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Journal Article
Atherosclerosis, ISSN 0021-9150, 2015, Volume 242, Issue 1, pp. 251 - 260
Abstract Background Calcific aortic valve disease (CAVD) is the most common heart valve disease in the Western world. We previously proposed that valvular... 
Cardiovascular | Calcification | Endothelial-to-mesenchymal transformation | Calcific aortic valve disease | Valvular interstitial cells | Valvular endothelial cells | Research Support, Non-U.S. Gov't | Journal Article | Research Support, N.I.H., Extramural | PROGENITOR CELLS | CARDIAC-VALVE | MITRAL REGURGITATION | HEART | GROWTH-FACTOR-BETA | WORKING GROUP | IN-VITRO | ADAPTATION | PERIPHERAL VASCULAR DISEASE | EXTRACELLULAR-MATRIX | AORTIC-VALVE DISEASE | Calcinosis - genetics | Aortic Valve Stenosis - genetics | Apolipoproteins E - deficiency | Coculture Techniques | Humans | Aortic Valve - drug effects | Male | RNA, Messenger - metabolism | Culture Media - metabolism | Aortic Valve - pathology | Cell Differentiation - genetics | Time Factors | Epithelial-Mesenchymal Transition | Calcinosis - metabolism | Osteogenesis - genetics | Transforming Growth Factor beta1 - pharmacology | Disease Models, Animal | Biomarkers - metabolism | Endothelial Cells - metabolism | Osteogenesis - drug effects | Cells, Cultured | Gene Expression Regulation | Aortic Valve - metabolism | Mice, Knockout | Animals | Aortic Valve Stenosis - pathology | Cell Differentiation - drug effects | Apolipoproteins E - genetics | Cell Communication - drug effects | Aortic Valve Stenosis - metabolism | Sheep | Calcinosis - pathology | Endothelial Cells - pathology | Cell Movement | Endothelial Cells - drug effects | Stem cells | Endothelium
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2012, Volume 7, Issue 7, p. e39969
Fibroblasts residing in connective tissues throughout the body are responsible for extracellular matrix (ECM) homeostasis and repair. In response to tissue... 
SMOOTH MUSCLE ACTIN | GROWTH-FACTOR-BETA | HEPATIC STELLATE CELLS | PHOTODEGRADABLE HYDROGELS | LUNG MYOFIBROBLASTS | GRANULATION-TISSUE | MULTIDISCIPLINARY SCIENCES | TRANSFORMING GROWTH-FACTOR-BETA-1 | EXTRACELLULAR-MATRIX | IDIOPATHIC PULMONARY-FIBROSIS | AORTIC-VALVE DISEASE | Aortic Valve - radiation effects | Gene Expression - drug effects | Hydrogels | Actins - metabolism | Aortic Valve - drug effects | Polyethylene Glycols - chemistry | Actins - genetics | Myofibroblasts - metabolism | Collagen Type I - genetics | Swine | Light | Myofibroblasts - radiation effects | Biomimetic Materials - chemistry | Transforming Growth Factor beta1 - pharmacology | Biomarkers - metabolism | Cell Differentiation - radiation effects | Oligopeptides - chemical synthesis | Collagen Type I - metabolism | Acrylates - chemistry | Cell Cycle - radiation effects | Aortic Valve - cytology | Myofibroblasts - drug effects | Aortic Valve - metabolism | Gene Expression - radiation effects | Fibronectins - metabolism | Elastic Modulus - radiation effects | Myofibroblasts - cytology | Animals | Cell Differentiation - drug effects | Cell Proliferation - drug effects | Connective Tissue Growth Factor - genetics | Fibronectins - genetics | Primary Cell Culture | Cell Cycle - drug effects | Connective Tissue Growth Factor - metabolism | Cell Proliferation - radiation effects | Fibronectins | Collagen | Genes | Bone morphogenetic proteins | Transforming growth factors | Intermediate filament proteins | Apoptosis | Vimentin | Bioengineering | Collagens | Homeostasis | Smooth muscle | Kinases | Tissues | Fibronectin | Mimicry | Connective tissues | Proteins | Engineering | Genotype & phenotype | Reduction | Cell fate | Actin | Topography | Rodents | Cell cycle | Fibroblasts | Extracellular matrix | Stiffness | Repair | Growth factors | Heart diseases | Phenotypes | Developmental biology | Contractility | Organs | Muscles | Mechanical properties | Connective tissue growth factor | Modulus of elasticity | Stiffening | Muscle contraction | Substrates | Fibrosis | Stem cells | Molecular biology
Journal Article
Journal Article
Circulation: Cardiovascular Imaging, ISSN 1941-9651, 2012, Volume 5, Issue 5, pp. 613 - 620
Background-Global longitudinal systolic strain (GLS) is often reduced in aortic stenosis despite normal ejection fraction. The importance of reduced... 
