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1. Full Text Bicuspid Aortic Cusp Fusion Morphology Alters Aortic Three-Dimensional Outflow Patterns, Wall Shear Stress, and Expression of Aortopathy
by Mahadevia, Riti and Barker, Alex J and Schnell, Susanne and Entezari, Pegah and Kansal, Preeti and Fedak, Paul W.M and Malaisrie, S Chris and McCarthy, Patrick and Collins, Jeremy and Carr, James and Markl, Michael
Circulation, ISSN 0009-7322, 02/2014, Volume 129, Issue 6, pp. 673 - 682
BACKGROUND—Aortic 3-dimensional blood flow was analyzed to investigate altered ascending aorta (AAo) hemodynamics in bicuspid aortic valve (BAV) patients and... 
Hemodynamics | Magnetic resonance imaging | Aortic diseases | Bicuspid aortic valve | ASCENDING AORTA | magnetic resonance imaging | CARDIAC & CARDIOVASCULAR SYSTEMS | SYSTOLIC FLOW | MANAGEMENT | FLOW PATTERNS | QUANTIFICATION | aortic diseases | CLASSIFICATION | BLOOD-FLOW | hemodynamics | bicuspid aortic valve | MAGNETIC-RESONANCE | PERIPHERAL VASCULAR DISEASE | PHASE-CONTRAST MRI | VALVE DISEASE | Prevalence | Heart Valve Diseases - pathology | Humans | Middle Aged | Magnetic Resonance Imaging - methods | Stress, Mechanical | Male | Aortic Valve - pathology | Young Adult | Heart Valve Diseases - epidemiology | Adult | Female | Aorta - physiopathology | Imaging, Three-Dimensional | Aortic Diseases - pathology | Heart Valve Diseases - physiopathology | Aortic Diseases - epidemiology | Heart Defects, Congenital - pathology | Aortic Valve - physiopathology | Aorta - pathology | Aortic Diseases - physiopathology | Blood Flow Velocity | Heart Defects, Congenital - epidemiology | Aged | Heart Defects, Congenital - physiopathology | Evaluation | Mitral valve | Shear (Mechanics) | Research | Blood flow | Index Medicus | Abridged Index Medicus
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2. Full Text Central Pressure More Strongly Relates to Vascular Disease and Outcome Than Does Brachial Pressure: The Strong Heart Study
by Roman, Mary J and Devereux, Richard B and Kizer, Jorge R and Lee, Elisa T and Galloway, James M and Ali, Tauqeer and Umans, Jason G and Howard, Barbara V
Hypertension, ISSN 0194-911X, 07/2007, Volume 50, Issue 1, pp. 197 - 203
Brachial blood pressure is predictive of cardiovascular outcome; however central pressure may better represent the load imposed on the coronary and cerebral... 
Arterial stiffness | Blood pressure | Atherosclerosis | arterial stiffness | atherosclerosis | blood pressure | INDEPENDENT PREDICTOR | PULSE-WAVE VELOCITY | MYOCARDIAL-INFARCTION | ASCENDING AORTIC PRESSURE | AMERICAN-INDIANS | CARDIOVASCULAR-DISEASE | PERIPHERAL VASCULAR DISEASE | DIASTOLIC BLOOD-PRESSURE | HYPERTENSIVE SUBJECTS | STAGE RENAL-DISEASE | Blood Pressure | Cerebrovascular Disorders - physiopathology | Outcome Assessment (Health Care) | Humans | Middle Aged | Carotid Artery Diseases - physiopathology | Male | Blood Pressure Determination - methods | Carotid Artery Diseases - diagnostic imaging | Cerebrovascular Disorders - diagnostic imaging | Ultrasonography | Brachial Artery - physiopathology | Female | Aged | Aorta - physiopathology | Intracranial Arteriosclerosis - diagnostic imaging | Intracranial Arteriosclerosis - physiopathology | Cohort Studies | Hypertrophy | Index Medicus
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3. Full Text Aortic dilation in bicuspid aortic valve disease: Flow pattern is a major contributor and differs with valve fusion type
by Bissell, Malenka M and Hess, Aaron T and Biasiolli, Luca and Glaze, Steffan J and Loudon, Margaret and Pitcher, Alex and Davis, Anne and Prendergast, Bernard and Markl, Michael and Barker, Alex J and Neubauer, Stefan and Myerson, Saul G
Circulation: Cardiovascular Imaging, ISSN 1941-9651, 07/2013, Volume 6, Issue 4, pp. 499 - 507
Background Ascending aortic dilation is important in bicuspid aortic valve (BAV) disease, with increased risk of aortic dissection. We used cardiovascular MR... 
