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2013, Genetics of cardiovascular disease : genetic interactions in a multifactorial disease
Web Resource
Journal of Clinical Investigation, ISSN 0021-9738, 02/2012, Volume 122, Issue 2, pp. 497 - 506
Journal Article
Nature Genetics, ISSN 1061-4036, 2008, Volume 40, Issue 2, pp. 217 - 224
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 02/2015, Volume 35, Issue 2, pp. 378 - 388
Journal Article
Science Translational Medicine, ISSN 1946-6234, 02/2012, Volume 4, Issue 122, pp. 122ra22 - 122ra22
Journal Article
by Jones, G.T and Tromp, G and Kuivaniemi, H and Gretarsdottir, S and Baas, A.F and Giusti, B and Strauss, E and Hof, F.N. van 't and Webb, T.R and Erdman, R and Ritchie, M.D and Elmore, J.R and Verma, A and Pendergrass, S and Kullo, I.J and Ye, Z and Peissig, P.L and Gottesman, O and Verma, S.S and Malinowski, J and Rasmussen-Torvik, L.J and Borthwick, K.M and Smelser, D.T and Crosslin, D.R and Anade, M. de and Ryer, E.J and McCarty, C.A and Bottinger, E.P and Pacheco, J.A and Crawford, D.C and Carrell, D.S and Gerhard, G.S and Franklin, D.P and Carey, D.J and Phillips, V.L and Williams, M.J and Wei, W and Blair, R and Hill, A.A and Vasudevan, T.M and Lewis, D.R and Thomson, I.A and Krysa, J and Hill, G.B and Roake, J and Merriman, T.R and Oszkinis, G and Galora, S and Saracini, C and Abbate, R and Pulli, R and Pratesi, C and Saratzis, A and Verissimo, A.R and Bumpstead, S and Badger, S.A and Clough, R.E and Cockerill, G and Hafez, H and Scott, D.J and Futers, T.S and Romaine, S.P and Bridge, K and Griffin, K.J and Bailey, M.A and Smith, A and Thompson, M.M and Bockxmeer, F.M. van and Matthiasson, S.E and Thorleifsson, G and Thorsteinsdottir, U and Blankensteijn, J.D and Teijink, J.A and Wijmenga, C and Graaf, J. de and Kiemeney, L.A.L.M and Lindholt, J.S and Hughes, A and Bradley, D.T and Stirrups, K and Golledge, J and Norman, P.E and Powell, J.T and Humphries, S.E and Hamby, S.E and Goodall, A.H and Nelson, C.P and Sakalihasan, N and Courtois, A and Ferrell, R.E and Eriksson, P and Folkersen, L and Franco-Cereceda, A and Eicher, J.D and Johnson, A.D and Betsholtz, C and Ruusalepp, A and Franzen, O and Schadt, E.E and Bjorkegren, J.L and ... and Cardiogenics Consortium and Int Consortium Blood Pressure and Medicinska fakulteten and Medicinska och farmaceutiska vetenskapsområdet and Institutionen för immunologi, genetik och patologi and Uppsala universitet and Vaskulärbiologi
Circulation Research, ISSN 0009-7330, 2017, Volume 120, Issue 2, pp. 341 - 353
RATIONALE: Abdominal aortic aneurysm (AAA) is a complex disease with both genetic and environmental risk factors. Together, 6 previously identified risk loci... 
computational biology | meta-analysis | genetics | aortic aneurysm abdominal | matrix metalloproteinases | genome-wide association study | C-REACTIVE PROTEIN | TRANSCRIPTION FACTORS | CARDIAC & CARDIOVASCULAR SYSTEMS | SEQUENCE VARIANT | aortic aneurysm, abdominal | SUSCEPTIBILITY LOCI | ELECTRONIC MEDICAL-RECORDS | HUMAN PREFRONTAL CORTEX | DENSITY-LIPOPROTEIN CHOLESTEROL | PERIPHERAL VASCULAR DISEASE | CANDIDATE GENE ASSOCIATION | HEMATOLOGY | RECEPTOR-RELATED PROTEIN-1 | CORONARY-ARTERY-DISEASE | Aortic Aneurysm, Abdominal - diagnosis | Genetic Predisposition to Disease - genetics | Humans | Genetic Loci - genetics | Genome-Wide Association Study - trends | Aortic Aneurysm, Abdominal - genetics | Genetic Variation - genetics | Aortic Aneurysm, Abdominal - epidemiology | Genetic Predisposition to Disease - epidemiology | Genome-Wide Association Study - methods | Diabetes mellitus | Coronary artery | Aneurysm | Aneurysms | Lipids | Cardiovascular disease | Genomes | Single-nucleotide polymorphism | Risk factors | Gelatinase B | Chromosome 1 | Interleukin 6 | Interleukin 6 receptors | Aorta | Lipoprotein (low density) receptors | Blood pressure | Chromosome 13 | Heritability | Cardiovascular diseases | Heart diseases | Index Medicus | 10082 | Clinical Track | 10084 | 10185 | 10195 | 10014 | Medical and Health Sciences | Hematology | Medicin och hälsovetenskap | Klinisk medicin | Kardiologi | Clinical Medicine | Cardiac and Cardiovascular Systems | aortic aneurysm | Hematologi | abdominal
Journal Article
The American Journal of Human Genetics, ISSN 0002-9297, 11/2011, Volume 89, Issue 5, pp. 619 - 627
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 02/2013, Volume 33, Issue 2, pp. 294 - 304
OBJECTIVE—Abdominal aortic aneurysms (AAAs) are common, but their exact pathogenesis remains unknown and no specific medical therapies are available. We sought... 
