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1. Full Text Effect of lipid lowering with rosuvastatin on progression of aortic stenosis: Results of the aortic stenosis progression observation: Measuring effects of rosuvastatin (Astronomer) trial
by Chan, Kwan Leung and Teo, Koon and Dumesnil, Jean G and Ni, Andy and Tam, James and ASTRONOMER Investigators
Circulation, ISSN 0009-7322, 01/2010, Volume 121, Issue 2, pp. 306 - 314
Background-Aortic stenosis (AS) is an active process with similarities to atherosclerosis. The objective of this study was to assess the effect of cholesterol... 
Lipids | Valves | Echocardiography | Trials | Cholesterol | lipids | FAMILIAL HYPERCHOLESTEROLEMIA | CARDIAC & CARDIOVASCULAR SYSTEMS | RISK-FACTORS | VALVE STENOSIS | valves | echocardiography | RANDOMIZED-TRIAL | STATINS | trials | EARLY LESION | PREDICTORS | CHOLESTEROL LEVELS | DISEASE | cholesterol | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | SEVERITY | Aortic Valve Stenosis - drug therapy | Follow-Up Studies | Cholesterol - blood | Humans | Middle Aged | Male | Fluorobenzenes - administration & dosage | Aortic Valve Stenosis - prevention & control | Fluorobenzenes - pharmacology | Young Adult | Lipids - blood | Treatment Failure | Aged, 80 and over | Electrocardiography | Adult | Female | Hydroxymethylglutaryl-CoA Reductase Inhibitors | Double-Blind Method | Pyrimidines - administration & dosage | Rosuvastatin Calcium | Pyrimidines - pharmacology | Sulfonamides - pharmacology | Disease Progression | Sulfonamides - therapeutic use | Pyrimidines - therapeutic use | Adolescent | Lipid Metabolism - drug effects | Aortic Valve Stenosis - metabolism | Aged | Fluorobenzenes - therapeutic use | Sulfonamides - administration & dosage | Control | Usage | Aortic valve stenosis | Development and progression | Rosuvastatin | Health aspects
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2. Full Text OxLDL-derived lysophosphatidic acid promotes the progression of aortic valve stenosis through a LPAR1-RhoA-NF-κB pathway
by Nsaibia, Mohamed Jalloul and Nsaibia, Mohamed Jalloul and Boulanger, Marie-Chloé and Boulanger, Marie-Chloé and Bouchareb, Rihab and Bouchareb, Rihab and Mkannez, Ghada and Mkannez, Ghada and Le Quang, Khai and Le Quang, Khai and Hadji, Fayez and Hadji, Fayez and Argaud, Deborah and Argaud, Deborah and Dahou, Abdellaziz and Dahou, Abdellaziz and Bossé, Yohan and Bossé, Yohan and Koschinsky, Marlys L and Koschinsky, Marlys L and Pibarot, Philippe and Pibarot, Philippe and Arsenault, Benoit J and Arsenault, Benoit J and Marette, André and Marette, André and Mathieu, Patrick and Mathieu, Patrick
Cardiovascular research, ISSN 0008-6363, 2017, Volume 113, Issue 11, pp. 1351 - 1363
Aims Oxidatively modified lipoproteins may promote the development/progression of calcific aortic valve stenosis (CAVS). Oxidative transformation of low-... 