Aorta | Cardiac MRI | Wall shear stress | Vascular function | Bicuspid aortic valve | vascular function | WALL SHEAR-STRESS | CARDIAC & CARDIOVASCULAR SYSTEMS | cardiac MRI | bicuspid aortic valve | ELASTIC PROPERTIES | wall shear stress | aorta | NATURAL-HISTORY | BLOOD-FLOW | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Predictive Value of Tests | Prognosis | Prospective Studies | Heart Valve Diseases - pathology | Pulse Wave Analysis | Aortic Valve - abnormalities | Humans | Middle Aged | Elasticity | Stress, Mechanical | Male | Aortic Aneurysm - etiology | Case-Control Studies | Aortic Valve - pathology | Young Adult | Aneurysm, Dissecting - physiopathology | Cardiac-Gated Imaging Techniques - methods | Heart Valve Diseases - complications | Adult | Female | Aorta - physiopathology | Aortic Aneurysm - pathology | Imaging, Three-Dimensional | Vascular Stiffness | Dilatation, Pathologic | Aneurysm, Dissecting - etiology | Severity of Illness Index | Heart Valve Diseases - physiopathology | Cross-Sectional Studies | Models, Cardiovascular | Risk Factors | Aortic Aneurysm - physiopathology | Aortic Valve - physiopathology | Aneurysm, Dissecting - pathology | Chi-Square Distribution | Regional Blood Flow | Aorta - pathology | Magnetic Resonance Imaging | Analysis of Variance | Hemodynamics | Index Medicus | cardiac magnetic resonance imaging
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4. Full Text Blood pressure and incidence of twelve cardiovascular diseases: lifetime risks, healthy life-years lost, and age-specific associations in 1·25 million people
by Rapsomaniki, Eleni, Dr and Timmis, Adam, Prof and George, Julie, PhD and Pujades-Rodriguez, Mar, PhD and Shah, Anoop D, MRCP and Denaxas, Spiros, PhD and White, Ian R, PhD and Caulfield, Mark J, Prof and Deanfield, John E, Prof and Smeeth, Liam, Prof and Williams, Bryan, Prof and Hingorani, Aroon, Prof and Hemingway, Harry, Prof
Lancet, The, ISSN 0140-6736, 2014, Volume 383, Issue 9932, pp. 1899 - 1911
Summary Background The associations of blood pressure with the different manifestations of incident cardiovascular disease in a contemporary population have... 
Internal Medicine | Risk Assessment - methods | Age Distribution | Follow-Up Studies | Humans | Middle Aged | Hypertension - drug therapy | Male | Angina Pectoris - etiology | Aortic Aneurysm, Abdominal - epidemiology | Incidence | England - epidemiology | Aged, 80 and over | Cardiovascular Diseases - epidemiology | Adult | Angina Pectoris - epidemiology | Female | Blood Pressure - physiology | Hypertension - epidemiology | Medical Record Linkage | Subarachnoid Hemorrhage - epidemiology | Cardiovascular Diseases - etiology | Acute Disease | Cardiovascular Diseases - physiopathology | Antihypertensive Agents - therapeutic use | Intracranial Hemorrhage, Hypertensive - epidemiology | Hypertension - complications | Subarachnoid Hemorrhage - etiology | Aged | Chronic Disease | Aortic Aneurysm, Abdominal - etiology | Blood pressure | Research | Cardiovascular diseases | Analysis | Studies | Medical research | Cardiovascular disease | Health risk assessment | Index Medicus | Abridged Index Medicus
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5. Full Text Arterial stiffness, pressure and flow pulsatility and brain structure and function: the Age, Gene/Environment Susceptibility - Reykjavik Study
by Mitchell, Gary F and van Buchem, Mark A and Sigurdsson, Sigurdur and Gotal, John D and Jonsdottir, Maria K and Kjartansson, Ólafur and Garcia, Melissa and Aspelund, Thor and Harris, Tamara B and Gudnason, Vilmundur and Launer, Lenore J
Brain, ISSN 0006-8950, 11/2011, Volume 134, Issue 11, pp. 3398 - 3407
Aortic stiffness increases with age and vascular risk factor exposure and is associated with increased risk for structural and functional abnormalities in the... 
