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Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 04/2015, Volume 35, Issue 4, pp. 911 - 917
Objective-Studies of mice with mild Marfan syndrome (MFS) have correlated the development of thoracic aortic aneurysm (TAA) with improper stimulation of... 
aortic aneurysm | receptor, angiotensin, type 1 | losartan | transforming growth factor β | Marfan syndrome | PATHOGENESIS | TGF-BETA | type 1 | transforming growth factor beta | MOUSE MODEL | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | receptor, angiotensin | Aortic Aneurysm, Thoracic - genetics | Phosphorylation | Aortic Aneurysm, Thoracic - prevention & control | Humans | Aortic Rupture - metabolism | Mice, 129 Strain | Angiotensin II Type 1 Receptor Blockers - pharmacology | Marfan Syndrome - drug therapy | Aortic Aneurysm, Thoracic - pathology | Time Factors | Mice, Mutant Strains | Aortic Rupture - prevention & control | Transforming Growth Factor beta - antagonists & inhibitors | Aorta, Thoracic - drug effects | Microfilament Proteins - genetics | Aorta, Thoracic - pathology | Disease Models, Animal | Transforming Growth Factor beta - immunology | Fibrillin-1 | Mice, Inbred C57BL | Losartan - pharmacology | Smad2 Protein - metabolism | Aorta, Thoracic - metabolism | Antibodies, Neutralizing - pharmacology | Aortic Rupture - pathology | Fibrillins | Disease Progression | Marfan Syndrome - genetics | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Signal Transduction - drug effects | Aortic Aneurysm, Thoracic - metabolism | Receptor, Angiotensin, Type 1 - metabolism | Aortic Rupture - genetics | Marfan Syndrome - metabolism | Marfan Syndrome - pathology | Mutation | Transforming Growth Factor beta - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 04/2017, Volume 37, Issue 4, pp. 694 - 706
OBJECTIVE—Increasing evidence suggests that contractile dysfunction in smooth muscle cells (SMCs) plays a critical role in aortic biomechanical dysfunction and... 
Caspase 1 | Glyburide | Inflammasomes | Contractile proteins | Proteolysis | Aortic aneurysm | OXIDATIVE STRESS | ACTIVATION | glyburide | inflammasomes | FOCUS | INJURY | caspase 1 | DELETION | aortic aneurysm | PERIPHERAL VASCULAR DISEASE | MICE | MUTATIONS | ISCHEMIA-REPERFUSION | HEMATOLOGY | proteolysis | contractile proteins | Aneurysm, Dissecting - genetics | Aortic Aneurysm, Abdominal - prevention & control | Inflammasomes - metabolism | Humans | Middle Aged | Caspase 1 - metabolism | Male | Mice, 129 Strain | Aorta, Abdominal - drug effects | Aneurysm, Dissecting - physiopathology | Glyburide - pharmacology | Inflammasomes - antagonists & inhibitors | Myocytes, Smooth Muscle - drug effects | Aneurysm, Dissecting - prevention & control | Disease Models, Animal | Muscle, Smooth, Vascular - drug effects | Genetic Predisposition to Disease | Myocytes, Smooth Muscle - enzymology | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Vasoconstriction - drug effects | Aortic Aneurysm, Thoracic - physiopathology | Mice, Knockout | Aorta, Thoracic - enzymology | Biomechanical Phenomena | Phenotype | Aortic Aneurysm, Abdominal - enzymology | Aortic Aneurysm, Abdominal - physiopathology | Caspase 1 - deficiency | Muscle, Smooth, Vascular - enzymology | Aortic Aneurysm, Thoracic - genetics | Aortic Aneurysm, Thoracic - prevention & control | Myocytes, Smooth Muscle - pathology | Muscle, Smooth, Vascular - physiopathology | NLR Family, Pyrin Domain-Containing 3 Protein - genetics | Aneurysm, Dissecting - enzymology | Muscle Proteins - metabolism | Female | Aorta, Abdominal - pathology | Aorta, Thoracic - drug effects | Angiotensin II | Aorta, Abdominal - physiopathology | Aorta, Thoracic - pathology | Aortic Aneurysm, Thoracic - enzymology | Mice, Inbred C57BL | Cells, Cultured | Aortic Aneurysm, Abdominal - genetics | Aorta, Thoracic - physiopathology | Aorta, Abdominal - enzymology | Inflammasomes - genetics | NLR Family, Pyrin Domain-Containing 3 Protein - deficiency | Muscle, Smooth, Vascular - pathology | Animals | Caspase 1 - genetics | Aged | aneurysm | cardiovascular diseases | contractility | vessels
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 07/2017, Volume 37, Issue 11, pp. 2102 - 2102
OBJECTIVE—The role of TGF-β (transforming growth factor-β) signaling in abdominal aortic aneurysm (AAA) formation is controversial. Others reported that... 