Bone morphogenetic protein 2 | Calcific aortic valve disease | NF-jB | p65 serine 536 | LPAR1 | Calcific aortic valve stenosis | RhoA | NF-κB | Osteogenic program | BMP2 | Lysophosphatidic acid | Mineralization | Calcification | Valve interstitial cells | OxLDL | CARDIAC & CARDIOVASCULAR SYSTEMS | PHOSPHORYLATION | LOW-DENSITY-LIPOPROTEIN | RECEPTOR | NF-kappa B | INFLAMMATION | DISEASE | INTERSTITIAL-CELLS PROMOTES | GENE-EXPRESSION | NF-KAPPA-B | ASSOCIATION | Receptors, Lysophosphatidic Acid - metabolism | Phosphorylation | Humans | NF-kappa B - metabolism | rhoA GTP-Binding Protein - metabolism | Aortic Valve - metabolism | Toll-Like Receptor 4 - metabolism | Aortic Valve - pathology | Animals | Signal Transduction - drug effects | Lysophospholipids - pharmacology | Aortic Valve Stenosis - metabolism | Signal Transduction - physiology | Lipoproteins, LDL - metabolism | Mice | Calcinosis - metabolism | Editor's Choice | Original
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3. Full Text Autotaxin derived from lipoprotein(a) and valve interstitial cells promotes inflammation and mineralization of the aortic valve
by Bouchareb, Rihab and Mahmut, Ablajan and Nsaibia, Mohamed Jalloul and Boulanger, Marie-Chloé and Dahou, Abdellaziz and Lépine, Jamie-Lee and Laflamme, Marie-Hélène and Hadji, Fayez and Couture, Christian and Trahan, Sylvain and Pagé, Sylvain and Bossé, Yohan and Pibarot, Philippe and Scipione, Corey A and Romagnuolo, Rocco and Koschinsky, Marlys L and Arsenault, Benoît J and Marette, André and Mathieu, Patrick
Circulation, ISSN 0009-7322, 08/2015, Volume 132, Issue 8, pp. 677 - 690
Background Mendelian randomization studies have highlighted that lipoprotein(a) [Lp(a)] was associated with calcific aortic valve disease (CAVD). Lp(a)... 
lysophosphatidylcholine | lysophosphatidic acid | autotaxin | calcific aortic valve disease | aortic valve stenosis | ENPP2 | lipoprotein(a) | lipoproteins | aortic stenosis calcific | CARDIAC & CARDIOVASCULAR SYSTEMS | STENOSIS | LOW-DENSITY-LIPOPROTEIN | RISK | calcific | aortic stenosis | ENDOTHELIUM | DISEASE | CALCIFICATION | PERIPHERAL VASCULAR DISEASE | OXIDIZED PHOSPHOLIPIDS | EXPRESSION | ASSOCIATION | Inflammation - pathology | Phosphoric Diester Hydrolases - biosynthesis | Humans | Mice, Inbred C57BL | Middle Aged | Aortic Valve - secretion | Male | Aortic Valve - metabolism | Aortic Valve - pathology | Mice, Knockout | Inflammation - metabolism | Animals | Aortic Valve Stenosis - pathology | Lipoprotein(a) - secretion | Lipoprotein(a) - biosynthesis | Aortic Valve Stenosis - metabolism | Female | Aged | Mice | Aortic valve insufficiency | Inflammation | Research | Health aspects | Aortic valve | Risk factors | Lipoprotein A
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4. Full Text Calcification in aortic stenosis: The skeleton key
by Pawade, Tania A and Newby, David E and Dweck, Marc R
Journal of the American College of Cardiology, ISSN 0735-1097, 08/2015, Volume 66, Issue 5, pp. 561 - 577
Aortic stenosis is a common, potentially fatal condition that is set to become an increasing public health burden. Once symptoms develop, there is an... 
computed tomography | aortic valve | diphosphonates | calcinosis | calcium | calcification of | positron emission tomography | ROSUVASTATIN ASTRONOMER TRIAL | CARDIAC & CARDIOVASCULAR SYSTEMS | BONE-MINERAL DENSITY | MATRIX GLA-PROTEIN | VASCULAR CALCIFICATION | LOW-DENSITY-LIPOPROTEIN | COMPUTED-TOMOGRAPHY | POSITRON-EMISSION-TOMOGRAPHY | calcification of calcinosis | VALVE INTERSTITIAL-CELLS | CARDIOVASCULAR RISK-FACTORS | KAPPA-B LIGAND | Calcinosis - diagnosis | Prognosis | Humans | Aortic Valve Stenosis - physiopathology | Heart Valve Prosthesis Implantation - methods | Aortic Valve Stenosis - diagnosis | Aortic Valve - surgery | Aortic Valve Stenosis - therapy | Disease Progression | Aortic Valve - pathology | Calcinosis - therapy | Aortic Valve Stenosis - metabolism | Disease Management | Calcinosis - metabolism
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5. Full Text Gla-Rich Protein Acts as a Calcification Inhibitor in the Human Cardiovascular System
by Viegas, Carla S. B and Rafael, Marta S and Enriquez, Jose L and Teixeira, Alexana and Vitorino, Rui and Luis, Ines M and Costa, Ruben M and Santos, Sofia and Cavaco, Sofia and Neves, Jose and Macedo, Anjos L and Willems, Brecht A. G and Vermeer, Cees and Simes, Dina C
Arteriosclerosis Thrombosis and Vascular Biology, ISSN 1079-5642, 02/2015, Volume 35, Issue 2, pp. 399 - 408
OBJECTIVE—Vascular and valvular calcifications are pathological processes regulated by resident cells, and depending on a complex interplay between... 