cognitive function | magnetic resonance imaging | aortic stiffness | brain structure | haemodynamics | INDEPENDENT PREDICTOR | PULSE-WAVE VELOCITY | COGNITIVE PERFORMANCE | AORTIC INPUT IMPEDANCE | RISK | NEUROSCIENCES | HYPERTENSIVE PATIENTS | CLINICAL NEUROLOGY | WHITE-MATTER LESIONS | ADVANCING AGE | SMALL-VESSEL DISEASE | CARDIOVASCULAR MORTALITY | Cardiovascular Diseases - physiopathology | Prospective Studies | Age Factors | Brain - physiopathology | Humans | Risk Factors | Male | Cardiovascular Diseases - pathology | Gene-Environment Interaction | Iceland | Brain - blood supply | Pulsatile Flow - physiology | Carotid Arteries - physiopathology | Vascular Stiffness - physiology | Aged, 80 and over | Brain - pathology | Female | Aged | Blood Pressure - physiology | Aorta - physiopathology | Blood Flow Velocity - physiology | Index Medicus | Abridged Index Medicus | Original
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6. Full Text Arterial and aortic valve calcification inversely correlates with osteoporotic bone remodelling: A role for inflammation
by Hjortnaes, Jesper and Butcher, Jonathan and Figueiredo, Jose-Luiz and Riccio, Mark and Kohler, Rainer H and Kozloff, Kenneth M and Weissleder, Ralph and Aikawa, Elena
European Heart Journal, ISSN 0195-668X, 08/2010, Volume 31, Issue 16, pp. 1975 - 1984
Aims Westernized countries face a growing burden of cardiovascular calcification and osteoporosis. Despite its vast clinical significance, the precise nature... 
Molecular imaging | Bone mineral density | Inflammation | Aortic valve calcification | Atherosclerosis | CELLS | MATRIX | CARDIAC & CARDIOVASCULAR SYSTEMS | VASCULAR CALCIFICATION | OSTEOPROTEGERIN | MECHANISMS | DEFICIENT MICE | PLAQUE | MINERAL DENSITY | DISEASE | POSTMENOPAUSAL WOMEN | Kidney Diseases - physiopathology | Femur | Bone Density - physiology | Atherosclerosis - physiopathology | Aortic Valve Stenosis - physiopathology | Carotid Artery Diseases - physiopathology | Bone Remodeling - physiology | Inflammation - complications | Animals | Calcinosis - etiology | Aortic Valve Stenosis - etiology | Mice | Chronic Disease | Osteoporosis - physiopathology | Calcinosis - physiopathology | Index Medicus | Fasttrack
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7. Full Text Endothelial-to-mesenchymal transition contributes to fibro-proliferative vascular disease and is modulated by fluid shear stress
by Moonen, Jan-Renier A. J and Lee, Ee Soo and Schmidt, Marc and Maleszewska, Monika and Koerts, Jasper A and Brouwer, Linda A and Van Kooten, Theo G and van Luyn, Marja J. A and Zeebregts, Clark J and Krenning, Guido and Harmsen, Martin C
Cardiovascular Research, ISSN 0008-6363, 12/2015, Volume 108, Issue 3, pp. 377 - 386
Neointimal hyperplasia is a common feature of fibro-proliferative vascular disease and characterizes initial stages of atherosclerosis. Neointimal lesions... 
