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Pharmacological Research, ISSN 1043-6618, 09/2012, Volume 66, Issue 3, pp. 251 - 259
Endocannabinoids exhibit vasodilatory properties and reduce blood pressure . However, the influence and mechanism of action of the prominent endocannabinoid,... 
Endocannabinoid | Abnormal cannabidiol | Pulmonary artery | Anandamide | Endothelium | VIRODHAMINE | VASORELAXATION | SMALL MESENTERIC-ARTERY | CANNABINOID RECEPTOR | VESSELS | VASCULATURE | RESISTANCE | PHARMACOLOGY & PHARMACY | CHANNELS | HYPERTENSION | ABNORMAL-CANNABIDIOL | Tetraethylammonium - pharmacology | Endocannabinoids - pharmacology | Rats, Wistar | Capsaicin - pharmacology | Anisoles - pharmacology | Cyclohexanes - pharmacology | Nitric Oxide Synthase - antagonists & inhibitors | Endothelium, Vascular - drug effects | Male | Apamin - pharmacology | Receptors, Cannabinoid - metabolism | TRPV Cation Channels - metabolism | Piperidines - pharmacology | Charybdotoxin - pharmacology | TRPV Cation Channels - antagonists & inhibitors | Potassium Chloride - metabolism | Cannabinoid Receptor Antagonists - pharmacology | Indoles - pharmacology | Benzamides - pharmacology | Potassium Channel Blockers - pharmacology | Carbamates - pharmacology | Pyrazoles - pharmacology | Amidohydrolases - metabolism | NG-Nitroarginine Methyl Ester - pharmacology | Receptors, Epoprostenol - metabolism | Rats | Amidohydrolases - antagonists & inhibitors | Capsaicin - analogs & derivatives | Imidazoles - pharmacology | Pulmonary Artery - drug effects | Arachidonic Acids - pharmacology | Indomethacin - pharmacology | Receptors, Epoprostenol - antagonists & inhibitors | Animals | Benzyl Compounds - pharmacology | Endothelium, Vascular - metabolism | Prostaglandin-Endoperoxide Synthases - metabolism | 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid - pharmacology | Polyunsaturated Alkamides - pharmacology | Nitric Oxide Synthase - metabolism | Vasodilation - drug effects | Hypertension | Enzymes | Vasodilators | Blood vessels | Glycerol | Fatty acids | Pulmonary hypertension | Glycerin | Cannabinoids | Dilatation | Dimethyl sulfoxide | Hydrolases | Indomethacin
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 11/2015, Volume 767, pp. 52 - 60
Journal Article
Hypertension, ISSN 0194-911X, 09/2004, Volume 44, Issue 3, pp. 271 - 276
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 11/2007, Volume 152, Issue 5, pp. 699 - 708
Background and purpose: Studies in isolated preparations of vascular tissue (mainly resistance vessels) provide evidence that anandamide exerts vasorelaxation.... 
vasorelaxation | anandamide | rat aorta | Rat aorta | Vasorelaxation | Anandamide | PHARMACOLOGICAL CHARACTERIZATION | SENSORY NERVES MEDIATE | OXIDATIVE-METABOLISM | PROSTANOID RECEPTORS | CANNABINOID RECEPTOR | ISOLATED MESENTERIC-ARTERY | HYPERPOLARIZING FACTOR | PROSTAGLANDIN E-2 ETHANOLAMIDE | VANILLOID RECEPTORS | CARDIOVASCULAR FUNCTION | PHARMACOLOGY & PHARMACY | Cannabinoid Receptor Modulators - pharmacology | Rats, Wistar | Capsaicin - pharmacology | Bornanes - pharmacology | Endothelium, Vascular - drug effects | Male | Peptide Fragments - pharmacology | Receptor, Cannabinoid, CB2 - antagonists & inhibitors | Apamin - pharmacology | Aorta, Abdominal - drug effects | Endothelium, Vascular - physiology | Dose-Response Relationship, Drug | Piperidines - pharmacology | Charybdotoxin - pharmacology | Benzamides - pharmacology | Vasodilation - physiology | Isoindoles - pharmacology | Endocannabinoids | Carbamates - pharmacology | Pyrazoles - pharmacology | NG-Nitroarginine Methyl Ester - pharmacology | Nitric Oxide - biosynthesis | Calcitonin Gene-Related Peptide - pharmacology | Nitric Oxide - antagonists & inhibitors | Rats | Capsaicin - analogs & derivatives | Aorta, Abdominal - physiology | Sulfonamides - pharmacology | Arachidonic Acids - pharmacology | Indomethacin - pharmacology | Pyrazoles - administration & dosage | Animals | Polyunsaturated Alkamides - pharmacology | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Vasodilation - drug effects | In Vitro Techniques | Research Papers
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 06/2014, Volume 171, Issue 11, pp. 2751 - 2766
Background and PurposeCardiovascular risk is higher in men and postmenopausal women compared with premenopausal women. This may be due to sex differences in... 