aortic valve | multivesicular bodies | calcification of | gene expression | vascular calcification | AORTIC-STENOSIS | MATRIX VESICLES | VALVE | aortic valve, calcification of | CARTILAGE | DISEASE | VITAMIN-K | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | EXPRESSION | FETUIN-A | INSIGHTS | Calcinosis - genetics | Aortic Valve Stenosis - genetics | Calcium - metabolism | Humans | Middle Aged | Vascular Calcification - genetics | Actins - metabolism | Osteocalcin - genetics | Male | Aorta - metabolism | Case-Control Studies | Aortic Valve - pathology | Coronary Vessels - metabolism | Aortic Valve Stenosis - prevention & control | Vascular Calcification - metabolism | Coronary Artery Disease - pathology | Aged, 80 and over | Adult | Female | Calcinosis - metabolism | Extracellular Matrix Proteins - metabolism | Calcium-Binding Proteins - metabolism | Coronary Vessels - pathology | Osteocalcin - metabolism | Tissue Culture Techniques | Coronary Artery Disease - metabolism | Extracellular Matrix Proteins - genetics | Coronary Artery Disease - prevention & control | Gene Expression Regulation | Vascular Calcification - prevention & control | Vascular Calcification - pathology | Aortic Valve - metabolism | Aorta - pathology | Proteins - genetics | Aortic Valve Stenosis - pathology | Proteins - metabolism | Coronary Artery Disease - genetics | alpha-2-HS-Glycoprotein - metabolism | Aortic Valve Stenosis - metabolism | Aged | Calcinosis - prevention & control | Calcinosis - pathology | Calcium-Binding Proteins - genetics
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6. Full Text Human non-contrast T1 values and correlation with histology in diffuse fibrosis
by Bull, Sacha and White, Steven K and Piechnik, Stefan K and Flett, Andrew S and Ferreira, Vanessa M and Loudon, Margaret and Francis, Jane M and Karamitsos, Theodoros D and Prendergast, Bernard D and Robson, Matthew D and Neubauer, Stefan and Moon, James C and Myerson, Saul G
Heart, ISSN 1355-6037, 07/2013, Volume 99, Issue 13, pp. 932 - 937
Background Aortic stenosis (AS) leads to diffuse fibrosis in the myocardium, which is linked to adverse outcome. Myocardial T1 values change with tissue... 
HEART | CARDIAC & CARDIOVASCULAR SYSTEMS | HYPERTROPHIC CARDIOMYOPATHY | CARDIOVASCULAR MAGNETIC-RESONANCE | DISEASE | GUIDELINES | ACUTE MYOCARDIAL-INFARCTION | DILATED CARDIOMYOPATHY | SOCIETY | AORTIC-VALVE STENOSIS | Multivariate Analysis | Predictive Value of Tests | Prospective Studies | Myocardium - chemistry | Humans | Middle Aged | England | Male | Asymptomatic Diseases | Case-Control Studies | Aortic Valve - pathology | Aged, 80 and over | Female | Heart Ventricles - pathology | Severity of Illness Index | Biomarkers - analysis | Myocardium - pathology | Aortic Valve Stenosis - diagnosis | Chi-Square Distribution | Heart Ventricles - chemistry | Magnetic Resonance Imaging | Aortic Valve Stenosis - pathology | Biopsy | Fibrosis | Aortic Valve Stenosis - metabolism | Aged | Aortic Valve - chemistry | Collagen - analysis | Complications and side effects | Usage | Aortic valve stenosis | Histology | Research | Risk factors | Heart muscle | Values | Fitness equipment | Investigations | Age | 1506 | Cardiovascular Imaging
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7. Full Text Regression of myocardial hypertrophy after aortic valve replacement: Faster in women?
