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Publication DateCirculation Research, ISSN 0009-7330, 04/2015, Volume 116, Issue 8, pp. 1448 - 1461
Thoracic aortic diseases that involve progressive enlargement, acute dissection, or rupture are influenced by the hemodynamic loads and mechanical properties...
Elastic fibers | Actomyosin | Marfan syndrome | Focal adhesion | focal adhesion | LIGHT-CHAIN KINASE | ASCENDING AORTA | DEVELOPING MOUSE AORTA | CARDIAC & CARDIOVASCULAR SYSTEMS | ANGIOTENSIN-II | GROWTH-FACTOR-BETA | actomyosin | MARFAN-SYNDROME | ARTERIAL-WALL | elastic fibers | PERIPHERAL VASCULAR DISEASE | SMOOTH-MUSCLE-CELLS | EXTRACELLULAR-MATRIX | HEMATOLOGY | EHLERS-DANLOS-SYNDROME | Aneurysm, Dissecting - genetics | Aortic Aneurysm, Thoracic - genetics | Humans | Stress, Mechanical | Aortic Rupture - metabolism | Aneurysm, Dissecting - physiopathology | Aortic Aneurysm, Thoracic - pathology | Aorta, Thoracic - pathology | Extracellular Matrix Proteins - metabolism | Aortic Rupture - physiopathology | Genetic Predisposition to Disease | Aneurysm, Dissecting - metabolism | Extracellular Matrix Proteins - genetics | Aorta, Thoracic - metabolism | Aortic Rupture - pathology | Aneurysm, Dissecting - pathology | Aneurysm, Dissecting - therapy | Aorta, Thoracic - physiopathology | Aortic Aneurysm, Thoracic - physiopathology | Disease Progression | Mechanotransduction, Cellular | Biomechanical Phenomena | Phenotype | Animals | Aortic Aneurysm, Thoracic - metabolism | Aortic Aneurysm, Thoracic - therapy | Aortic Rupture - genetics | Aortic Rupture - therapy | Hemodynamics | familial thoracic aortic aneurysms and dissections | mechanosensing
Elastic fibers | Actomyosin | Marfan syndrome | Focal adhesion | focal adhesion | LIGHT-CHAIN KINASE | ASCENDING AORTA | DEVELOPING MOUSE AORTA | CARDIAC & CARDIOVASCULAR SYSTEMS | ANGIOTENSIN-II | GROWTH-FACTOR-BETA | actomyosin | MARFAN-SYNDROME | ARTERIAL-WALL | elastic fibers | PERIPHERAL VASCULAR DISEASE | SMOOTH-MUSCLE-CELLS | EXTRACELLULAR-MATRIX | HEMATOLOGY | EHLERS-DANLOS-SYNDROME | Aneurysm, Dissecting - genetics | Aortic Aneurysm, Thoracic - genetics | Humans | Stress, Mechanical | Aortic Rupture - metabolism | Aneurysm, Dissecting - physiopathology | Aortic Aneurysm, Thoracic - pathology | Aorta, Thoracic - pathology | Extracellular Matrix Proteins - metabolism | Aortic Rupture - physiopathology | Genetic Predisposition to Disease | Aneurysm, Dissecting - metabolism | Extracellular Matrix Proteins - genetics | Aorta, Thoracic - metabolism | Aortic Rupture - pathology | Aneurysm, Dissecting - pathology | Aneurysm, Dissecting - therapy | Aorta, Thoracic - physiopathology | Aortic Aneurysm, Thoracic - physiopathology | Disease Progression | Mechanotransduction, Cellular | Biomechanical Phenomena | Phenotype | Animals | Aortic Aneurysm, Thoracic - metabolism | Aortic Aneurysm, Thoracic - therapy | Aortic Rupture - genetics | Aortic Rupture - therapy | Hemodynamics | familial thoracic aortic aneurysms and dissections | mechanosensing
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Loading RightsThe American Journal of Human Genetics, ISSN 0002-9297, 08/2013, Volume 93, Issue 2, pp. 398 - 404
Gene mutations that lead to decreased contraction of vascular smooth-muscle cells (SMCs) can cause inherited thoracic aortic aneurysms and dissections. Exome...
