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1. Full Text Role of mechanotransduction in vascular biology: Focus on thoracic aortic aneurysms and dissections
by Humphrey, Jay D and Schwartz, Martin A and Tellides, George and Milewicz, Dianna M
Circulation research, ISSN 0009-7330, 04/2015, Volume 116, Issue 8, pp. 1448 - 1461
Elastic fibers | Actomyosin | Marfan syndrome | Focal adhesion | Cardiac & Cardiovascular Systems | Peripheral Vascular Disease | Life Sciences & Biomedicine | Hematology | Cardiovascular System & Cardiology | Science & Technology | Aneurysm, Dissecting - genetics | Aortic Aneurysm, Thoracic - genetics | Humans | Stress, Mechanical | Aortic Rupture - metabolism | Aneurysm, Dissecting - physiopathology | Aortic Aneurysm, Thoracic - pathology | Aorta, Thoracic - pathology | Extracellular Matrix Proteins - metabolism | Aortic Rupture - physiopathology | Genetic Predisposition to Disease | Aneurysm, Dissecting - metabolism | Extracellular Matrix Proteins - genetics | Aorta, Thoracic - metabolism | Aortic Rupture - pathology | Aneurysm, Dissecting - pathology | Aneurysm, Dissecting - therapy | Aorta, Thoracic - physiopathology | Aortic Aneurysm, Thoracic - physiopathology | Disease Progression | Mechanotransduction, Cellular | Biomechanical Phenomena | Phenotype | Animals | Aortic Aneurysm, Thoracic - metabolism | Aortic Aneurysm, Thoracic - therapy | Aortic Rupture - genetics | Aortic Rupture - therapy | Hemodynamics | Index Medicus | focal adhesion | familial thoracic aortic aneurysms and dissections | elastic fibers | mechanosensing | actomyosin
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2. Full Text NLRP3 (Nucleotide Oligomerization Domain–Like Receptor Family, Pyrin Domain Containing 3)–Caspase-1 Inflammasome Degrades Contractile Proteins: Implications for Aortic Biomechanical Dysfunction and Aneurysm and Dissection Formation
by Wu, Darrell and Ren, Pingping and Zheng, Yanqiu and Zhang, Lin and Xu, Gaiping and Xie, Wanmu and Lloyd, Eric E and Zhang, Sui and Zhang, Qianzi and Curci, John A and Coselli, Joseph S and Milewicz, Dianna M and Shen, Ying H and LeMaire, Scott A
Arteriosclerosis, thrombosis, and vascular biology, ISSN 1079-5642, 04/2017, Volume 37, Issue 4, pp. 694 - 706
Caspase 1 | Glyburide | Inflammasomes | Contractile proteins | Proteolysis | Aortic aneurysm | Peripheral Vascular Disease | Life Sciences & Biomedicine | Hematology | Cardiovascular System & Cardiology | Science & Technology | Aneurysm, Dissecting - genetics | Aortic Aneurysm, Abdominal - prevention & control | Inflammasomes - metabolism | Humans | Middle Aged | Caspase 1 - metabolism | Male | Mice, 129 Strain | Aorta, Abdominal - drug effects | Aneurysm, Dissecting - physiopathology | Glyburide - pharmacology | Inflammasomes - antagonists & inhibitors | Myocytes, Smooth Muscle - drug effects | Aneurysm, Dissecting - prevention & control | Disease Models, Animal | Muscle, Smooth, Vascular - drug effects | Genetic Predisposition to Disease | Myocytes, Smooth Muscle - enzymology | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Vasoconstriction - drug effects | Aortic Aneurysm, Thoracic - physiopathology | Mice, Knockout | Aorta, Thoracic - enzymology | Biomechanical Phenomena | Phenotype | Aortic Aneurysm, Abdominal - enzymology | Aortic Aneurysm, Abdominal - physiopathology | Caspase 1 - deficiency | Muscle, Smooth, Vascular - enzymology | Aortic Aneurysm, Thoracic - genetics | Aortic Aneurysm, Thoracic - prevention & control | Myocytes, Smooth Muscle - pathology | Muscle, Smooth, Vascular - physiopathology | NLR Family, Pyrin Domain-Containing 3 Protein - genetics | Aneurysm, Dissecting - enzymology | Muscle Proteins - metabolism | Female | Aorta, Abdominal - pathology | Aorta, Thoracic - drug effects | Angiotensin II | Aorta, Abdominal - physiopathology | Aorta, Thoracic - pathology | Aortic Aneurysm, Thoracic - enzymology | Mice, Inbred C57BL | Cells, Cultured | Aortic Aneurysm, Abdominal - genetics | Aorta, Thoracic - physiopathology | Aorta, Abdominal - enzymology | Inflammasomes - genetics | NLR Family, Pyrin Domain-Containing 3 Protein - deficiency | Muscle, Smooth, Vascular - pathology | Animals | Caspase 1 - genetics | Aged | Index Medicus | aneurysm | cardiovascular diseases | contractility | vessels
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3. Full Text Altered Smooth Muscle Cell Force Generation as a Driver of Thoracic Aortic Aneurysms and Dissections
by Milewicz, Dianna M and Trybus, Kathleen M and Guo, Dong-chuan and Sweeney, H Lee and Regalado, Ellen and Kamm, Kristine and Stull, James T
Arteriosclerosis, thrombosis, and vascular biology, ISSN 1079-5642, 01/2017, Volume 37, Issue 1, pp. 26 - 34
mutation | thoracic aorta | aortic aneurysm | aortic dissection | vascular smooth muscle cells | Marfan syndrome | Peripheral Vascular Disease | Life Sciences & Biomedicine | Hematology | Cardiovascular System & Cardiology | Science & Technology | Myosin-Light-Chain Kinase - genetics | Aneurysm, Dissecting - genetics | Aortic Aneurysm, Thoracic - genetics | Genetic Testing | Muscle, Smooth, Vascular - metabolism | Pulsatile Flow | Humans | Actins - metabolism | Myocytes, Smooth Muscle - pathology | Myosin Heavy Chains - genetics | Cyclic GMP-Dependent Protein Kinase Type I - genetics | Muscle, Smooth, Vascular - physiopathology | Myosin Heavy Chains - metabolism | Actins - genetics | Cyclic GMP-Dependent Protein Kinase Type I - metabolism | Aneurysm, Dissecting - physiopathology | Aortic Aneurysm, Thoracic - pathology | Dilatation, Pathologic | Myocytes, Smooth Muscle - metabolism | Calcium-Binding Proteins - metabolism | Vasoconstriction - genetics | Elastin - metabolism | Aneurysm, Dissecting - metabolism | Myosin-Light-Chain Kinase - metabolism | Heredity | Aneurysm, Dissecting - pathology | Genetic Markers | Aortic Aneurysm, Thoracic - physiopathology | Mechanotransduction, Cellular | Muscle, Smooth, Vascular - pathology | Phenotype | Animals | Aortic Aneurysm, Thoracic - metabolism | Mutation | Calcium-Binding Proteins - genetics | Index Medicus | elastin-contractile unit | Contractile Function | Vascular Biology | Aneurysm | Genetics | vascular smooth muscle cell | Aortic Dissection | thoracic
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4. Full Text Recurrent Gain-of-Function Mutation in PRKG1 Causes Thoracic Aortic Aneurysms and Acute Aortic Dissections
by Guo, Dong-chuan and Regalado, Ellen and Casteel, Darren E and Santos-Cortez, Regie L and Gong, Limin and Kim, Jeong Joo and Dyack, Sarah and Horne, S. Gabrielle and Chang, Guijuan and Jondeau, Guillaume and Boileau, Catherine and Coselli, Joseph S and Li, Zhenyu and Leal, Suzanne M and Shendure, Jay and Rieder, Mark J and Bamshad, Michael J and Nickerson, Deborah A and Kim, Choel and Milewicz, Dianna M and GenTAC Registry Consortium and National Heart, Lung, and Blood Institute Grand Opportunity Exome Sequencing Project and Natl Heart Lung Blood Inst Grand O
American journal of human genetics, ISSN 0002-9297, 08/2013, Volume 93, Issue 2, pp. 398 - 404
Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Aneurysm, Dissecting - genetics | Aortic Aneurysm, Thoracic - genetics | Fibroblasts - enzymology | Myosin Light Chains - genetics | Humans | Middle Aged | Molecular Sequence Data | Cyclic GMP-Dependent Protein Kinase Type I - genetics | Male | Muscle, Smooth, Vascular - physiopathology | Exome | Cyclic GMP-Dependent Protein Kinase Type I - metabolism | Aneurysm, Dissecting - enzymology | Aneurysm, Dissecting - physiopathology | Adult | Female | Amino Acid Sequence | Acute Disease | Aortic Aneurysm, Thoracic - enzymology | Aorta, Thoracic - physiopathology | Fibroblasts - pathology | Aortic Aneurysm, Thoracic - physiopathology | Aorta, Thoracic - enzymology | Muscle Contraction | Cyclic GMP - metabolism | Pedigree | Adolescent | High-Throughput Nucleotide Sequencing | Myosin Light Chains - metabolism | Mutation | Muscle, Smooth, Vascular - enzymology | Physiological aspects | Aortic aneurysms | Genetic aspects | Research | Gene mutations | Gene expression | Aneurysms | Phosphorylation | Kinases | Dissection | Cells | Index Medicus | Report
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5. Full Text Genetic basis of thoracic aortic aneurysms and dissections: Focus on smooth muscle cell contractile dysfunction
by Milewicz, Dianna M and Guo, Dong-Chuan and Van Tran-Fadulu, Tran-Fadulu and Lafont, Andrea L and Papke, Christina L and Inamoto, Sakiko and Kwartler, Carrie S and Pannu, Hariyadarshi
Annual review of genomics and human genetics, ISSN 1527-8204, 2008, Volume 9, Issue 1, pp. 283 - 302
α-actin | Fibrillin | β-myosin | TGFBR1 | TGFBR2 | Aneurysm, Dissecting - genetics | Aortic Aneurysm, Thoracic - genetics | Muscle Contraction - genetics | Humans | Male | Aneurysm, Dissecting - therapy | Muscle, Smooth, Vascular - physiopathology | Aortic Aneurysm, Thoracic - etiology | Aortic Aneurysm, Thoracic - physiopathology | Syndrome | Animals | Aneurysm, Dissecting - physiopathology | Pedigree | Aortic Aneurysm, Thoracic - therapy | Female | Models, Genetic | Mutation | Aneurysm, Dissecting - etiology | Index Medicus
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6. Full Text Prospective, nonrandomized study to evaluate endovascular repair of pararenal and thoracoabdominal aortic aneurysms using fenestrated-branched endografts based on supraceliac sealing zones
by Oderich, Gustavo S., MD and Ribeiro, Mauricio, MD, PhD and Hofer, Jan, RN and Wigham, Jean, RN and Cha, Stephen, MS and Chini, Julia and Macedo, Thanila A., MD and Gloviczki, Peter, MD
Journal of vascular surgery, ISSN 0741-5214, 2016, Volume 65, Issue 5, pp. 1249 - 1259.e10
Surgery | Peripheral Vascular Disease | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Postoperative Complications - etiology | Aortic Aneurysm, Abdominal - mortality | Aortic Aneurysm, Abdominal - surgery | Aortic Aneurysm, Thoracic - diagnostic imaging | Humans | Aortic Aneurysm, Abdominal - diagnostic imaging | Male | Blood Vessel Prosthesis | Prosthesis Design | Aortography - methods | Endovascular Procedures - instrumentation | Blood Vessel Prosthesis Implantation - adverse effects | Time Factors | Aged, 80 and over | Aortic Aneurysm, Thoracic - mortality | Female | Ultrasonography, Doppler, Duplex | Stents | Postoperative Complications - physiopathology | Blood Vessel Prosthesis Implantation - instrumentation | Endovascular Procedures - adverse effects | Risk Factors | Kaplan-Meier Estimate | Postoperative Complications - therapy | Treatment Outcome | Minnesota | Endovascular Procedures - mortality | Aortic Aneurysm, Thoracic - physiopathology | Blood Vessel Prosthesis Implantation - mortality | Computed Tomography Angiography | Retreatment | Aortic Aneurysm, Abdominal - physiopathology | Aortic Aneurysm, Thoracic - surgery | Aged | Vascular Patency | Aneurysms | Epidemiology | Index Medicus