aneurysm | smooth muscle | SERVICES TASK-FORCE | ATHEROSCLEROSIS | RECEPTOR | mice | macrophages | TGF-beta | DISRUPTION | angiotensin II | ANEURYSM MOUSE MODEL | PERIPHERAL VASCULAR DISEASE | aorta | SMOOTH-MUSCLE-CELLS | APOE(-/-) MICE | HEMATOLOGY | E-DEFICIENT MICE | PROMOTES | PROGRESSION | Protein-Serine-Threonine Kinases - deficiency | Tunica Media - pathology | Aortic Aneurysm, Abdominal - chemically induced | Receptors, Transforming Growth Factor beta - genetics | Aortic Aneurysm, Abdominal - prevention & control | Muscle, Smooth, Vascular - metabolism | Transforming Growth Factor beta1 - antagonists & inhibitors | Transforming Growth Factor beta2 - metabolism | Aortic Aneurysm, Thoracic - prevention & control | Transforming Growth Factor beta1 - metabolism | Male | Aortic Aneurysm, Thoracic - chemically induced | Transforming Growth Factor beta3 - metabolism | Aorta, Abdominal - drug effects | Aortic Aneurysm, Abdominal - metabolism | Adventitia - metabolism | Receptor, Transforming Growth Factor-beta Type II | Aortic Aneurysm, Thoracic - pathology | Tunica Media - metabolism | Transforming Growth Factor beta - antagonists & inhibitors | Female | Aorta, Abdominal - pathology | Aorta, Thoracic - drug effects | Vascular Remodeling - drug effects | Angiotensin II | Aorta, Abdominal - metabolism | Dilatation, Pathologic | Aorta, Thoracic - pathology | Aortic Aneurysm, Abdominal - pathology | Disease Models, Animal | Muscle, Smooth, Vascular - drug effects | Severity of Illness Index | Genetic Predisposition to Disease | Mice, Inbred C57BL | Protein-Serine-Threonine Kinases - genetics | Aorta, Thoracic - metabolism | Transforming Growth Factor beta3 - antagonists & inhibitors | Mice, Knockout | Antibodies - pharmacology | Muscle, Smooth, Vascular - pathology | Phenotype | Animals | Signal Transduction - drug effects | Aortic Aneurysm, Thoracic - metabolism | Transforming Growth Factor beta2 - antagonists & inhibitors | Adventitia - pathology | Transforming Growth Factor beta - metabolism | Receptors, Transforming Growth Factor beta - deficiency | growth factor | Animal Models of Human Disease | Vascular Disease | Genetically Altered and Transgenic Models | Aortic Dissection | genetically altered mice
Journal Article
Circulation, ISSN 0009-7322, 09/2014, Volume 130, Issue 11 Suppl 1, pp. S51 - S59
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 05/2016, Volume 36, Issue 5, pp. 919 - 927
OBJECTIVE—Transforming growth factor-beta is a pleiotropic cytokine having diverse roles in vascular morphogenesis, homeostasis, and pathogenesis. Altered... 
transforming growth factor-beta | aneurysm | aorta | strength | stiffness | rapamycin | KINASE | RECEPTOR | ANGIOTENSIN-II | TGFBR2 | ANEURYSMS | DISEASE | PERIPHERAL VASCULAR DISEASE | SMOOTH-MUSCLE-CELLS | MUTATIONS | DIFFERENTIATION | HYPERTENSION | HEMATOLOGY | Protein-Serine-Threonine Kinases - deficiency | Aneurysm, Dissecting - genetics | Aortic Aneurysm, Thoracic - genetics | Receptors, Transforming Growth Factor beta - genetics | Muscle, Smooth, Vascular - metabolism | TOR Serine-Threonine Kinases - metabolism | Aortic Aneurysm, Thoracic - prevention & control | Elasticity | Extracellular Matrix - metabolism | Stress, Mechanical | Male | Muscle, Smooth, Vascular - physiopathology | TOR Serine-Threonine Kinases - antagonists & inhibitors | Arterial Pressure | Aneurysm, Dissecting - physiopathology | Aorta, Thoracic - drug effects | Aneurysm, Dissecting - prevention & control | Muscle, Smooth, Vascular - drug effects | Genetic Predisposition to Disease | Aneurysm, Dissecting - metabolism | Extracellular Matrix - drug effects | Protein-Serine-Threonine Kinases - genetics | Aorta, Thoracic - metabolism | Aorta, Thoracic - physiopathology | Sirolimus - pharmacology | Vasoconstriction - drug effects | Aortic Aneurysm, Thoracic - physiopathology | Mice, Knockout | Muscle, Smooth, Vascular - pathology | Phenotype | Animals | Aortic Aneurysm, Thoracic - metabolism | Vascular Stiffness - drug effects | Protein Kinase Inhibitors - pharmacology | Extracellular Matrix - pathology | Receptors, Transforming Growth Factor beta - deficiency
Journal Article
Arteriosclerosis, thrombosis, and vascular biology, ISSN 1079-5642, 04/2015, Volume 35, Issue 4, pp. 888 - 898
Objective-Aortic aneurysm, focal dilation of the aorta, results from impaired integrity of aortic extracellular matrix (ECM). Matrix metalloproteinases (MMPs)... 