by Petrov, George and Regitz-Zagrosek, Vera and Lehmkuhl, Elke and Krabatsch, Thomas and Dunkel, Anne and Dandel, Michael and Dworatzek, Elke and Mahmoodzadeh, Shokoufeh and Schubert, Carola and Becher, Eva and Hampl, Hannah and Hetzer, Roland
Circulation, ISSN 0009-7322, 09/2010, Volume 122, Issue 11, pp. S23 - S28
Background-In patients with aortic stenosis, pressure overload induces cardiac hypertrophy and fibrosis. Female sex and estrogens influence cardiac remodeling... 
aortic valve stenosis | estrogen | remodeling | hypertrophy | sex | PRESSURE-OVERLOAD | CARDIAC & CARDIOVASCULAR SYSTEMS | STENOSIS | LEFT-VENTRICULAR HYPERTROPHY | 17-BETA-ESTRADIOL | FIBROBLASTS | DISEASE | PERIPHERAL VASCULAR DISEASE | MICE | HEMATOLOGY | GENDER-DIFFERENCES | EXPRESSION | Estrogens - pharmacology | Prospective Studies | Extracellular Matrix Proteins - biosynthesis | Rats, Wistar | Humans | Middle Aged | Male | Aortic Valve - surgery | Aortic Valve - pathology | Muscle Proteins - biosynthesis | Hypertrophy, Left Ventricular - pathology | Aged, 80 and over | Female | Aortic Valve Stenosis - surgery | Estrogens - metabolism | Estradiol - pharmacology | Heart Ventricles - pathology | Fibroblasts - metabolism | Estradiol - metabolism | Hypertrophy, Left Ventricular - etiology | Hypertrophy, Left Ventricular - metabolism | Cells, Cultured | Gene Expression Regulation | Prostheses and Implants | Rats | Sex Characteristics | Fibroblasts - pathology | Aortic Valve - metabolism | Aortic Valve Stenosis - complications | Animals | Aortic Valve Stenosis - pathology | Sex Factors | Aortic Valve Stenosis - metabolism | Aged | Heart Ventricles - metabolism
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8. Full Text P2Y2 receptor represses IL-6 expression by valve interstitial cells through Akt: Implication for calcific aortic valve disease
by El Husseini, Diala and Boulanger, Marie-Chloé and Mahmut, Ablajan and Bouchareb, Rihab and Laflamme, Marie-Hélène and Fournier, Dominique and Pibarot, Philippe and Bossé, Yohan and Mathieu, Patrick
Journal of Molecular and Cellular Cardiology, ISSN 0022-2828, 2014, Volume 72, pp. 146 - 156
Abstract Calcific aortic valve disease (CAVD) is a disorder characterized by an abnormal mineralization, which may have intricate links with inflammation.... 
Cardiovascular | Aortic stenosis | Calcific aortic stenosis | P2Y2 receptor | NF-kappa B | Calcific aortic valve disease | IL-6 | CYTOKINES | ACTIVATION | CARDIAC & CARDIOVASCULAR SYSTEMS | STENOSIS | RISK | INTERLEUKIN-6 | PREVENTS | FAMILY | CELL BIOLOGY | DENSITY | PATHWAY | NF-KAPPA-B | Calcinosis - genetics | RNA, Small Interfering - genetics | Aortic Valve Stenosis - genetics | Interleukin-6 - antagonists & inhibitors | Humans | Aortic Valve - drug effects | NF-kappa B - metabolism | Gene Expression Profiling | Phosphatidylinositol 3-Kinases - metabolism | Calcinosis - chemically induced | Proto-Oncogene Proteins c-akt - genetics | Aortic Valve - pathology | Aortic Valve Stenosis - chemically induced | Receptors, Purinergic P2Y2 - metabolism | Calcinosis - metabolism | Culture Media - chemistry | Proto-Oncogene Proteins c-akt - metabolism | Interleukin-6 - metabolism | Phosphates - pharmacology | Receptors, Purinergic P2Y2 - genetics | Interleukin-6 - genetics | Signal Transduction | Cells, Cultured | Gene Expression Regulation | Aortic Valve - metabolism | Mice, Knockout | Phosphatidylinositol 3-Kinases - genetics | Animals | Aortic Valve Stenosis - pathology | NF-kappa B - genetics | Culture Media - pharmacology | Aortic Valve Stenosis - metabolism | Mice | Calcinosis - pathology | RNA, Small Interfering - metabolism | Phosphates | Heart valve diseases | Interleukins | Analysis
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9. Full Text Diabetes Mellitus Worsens Diastolic Left Ventricular Dysfunction in Aortic Stenosis Through Altered Myocardial Structure and Cardiomyocyte Stiffness
by Falcao-Pires, Ines and Hamdani, Nazha and Borbely, Attila and Gavina, Cristina and Schalkwijk, Casper G and van der Velden, Jolanda and van Heerebeek, Loek and Stienen, Ger J. M and Niessen, Hans W. M and Leite-Moreira, Adelino F and Paulus, Walter J
Circulation, ISSN 0009-7322, 09/2011, Volume 124, Issue 10, pp. 1151 - 1159
Background-Aortic stenosis (AS) and diabetes mellitus (DM) are frequent comorbidities in aging populations. In heart failure, DM worsens diastolic left... 
