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Circulation Research, ISSN 0009-7330, 04/2015, Volume 116, Issue 8, pp. 1448 - 1461
Thoracic aortic diseases that involve progressive enlargement, acute dissection, or rupture are influenced by the hemodynamic loads and mechanical properties... 
Elastic fibers | Actomyosin | Marfan syndrome | Focal adhesion | focal adhesion | LIGHT-CHAIN KINASE | ASCENDING AORTA | DEVELOPING MOUSE AORTA | CARDIAC & CARDIOVASCULAR SYSTEMS | ANGIOTENSIN-II | GROWTH-FACTOR-BETA | actomyosin | MARFAN-SYNDROME | ARTERIAL-WALL | elastic fibers | PERIPHERAL VASCULAR DISEASE | SMOOTH-MUSCLE-CELLS | EXTRACELLULAR-MATRIX | HEMATOLOGY | EHLERS-DANLOS-SYNDROME | Aneurysm, Dissecting - genetics | Aortic Aneurysm, Thoracic - genetics | Humans | Stress, Mechanical | Aortic Rupture - metabolism | Aneurysm, Dissecting - physiopathology | Aortic Aneurysm, Thoracic - pathology | Aorta, Thoracic - pathology | Extracellular Matrix Proteins - metabolism | Aortic Rupture - physiopathology | Genetic Predisposition to Disease | Aneurysm, Dissecting - metabolism | Extracellular Matrix Proteins - genetics | Aorta, Thoracic - metabolism | Aortic Rupture - pathology | Aneurysm, Dissecting - pathology | Aneurysm, Dissecting - therapy | Aorta, Thoracic - physiopathology | Aortic Aneurysm, Thoracic - physiopathology | Disease Progression | Mechanotransduction, Cellular | Biomechanical Phenomena | Phenotype | Animals | Aortic Aneurysm, Thoracic - metabolism | Aortic Aneurysm, Thoracic - therapy | Aortic Rupture - genetics | Aortic Rupture - therapy | Hemodynamics | familial thoracic aortic aneurysms and dissections | mechanosensing
Journal Article
The American Journal of Human Genetics, ISSN 0002-9297, 08/2013, Volume 93, Issue 2, pp. 398 - 404
Journal Article
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 04/2017, Volume 37, Issue 4, pp. 694 - 706
OBJECTIVE—Increasing evidence suggests that contractile dysfunction in smooth muscle cells (SMCs) plays a critical role in aortic biomechanical dysfunction and... 
Caspase 1 | Glyburide | Inflammasomes | Contractile proteins | Proteolysis | Aortic aneurysm | OXIDATIVE STRESS | ACTIVATION | glyburide | inflammasomes | FOCUS | INJURY | caspase 1 | DELETION | aortic aneurysm | PERIPHERAL VASCULAR DISEASE | MICE | MUTATIONS | ISCHEMIA-REPERFUSION | HEMATOLOGY | proteolysis | contractile proteins | Aneurysm, Dissecting - genetics | Aortic Aneurysm, Abdominal - prevention & control | Inflammasomes - metabolism | Humans | Middle Aged | Caspase 1 - metabolism | Male | Mice, 129 Strain | Aorta, Abdominal - drug effects | Aneurysm, Dissecting - physiopathology | Glyburide - pharmacology | Inflammasomes - antagonists & inhibitors | Myocytes, Smooth Muscle - drug effects | Aneurysm, Dissecting - prevention & control | Disease Models, Animal | Muscle, Smooth, Vascular - drug effects | Genetic Predisposition to Disease | Myocytes, Smooth Muscle - enzymology | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Vasoconstriction - drug effects | Aortic Aneurysm, Thoracic - physiopathology | Mice, Knockout | Aorta, Thoracic - enzymology | Biomechanical Phenomena | Phenotype | Aortic Aneurysm, Abdominal - enzymology | Aortic Aneurysm, Abdominal - physiopathology | Caspase 1 - deficiency | Muscle, Smooth, Vascular - enzymology | Aortic Aneurysm, Thoracic - genetics | Aortic Aneurysm, Thoracic - prevention & control | Myocytes, Smooth Muscle - pathology | Muscle, Smooth, Vascular - physiopathology | NLR Family, Pyrin Domain-Containing 3 Protein - genetics | Aneurysm, Dissecting - enzymology | Muscle Proteins - metabolism | Female | Aorta, Abdominal - pathology | Aorta, Thoracic - drug effects | Angiotensin II | Aorta, Abdominal - physiopathology | Aorta, Thoracic - pathology | Aortic Aneurysm, Thoracic - enzymology | Mice, Inbred C57BL | Cells, Cultured | Aortic Aneurysm, Abdominal - genetics | Aorta, Thoracic - physiopathology | Aorta, Abdominal - enzymology | Inflammasomes - genetics | NLR Family, Pyrin Domain-Containing 3 Protein - deficiency | Muscle, Smooth, Vascular - pathology | Animals | Caspase 1 - genetics | Aged | aneurysm | cardiovascular diseases | contractility | vessels
Journal Article
Journal Article
Journal of Vascular Surgery, ISSN 0741-5214, 2016, Volume 65, Issue 5, pp. 1249 - 1259.e10
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 01/2017, Volume 37, Issue 1, pp. 26 - 34
The importance of maintaining contractile function in aortic smooth muscle cells (SMCs) is evident by the fact that heterozygous mutations in the major... 