aortic aneurysm, thoracic | matrix metalloproteinase 2 | ACTIVATION | TGF-BETA | CONVERTING ENZYME-INHIBITORS | ANGIOTENSIN RECEPTOR BLOCKERS | aortic aneurysm | GROWTH-FACTOR-BETA | GENE | MARFAN-SYNDROME | TISSUE INHIBITOR | DOXYCYCLINE | PERIPHERAL VASCULAR DISEASE | EXTRACELLULAR-MATRIX | HEMATOLOGY | thoracic | Aortic Aneurysm, Thoracic - genetics | Vascular Remodeling | Aortic Aneurysm, Thoracic - prevention & control | Myocytes, Smooth Muscle - pathology | Male | Smad3 Protein - metabolism | Aortic Aneurysm, Thoracic - chemically induced | RNA, Messenger - metabolism | Muscle, Smooth, Vascular - diagnostic imaging | Aortic Aneurysm, Thoracic - diagnosis | Ultrasonography | Collagen - genetics | Angiotensin II | Dilatation, Pathologic | Aorta, Thoracic - pathology | Disease Models, Animal | Elastin - metabolism | Calcium Chloride | Signal Transduction | Aortic Aneurysm, Thoracic - enzymology | Matrix Metalloproteinase 2 - metabolism | Myocytes, Smooth Muscle - enzymology | Mice, Inbred C57BL | Cells, Cultured | Smad2 Protein - metabolism | Genotype | Aorta, Thoracic - enzymology | Collagen - metabolism | Matrix Metalloproteinase 2 - genetics | Muscle, Smooth, Vascular - pathology | Phenotype | Animals | Elastin - genetics | Matrix Metalloproteinase 2 - deficiency | Muscle, Smooth, Vascular - enzymology | Transforming Growth Factor beta - metabolism | Aorta, Thoracic - diagnostic imaging
Journal Article
Annual Review of Medicine, ISSN 0066-4219, 1/2017, Volume 68, Issue 1, pp. 51 - 67
Journal Article
Hypertension, ISSN 0194-911X, 05/2010, Volume 55, Issue 5, pp. 1267 - 1274
Journal Article
Journal of the American College of Cardiology, ISSN 0735-1097, 2015, Volume 65, Issue 3, pp. 246 - 254
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 11/2016, Volume 36, Issue 11, pp. 2158 - 2162
OBJECTIVE—The purpose of this study was to determine the role of smooth muscle cell–derived hypoxia-inducible factor-1α (Hif-1α) in the pathogenesis of aortic... 
aneurysm | hypoxia | angiotensin II | smooth muscle | vascular remodeling | elastin | extracellular matrix | WALL | ANGIOTENSIN-II | INACTIVATION | GENE | DISSECTION | LEADS | PERIPHERAL VASCULAR DISEASE | MICE | HIF-1-ALPHA | HEMATOLOGY | Aminopropionitrile | Aortic Aneurysm, Abdominal - chemically induced | Vascular Remodeling | Aortic Aneurysm, Abdominal - prevention & control | Muscle, Smooth, Vascular - metabolism | Aortic Aneurysm, Thoracic - prevention & control | Myocytes, Smooth Muscle - pathology | Male | Aortic Aneurysm, Thoracic - chemically induced | Aortic Aneurysm, Abdominal - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - deficiency | Elastic Tissue - metabolism | Aortic Aneurysm, Thoracic - pathology | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Tropoelastin - metabolism | Aorta, Abdominal - pathology | Angiotensin II | Aorta, Abdominal - metabolism | Dilatation, Pathologic | Myocytes, Smooth Muscle - metabolism | Aorta, Thoracic - pathology | Aortic Aneurysm, Abdominal - pathology | Disease Models, Animal | Genetic Predisposition to Disease | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Cells, Cultured | Aorta, Thoracic - metabolism | Mice, Knockout | Elastic Tissue - pathology | Muscle, Smooth, Vascular - pathology | Phenotype | Animals | Tropoelastin - genetics | Aortic Aneurysm, Thoracic - metabolism | Protein-Lysine 6-Oxidase - metabolism
Journal Article