gap junctions | nitric oxide | hydrogen peroxide | EDH | channel | bradykinin | SKc | endothelium‐derived hyperpolarization | PCA | porcine coronary artery | small‐conductance calcium‐activated | sex differences | connexin | intermediate‐conductance calcium‐activated | porcine coronary artery (PCA) | nitric oxide (NO) | connexin (Cx) | endothelium-derived hyperpolarization (EDH) | small-conductance calcium-activated K+ channel (SKc(a)) | MESENTERIC-ARTERIES | CA2+-ACTIVATED K+ CHANNELS | ACTIVATED POTASSIUM CHANNELS | intermediate-conductance calcium-activated K+ channel (IKca) | HYPERPOLARIZING FACTOR | NITRIC-OXIDE | hydrogen peroxide (H2O2) | PHARMACOLOGY & PHARMACY | PIG CAROTID-ARTERY | HYDROGEN-PEROXIDE | DEPENDENT RELAXATIONS | GENDER-DIFFERENCES | SMALL-CONDUCTANCE | Catalase - pharmacology | NG-Nitroarginine Methyl Ester - pharmacology | Vasoconstrictor Agents - pharmacology | Vasodilator Agents - pharmacology | Coronary Vessels - physiology | Glycyrrhetinic Acid - analogs & derivatives | Hydrogen Peroxide - pharmacology | Male | Sex Characteristics | Apamin - pharmacology | Indomethacin - pharmacology | Vasodilation | Connexins - metabolism | Endothelium, Vascular - physiology | Carbenoxolone - pharmacology | Glycyrrhetinic Acid - pharmacology | Animals | Gap Junctions - physiology | Swine | 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid - pharmacology | Female | Bradykinin - pharmacology | Polyethylene Glycols - pharmacology | Pyrazoles - pharmacology | Postmenopausal women | Hydrogen peroxide | Nitric oxide | Arteries | Endothelium | Research Papers | small-conductance calcium-activated K+ channel (SKca)
Journal Article
Clinical and Experimental Pharmacology and Physiology, ISSN 0305-1870, 02/2008, Volume 35, Issue 2, pp. 192 - 200
SUMMARY • The present study evaluated the effect of diabetes, hypercholesterolaemia and their combination on the contribution of nitric oxide (NO) and... 