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7. Full Text Acute Aortic Syndromes and Thoracic Aortic Aneurysm
by Ramanath, Vijay S and Oh, Jae K and Sundt, Thoralf M and Eagle, Kim A
Mayo Clinic proceedings, ISSN 0025-6196, 05/2009, Volume 84, Issue 5, pp. 465 - 481
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Acute Disease | Aortic Diseases - classification | Humans | Risk Factors | Aortic Diseases - therapy | Aortic Diseases - diagnosis | Aortic Aneurysm, Thoracic - physiopathology | Syndrome | Aortic Aneurysm, Thoracic - classification | Diagnostic Imaging | Aortic Diseases - physiopathology | Aortic Aneurysm, Thoracic - diagnosis | Aortic Aneurysm, Thoracic - therapy | Symposium on Cardiovascular Diseases
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8. Full Text Acute Aortic Syndromes and Thoracic Aortic Aneurysm
by Ramanath, Vijay S and Oh, Jae K and Sundt, Thoralf M and Eagle, Kim A
Mayo Clinic proceedings, ISSN 0025-6196, 2009, Volume 84, Issue 5, pp. 465 - 481
Biological and medical sciences | General aspects | Medical sciences | Development and progression | Care and treatment | Prognosis | Diagnosis | Cardiovascular diseases | Risk factors | Index Medicus | Abridged Index Medicus
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9. Full Text Pharmacologically Improved Contractility Protects Against Aortic Dissection in Mice With Disrupted Transforming Growth Factor-β Signaling Despite Compromised Extracellular Matrix Properties
by Ferruzzi, Jacopo and Murtada, Sae-Il and Li, Guangxin and Jiao, Yang and Uman, Selen and Ting, Magdalene Y.L and Tellides, George and Humphrey, Jay D
Arteriosclerosis, thrombosis, and vascular biology, ISSN 1079-5642, 05/2016, Volume 36, Issue 5, pp. 919 - 927
transforming growth factor-beta | aneurysm | aorta | strength | stiffness | rapamycin | Peripheral Vascular Disease | Life Sciences & Biomedicine | Hematology | Cardiovascular System & Cardiology | Science & Technology | Protein-Serine-Threonine Kinases - deficiency | Aneurysm, Dissecting - genetics | Aortic Aneurysm, Thoracic - genetics | Receptors, Transforming Growth Factor beta - genetics | Muscle, Smooth, Vascular - metabolism | TOR Serine-Threonine Kinases - metabolism | Aortic Aneurysm, Thoracic - prevention & control | Elasticity | Extracellular Matrix - metabolism | Stress, Mechanical | Male | Muscle, Smooth, Vascular - physiopathology | TOR Serine-Threonine Kinases - antagonists & inhibitors | Arterial Pressure | Aneurysm, Dissecting - physiopathology | Aorta, Thoracic - drug effects | Aneurysm, Dissecting - prevention & control | Muscle, Smooth, Vascular - drug effects | Genetic Predisposition to Disease | Aneurysm, Dissecting - metabolism | Extracellular Matrix - drug effects | Protein-Serine-Threonine Kinases - genetics | Aorta, Thoracic - metabolism | Aorta, Thoracic - physiopathology | Sirolimus - pharmacology | Vasoconstriction - drug effects | Aortic Aneurysm, Thoracic - physiopathology | Mice, Knockout | Muscle, Smooth, Vascular - pathology | Phenotype | Animals | Aortic Aneurysm, Thoracic - metabolism | Vascular Stiffness - drug effects | Protein Kinase Inhibitors - pharmacology | Extracellular Matrix - pathology | Receptors, Transforming Growth Factor beta - deficiency | Index Medicus
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