mutation | thoracic aorta | aortic aneurysm | aortic dissection | vascular smooth muscle cells | Marfan syndrome | LIGHT-CHAIN KINASE | ACTIN POLYMERIZATION | DOMAIN-STRUCTURE | TGFBR2 MUTATIONS | MYOSIN HEAVY-CHAIN | BETA RECEPTOR | MARFAN-SYNDROME | MOUSE MODEL | DISEASE | PERIPHERAL VASCULAR DISEASE | PATENT DUCTUS-ARTERIOSUS | HEMATOLOGY | Myosin-Light-Chain Kinase - genetics | Aneurysm, Dissecting - genetics | Aortic Aneurysm, Thoracic - genetics | Genetic Testing | Muscle, Smooth, Vascular - metabolism | Pulsatile Flow | Humans | Actins - metabolism | Myocytes, Smooth Muscle - pathology | Myosin Heavy Chains - genetics | Cyclic GMP-Dependent Protein Kinase Type I - genetics | Muscle, Smooth, Vascular - physiopathology | Myosin Heavy Chains - metabolism | Actins - genetics | Cyclic GMP-Dependent Protein Kinase Type I - metabolism | Aneurysm, Dissecting - physiopathology | Aortic Aneurysm, Thoracic - pathology | Dilatation, Pathologic | Myocytes, Smooth Muscle - metabolism | Calcium-Binding Proteins - metabolism | Vasoconstriction - genetics | Elastin - metabolism | Aneurysm, Dissecting - metabolism | Myosin-Light-Chain Kinase - metabolism | Heredity | Aneurysm, Dissecting - pathology | Genetic Markers | Aortic Aneurysm, Thoracic - physiopathology | Mechanotransduction, Cellular | Muscle, Smooth, Vascular - pathology | Phenotype | Animals | Aortic Aneurysm, Thoracic - metabolism | Mutation | Calcium-Binding Proteins - genetics | elastin-contractile unit | Contractile Function | Vascular Biology | Aneurysm | Genetics | vascular smooth muscle cell | Aortic Dissection | thoracic
Journal Article
Journal of Thoracic and Cardiovascular Surgery, The, ISSN 0022-5223, 2015, Volume 149, Issue 2, pp. S65 - S73
Objectives Antegrade cerebral perfusion and hypothermic circulatory arrest, with or without retrograde cerebral perfusion, are 2 major types of brain... 
Cardiothoracic Surgery | ASCENDING AORTA | MORTALITY | STROKE | SURGERY | CARDIAC & CARDIOVASCULAR SYSTEMS | DEEP HYPOTHERMIA | OPERATIONS | DETERMINANTS | RESPIRATORY SYSTEM | AORTIC-ARCH | ANEURYSMS | THORACIC AORTA | Aneurysm, Dissecting - diagnosis | Humans | Middle Aged | Circulatory Arrest, Deep Hypothermia Induced - mortality | Male | Postoperative Complications - mortality | Perfusion - mortality | Aortic Rupture - diagnosis | Perfusion - adverse effects | Aneurysm, Dissecting - physiopathology | Blood Vessel Prosthesis Implantation - adverse effects | Time Factors | Aneurysm, Dissecting - surgery | Aortic Aneurysm, Thoracic - diagnosis | Matched-Pair Analysis | Aged, 80 and over | Aortic Aneurysm, Thoracic - mortality | Female | Retrospective Studies | Aortic Rupture - mortality | Databases, Factual | Length of Stay | Circulatory Arrest, Deep Hypothermia Induced - adverse effects | Acute Disease | Aortic Rupture - physiopathology | Intensive Care Units | Hospital Mortality | Japan | Risk Factors | Postoperative Complications - therapy | Treatment Outcome | Cerebrovascular Circulation | Aorta, Thoracic - physiopathology | Aortic Aneurysm, Thoracic - physiopathology | Blood Vessel Prosthesis Implantation - mortality | Perfusion - methods | Propensity Score | Aorta, Thoracic - surgery | Aortic Aneurysm, Thoracic - surgery | Aged | Aortic Rupture - surgery | Aneurysm, Dissecting - mortality | Medical care | Brain | Databases | Analysis | Quality management
Journal Article
Journal Article