endothelium-derived hyperpolarising factor | diabetes | endothelium-dependent relaxation | hypercholesterolaemia | superoxide anion | endothelium‐derived hyperpolarising factor | endothelium‐dependent relaxation | Superoxide anion | Diabetes | Hypercholesterolaemia | Endothelium-dependent relaxation | Endothelium-derived hyperpolarising factor | PHYSIOLOGY | ACETYLCHOLINE | NITRIC-OXIDE SYNTHASE | MESENTERIC-ARTERY | MELLITUS | SODIUM-NITROPRUSSIDE | NAD(P)H OXIDASE | DISEASE | PHARMACOLOGY & PHARMACY | SMOOTH-MUSCLE-CELLS | DYSFUNCTION | Body Weight | Oxidative Stress | Cholesterol - blood | Diabetes Mellitus, Type 1 - metabolism | Nitric Oxide Synthase - antagonists & inhibitors | Male | Guanylate Cyclase - antagonists & inhibitors | Nitroprusside - pharmacology | Apamin - pharmacology | Dose-Response Relationship, Drug | Quinoxalines - pharmacology | Charybdotoxin - pharmacology | Oxadiazoles - pharmacology | Potassium Channels, Calcium-Activated - metabolism | Superoxides - metabolism | Aorta, Thoracic - drug effects | Biological Factors - metabolism | Diabetes Mellitus, Experimental - metabolism | Potassium Channel Blockers - pharmacology | Diabetes Mellitus, Experimental - physiopathology | Disease Models, Animal | Vasodilator Agents - pharmacology | Acetylcholine - pharmacology | Diabetes Mellitus, Type 1 - physiopathology | Enzyme Inhibitors - pharmacology | Aorta, Thoracic - metabolism | Rats | Guanylate Cyclase - metabolism | Soluble Guanylyl Cyclase | Aorta, Thoracic - physiopathology | Rats, Sprague-Dawley | Indomethacin - pharmacology | Cyclooxygenase Inhibitors - pharmacology | Nitroarginine - pharmacology | Aorta, Thoracic - enzymology | Animals | Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors | Hypercholesterolemia - physiopathology | Nitric Oxide Synthase - metabolism | Potassium Channels, Calcium-Activated - antagonists & inhibitors | Vasodilation - drug effects | Blood Glucose - metabolism | Nitric Oxide - metabolism | Hypercholesterolemia - metabolism | Receptors, Cytoplasmic and Nuclear - metabolism | Charybdotoxin, pharmacology | Diabetes Mellitus, Type 1, physiopathology | Nitric Oxide Synthase, antagonists and inhibitors | Aorta, Thoracic, physiopathology | Potassium Channels, Calcium-Activated, antagonists and inhibitors | Hypercholesterolemia, metabolism | Quinoxalines, pharmacology | Enzyme Inhibitors, pharmacology | Aorta, Thoracic, drug effects | Aorta, Thoracic, metabolism | Receptors, Cytoplasmic and Nuclear, antagonists and inhibitors | Vasodilator Agents, pharmacology | Vasodilation | Nitric Oxide Synthase, metabolism | Cyclooxygenase Inhibitors, pharmacology | Apamin, pharmacology | Nitroarginine, pharmacology | Potassium Channel Blockers, pharmacology | Vasodilation, drug effects | Cholesterol, blood | Receptors, Cytoplasmic and Nuclear, metabolism | Biological Factors, metabolism | Diabetes Mellitus, Experimental, physiopathology | Nitric Oxide, metabolism | Acetylcholine, pharmacology | Diabetes Mellitus, Experimental, metabolism | Nitroprusside, pharmacology | Oxadiazoles, pharmacology | Blood Glucose, metabolism | Potassium Channels, Calcium-Activated, metabolism | Aorta, Thoracic, enzymology | Hypercholesterolemia, physiopathology | Diabetes Mellitus, Type 1, metabolism | Guanylate Cyclase, antagonists and inhibitors | Guanylate Cyclase, metabolism | Superoxides, metabolism | Indomethacin, pharmacology | Superoxide | Hypercholesterolemia | Endothelium-derived relaxing factors | Type 1 diabetes | Endothelium
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 2006, Volume 531, Issue 1, pp. 87 - 95
The possible participation of the nitric oxide (NO)-cyclic GMP-protein kinase G (PKG) pathway on gabapentin-induced spinal antiallodynic activity was assessed... 