BETA RECEPTOR | NITRIC-OXIDE | CGMP ACTION | DEPENDENT PROTEIN-KINASES | GENETICS & HEREDITY | Aneurysm, Dissecting - genetics | Aortic Aneurysm, Thoracic - genetics | Fibroblasts - enzymology | Myosin Light Chains - genetics | Humans | Middle Aged | Molecular Sequence Data | Cyclic GMP-Dependent Protein Kinase Type I - genetics | Male | Muscle, Smooth, Vascular - physiopathology | Exome | Cyclic GMP-Dependent Protein Kinase Type I - metabolism | Aneurysm, Dissecting - enzymology | Aneurysm, Dissecting - physiopathology | Adult | Female | Amino Acid Sequence | Acute Disease | Aortic Aneurysm, Thoracic - enzymology | Aorta, Thoracic - physiopathology | Fibroblasts - pathology | Aortic Aneurysm, Thoracic - physiopathology | Aorta, Thoracic - enzymology | Muscle Contraction | Cyclic GMP - metabolism | Pedigree | Adolescent | High-Throughput Nucleotide Sequencing | Myosin Light Chains - metabolism | Mutation | Muscle, Smooth, Vascular - enzymology | Physiological aspects | Aortic aneurysms | Genetic aspects | Research | Gene mutations | Gene expression | Report
BETA RECEPTOR | NITRIC-OXIDE | CGMP ACTION | DEPENDENT PROTEIN-KINASES | GENETICS & HEREDITY | Aneurysm, Dissecting - genetics | Aortic Aneurysm, Thoracic - genetics | Fibroblasts - enzymology | Myosin Light Chains - genetics | Humans | Middle Aged | Molecular Sequence Data | Cyclic GMP-Dependent Protein Kinase Type I - genetics | Male | Muscle, Smooth, Vascular - physiopathology | Exome | Cyclic GMP-Dependent Protein Kinase Type I - metabolism | Aneurysm, Dissecting - enzymology | Aneurysm, Dissecting - physiopathology | Adult | Female | Amino Acid Sequence | Acute Disease | Aortic Aneurysm, Thoracic - enzymology | Aorta, Thoracic - physiopathology | Fibroblasts - pathology | Aortic Aneurysm, Thoracic - physiopathology | Aorta, Thoracic - enzymology | Muscle Contraction | Cyclic GMP - metabolism | Pedigree | Adolescent | High-Throughput Nucleotide Sequencing | Myosin Light Chains - metabolism | Mutation | Muscle, Smooth, Vascular - enzymology | Physiological aspects | Aortic aneurysms | Genetic aspects | Research | Gene mutations | Gene expression | Report
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Loading RightsARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, ISSN 1079-5642, 06/2017, Volume 37, Issue 6, pp. E59 - E65
CORONARY ARTERITIS | MURINE MODEL | OXIDATIVE STRESS | RISK-FACTORS | MOUSE MODEL | MARFAN-SYNDROME | ANIMAL-MODELS | PERIPHERAL VASCULAR DISEASE | ANGIOTENSIN-II | MICE | CONVERTING ENZYME-INHIBITORS | HEMATOLOGY | Vascular Remodeling | Signal Transduction | Humans | Risk Factors | Aorta, Thoracic - metabolism | Aorta, Thoracic - physiopathology | Aortic Aneurysm, Abdominal - epidemiology | Aortic Aneurysm, Thoracic - physiopathology | Aortic Aneurysm, Abdominal - metabolism | Animals | Aortic Aneurysm, Thoracic - pathology | Aortic Aneurysm, Abdominal - physiopathology | Aortic Aneurysm, Thoracic - metabolism | Aortic Aneurysm, Thoracic - epidemiology | Aorta, Abdominal - pathology | Aorta, Abdominal - physiopathology | Aorta, Abdominal - metabolism | Aorta, Thoracic - pathology | Aortic Aneurysm, Abdominal - pathology | Disease Models, Animal
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Loading RightsJournal of Vascular Surgery, ISSN 0741-5214, 2015, Volume 63, Issue 4, pp. 930 - 942
Objective Thoracoabdominal aortic aneurysm (TAAA) repair remains a challenging clinical pathology. Endovascular technology, in particular the evolution of...