titin | myocytes, cardiac | myofilamentary proteins | aortic valve stenosis | diabetes mellitus | fibrosis | diastole | METABOLIC SYNDROME | CARDIAC & CARDIOVASCULAR SYSTEMS | HEART-FAILURE | RESTING TENSION | CARDIAC TITIN | RANDOMIZED-TRIAL | PRESERVED EJECTION FRACTION | INFARCTION | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | PROGRESSION | GLYCATION END-PRODUCTS | VALVE DISEASE | Protein Kinases - metabolism | Connectin | Coronary Circulation - physiology | Humans | Middle Aged | Male | Diabetes Mellitus, Type 2 - metabolism | Aortic Valve Stenosis - diagnostic imaging | Sarcomeres - pathology | Diabetes Mellitus, Type 2 - diagnostic imaging | Echocardiography, Doppler | Muscle Proteins - metabolism | Heart Rate - physiology | Female | Sarcomeres - metabolism | Aortic Valve Stenosis - physiopathology | Ventricular Dysfunction, Left - diagnostic imaging | Ventricular Dysfunction, Left - physiopathology | Ventricular Dysfunction, Left - metabolism | Collagen - metabolism | Diabetes Mellitus, Type 2 - physiopathology | Biopsy | Glycation End Products, Advanced - metabolism | Fibrosis | Aortic Valve Stenosis - metabolism | Aged | Physiological aspects | Research | Diabetes | Aortic valve stenosis | Left ventricular function
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10. Full Text Arterial and aortic valve calcification abolished by elastolytic cathepsin S deficiency in chronic renal disease
by Aikawa, Elena and Aikawa, Masanori and Rusanescu, Gabriel and Iwamoto, Yoshiko and Shi, Guo-Ping and Jaffer, Farouc A and Libby, Peter and Figueiredo, Jose-Luiz and Fukuda, Daiju and Kohler, Rainer H and Weissleder, Ralph
Circulation, ISSN 0009-7322, 04/2009, Volume 119, Issue 13, pp. 1785 - 1794
Background-Clinical studies have demonstrated that 50% of individuals with chronic renal disease (CRD) die of cardiovascular causes, including advanced... 
Calcification | Chronic | Kidney failure | Aortic valve | Elastin | Atherosclerosis | atherosclerosis | kidney failure, chronic | aortic valve | ELASTIN PEPTIDES | CARDIAC & CARDIOVASCULAR SYSTEMS | ATHEROSCLEROTIC PLAQUES | VASCULAR CALCIFICATION | elastin | POTENTIAL MECHANISM | FAILURE | IN-VIVO | CYSTATIN-C | PERIPHERAL VASCULAR DISEASE | SMOOTH-MUSCLE-CELLS | calcification | CHRONIC KIDNEY-DISEASE | VULNERABLE PLAQUE | Tunica Media - pathology | Osteogenesis - physiology | Cystatin C - blood | Humans | Carotid Artery Diseases - physiopathology | Aorta - metabolism | Aortic Valve - pathology | Nephrectomy | Carotid Artery Diseases - pathology | Mice, Mutant Strains | Tunica Media - metabolism | Phosphates - blood | Calcinosis - metabolism | Carotid Artery Diseases - metabolism | Phosphates - pharmacology | Muscle, Smooth, Vascular - physiology | Kidney Failure, Chronic - physiopathology | Elastin - metabolism | Mice, Inbred C57BL | Osteogenesis - drug effects | Aortic Valve Stenosis - physiopathology | Cells, Cultured | Elastin - pharmacology | Muscle, Smooth, Vascular - cytology | Aortic Valve - metabolism | Kidney Failure, Chronic - metabolism | Aorta - pathology | Tunica Intima - metabolism | Animals | Aortic Valve Stenosis - pathology | Tunica Intima - pathology | Cathepsins - genetics | Cathepsins - metabolism | Apolipoproteins E - genetics | Creatinine - blood | Aortic Valve Stenosis - metabolism | Mice | Calcinosis - pathology | Cathepsins - deficiency | Calcinosis - physiopathology | Cathepsins | Physiological aspects | Research | Chronic kidney failure | Diseases
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11. Full Text Conserved Transcriptional Regulatory Mechanisms in Aortic Valve Development and Disease
by Wirrig, Elaine E and Yutzey, Katherine E
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 04/2014, Volume 34, Issue 4, pp. 737 - 741
There is increasing evidence for activation of developmental transcriptional regulatory pathways in heart valve disease. Here, we review molecular regulatory... 