Shear stress | Endothelial-to-mesenchymal transition | Neointimal hyperplasia | ERK5 | Fibrosis | ARTERIAL INJURY | MYOCARDIN | ACTIVATION | CARDIAC & CARDIOVASCULAR SYSTEMS | ATHEROSCLEROSIS | MECHANISMS | FLOW | GROWTH | SMOOTH-MUSCLE-CELLS | EXPRESSION | TRANSDIFFERENTIATION | Carotid Arteries - metabolism | Vascular Remodeling | Cell Proliferation | Human Umbilical Vein Endothelial Cells - metabolism | Humans | Carotid Artery Diseases - physiopathology | Stress, Mechanical | Male | Aortic Diseases - metabolism | Neointima | Transfection | RNA Interference | Time Factors | Carotid Artery Diseases - pathology | Swine | MAP Kinase Kinase 5 - metabolism | Epithelial-Mesenchymal Transition | HEK293 Cells | Carotid Artery Diseases - metabolism | Aorta, Thoracic - pathology | Aortic Diseases - pathology | Disease Models, Animal | Endothelial Cells - metabolism | Mice, Inbred C57BL | Aorta, Thoracic - metabolism | Mitogen-Activated Protein Kinase 7 - genetics | MAP Kinase Kinase 5 - genetics | Mitogen-Activated Protein Kinase 7 - metabolism | Aorta, Thoracic - physiopathology | Plaque, Atherosclerotic | Regional Blood Flow | Mechanotransduction, Cellular | Aortic Diseases - genetics | Aortic Diseases - physiopathology | Animals | Carotid Arteries - physiopathology | Carotid Artery Diseases - genetics | Human Umbilical Vein Endothelial Cells - pathology | Carotid Arteries - pathology | Endothelial Cells - pathology | Index Medicus
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8. Full Text Left Ventricular Failure Produces Profound Lung Remodeling and Pulmonary Hypertension in Mice: Heart Failure Causes Severe Lung Disease
by Chen, Yingjie and Guo, Haipeng and Xu, Dachun and Xu, Xin and Wang, Huan and Hu, Xinli and Lu, Zhongbing and Kwak, Dongmin and Xu, Yawei and Gunther, Roland and Huo, Yuqing and Weir, E Kenneth
Hypertension, ISSN 0194-911X, 06/2012, Volume 59, Issue 6, pp. 1170 - 1178
Chronic left ventricular failure causes pulmonary congestion with increased lung weight and type 2 pulmonary hypertension. Understanding the molecular... 
Transverse aortic constriction | Pulmonary vascular morphology | Pulmonary hypertension | OVERLOAD | PRESSURE | HYPERTROPHY | OXIDATIVE STRESS | pulmonary hypertension | ARTERIAL-HYPERTENSION | transverse aortic constriction | PERIPHERAL VASCULAR DISEASE | EXTRACELLULAR-SUPEROXIDE DISMUTASE | EXPRESSION | pulmonary vascular morphology | Leukocytes - pathology | Lung Diseases - metabolism | Heart Failure - physiopathology | Hypertension, Pulmonary - physiopathology | Ventricular Dysfunction, Left - complications | Male | Pulmonary Edema - etiology | Lung Diseases - etiology | Pulmonary Edema - physiopathology | Collagen - genetics | Lung - metabolism | Pulmonary Edema - metabolism | Heart Failure - complications | Lung - pathology | Hypertrophy, Left Ventricular - metabolism | Mice, Inbred C57BL | Water - metabolism | Organ Size | Heart Failure - metabolism | Hypertension, Pulmonary - metabolism | Lung - physiopathology | Reverse Transcriptase Polymerase Chain Reaction | Constriction, Pathologic - complications | Blotting, Western | Ventricular Dysfunction, Left - physiopathology | Aorta - pathology | Ventricular Dysfunction, Left - metabolism | Collagen - metabolism | Animals | Transforming Growth Factor beta - genetics | Fibrosis - etiology | Hypertrophy, Left Ventricular - complications | Hypoxia - physiopathology | Lung Diseases - physiopathology | Mice | Hypertrophy, Left Ventricular - physiopathology | Hypertension, Pulmonary - etiology | Leukocytes - metabolism | Transforming Growth Factor beta - metabolism | Index Medicus
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9. Full Text Wave Reflection and Arterial Stiffness in the Prediction of 15-Year All-Cause and Cardiovascular Mortalities: A Community-Based Study
by Wang, Kang-Ling and Cheng, Hao-Min and Sung, Shih-Hsien and Chuang, Shao-Yuan and Li, Cheng-Hung and Spurgeon, Harold A and Ting, Chih-Tai and Najjar, Samer S and Lakatta, Edward G and Yin, Frank C.P and Chou, Pesus and Chen, Chen-Huan
Hypertension, ISSN 0194-911X, 03/2010, Volume 55, Issue 3, pp. 799 - 805
The value of increased arterial wave reflection, usually assessed by the transit time–dependent augmentation index and augmented pressure (Pa), in the... 