Surgery | SURGERY | DURABILITY | EVENTS | ERA | ENDOGRAFTS | STENT GRAFTS | RISK | PERIPHERAL VASCULAR DISEASE | PERFUSION | PATENCY | Multivariate Analysis | Prospective Studies | Age Factors | Aortic Aneurysm, Thoracic - diagnostic imaging | Humans | Middle Aged | Male | Blood Vessel Prosthesis | Postoperative Complications - mortality | Prosthesis Design | Endovascular Procedures - instrumentation | Blood Vessel Prosthesis Implantation - adverse effects | Time Factors | Aged, 80 and over | Aortic Aneurysm, Thoracic - mortality | Female | Stents | Length of Stay | Hospital Mortality | Blood Vessel Prosthesis Implantation - instrumentation | Endovascular Procedures - adverse effects | Risk Factors | Kaplan-Meier Estimate | Postoperative Complications - therapy | Treatment Outcome | Endovascular Procedures - mortality | Chi-Square Distribution | Aortic Aneurysm, Thoracic - physiopathology | Blood Vessel Prosthesis Implantation - mortality | Retreatment | Aortic Aneurysm, Thoracic - surgery | Aged | Ohio | Aortography | Vascular Patency | Aneurysms | Medical colleges
Surgery | SURGERY | DURABILITY | EVENTS | ERA | ENDOGRAFTS | STENT GRAFTS | RISK | PERIPHERAL VASCULAR DISEASE | PERFUSION | PATENCY | Multivariate Analysis | Prospective Studies | Age Factors | Aortic Aneurysm, Thoracic - diagnostic imaging | Humans | Middle Aged | Male | Blood Vessel Prosthesis | Postoperative Complications - mortality | Prosthesis Design | Endovascular Procedures - instrumentation | Blood Vessel Prosthesis Implantation - adverse effects | Time Factors | Aged, 80 and over | Aortic Aneurysm, Thoracic - mortality | Female | Stents | Length of Stay | Hospital Mortality | Blood Vessel Prosthesis Implantation - instrumentation | Endovascular Procedures - adverse effects | Risk Factors | Kaplan-Meier Estimate | Postoperative Complications - therapy | Treatment Outcome | Endovascular Procedures - mortality | Chi-Square Distribution | Aortic Aneurysm, Thoracic - physiopathology | Blood Vessel Prosthesis Implantation - mortality | Retreatment | Aortic Aneurysm, Thoracic - surgery | Aged | Ohio | Aortography | Vascular Patency | Aneurysms | Medical colleges
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Loading RightsArteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 04/2017, Volume 37, Issue 4, pp. 694 - 706
OBJECTIVE—Increasing evidence suggests that contractile dysfunction in smooth muscle cells (SMCs) plays a critical role in aortic biomechanical dysfunction and...
Caspase 1 | Glyburide | Inflammasomes | Contractile proteins | Proteolysis | Aortic aneurysm | OXIDATIVE STRESS | ACTIVATION | glyburide | inflammasomes | FOCUS | INJURY | caspase 1 | DELETION | aortic aneurysm | PERIPHERAL VASCULAR DISEASE | MICE | MUTATIONS | ISCHEMIA-REPERFUSION | HEMATOLOGY | proteolysis | contractile proteins | Aneurysm, Dissecting - genetics | Aortic Aneurysm, Abdominal - prevention & control | Inflammasomes - metabolism | Humans | Middle Aged | Caspase 1 - metabolism | Male | Mice, 129 Strain | Aorta, Abdominal - drug effects | Aneurysm, Dissecting - physiopathology | Glyburide - pharmacology | Inflammasomes - antagonists & inhibitors | Myocytes, Smooth Muscle - drug effects | Aneurysm, Dissecting - prevention & control | Disease Models, Animal | Muscle, Smooth, Vascular - drug effects | Genetic Predisposition to Disease | Myocytes, Smooth Muscle - enzymology | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Vasoconstriction - drug effects | Aortic Aneurysm, Thoracic - physiopathology | Mice, Knockout | Aorta, Thoracic - enzymology | Biomechanical Phenomena | Phenotype | Aortic Aneurysm, Abdominal - enzymology | Aortic Aneurysm, Abdominal - physiopathology | Caspase 1 - deficiency | Muscle, Smooth, Vascular - enzymology | Aortic Aneurysm, Thoracic - genetics | Aortic Aneurysm, Thoracic - prevention & control | Myocytes, Smooth Muscle - pathology | Muscle, Smooth, Vascular - physiopathology | NLR Family, Pyrin Domain-Containing 3 Protein - genetics | Aneurysm, Dissecting - enzymology | Muscle Proteins - metabolism | Female | Aorta, Abdominal - pathology | Aorta, Thoracic - drug effects | Angiotensin II | Aorta, Abdominal - physiopathology | Aorta, Thoracic - pathology | Aortic Aneurysm, Thoracic - enzymology | Mice, Inbred C57BL | Cells, Cultured | Aortic Aneurysm, Abdominal - genetics | Aorta, Thoracic - physiopathology | Aorta, Abdominal - enzymology | Inflammasomes - genetics | NLR Family, Pyrin Domain-Containing 3 Protein - deficiency | Muscle, Smooth, Vascular - pathology | Animals | Caspase 1 - genetics | Aged | aneurysm | cardiovascular diseases | contractility | vessels
