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Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 12/2016, Volume 36, Issue 12, pp. 2468 - 2477
Journal Article
The Journal of clinical investigation, ISSN 0021-9738, 2012, Volume 122, Issue 2, pp. 497 - 506
Journal Article
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 04/2017, Volume 37, Issue 4, pp. 694 - 706
...) plays a critical role in aortic biomechanical dysfunction and aortic aneurysm and dissection (AAD) development... 
Caspase 1 | Glyburide | Inflammasomes | Contractile proteins | Proteolysis | Aortic aneurysm | OXIDATIVE STRESS | ACTIVATION | glyburide | inflammasomes | FOCUS | INJURY | caspase 1 | DELETION | aortic aneurysm | PERIPHERAL VASCULAR DISEASE | MICE | MUTATIONS | ISCHEMIA-REPERFUSION | HEMATOLOGY | proteolysis | contractile proteins | Aneurysm, Dissecting - genetics | Aortic Aneurysm, Abdominal - prevention & control | Inflammasomes - metabolism | Humans | Middle Aged | Caspase 1 - metabolism | Male | Mice, 129 Strain | Aorta, Abdominal - drug effects | Aneurysm, Dissecting - physiopathology | Glyburide - pharmacology | Inflammasomes - antagonists & inhibitors | Myocytes, Smooth Muscle - drug effects | Aneurysm, Dissecting - prevention & control | Disease Models, Animal | Muscle, Smooth, Vascular - drug effects | Genetic Predisposition to Disease | Myocytes, Smooth Muscle - enzymology | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Vasoconstriction - drug effects | Aortic Aneurysm, Thoracic - physiopathology | Mice, Knockout | Aorta, Thoracic - enzymology | Biomechanical Phenomena | Phenotype | Aortic Aneurysm, Abdominal - enzymology | Aortic Aneurysm, Abdominal - physiopathology | Caspase 1 - deficiency | Muscle, Smooth, Vascular - enzymology | Aortic Aneurysm, Thoracic - genetics | Aortic Aneurysm, Thoracic - prevention & control | Myocytes, Smooth Muscle - pathology | Muscle, Smooth, Vascular - physiopathology | NLR Family, Pyrin Domain-Containing 3 Protein - genetics | Aneurysm, Dissecting - enzymology | Muscle Proteins - metabolism | Female | Aorta, Abdominal - pathology | Aorta, Thoracic - drug effects | Angiotensin II | Aorta, Abdominal - physiopathology | Aorta, Thoracic - pathology | Aortic Aneurysm, Thoracic - enzymology | Mice, Inbred C57BL | Cells, Cultured | Aortic Aneurysm, Abdominal - genetics | Aorta, Thoracic - physiopathology | Aorta, Abdominal - enzymology | Inflammasomes - genetics | NLR Family, Pyrin Domain-Containing 3 Protein - deficiency | Muscle, Smooth, Vascular - pathology | Animals | Caspase 1 - genetics | Aged | aneurysm | cardiovascular diseases | contractility | vessels
Journal Article
Journal Article
Circulation research, ISSN 1524-4571, 2015, Volume 117, Issue 11, pp. e80 - e89
RATIONALE:Matrix metalloproteinases (MMPs)–mediated extracellular matrix destruction is the major cause of development and progression of abdominal aortic aneurysms... 