aneurysm | vascular inflammation | animal model surgery | interleukin-1 receptor antagonist | aortic disease | RHEUMATOID-ARTHRITIS | MUSCLE PHENOTYPIC MODULATION | ANAKINRA | MODEL | RECEPTOR ANTAGONIST | PATHOPHYSIOLOGY | INFLAMMATION | DISEASE | PERIPHERAL VASCULAR DISEASE | IL-1-BETA | MICE | HEMATOLOGY | Aortic Aneurysm, Abdominal - chemically induced | Aortic Aneurysm, Abdominal - prevention & control | Humans | Receptors, Interleukin-1 - genetics | Male | Interleukin-1beta - genetics | RNA, Messenger - metabolism | Aorta, Abdominal - drug effects | Interleukin-1beta - deficiency | Aortic Aneurysm, Abdominal - metabolism | Dose-Response Relationship, Drug | Time Factors | Receptors, Interleukin-1 - deficiency | Aorta, Abdominal - pathology | Interleukin 1 Receptor Antagonist Protein - pharmacology | Aorta, Abdominal - metabolism | Dilatation, Pathologic | Neutrophils - metabolism | Aortic Aneurysm, Abdominal - pathology | Disease Models, Animal | Interleukin-1beta - antagonists & inhibitors | Neutrophils - pathology | Elastin - metabolism | Macrophages - pathology | Mice, Inbred C57BL | Neutrophils - drug effects | Gene Expression Regulation | Aortic Aneurysm, Abdominal - genetics | Mice, Knockout | Macrophages - metabolism | Animals | Signal Transduction - drug effects | Pancreatic Elastase | Macrophages - drug effects | Mice | Receptors, Interleukin-1 - antagonists & inhibitors | Index Medicus | Interleukin-1 Receptor Antagonist | Aortic disease | Vascular Inflammation | Animal model surgery | Aneurysm
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 04/2017, Volume 37, Issue 4, pp. 694 - 706
OBJECTIVE—Increasing evidence suggests that contractile dysfunction in smooth muscle cells (SMCs) plays a critical role in aortic biomechanical dysfunction and... 
Caspase 1 | Glyburide | Inflammasomes | Contractile proteins | Proteolysis | Aortic aneurysm | OXIDATIVE STRESS | ACTIVATION | glyburide | inflammasomes | FOCUS | INJURY | caspase 1 | DELETION | aortic aneurysm | PERIPHERAL VASCULAR DISEASE | MICE | MUTATIONS | ISCHEMIA-REPERFUSION | HEMATOLOGY | proteolysis | contractile proteins | Aneurysm, Dissecting - genetics | Aortic Aneurysm, Abdominal - prevention & control | Inflammasomes - metabolism | Humans | Middle Aged | Caspase 1 - metabolism | Male | Mice, 129 Strain | Aorta, Abdominal - drug effects | Aneurysm, Dissecting - physiopathology | Glyburide - pharmacology | Inflammasomes - antagonists & inhibitors | Myocytes, Smooth Muscle - drug effects | Aneurysm, Dissecting - prevention & control | Disease Models, Animal | Muscle, Smooth, Vascular - drug effects | Genetic Predisposition to Disease | Myocytes, Smooth Muscle - enzymology | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Vasoconstriction - drug effects | Aortic Aneurysm, Thoracic - physiopathology | Mice, Knockout | Aorta, Thoracic - enzymology | Biomechanical Phenomena | Phenotype | Aortic Aneurysm, Abdominal - enzymology | Aortic Aneurysm, Abdominal - physiopathology | Caspase 1 - deficiency | Muscle, Smooth, Vascular - enzymology | Aortic Aneurysm, Thoracic - genetics | Aortic Aneurysm, Thoracic - prevention & control | Myocytes, Smooth Muscle - pathology | Muscle, Smooth, Vascular - physiopathology | NLR Family, Pyrin Domain-Containing 3 Protein - genetics | Aneurysm, Dissecting - enzymology | Muscle Proteins - metabolism | Female | Aorta, Abdominal - pathology | Aorta, Thoracic - drug effects | Angiotensin II | Aorta, Abdominal - physiopathology | Aorta, Thoracic - pathology | Aortic Aneurysm, Thoracic - enzymology | Mice, Inbred C57BL | Cells, Cultured | Aortic Aneurysm, Abdominal - genetics | Aorta, Thoracic - physiopathology | Aorta, Abdominal - enzymology | Inflammasomes - genetics | NLR Family, Pyrin Domain-Containing 3 Protein - deficiency | Muscle, Smooth, Vascular - pathology | Animals | Caspase 1 - genetics | Aged | Index Medicus | aneurysm | cardiovascular diseases | contractility | vessels
Journal Article
Cardiovascular Research, ISSN 0008-6363, 08/2017, Volume 113, Issue 10, pp. 1230 - 1242
Journal Article
Circulation, ISSN 0009-7322, 09/2013, Volume 128, Issue 26_suppl_1 Suppl 1, pp. S163 - S174
Journal Article
Circulation, ISSN 0009-7322, 09/2012, Volume 126, Issue 11, pp. S38 - S45
Journal Article