Vascular aging | Pulse wave velocity | Arterial stiffness | Epidemiology | Mortality | Wave reflection | arterial stiffness | AUGMENTATION INDEX | UPPER-LIMB | VELOCITY | EVENTS | pulse wave velocity | PULSE PRESSURE | AORTIC STIFFNESS | BLOOD-PRESSURE | epidemiology | WOMEN | HEART-DISEASE | vascular aging | mortality | PERIPHERAL VASCULAR DISEASE | wave reflection | LEFT-VENTRICULAR MASS | Multivariate Analysis | Predictive Value of Tests | Cardiovascular Diseases - physiopathology | Follow-Up Studies | Models, Cardiovascular | Femoral Artery - physiopathology | Humans | Middle Aged | Proportional Hazards Models | Male | Pulsatile Flow - physiology | Carotid Arteries - physiopathology | Arteries - physiopathology | Taiwan - epidemiology | Aging | Cardiovascular Diseases - mortality | Adult | Brachial Artery - physiopathology | Female | Registries | Aged | Blood Pressure - physiology | Index Medicus
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10. Full Text The role of TNF- α and TNF superfamily members in the pathogenesis of calcific aortic valvular disease
by Galeone, Antonella and Paparella, Domenico and Colucci, Silvia and Grano, Maria and Brunetti, Giacomina
The Scientific World Journal, ISSN 1537-744X, 2013, Volume 2013, pp. 875363 - 10
Calcific aortic valve disease (CAVD) represents a slowly progressive pathologic process associated with major morbidity and mortality. The process is... 
TUMOR-NECROSIS-FACTOR | IN-VITRO | APOPTOSIS-INDUCING LIGAND | FACTOR RECEPTOR FAMILY | FACTOR FAMILY-MEMBER | CELLS SUPPORT OSTEOCLASTOGENESIS | MULTIDISCIPLINARY SCIENCES | MATRIX-METALLOPROTEINASE EXPRESSION | CYTOCHROME-C RELEASE | NF-KAPPA-B | VALVE DISEASE | Aortic Valve - physiopathology | Heart Valve Diseases - physiopathology | Heart Defects, Congenital - physiopathology | Calcinosis | Humans | Tumor Necrosis Factor-alpha - physiology | Enzymes | Disease | Cytokines | Pathogenesis | Colleges & universities | Cytotoxicity | Lipids | Smooth muscle | Morbidity | Lipoproteins | Mineralization | Ligands | Apoptosis | Index Medicus
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11. Full Text Valve-Related Hemodynamics Mediate Human Bicuspid Aortopathy: Insights From Wall Shear Stress Mapping
by Guzzardi, David G and Barker, Alex J and van Ooij, Pim and Malaisrie, S. Chris and Puthumana, Jyothy J and Belke, Darrell D and Mewhort, Holly E. M and Svystonyuk, Daniyil A and Kang, Sean and Verma, Subodh and Collins, Jeremy and Carr, James and Bonow, Robert O and Markl, Michael and Thomas, James D and McCarthy, Patrick M and Fedak, Paul W. M
Journal of the American College of Cardiology, ISSN 0735-1097, 2015, Volume 66, Issue 8, pp. 892 - 900
Suspected genetic causes for extracellular matrix (ECM) dysregulation in the ascending aorta in patients with bicuspid aortic valves (BAV) have influenced... 