Caspase 1 | Glyburide | Inflammasomes | Contractile proteins | Proteolysis | Aortic aneurysm | OXIDATIVE STRESS | ACTIVATION | glyburide | inflammasomes | FOCUS | INJURY | caspase 1 | DELETION | aortic aneurysm | PERIPHERAL VASCULAR DISEASE | MICE | MUTATIONS | ISCHEMIA-REPERFUSION | HEMATOLOGY | proteolysis | contractile proteins | Aneurysm, Dissecting - genetics | Aortic Aneurysm, Abdominal - prevention & control | Inflammasomes - metabolism | Humans | Middle Aged | Caspase 1 - metabolism | Male | Mice, 129 Strain | Aorta, Abdominal - drug effects | Aneurysm, Dissecting - physiopathology | Glyburide - pharmacology | Inflammasomes - antagonists & inhibitors | Myocytes, Smooth Muscle - drug effects | Aneurysm, Dissecting - prevention & control | Disease Models, Animal | Muscle, Smooth, Vascular - drug effects | Genetic Predisposition to Disease | Myocytes, Smooth Muscle - enzymology | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Vasoconstriction - drug effects | Aortic Aneurysm, Thoracic - physiopathology | Mice, Knockout | Aorta, Thoracic - enzymology | Biomechanical Phenomena | Phenotype | Aortic Aneurysm, Abdominal - enzymology | Aortic Aneurysm, Abdominal - physiopathology | Caspase 1 - deficiency | Muscle, Smooth, Vascular - enzymology | Aortic Aneurysm, Thoracic - genetics | Aortic Aneurysm, Thoracic - prevention & control | Myocytes, Smooth Muscle - pathology | Muscle, Smooth, Vascular - physiopathology | NLR Family, Pyrin Domain-Containing 3 Protein - genetics | Aneurysm, Dissecting - enzymology | Muscle Proteins - metabolism | Female | Aorta, Abdominal - pathology | Aorta, Thoracic - drug effects | Angiotensin II | Aorta, Abdominal - physiopathology | Aorta, Thoracic - pathology | Aortic Aneurysm, Thoracic - enzymology | Mice, Inbred C57BL | Cells, Cultured | Aortic Aneurysm, Abdominal - genetics | Aorta, Thoracic - physiopathology | Aorta, Abdominal - enzymology | Inflammasomes - genetics | NLR Family, Pyrin Domain-Containing 3 Protein - deficiency | Muscle, Smooth, Vascular - pathology | Animals | Caspase 1 - genetics | Aged | aneurysm | cardiovascular diseases | contractility | vessels
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Loading RightsAnnals of Thoracic Surgery, ISSN 0003-4975, 2008, Volume 85, Issue 1, pp. S1 - S41
Between 43,000 and 47,000 people die annually in the United States from diseases of the aorta and its branches and continues to increase. For the thoracic...
Surgery | Cardiothoracic Surgery | SURGERY | SINGLE-CENTER EXPERIENCE | CARDIAC & CARDIOVASCULAR SYSTEMS | MIDTERM FOLLOW-UP | LEFT SUBCLAVIAN ARTERY | RANDOMIZED CONTROLLED-TRIAL | ELEPHANT TRUNK TECHNIQUE | CEREBROSPINAL-FLUID DRAINAGE | POWERLINK BIFURCATED SYSTEM | RESPIRATORY SYSTEM | SPINAL-CORD PROTECTION | PENETRATING ATHEROSCLEROTIC ULCER | HYPOTHERMIC CARDIOPULMONARY BYPASS | Humans | Aortic Aneurysm, Thoracic - therapy | Aortic Aneurysm, Abdominal - therapy | Blood Vessel Prosthesis | Aneurysm, Dissecting - therapy | Stents | Aortic Aneurysm, Thoracic - physiopathology
Surgery | Cardiothoracic Surgery | SURGERY | SINGLE-CENTER EXPERIENCE | CARDIAC & CARDIOVASCULAR SYSTEMS | MIDTERM FOLLOW-UP | LEFT SUBCLAVIAN ARTERY | RANDOMIZED CONTROLLED-TRIAL | ELEPHANT TRUNK TECHNIQUE | CEREBROSPINAL-FLUID DRAINAGE | POWERLINK BIFURCATED SYSTEM | RESPIRATORY SYSTEM | SPINAL-CORD PROTECTION | PENETRATING ATHEROSCLEROTIC ULCER | HYPOTHERMIC CARDIOPULMONARY BYPASS | Humans | Aortic Aneurysm, Thoracic - therapy | Aortic Aneurysm, Abdominal - therapy | Blood Vessel Prosthesis | Aneurysm, Dissecting - therapy | Stents | Aortic Aneurysm, Thoracic - physiopathology
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Loading RightsJournal of Vascular Surgery, ISSN 0741-5214, 2016, Volume 65, Issue 5, pp. 1249 - 1259.e10
Abstract Purpose To investigate outcomes of manufactured fenestrated and branched endovascular aortic repair (F-BEVAR) endografts based on supraceliac sealing...
