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Journal Article
CARDIOVASCULAR RESEARCH, ISSN 0008-6363, 01/2017, Volume 113, Issue 1, pp. 40 - 51
Aims Myxomatous valve disease (MVD) is the most common aetiology of primary mitral regurgitation. Recent studies suggest that defects in heart valve... 
CARDIAC & CARDIOVASCULAR SYSTEMS | MOUSE | ECM remodelling | BETA-CATENIN | INTERSTITIAL-CELLS | Wnt/beta-catenin signalling | PATHOGENESIS | ORGANIZATION | Myxomatous valve disease | MARFAN-SYNDROME | Heart valve development | Axin2 | EXTRACELLULAR-MATRIX | DIFFERENTIATION | MITRAL-VALVE | UP-REGULATION | Axin Protein - deficiency | Cell Proliferation | Axin Protein - genetics | Aortic Valve - abnormalities | Extracellular Matrix - metabolism | Mitral Valve - metabolism | Mitral Valve - physiopathology | Mitral Valve Insufficiency - genetics | Morphogenesis | Heart Defects, Congenital - genetics | Bone Morphogenetic Proteins - metabolism | Gene Expression Regulation, Developmental | Fibrillin-1 - metabolism | Fibrillin-1 - genetics | Wnt Signaling Pathway | SOX9 Transcription Factor - metabolism | Aortic Valve Insufficiency - metabolism | Genetic Predisposition to Disease | Heart Defects, Congenital - pathology | Aortic Valve - physiopathology | Aortic Valve Insufficiency - physiopathology | Aortic Valve Insufficiency - pathology | Aggrecans - metabolism | Aortic Valve - metabolism | Marfan Syndrome - genetics | Mice, Knockout | Collagen - metabolism | Mitral Valve Insufficiency - pathology | Phenotype | Animals | Marfan Syndrome - metabolism | Marfan Syndrome - pathology | Heart Defects, Congenital - metabolism | Heart Defects, Congenital - physiopathology | Mutation | Extracellular Matrix - pathology | Mitral Valve Insufficiency - physiopathology | SOX9 Transcription Factor - genetics | Mitral Valve - abnormalities | Mitral Valve Insufficiency - metabolism | Index Medicus | β-catenin signalling | Original | Axin2 • Heart valve development • Myxomatous valve disease • ECM remodelling • Wnt
Journal Article
Circulation, ISSN 0009-7322, 08/2015, Volume 132, Issue 8, pp. 677 - 690
Journal Article
Arteriosclerosis Thrombosis and Vascular Biology, ISSN 1079-5642, 02/2015, Volume 35, Issue 2, pp. 399 - 408
OBJECTIVE—Vascular and valvular calcifications are pathological processes regulated by resident cells, and depending on a complex interplay between... 
aortic valve | multivesicular bodies | calcification of | gene expression | vascular calcification | AORTIC-STENOSIS | MATRIX VESICLES | VALVE | aortic valve, calcification of | CARTILAGE | DISEASE | VITAMIN-K | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | EXPRESSION | FETUIN-A | INSIGHTS | Calcinosis - genetics | Aortic Valve Stenosis - genetics | Calcium - metabolism | Humans | Middle Aged | Vascular Calcification - genetics | Actins - metabolism | Osteocalcin - genetics | Male | Aorta - metabolism | Case-Control Studies | Aortic Valve - pathology | Coronary Vessels - metabolism | Aortic Valve Stenosis - prevention & control | Vascular Calcification - metabolism | Coronary Artery Disease - pathology | Aged, 80 and over | Adult | Female | Calcinosis - metabolism | Extracellular Matrix Proteins - metabolism | Calcium-Binding Proteins - metabolism | Coronary Vessels - pathology | Osteocalcin - metabolism | Tissue Culture Techniques | Coronary Artery Disease - metabolism | Extracellular Matrix Proteins - genetics | Coronary Artery Disease - prevention & control | Gene Expression Regulation | Vascular Calcification - prevention & control | Vascular Calcification - pathology | Aortic Valve - metabolism | Aorta - pathology | Proteins - genetics | Aortic Valve Stenosis - pathology | Proteins - metabolism | Coronary Artery Disease - genetics | alpha-2-HS-Glycoprotein - metabolism | Aortic Valve Stenosis - metabolism | Aged | Calcinosis - prevention & control | Calcinosis - pathology | Calcium-Binding Proteins - genetics | Index Medicus
Journal Article
Cardiovascular research, ISSN 0008-6363, 2017, Volume 113, Issue 11, pp. 1351 - 1363
Journal Article
Journal Article
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 01/2013, Volume 33, Issue 1, pp. 121 - 130
OBJECTIVE—Inflammatory activation of valve endothelium is an early phase of aortic valve disease pathogenesis, but subsequent mechanisms are poorly understood.... 