aortic valve stenosis | fetal heart | bicuspid aortic valve | transcription factors | extracellular matrix | STENOSIS | LEAFLETS | GATA5 | ADULT | HEART | NF-ATC | CALCIFICATION | PERIPHERAL VASCULAR DISEASE | CUSHION CELL-PROLIFERATION | DIFFERENTIATION | HEMATOLOGY | LINEAGE | Calcinosis - genetics | Aortic Valve Stenosis - genetics | Heart Valve Diseases - pathology | Humans | Aortic Valve - embryology | Transcription Factors - genetics | Aortic Valve - metabolism | Aortic Valve - pathology | Morphogenesis | Transcription Factors - metabolism | Animals | Aortic Valve Stenosis - pathology | Gene Expression Regulation, Developmental | Heart Valve Diseases - metabolism | Epithelial-Mesenchymal Transition | Heart Valve Diseases - genetics | Aortic Valve Stenosis - metabolism | Heart Valve Diseases - therapy | Transcription, Genetic | Calcinosis - metabolism | Calcinosis - pathology | Heart valve development | transcription factor | calcific aortic valve disease
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12. Full Text B-type natriuretic peptide clinical activation in aortic stenosis: Impact on long-term survival
by Clavel, Marie-Annick and Malouf, Joseph and Michelena, Hector I and Suri, Rakesh M and Jaffe, Allan S and Mahoney, Douglas W and Enriquez-Sarano, Maurice
Journal of the American College of Cardiology, ISSN 0735-1097, 05/2014, Volume 63, Issue 19, pp. 2016 - 2025
Objectives This study was conducted to define the association between serum B-type natriuretic peptide (BNP) activation and survival after the diagnosis of... 
valvular heart disease | natriuretic peptide | aortic stenosis | Doppler echocardiography | Biomarkers - metabolism | Prospective Studies | Survival Rate - trends | Follow-Up Studies | Humans | Middle Aged | Natriuretic Peptide, Brain - metabolism | Aortic Valve Stenosis - blood | Male | Biomarkers - blood | Aortic Valve Stenosis - mortality | Pilot Projects | Time Factors | Aged, 80 and over | Aortic Valve Stenosis - metabolism | Female | Aged | Natriuretic Peptide, Brain - blood | Cohort Studies
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13. Full Text Interleukin-37 suppresses the osteogenic responses of human aortic valve interstitial cells in vitro and alleviates valve lesions in mice
by Zeng, Q and Song, R and Fullerton, D.A and Ao, L and Zhai, Y and Li, S and Ballak, D.B and Cleveland, J.C., Jr and Reece, T.B and McKinsey, T.A and Xu, D and Dinarello, C.A and Meng, X
Proceedings of the National Academy of Science USA, ISSN 0027-8424, 2017, Volume 114, Issue 7, pp. 1631 - 1636
Calcific aortic valve disease is a chronic inflammatory process, and aortic valve interstitial cells (AVICs) from diseased aortic valves express greater levels... 