Surgery | SURGERY | SPINAL-CORD ISCHEMIA | DURABILITY | IMPACT | TRIPLE | INJURY | PERIPHERAL VASCULAR DISEASE | OUTCOMES | EDITORS CHOICE | STENT-GRAFTS | Postoperative Complications - etiology | Aortic Aneurysm, Abdominal - mortality | Aortic Aneurysm, Abdominal - surgery | Aortic Aneurysm, Thoracic - diagnostic imaging | Humans | Aortic Aneurysm, Abdominal - diagnostic imaging | Male | Blood Vessel Prosthesis | Prosthesis Design | Aortography - methods | Endovascular Procedures - instrumentation | Blood Vessel Prosthesis Implantation - adverse effects | Time Factors | Aged, 80 and over | Aortic Aneurysm, Thoracic - mortality | Female | Ultrasonography, Doppler, Duplex | Stents | Postoperative Complications - physiopathology | Blood Vessel Prosthesis Implantation - instrumentation | Endovascular Procedures - adverse effects | Risk Factors | Kaplan-Meier Estimate | Postoperative Complications - therapy | Treatment Outcome | Minnesota | Endovascular Procedures - mortality | Aortic Aneurysm, Thoracic - physiopathology | Blood Vessel Prosthesis Implantation - mortality | Computed Tomography Angiography | Retreatment | Aortic Aneurysm, Abdominal - physiopathology | Aortic Aneurysm, Thoracic - surgery | Aged | Vascular Patency | Aneurysms | Epidemiology
Surgery | SURGERY | SPINAL-CORD ISCHEMIA | DURABILITY | IMPACT | TRIPLE | INJURY | PERIPHERAL VASCULAR DISEASE | OUTCOMES | EDITORS CHOICE | STENT-GRAFTS | Postoperative Complications - etiology | Aortic Aneurysm, Abdominal - mortality | Aortic Aneurysm, Abdominal - surgery | Aortic Aneurysm, Thoracic - diagnostic imaging | Humans | Aortic Aneurysm, Abdominal - diagnostic imaging | Male | Blood Vessel Prosthesis | Prosthesis Design | Aortography - methods | Endovascular Procedures - instrumentation | Blood Vessel Prosthesis Implantation - adverse effects | Time Factors | Aged, 80 and over | Aortic Aneurysm, Thoracic - mortality | Female | Ultrasonography, Doppler, Duplex | Stents | Postoperative Complications - physiopathology | Blood Vessel Prosthesis Implantation - instrumentation | Endovascular Procedures - adverse effects | Risk Factors | Kaplan-Meier Estimate | Postoperative Complications - therapy | Treatment Outcome | Minnesota | Endovascular Procedures - mortality | Aortic Aneurysm, Thoracic - physiopathology | Blood Vessel Prosthesis Implantation - mortality | Computed Tomography Angiography | Retreatment | Aortic Aneurysm, Abdominal - physiopathology | Aortic Aneurysm, Thoracic - surgery | Aged | Vascular Patency | Aneurysms | Epidemiology
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Loading RightsArteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 01/2017, Volume 37, Issue 1, pp. 26 - 34
The importance of maintaining contractile function in aortic smooth muscle cells (SMCs) is evident by the fact that heterozygous mutations in the major...