calcification | invasion | transforming growth factor-β | smooth muscle actin | tumor necrosis factor-α | PROGENITOR CELLS | ENDOCARDIAL CUSHION TISSUE | ATHEROSCLEROSIS | FACTOR-KAPPA-B | INTERSTITIAL-CELLS | transforming growth factor-beta | tumor necrosis factor-alpha | HEART | ARTERIAL | GROWTH | RECEPTOR ACTIVATOR | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | Tumor Necrosis Factor-alpha - metabolism | Inflammation - pathology | Heart Valve Diseases - pathology | Humans | Transforming Growth Factor beta1 - metabolism | NF-kappa B - metabolism | Epithelial-Mesenchymal Transition - genetics | Heart Valve Diseases - immunology | Aortic Valve - pathology | Inflammation - metabolism | Transfection | Time Factors | Swine | Inflammation Mediators - metabolism | Calcinosis - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Interleukin-6 - metabolism | Protein-Serine-Threonine Kinases - metabolism | Aortic Valve - immunology | Recombinant Proteins - metabolism | Signal Transduction | Endothelial Cells - metabolism | Aortic Valve - embryology | Cells, Cultured | Gene Expression Regulation | Activin Receptors, Type I - metabolism | Inflammation - immunology | Quail | Aortic Valve - metabolism | Chick Embryo | Endothelial Cells - immunology | Animals | NF-kappa B - genetics | Receptors, Transforming Growth Factor beta - metabolism | Heart Valve Diseases - metabolism | Heart Valve Diseases - genetics | Inflammation - genetics | Calcinosis - immunology | Primary Cell Culture | Calcinosis - pathology | Endothelial Cells - pathology | Cell Movement | Index Medicus
Journal Article
Circulation, ISSN 0009-7322, 04/2009, Volume 119, Issue 13, pp. 1785 - 1794
Background-Clinical studies have demonstrated that 50% of individuals with chronic renal disease (CRD) die of cardiovascular causes, including advanced... 
Calcification | Chronic | Kidney failure | Aortic valve | Elastin | Atherosclerosis | atherosclerosis | kidney failure, chronic | aortic valve | ELASTIN PEPTIDES | CARDIAC & CARDIOVASCULAR SYSTEMS | ATHEROSCLEROTIC PLAQUES | VASCULAR CALCIFICATION | elastin | POTENTIAL MECHANISM | FAILURE | IN-VIVO | CYSTATIN-C | PERIPHERAL VASCULAR DISEASE | SMOOTH-MUSCLE-CELLS | calcification | CHRONIC KIDNEY-DISEASE | VULNERABLE PLAQUE | Tunica Media - pathology | Osteogenesis - physiology | Cystatin C - blood | Humans | Carotid Artery Diseases - physiopathology | Aorta - metabolism | Aortic Valve - pathology | Nephrectomy | Carotid Artery Diseases - pathology | Mice, Mutant Strains | Tunica Media - metabolism | Phosphates - blood | Calcinosis - metabolism | Carotid Artery Diseases - metabolism | Phosphates - pharmacology | Muscle, Smooth, Vascular - physiology | Kidney Failure, Chronic - physiopathology | Elastin - metabolism | Mice, Inbred C57BL | Osteogenesis - drug effects | Aortic Valve Stenosis - physiopathology | Cells, Cultured | Elastin - pharmacology | Muscle, Smooth, Vascular - cytology | Aortic Valve - metabolism | Kidney Failure, Chronic - metabolism | Aorta - pathology | Tunica Intima - metabolism | Animals | Aortic Valve Stenosis - pathology | Tunica Intima - pathology | Cathepsins - genetics | Cathepsins - metabolism | Apolipoproteins E - genetics | Creatinine - blood | Aortic Valve Stenosis - metabolism | Mice | Calcinosis - pathology | Cathepsins - deficiency | Calcinosis - physiopathology | Cathepsins | Physiological aspects | Research | Chronic kidney failure | Diseases | Index Medicus | Abridged Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2012, Volume 7, Issue 10, pp. e48843 - e48843
The bicuspid aortic valve (BAV) is the most common congenital cardiac anomaly and is frequently associated with calcific aortic valve disease (CAVD). The most... 