Calcification | Toll-like receptors | Signal transduction | Inflammation | Oxidized low-density lipoprotein | KAPPA-B ACTIVATION | STENOSIS | signal transduction | BONE MORPHOGENETIC PROTEIN-2 | IL-1 FAMILY | MULTIDISCIPLINARY SCIENCES | LOW-DENSITY-LIPOPROTEIN | OXIDIZED LDL | NECROSIS-FACTOR-ALPHA | inflammation | INNATE INFLAMMATION | DISEASE | calcification | oxidized low-density lipoprotein | EXPRESSION | Calcinosis - genetics | Aortic Valve Stenosis - genetics | Humans | Middle Aged | Alkaline Phosphatase - metabolism | Aortic Valve - drug effects | Male | NF-kappa B - metabolism | Interleukins - metabolism | Aortic Valve - pathology | Aortic Valve Stenosis - prevention & control | Interleukins - genetics | Bone Morphogenetic Protein 2 - metabolism | Female | Interleukins - pharmacology | Calcinosis - metabolism | Bone Morphogenetic Protein 2 - genetics | Mice, Inbred C57BL | Osteogenesis - drug effects | Cells, Cultured | Mice, Transgenic | Recombinant Proteins - pharmacology | Aortic Valve - metabolism | Mice, Knockout | Animals | Aortic Valve Stenosis - metabolism | Aged | Calcinosis - prevention & control | Cell interaction | Interleukins | Health aspects | Heart valves | Biological Sciences
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14. Full Text Calcific aortic valve stenosis in old hypercholesterolemic mice
by Weiss, Robert M and Ohashi, Masuo and Miller, Jordan D and Young, Stephen G and Heistad, Donald D
Circulation, ISSN 0009-7322, 11/2006, Volume 114, Issue 19, pp. 2065 - 2069
Background - Hypercholesterolemia and old age are clinical risk factors for development of aortic valve stenosis, and hypercholesterolemia is a putative... 
Valves | Cholesterol | Free radicals | LIPOPROTEIN | free radicals | OXIDATIVE STRESS | CARDIAC & CARDIOVASCULAR SYSTEMS | valves | DISEASE | cholesterol | PERIPHERAL VASCULAR DISEASE | MECHANISMS | HEMATOLOGY | STATINS | PROGRESSION | Calcinosis - genetics | Receptors, LDL - genetics | Mice, Inbred C57BL | Aortic Valve Stenosis - physiopathology | Mice, Transgenic | Aging - pathology | Animals | Aging - genetics | Receptors, LDL - deficiency | Aortic Valve Stenosis - metabolism | Hypercholesterolemia - physiopathology | Mice | Hypercholesterolemia - genetics | Calcinosis - metabolism | Hypercholesterolemia - metabolism | Aging - metabolism | Calcinosis - physiopathology
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15. Tumor necrosis factor-α accelerates the calcification of human aortic valve interstitial cells obtained from patients with calcific aortic valve stenosis via the BMP2-Dlx5 pathway
by Yu, Zaiqiang and Seya, Kazuhiko and Daitoku, Kazuyuki and Motomura, Shigeru and Fukuda, Ikuo and Furukawa, Ken-Ichi
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 04/2011, Volume 337, Issue 1, pp. 16 - 23
Calcific aortic valve stenosis (CAS) is the most frequent heart valve disease in the elderly, accompanied by valve calcification. Tumor necrosis factor-alpha... 
BONE-FORMATION | INFLAMMATION | ARTERIAL CALCIFICATION | DISEASE | PHARMACOLOGY & PHARMACY | MECHANISMS | PROLIFERATION | TNF-ALPHA | DIFFERENTIATION | EXPRESSION | PROGRESSION | Transcription Factors - physiology | Humans | Middle Aged | Alkaline Phosphatase - metabolism | Cells, Cultured | Male | Calcinosis - enzymology | Tumor Necrosis Factor-alpha - toxicity | Aortic Valve - metabolism | Bone Morphogenetic Protein 2 - physiology | Aortic Valve - pathology | Aortic Valve Stenosis - enzymology | Aortic Valve Stenosis - pathology | Alkaline Phosphatase - biosynthesis | Signal Transduction - drug effects | Aged, 80 and over | Adult | Aortic Valve Stenosis - metabolism | Female | Signal Transduction - physiology | Aged | Calcinosis - metabolism | Calcinosis - pathology | Homeodomain Proteins - physiology
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