mutation | thoracic aorta | aortic aneurysm | aortic dissection | vascular smooth muscle cells | Marfan syndrome | LIGHT-CHAIN KINASE | ACTIN POLYMERIZATION | DOMAIN-STRUCTURE | TGFBR2 MUTATIONS | MYOSIN HEAVY-CHAIN | BETA RECEPTOR | MARFAN-SYNDROME | MOUSE MODEL | DISEASE | PERIPHERAL VASCULAR DISEASE | PATENT DUCTUS-ARTERIOSUS | HEMATOLOGY | Myosin-Light-Chain Kinase - genetics | Aneurysm, Dissecting - genetics | Aortic Aneurysm, Thoracic - genetics | Genetic Testing | Muscle, Smooth, Vascular - metabolism | Pulsatile Flow | Humans | Actins - metabolism | Myocytes, Smooth Muscle - pathology | Myosin Heavy Chains - genetics | Cyclic GMP-Dependent Protein Kinase Type I - genetics | Muscle, Smooth, Vascular - physiopathology | Myosin Heavy Chains - metabolism | Actins - genetics | Cyclic GMP-Dependent Protein Kinase Type I - metabolism | Aneurysm, Dissecting - physiopathology | Aortic Aneurysm, Thoracic - pathology | Dilatation, Pathologic | Myocytes, Smooth Muscle - metabolism | Calcium-Binding Proteins - metabolism | Vasoconstriction - genetics | Elastin - metabolism | Aneurysm, Dissecting - metabolism | Myosin-Light-Chain Kinase - metabolism | Heredity | Aneurysm, Dissecting - pathology | Genetic Markers | Aortic Aneurysm, Thoracic - physiopathology | Mechanotransduction, Cellular | Muscle, Smooth, Vascular - pathology | Phenotype | Animals | Aortic Aneurysm, Thoracic - metabolism | Mutation | Calcium-Binding Proteins - genetics | elastin-contractile unit | Contractile Function | Vascular Biology | Aneurysm | Genetics | vascular smooth muscle cell | Aortic Dissection | thoracic
mutation | thoracic aorta | aortic aneurysm | aortic dissection | vascular smooth muscle cells | Marfan syndrome | LIGHT-CHAIN KINASE | ACTIN POLYMERIZATION | DOMAIN-STRUCTURE | TGFBR2 MUTATIONS | MYOSIN HEAVY-CHAIN | BETA RECEPTOR | MARFAN-SYNDROME | MOUSE MODEL | DISEASE | PERIPHERAL VASCULAR DISEASE | PATENT DUCTUS-ARTERIOSUS | HEMATOLOGY | Myosin-Light-Chain Kinase - genetics | Aneurysm, Dissecting - genetics | Aortic Aneurysm, Thoracic - genetics | Genetic Testing | Muscle, Smooth, Vascular - metabolism | Pulsatile Flow | Humans | Actins - metabolism | Myocytes, Smooth Muscle - pathology | Myosin Heavy Chains - genetics | Cyclic GMP-Dependent Protein Kinase Type I - genetics | Muscle, Smooth, Vascular - physiopathology | Myosin Heavy Chains - metabolism | Actins - genetics | Cyclic GMP-Dependent Protein Kinase Type I - metabolism | Aneurysm, Dissecting - physiopathology | Aortic Aneurysm, Thoracic - pathology | Dilatation, Pathologic | Myocytes, Smooth Muscle - metabolism | Calcium-Binding Proteins - metabolism | Vasoconstriction - genetics | Elastin - metabolism | Aneurysm, Dissecting - metabolism | Myosin-Light-Chain Kinase - metabolism | Heredity | Aneurysm, Dissecting - pathology | Genetic Markers | Aortic Aneurysm, Thoracic - physiopathology | Mechanotransduction, Cellular | Muscle, Smooth, Vascular - pathology | Phenotype | Animals | Aortic Aneurysm, Thoracic - metabolism | Mutation | Calcium-Binding Proteins - genetics | elastin-contractile unit | Contractile Function | Vascular Biology | Aneurysm | Genetics | vascular smooth muscle cell | Aortic Dissection | thoracic
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Loading RightsAnnual Review of Genomics and Human Genetics, ISSN 1527-8204, 2008, Volume 9, Issue 1, pp. 283 - 302
Thoracic aortic aneurysms leading to type A dissections (TAAD) call be inherited in isolation or in association with genetic syndromes, such as Marfan syndrome...
α-actin | Fibrillin | β-myosin | TGFBR1 | TGFBR2 | beta-myosin | TGF-BETA | POLYCYSTIC KIDNEY-DISEASE | alpha-actin | GROWTH-FACTOR-BETA | HYPERTROPHIC CARDIOMYOPATHY | MARFAN-SYNDROME | MOUSE MODEL | GENETICS & HEREDITY | PATENT DUCTUS-ARTERIOSUS | EXTRACELLULAR-MATRIX | fibrillin | EHLERS-DANLOS-SYNDROME | SYNDROME TYPE-IV | Aneurysm, Dissecting - genetics | Aortic Aneurysm, Thoracic - genetics | Muscle Contraction - genetics | Humans | Male | Aneurysm, Dissecting - therapy | Muscle, Smooth, Vascular - physiopathology | Aortic Aneurysm, Thoracic - etiology | Aortic Aneurysm, Thoracic - physiopathology | Syndrome | Animals | Aneurysm, Dissecting - physiopathology | Pedigree | Aortic Aneurysm, Thoracic - therapy | Female | Models, Genetic | Mutation | Aneurysm, Dissecting - etiology
α-actin | Fibrillin | β-myosin | TGFBR1 | TGFBR2 | beta-myosin | TGF-BETA | POLYCYSTIC KIDNEY-DISEASE | alpha-actin | GROWTH-FACTOR-BETA | HYPERTROPHIC CARDIOMYOPATHY | MARFAN-SYNDROME | MOUSE MODEL | GENETICS & HEREDITY | PATENT DUCTUS-ARTERIOSUS | EXTRACELLULAR-MATRIX | fibrillin | EHLERS-DANLOS-SYNDROME | SYNDROME TYPE-IV | Aneurysm, Dissecting - genetics | Aortic Aneurysm, Thoracic - genetics | Muscle Contraction - genetics | Humans | Male | Aneurysm, Dissecting - therapy | Muscle, Smooth, Vascular - physiopathology | Aortic Aneurysm, Thoracic - etiology | Aortic Aneurysm, Thoracic - physiopathology | Syndrome | Animals | Aneurysm, Dissecting - physiopathology | Pedigree | Aortic Aneurysm, Thoracic - therapy | Female | Models, Genetic | Mutation | Aneurysm, Dissecting - etiology
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Loading RightsJournal of Vascular Surgery, ISSN 0741-5214, 2012, Volume 56, Issue 2, pp. 565 - 571
Understanding the natural history of thoracic aortic aneurysms (TAAs) is essential to patient care and surgical decision making. In this evidence summary we...