MATRIX METALLOPROTEINASES | OSTEOPONTIN | STENOSIS | MULTIDISCIPLINARY SCIENCES | FREQUENCY | MATRIX-METALLOPROTEINASE-9 | PHENOTYPES | BIOLOGICAL-PROPERTIES | CYCLIC PRESSURE | EXPRESSION | INTERSTITIAL-CELLS | Aorta - abnormalities | Immunohistochemistry | Heart Valve Diseases - pathology | Aortic Valve - abnormalities | Transforming Growth Factor beta1 - metabolism | Stress, Mechanical | Aorta - metabolism | Bone Morphogenetic Protein 4 - metabolism | Aortic Valve - pathology | Tissue Inhibitor of Metalloproteinase-2 - metabolism | Matrix Metalloproteinase 9 - metabolism | Swine | Aorta - physiopathology | Calcinosis - metabolism | Heart Valve Diseases - physiopathology | Matrix Metalloproteinase 2 - metabolism | Models, Cardiovascular | Tricuspid Valve - metabolism | Aortic Valve - physiopathology | Tricuspid Valve - physiopathology | Aortic Valve - metabolism | Blotting, Western | Algorithms | Animals | Tricuspid Valve - pathology | Heart Valve Diseases - metabolism | Blood Flow Velocity | Hemodynamics | Calcinosis - pathology | In Vitro Techniques | Apoptosis | Calcinosis - physiopathology | Transforming growth factors | Heart valve diseases | Bone morphogenetic proteins | Calcification (ectopic) | Heart | Tissue inhibitor of metalloproteinases | Laboratories | Pathogenesis | Homeostasis | Immunoblotting | Activation | Shear stresses | Mechanical engineering | Genotype & phenotype | Cell activation | Biomedical materials | Biocompatibility | Aorta | Extracellular matrix | Rheumatic heart disease | Bone matrix | Acute effects | Growth factors | Heart diseases | Cbfa-1 protein | Osteocalcin | Bone morphogenetic protein 4 | Cathepsin L | Congenital diseases | Cytokines | Secretion | Abnormalities | Inflammation | Cathepsin S | Gene expression | Gelatinase B | Blood flow | Gelatinase A | Signaling | Valve leaflets | Calcification | Shear stress | Mechanical stimuli | Aortic valve | Osteogenesis | Index Medicus
Journal Article
Journal of Cellular Physiology, ISSN 0021-9541, 11/2017, Volume 232, Issue 11, pp. 2985 - 2995
Matrix vesicle (MV) deposition in the extracellular matrix of human calcified aortic valve tissue. Aortic valve calcification was confirmed by Alizarin red and... 