aneurysm | imaging | remodeling | ASCENDING AORTA | CARDIAC & CARDIOVASCULAR SYSTEMS | MRI | PATTERNS | THORACIC AORTIC-ANEURYSM | BLOOD-FLOW | MATRIX METALLOPROTEINASES | MARFAN-SYNDROME | DISEASE | DILATATION | EXPRESSION | Elastin - metabolism | Heart Valve Diseases - physiopathology | Aortic Valve - abnormalities | Humans | Middle Aged | Aortic Valve - physiopathology | Stress, Mechanical | Male | Aorta - metabolism | Aortic Valve - metabolism | Case-Control Studies | Tissue Inhibitor of Metalloproteinases - metabolism | Magnetic Resonance Imaging | Heart Valve Diseases - metabolism | Adult | Female | Aorta - physiopathology | Hemodynamics | Matrix Metalloproteinases - metabolism | Index Medicus | Abridged Index Medicus
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12. Full Text Congenital heart defects in molecularly proven Kabuki syndrome patients
by Digilio, Maria Cristina and Gnazzo, Maria and Lepri, Francesca and Dentici, Maria Lisa and Pisaneschi, Elisa and Baban, Anwar and Passarelli, Chiara and Capolino, Rossella and Angioni, Adriano and Novelli, Antonio and Marino, Bruno and Dallapiccola, Bruno
American Journal of Medical Genetics Part A, ISSN 1552-4825, 11/2017, Volume 173, Issue 11, pp. 2912 - 2922
The prevalence of congenital heart defects (CHD) in Kabuki syndrome ranges from 28% to 80%. Between January 2012 and December 2015, 28 patients had a... 
KMT2D | Kabuki syndrome | gene | congenital heart defect | KDM6A | KMT2D gene | KDM6A gene | HORMONE DEFICIENCY | MENTAL-RETARDATION | NIIKAWA-KUROKI-SYNDROME | TURNERS-SYNDROME | SYNDROME GENES KMT2D | MAKE-UP-SYNDROME | PHENOTYPIC SPECTRUM | CARDIOVASCULAR MALFORMATIONS | GENETICS & HEREDITY | MUTATIONS | ADAMS-OLIVER-SYNDROME | Aortic Valve Stenosis - genetics | Vestibular Diseases - complications | Aortic Valve - abnormalities | Face - abnormalities | Humans | Male | Heart Septal Defects, Ventricular - physiopathology | Heart Septal Defects, Atrial - physiopathology | Histone Demethylases - genetics | Aortic Coarctation - physiopathology | Heart Defects, Congenital - genetics | Aortic Coarctation - complications | Female | Heart Septal Defects, Atrial - genetics | Vestibular Diseases - physiopathology | Neoplasm Proteins - genetics | Nuclear Proteins - genetics | Abnormalities, Multiple - genetics | Heart Valve Diseases - physiopathology | Hematologic Diseases - complications | Heart Septal Defects, Ventricular - genetics | Aortic Valve Stenosis - physiopathology | Aortic Valve - physiopathology | DNA-Binding Proteins - genetics | Abnormalities, Multiple - physiopathology | Face - physiopathology | Aortic Valve Stenosis - complications | Heart Defects, Congenital - complications | Hematologic Diseases - physiopathology | Heart Valve Diseases - genetics | Hematologic Diseases - genetics | Aortic Coarctation - genetics | Heart Defects, Congenital - physiopathology | Vestibular Diseases - genetics | Heart | Congenital heart disease | Genetic disorders | Coronary heart disease | Echocardiography | Congenital defects | Aortic arch | Aorta | Ventricle | Health risk assessment | Aortic valve | Defects | Index Medicus
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