Surgery | SURVIVAL | SURGERY | REPAIR | DISEASES | MEDICAL THERAPY | DISSECTION | RUPTURE | PERIPHERAL VASCULAR DISEASE | INTERNATIONAL REGISTRY | MUTATIONS | BLOCKADE | INSIGHTS | Aneurysm, Dissecting - diagnosis | Aortic Aneurysm, Thoracic - genetics | Humans | Aortic Rupture - pathology | Aneurysm, Dissecting - pathology | Aortic Aneurysm, Thoracic - physiopathology | Aortic Rupture - diagnosis | Pedigree | Aortic Aneurysm, Thoracic - diagnosis | Aortic Aneurysm, Thoracic - epidemiology | Aortic Aneurysm, Thoracic - surgery | Dilatation, Pathologic | Aorta, Thoracic - pathology | Aneurysms
Surgery | SURVIVAL | SURGERY | REPAIR | DISEASES | MEDICAL THERAPY | DISSECTION | RUPTURE | PERIPHERAL VASCULAR DISEASE | INTERNATIONAL REGISTRY | MUTATIONS | BLOCKADE | INSIGHTS | Aneurysm, Dissecting - diagnosis | Aortic Aneurysm, Thoracic - genetics | Humans | Aortic Rupture - pathology | Aneurysm, Dissecting - pathology | Aortic Aneurysm, Thoracic - physiopathology | Aortic Rupture - diagnosis | Pedigree | Aortic Aneurysm, Thoracic - diagnosis | Aortic Aneurysm, Thoracic - epidemiology | Aortic Aneurysm, Thoracic - surgery | Dilatation, Pathologic | Aorta, Thoracic - pathology | Aneurysms
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Loading RightsJournal of Thoracic and Cardiovascular Surgery, The, ISSN 0022-5223, 2015, Volume 149, Issue 2, pp. S65 - S73
Objectives Antegrade cerebral perfusion and hypothermic circulatory arrest, with or without retrograde cerebral perfusion, are 2 major types of brain...
Cardiothoracic Surgery | ASCENDING AORTA | MORTALITY | STROKE | SURGERY | CARDIAC & CARDIOVASCULAR SYSTEMS | DEEP HYPOTHERMIA | OPERATIONS | DETERMINANTS | RESPIRATORY SYSTEM | AORTIC-ARCH | ANEURYSMS | THORACIC AORTA | Aneurysm, Dissecting - diagnosis | Humans | Middle Aged | Circulatory Arrest, Deep Hypothermia Induced - mortality | Male | Postoperative Complications - mortality | Perfusion - mortality | Aortic Rupture - diagnosis | Perfusion - adverse effects | Aneurysm, Dissecting - physiopathology | Blood Vessel Prosthesis Implantation - adverse effects | Time Factors | Aneurysm, Dissecting - surgery | Aortic Aneurysm, Thoracic - diagnosis | Matched-Pair Analysis | Aged, 80 and over | Aortic Aneurysm, Thoracic - mortality | Female | Retrospective Studies | Aortic Rupture - mortality | Databases, Factual | Length of Stay | Circulatory Arrest, Deep Hypothermia Induced - adverse effects | Acute Disease | Aortic Rupture - physiopathology | Intensive Care Units | Hospital Mortality | Japan | Risk Factors | Postoperative Complications - therapy | Treatment Outcome | Cerebrovascular Circulation | Aorta, Thoracic - physiopathology | Aortic Aneurysm, Thoracic - physiopathology | Blood Vessel Prosthesis Implantation - mortality | Perfusion - methods | Propensity Score | Aorta, Thoracic - surgery | Aortic Aneurysm, Thoracic - surgery | Aged | Aortic Rupture - surgery | Aneurysm, Dissecting - mortality | Medical care | Brain | Databases | Analysis | Quality management