Annexin VI | calcification | calcific aortic valve disease | matrix vesicles | PHYSIOLOGY | MECHANISM | PROTEOME | VASCULAR CALCIFICATION | ATHEROSCLEROSIS | CELL BIOLOGY | CALCIUM | MINERALIZATION | OSTEOBLASTS | SMOOTH-MUSCLE-CELLS | CHRONIC KIDNEY-DISEASE | PROGRESSION | Calcinosis - genetics | Up-Regulation | Aortic Valve Stenosis - genetics | Extracellular Vesicles - ultrastructure | Calcium - metabolism | Homeodomain Proteins - metabolism | Humans | Alkaline Phosphatase - metabolism | Extracellular Matrix - metabolism | Male | RNA, Messenger - metabolism | Core Binding Factor Alpha 1 Subunit - metabolism | Extracellular Vesicles - metabolism | Aortic Valve - pathology | Protein Interaction Maps | Aortic Valve - ultrastructure | Calcinosis - etiology | Aortic Valve Stenosis - etiology | Female | Proteomics - methods | Calcinosis - metabolism | Microscopy, Electron, Transmission | Alkaline Phosphatase - genetics | Kidney Failure, Chronic - diagnosis | RNA, Messenger - genetics | Cells, Cultured | Aortic Valve - metabolism | Rats, Sprague-Dawley | Homeodomain Proteins - genetics | Annexin A6 - metabolism | Extracellular Matrix - ultrastructure | Animals | Aortic Valve Stenosis - pathology | Hypercalcemia - diagnosis | Hypercalcemia - etiology | Kidney Failure, Chronic - complications | Aortic Valve Stenosis - metabolism | Aged | Calcinosis - pathology | Core Binding Factor Alpha 1 Subunit - genetics | Phosphates | Heart valve diseases | Chronic kidney failure | RNA | Analysis | Calcification | Development and progression | Binding proteins | Electron microscopy | Protein binding | Enrichment | Calcification (ectopic) | End-stage renal disease | CD9 antigen | Media (enrichment) | Calcium | Interstitial cells | mRNA | Aldosterone | Proteins | Vesicles | Biomedical materials | Msx2 protein | Aorta | Extracellular matrix | Biocompatibility | Rheumatic heart disease | Localization | Binding | Cardiovascular system | LAMP-1 protein | Cbfa-1 protein | LAMP-2 protein | CD63 antigen | Matrix vesicles | Patients | Calcium phosphates | Hypercalcemia | Transmission electron microscopy | Proteomics | Kidney diseases | Position (location) | Aortic valve | Kidney transplantation | Index Medicus | Original | Original s
Journal Article
Circulation Research, ISSN 0009-7330, 03/2010, Volume 106, Issue 4, pp. 712 - 719
RATIONALE:Calcification of heart valve structures is the most common form of valvular disease and is characterized by the appearance of bone-like phenotypes... 
Calcification | Extracellular matrix | Mouse model | Sox9 | Heart valves | CARDIAC & CARDIOVASCULAR SYSTEMS | mouse model | MOUSE EMBRYOS | AORTIC-VALVE | INTERSTITIAL-CELLS | CELL LINEAGE | MATRIX METALLOPROTEINASES | RETINOIC ACID | heart valves | BONE-FORMATION | TOLL-LIKE RECEPTORS | GENE-EXPRESSION | PERIPHERAL VASCULAR DISEASE | calcification | HEMATOLOGY | extracellular matrix | CARDIAC VALVES | Calcinosis - genetics | Inflammation - pathology | Age Factors | Heart Valve Diseases - pathology | Calcium - metabolism | Extracellular Matrix - metabolism | Male | Mitral Valve - metabolism | Gene Knockdown Techniques | Tricuspid Valve - embryology | Tricuspid Valve - drug effects | Inflammation - metabolism | Transfection | Mitral Valve - drug effects | Aging | Female | Calcinosis - metabolism | Osteogenesis - genetics | Disease Models, Animal | Tretinoin - pharmacology | Animals, Newborn | SOX9 Transcription Factor - metabolism | Tissue Culture Techniques | Tricuspid Valve - metabolism | Down-Regulation | Genotype | Mice, Transgenic | Chick Embryo | Collagen Type II - genetics | Phenotype | Animals | Tricuspid Valve - pathology | Heart Valve Diseases - metabolism | Heart Valve Diseases - genetics | Mitral Valve - embryology | Mice | Mitral Valve - pathology | Calcinosis - pathology | Extracellular Matrix - pathology | Integrases - genetics | SOX9 Transcription Factor - genetics | Index Medicus
Journal Article