI | bicuspid aortic valve | ELASTIC PROPERTIES | wall shear stress | aorta | NATURAL-HISTORY | BLOOD-FLOW | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Predictive Value of Tests | Prognosis | Prospective Studies | Heart Valve Diseases - pathology | Pulse Wave Analysis | Aortic Valve - abnormalities | Humans | Middle Aged | Elasticity | Stress, Mechanical | Male | Aortic Aneurysm - etiology | Case-Control Studies | Aortic Valve - pathology | Young Adult | Aneurysm, Dissecting - physiopathology | Cardiac-Gated Imaging Techniques - methods | Heart Valve Diseases - complications | Adult | Female | Aorta - physiopathology | Aortic Aneurysm - pathology | Imaging, Three-Dimensional | Vascular Stiffness | Dilatation, Pathologic | Aneurysm, Dissecting - etiology | Severity of Illness Index | Heart Valve Diseases - physiopathology | Cross-Sectional Studies | Models, Cardiovascular | Risk Factors | Aortic Aneurysm - physiopathology | Aortic Valve - physiopathology | Aneurysm, Dissecting - pathology | Chi-Square Distribution | Regional Blood Flow | Aorta - pathology | Magnetic Resonance Imaging | Analysis of Variance | Hemodynamics | cardiac magnetic resonance imaging
Journal Article
Science, ISSN 0036-8075, 4/2011, Volume 332, Issue 6027, pp. 358 - 361
Transforming growth factor—β (TGFβ) signaling drives aneurysm progression in multiple disorders, including Marfan syndrome (MFS), and therapies that inhibit... 
Transcriptional regulatory elements | Echocardiography | Aortic diseases | Root growth | REPORTS | Placebos | Aneurysms | Aorta | Mice | Aortic aneurysm | Marfan syndrome | PATHOGENESIS | CELLS | ACTIVATION | VALSALVA | MULTIDISCIPLINARY SCIENCES | N-TERMINAL KINASE | MOUSE MODEL | NOONANS-SYNDROME | RECEPTOR | MUTATIONS | INHIBITOR | Diphenylamine - pharmacology | Aortic Aneurysm - metabolism | Mitogen-Activated Protein Kinase 8 - antagonists & inhibitors | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Anthracenes - therapeutic use | MAP Kinase Signaling System | Diphenylamine - analogs & derivatives | Marfan Syndrome - drug therapy | Smad4 Protein - genetics | Transforming Growth Factor beta - antagonists & inhibitors | Aortic Aneurysm - pathology | Aortic Aneurysm - prevention & control | Disease Models, Animal | Transforming Growth Factor beta - immunology | Diphenylamine - therapeutic use | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Mitogen-Activated Protein Kinase 8 - metabolism | Aortic Aneurysm - physiopathology | Losartan - pharmacology | Smad2 Protein - metabolism | Sulfonamides - pharmacology | Anthracenes - pharmacology | Disease Progression | Aorta - pathology | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Sulfonamides - therapeutic use | Protein Kinase Inhibitors - therapeutic use | Losartan - therapeutic use | Marfan Syndrome - metabolism | Marfan Syndrome - pathology | Protein Kinase Inhibitors - pharmacology | Smad4 Protein - deficiency | Enzyme Activation | Transforming Growth Factor beta - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism
Journal Article
Journal of Thoracic and Cardiovascular Surgery, The, ISSN 0022-5223, 2014, Volume 148, Issue 3, pp. 872 - 880
Journal Article
Journal of Thoracic and Cardiovascular Surgery, The, ISSN 0022-5223, 2015, Volume 149, Issue 2, pp. S30 - S36
Objective Root remodeling was proposed as valve-preserving root replacement to treat patients with aortic regurgitation and root aneurysm. The objective of... 
Cardiothoracic Surgery | ASCENDING AORTA | PRESERVATION | SURGERY | AORTIC ROOT REPLACEMENT | REPAIR | CARDIAC & CARDIOVASCULAR SYSTEMS | RESPIRATORY SYSTEM | RECONSTRUCTION | MARFAN-SYNDROME | REIMPLANTATION | EXPERIENCE | VALVE-SPARING OPERATIONS | Aneurysm, Dissecting - diagnosis | Multivariate Analysis | Aortic Aneurysm - diagnosis | Aortic Valve - abnormalities | Humans | Middle Aged | Male | Cardiac Surgical Procedures - adverse effects | Cardiac Surgical Procedures - mortality | Heart Valve Diseases - surgery | Aortic Valve - surgery | Aneurysm, Dissecting - physiopathology | Time Factors | Aneurysm, Dissecting - surgery | Heart Valve Diseases - mortality | Adult | Female | Heart Valve Diseases - diagnosis | Retrospective Studies | Suture Techniques | Severity of Illness Index | Heart Valve Diseases - physiopathology | Reoperation | Hospital Mortality | Aortic Aneurysm - mortality | Risk Factors | Aortic Aneurysm - physiopathology | Kaplan-Meier Estimate | Proportional Hazards Models | Aortic Aneurysm - surgery | Aortic Valve - physiopathology | Aortic Valve Insufficiency - physiopathology | Treatment Outcome | Disease-Free Survival | Aortic Valve Insufficiency - surgery | Aged | Cardiac Valve Annuloplasty | Aortic Valve Insufficiency - mortality | Aortic Valve Insufficiency - diagnosis | Blood Vessel Prosthesis Implantation | Aneurysm, Dissecting - mortality | Aneurysms | Valves
Journal Article
Journal of the Royal Society Interface, ISSN 1742-5689, 11/2017, Volume 14, Issue 136, pp. 20170327 - 20170327
The embryonic lineage of intramural cells, microstructural organization of the extracellular matrix, local luminal and wall geometry, and haemodynamic loads... 
Smooth muscle | Inflammatory cells | Angiotensin II | Stress | Aortic stiffness | stress | MULTIDISCIPLINARY SCIENCES | INVOLVEMENT | smooth muscle | ATHEROSCLEROSIS | ANGIOTENSIN-II | MODEL | II-INDUCED HYPERTENSION | aortic stiffness | angiotensin II | inflammatory cells | GROWTH | SMOOTH-MUSCLE-CELLS | EXTRACELLULAR-MATRIX | MICE | MECHANOTRANSDUCTION | Aneurysm, Dissecting - genetics | Aneurysm, Dissecting - metabolism | Aortic Aneurysm - metabolism | Muscle, Smooth, Vascular - metabolism | Models, Cardiovascular | Aortic Aneurysm - physiopathology | Extracellular Matrix - metabolism | Male | Aneurysm, Dissecting - pathology | Muscle, Smooth, Vascular - physiopathology | Neointima - metabolism | Mice, Knockout | Extracellular Matrix - genetics | Neointima - physiopathology | Muscle, Smooth, Vascular - pathology | Neointima - genetics | Animals | Aneurysm, Dissecting - physiopathology | Fibrosis | Neointima - pathology | Mice | Aortic Aneurysm - pathology | Aortic Aneurysm - genetics | Extracellular Matrix - pathology | Hypertension | Animal models | Contractility | Cyclic loads | Aneurysm | Muscles | Mechanical properties | Aneurysms | Stiffening | Muscle contraction | Biomechanics | Arteriosclerosis | Coronary vessels | Collagen | Atherosclerosis | Aorta | Extracellular matrix | Stiffness | Blood pressure | Dissection | Stretching | 1004 | Life Sciences–Engineering interface
Journal Article