Cardiothoracic Surgery | ASCENDING AORTA | MORTALITY | STROKE | SURGERY | CARDIAC & CARDIOVASCULAR SYSTEMS | DEEP HYPOTHERMIA | OPERATIONS | DETERMINANTS | RESPIRATORY SYSTEM | AORTIC-ARCH | ANEURYSMS | THORACIC AORTA | Aneurysm, Dissecting - diagnosis | Humans | Middle Aged | Circulatory Arrest, Deep Hypothermia Induced - mortality | Male | Postoperative Complications - mortality | Perfusion - mortality | Aortic Rupture - diagnosis | Perfusion - adverse effects | Aneurysm, Dissecting - physiopathology | Blood Vessel Prosthesis Implantation - adverse effects | Time Factors | Aneurysm, Dissecting - surgery | Aortic Aneurysm, Thoracic - diagnosis | Matched-Pair Analysis | Aged, 80 and over | Aortic Aneurysm, Thoracic - mortality | Female | Retrospective Studies | Aortic Rupture - mortality | Databases, Factual | Length of Stay | Circulatory Arrest, Deep Hypothermia Induced - adverse effects | Acute Disease | Aortic Rupture - physiopathology | Intensive Care Units | Hospital Mortality | Japan | Risk Factors | Postoperative Complications - therapy | Treatment Outcome | Cerebrovascular Circulation | Aorta, Thoracic - physiopathology | Aortic Aneurysm, Thoracic - physiopathology | Blood Vessel Prosthesis Implantation - mortality | Perfusion - methods | Propensity Score | Aorta, Thoracic - surgery | Aortic Aneurysm, Thoracic - surgery | Aged | Aortic Rupture - surgery | Aneurysm, Dissecting - mortality | Medical care | Brain | Databases | Analysis | Quality management
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Loading RightsJournal of Thoracic and Cardiovascular Surgery, The, ISSN 0022-5223, 2012, Volume 143, Issue 2, pp. 460 - 467
Objectives The acute dissection of an ascending thoracic aortic aneurysm (ATAA) represents a devastating separation of elastic layers occurring when the...
Cardiothoracic Surgery | MORTALITY | SURGERY | RATES | CARDIAC & CARDIOVASCULAR SYSTEMS | MODELS | RESPIRATORY SYSTEM | BIOMECHANICAL BEHAVIOR | STRENGTH | EXPRESSION | VALVE PATIENTS | PROPAGATION | Aortic Valve - abnormalities | Humans | Middle Aged | Male | Aneurysm, Dissecting - physiopathology | Aortic Aneurysm, Thoracic - pathology | Adult | Female | Aneurysm, Dissecting - etiology | Tensile Strength | Microscopy, Electron, Scanning | Risk Assessment | Risk Factors | Heart Defects, Congenital - pathology | Aortic Valve - physiopathology | Aneurysm, Dissecting - pathology | Aorta, Thoracic - physiopathology | Aortic Aneurysm, Thoracic - physiopathology | Aorta, Thoracic - ultrastructure | Pennsylvania | Biomechanical Phenomena | Heart Defects, Congenital - complications | Analysis of Variance | Aged | Heart Defects, Congenital - physiopathology | Hemodynamics | Aortic Aneurysm, Thoracic - complications | Mechanical properties | Aneurysms | Laminated materials | Surgery | Analysis
Cardiothoracic Surgery | MORTALITY | SURGERY | RATES | CARDIAC & CARDIOVASCULAR SYSTEMS | MODELS | RESPIRATORY SYSTEM | BIOMECHANICAL BEHAVIOR | STRENGTH | EXPRESSION | VALVE PATIENTS | PROPAGATION | Aortic Valve - abnormalities | Humans | Middle Aged | Male | Aneurysm, Dissecting - physiopathology | Aortic Aneurysm, Thoracic - pathology | Adult | Female | Aneurysm, Dissecting - etiology | Tensile Strength | Microscopy, Electron, Scanning | Risk Assessment | Risk Factors | Heart Defects, Congenital - pathology | Aortic Valve - physiopathology | Aneurysm, Dissecting - pathology | Aorta, Thoracic - physiopathology | Aortic Aneurysm, Thoracic - physiopathology | Aorta, Thoracic - ultrastructure | Pennsylvania | Biomechanical Phenomena | Heart Defects, Congenital - complications | Analysis of Variance | Aged | Heart Defects, Congenital - physiopathology | Hemodynamics | Aortic Aneurysm, Thoracic - complications | Mechanical properties | Aneurysms | Laminated materials | Surgery | Analysis
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