drug delivery systems | batimastat | matrix metalloproteinase inhibitors | nanoparticles | cardiovascular diseases | vascular remodeling | abdominal aortic aneurysm | CELLS | PROPRANOLOL | CARDIAC & CARDIOVASCULAR SYSTEMS | BB-94 | CANCER | TRIAL | THERAPY | DISEASE | DOXYCYCLINE | PERIPHERAL VASCULAR DISEASE | MICE | HEMATOLOGY | Aortic Aneurysm, Abdominal - chemically induced | Aortic Aneurysm, Abdominal - immunology | Phenylalanine - analogs & derivatives | Matrix Metalloproteinase Inhibitors - administration & dosage | Male | Thiophenes - metabolism | Thiophenes - administration & dosage | Immunoconjugates - administration & dosage | Aorta, Abdominal - drug effects | Drug Carriers | Nanoparticles | Time Factors | Phenylalanine - chemistry | Proteolysis | Vascular Calcification - enzymology | Aorta, Abdominal - pathology | Aortic Aneurysm, Abdominal - pathology | Disease Models, Animal | Elastin - metabolism | Calcium Chloride | Aortic Aneurysm, Abdominal - drug therapy | Phenylalanine - metabolism | Immunoconjugates - metabolism | Vascular Calcification - prevention & control | Matrix Metalloproteinase Inhibitors - chemistry | Vascular Calcification - pathology | Aorta, Abdominal - enzymology | Immunoconjugates - chemistry | Matrix Metalloproteinase Inhibitors - metabolism | Rats, Sprague-Dawley | Chemistry, Pharmaceutical | Disease Progression | Macrophages - enzymology | Aorta, Abdominal - immunology | Polyesters - chemistry | Animals | Aortic Aneurysm, Abdominal - enzymology | Macrophages - drug effects | RAW 264.7 Cells | Mice | Matrix Metalloproteinases - metabolism | Phenylalanine - administration & dosage | Thiophenes - chemistry | Elastin - immunology | targeted therapy | cardiovascular disease | Animal models of human disease | Treatment | MMP inhibitors | nanoparticle | Pharmacology | drug delivery system | Aneurysm Abdominal aortic aneurysm
Journal Article
Journal Article
Circulation (New York, N.Y.), ISSN 1524-4539, 2016, Volume 134, Issue 16, pp. 1141 - 1148
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 07/2017, Volume 37, Issue 11, pp. 2102 - 2102
OBJECTIVE—The role of TGF-β (transforming growth factor-β) signaling in abdominal aortic aneurysm (AAA... 
aneurysm | smooth muscle | SERVICES TASK-FORCE | ATHEROSCLEROSIS | RECEPTOR | mice | macrophages | TGF-beta | DISRUPTION | angiotensin II | ANEURYSM MOUSE MODEL | PERIPHERAL VASCULAR DISEASE | aorta | SMOOTH-MUSCLE-CELLS | APOE(-/-) MICE | HEMATOLOGY | E-DEFICIENT MICE | PROMOTES | PROGRESSION | Protein-Serine-Threonine Kinases - deficiency | Tunica Media - pathology | Aortic Aneurysm, Abdominal - chemically induced | Receptors, Transforming Growth Factor beta - genetics | Aortic Aneurysm, Abdominal - prevention & control | Muscle, Smooth, Vascular - metabolism | Transforming Growth Factor beta1 - antagonists & inhibitors | Transforming Growth Factor beta2 - metabolism | Aortic Aneurysm, Thoracic - prevention & control | Transforming Growth Factor beta1 - metabolism | Male | Aortic Aneurysm, Thoracic - chemically induced | Transforming Growth Factor beta3 - metabolism | Aorta, Abdominal - drug effects | Aortic Aneurysm, Abdominal - metabolism | Adventitia - metabolism | Receptor, Transforming Growth Factor-beta Type II | Aortic Aneurysm, Thoracic - pathology | Tunica Media - metabolism | Transforming Growth Factor beta - antagonists & inhibitors | Female | Aorta, Abdominal - pathology | Aorta, Thoracic - drug effects | Vascular Remodeling - drug effects | Angiotensin II | Aorta, Abdominal - metabolism | Dilatation, Pathologic | Aorta, Thoracic - pathology | Aortic Aneurysm, Abdominal - pathology | Disease Models, Animal | Muscle, Smooth, Vascular - drug effects | Severity of Illness Index | Genetic Predisposition to Disease | Mice, Inbred C57BL | Protein-Serine-Threonine Kinases - genetics | Aorta, Thoracic - metabolism | Transforming Growth Factor beta3 - antagonists & inhibitors | Mice, Knockout | Antibodies - pharmacology | Muscle, Smooth, Vascular - pathology | Phenotype | Animals | Signal Transduction - drug effects | Aortic Aneurysm, Thoracic - metabolism | Transforming Growth Factor beta2 - antagonists & inhibitors | Adventitia - pathology | Transforming Growth Factor beta - metabolism | Receptors, Transforming Growth Factor beta - deficiency | growth factor | Animal Models of Human Disease | Vascular Disease | Genetically Altered and Transgenic Models | Aortic Dissection | genetically altered mice
Journal Article
Annals of Surgery, ISSN 0003-4932, 10/2012, Volume 256, Issue 4, pp. 651 - 658
To examine the modern epidemiology of abdominal aortic aneurysm (AAA) rupture and short-term AAA-related mortality after the introduction of endovascular aneurysm repair (EVAR... 
mortality | endovascular aortic aneurysm repair | abdominal aortic aneurysm | rupture | United States - epidemiology