Survival | Aortic valve stenosis | Global strain | CARDIAC & CARDIOVASCULAR SYSTEMS | QUANTIFICATION | survival | aortic valve stenosis | global strain | SYSTOLIC FUNCTION | MYOCARDIAL FIBROSIS | RECOMMENDATIONS | LONGITUDINAL STRAIN | EJECTION FRACTION | 2-DIMENSIONAL SPECKLE-TRACKING | ECHOCARDIOGRAPHY | DYSFUNCTION | BLOCKADE | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Multivariate Analysis | Prospective Studies | Angiotensin II Type 1 Receptor Blockers - therapeutic use | Humans | Middle Aged | Aortic Valve - drug effects | Male | Aortic Valve - surgery | Systole | Aortic Valve Stenosis - diagnostic imaging | Aortic Valve Stenosis - mortality | Ventricular Remodeling | Time Factors | Ultrasonography | Aged, 80 and over | Cardiovascular Diseases - mortality | Female | Aortic Valve Stenosis - surgery | Benzimidazoles - therapeutic use | Severity of Illness Index | Cardiovascular Diseases - etiology | Cardiovascular Diseases - physiopathology | Aortic Valve - diagnostic imaging | Risk Assessment | Risk Factors | Ventricular Function, Left - drug effects | Aortic Valve Stenosis - physiopathology | Kaplan-Meier Estimate | Proportional Hazards Models | Aortic Valve - physiopathology | Heart Valve Prosthesis Implantation - mortality | Treatment Outcome | Aortic Valve Stenosis - diagnosis | Chi-Square Distribution | Stroke Volume | Biomechanical Phenomena | Heart Valve Prosthesis Implantation - adverse effects | Denmark | Tetrazoles - therapeutic use | Aged
Journal Article
Atherosclerosis, ISSN 0021-9150, 2016, Volume 246, pp. 318 - 324
Journal Article
Clinical Research in Cardiology, ISSN 1861-0684, 2/2017, Volume 106, Issue 2, pp. 85 - 95
Journal Article
Atherosclerosis, ISSN 0021-9150, 10/2018, Volume 277, pp. 60 - 65
Journal Article
Circulation Research, ISSN 0009-7330, 03/2010, Volume 106, Issue 4, pp. 712 - 719
RATIONALE:Calcification of heart valve structures is the most common form of valvular disease and is characterized by the appearance of bone-like phenotypes... 
Calcification | Extracellular matrix | Mouse model | Sox9 | Heart valves | CARDIAC & CARDIOVASCULAR SYSTEMS | mouse model | MOUSE EMBRYOS | AORTIC-VALVE | INTERSTITIAL-CELLS | CELL LINEAGE | MATRIX METALLOPROTEINASES | RETINOIC ACID | heart valves | BONE-FORMATION | TOLL-LIKE RECEPTORS | GENE-EXPRESSION | PERIPHERAL VASCULAR DISEASE | calcification | HEMATOLOGY | extracellular matrix | CARDIAC VALVES | Calcinosis - genetics | Inflammation - pathology | Age Factors | Heart Valve Diseases - pathology | Calcium - metabolism | Extracellular Matrix - metabolism | Male | Mitral Valve - metabolism | Gene Knockdown Techniques | Tricuspid Valve - embryology | Tricuspid Valve - drug effects | Inflammation - metabolism | Transfection | Mitral Valve - drug effects | Aging | Female | Calcinosis - metabolism | Osteogenesis - genetics | Disease Models, Animal | Tretinoin - pharmacology | Animals, Newborn | SOX9 Transcription Factor - metabolism | Tissue Culture Techniques | Tricuspid Valve - metabolism | Down-Regulation | Genotype | Mice, Transgenic | Chick Embryo | Collagen Type II - genetics | Phenotype | Animals | Tricuspid Valve - pathology | Heart Valve Diseases - metabolism | Heart Valve Diseases - genetics | Mitral Valve - embryology | Mice | Mitral Valve - pathology | Calcinosis - pathology | Extracellular Matrix - pathology | Integrases - genetics | SOX9 Transcription Factor - genetics
Journal Article
Journal Article
Circulation: Cardiovascular Imaging, ISSN 1941-9651, 10/2017, Volume 10, Issue 10
Journal Article