Pinacidil | Gabapentin | Nitric oxide | Protein kinase G | Diazoxide | Guanylyl cyclase | K + channel opener | Neuropathic pain | channel opener | SENSITIVE POTASSIUM CHANNELS | nitric oxide | TACTILE ALLODYNIA | K+ channel opener | RANDOMIZED CONTROLLED-TRIAL | NERVE INJURY | VASCULAR SMOOTH-MUSCLE | guanylyl cyclase | neuropathic pain | gabapentin | diazoxide | pinacidil | RABBIT VENTRICULAR MYOCYTES | PHARMACOLOGY & PHARMACY | protein kinase G | UP-REGULATION | CALCIUM-CHANNEL | PERIPHERAL ANTINOCICEPTIVE ACTION | Analgesics - pharmacology | Okadaic Acid - pharmacology | Potassium Channels - physiology | Pinacidil - administration & dosage | Cyclic GMP-Dependent Protein Kinases - antagonists & inhibitors | Glyburide - pharmacology | Time Factors | Charybdotoxin - pharmacology | Oxadiazoles - pharmacology | Potassium Channel Blockers - pharmacology | Spinal Nerves - injuries | Spinal Nerves - physiopathology | Enzyme Inhibitors - pharmacology | Cyclohexanecarboxylic Acids - administration & dosage | Rats | gamma-Aminobutyric Acid - pharmacology | Indazoles - pharmacology | NG-Nitroarginine Methyl Ester - chemistry | Cyclic GMP - metabolism | Signal Transduction - drug effects | Pain - physiopathology | Nitric Oxide Synthase - metabolism | Carbazoles - pharmacology | Amines - pharmacology | Diazoxide - administration & dosage | Cyclic GMP - antagonists & inhibitors | Diazoxide - pharmacology | Rats, Wistar | Stereoisomerism | Nitric Oxide Synthase - antagonists & inhibitors | gamma-Aminobutyric Acid - administration & dosage | Apamin - pharmacology | Cyclic GMP-Dependent Protein Kinases - metabolism | Dose-Response Relationship, Drug | Quinoxalines - pharmacology | Amines - administration & dosage | Female | Indoles - pharmacology | Injections, Spinal | NG-Nitroarginine Methyl Ester - pharmacology | Pinacidil - pharmacology | Vasodilator Agents - pharmacology | Pain - prevention & control | Nitric Oxide - antagonists & inhibitors | Analgesics - administration & dosage | Animals | Cyclohexanecarboxylic Acids - pharmacology | Signal Transduction - physiology | Protein Kinase Inhibitors - pharmacology | Nitric Oxide - metabolism | Vasodilator Agents - administration & dosage
Journal Article
Neuroscience, ISSN 0306-4522, 2005, Volume 131, Issue 3, pp. 717 - 731
The olfactory bulb, first relay of olfactory pathways, is densely innervated by serotoninergic centrifugal fibers originating from the raphe nuclei. Although... 
5HT | 5HT 2A receptors | 5HT 2C receptors | olfactory bulb | rat | whole-cell recordings | Olfactory bulb | receptors | Rat | Whole-cell recordings | 5HT(2A) receptors | RETROGRADE AXONAL-TRANSPORT | SEROTONERGIC MODULATION | 5HT(2C) receptors | 5-HT2A RECEPTOR | NEUROSCIENCES | CEREBRAL-CORTEX | DEFINED NEURON GROUPS | NERVE-TERMINALS | GLOMERULAR LAYER | RECIPROCAL SYNAPSES | NEONATE RAT | ACTIVATED CATION CURRENT | Free Radical Scavengers - pharmacology | Rats, Wistar | Electrophysiology | Membrane Potentials - radiation effects | Methysergide - pharmacology | Apamin - pharmacology | Serotonin - pharmacology | Patch-Clamp Techniques - methods | Mianserin - pharmacology | Neurons - classification | Olfactory Pathways - physiology | Drug Interactions | Kynurenic Acid - pharmacology | Neurons - drug effects | Nickel - pharmacology | Olfactory Pathways - drug effects | Electric Stimulation - methods | 4-Aminopyridine - pharmacology | Potassium Channel Blockers - pharmacology | Olfactory Bulb - cytology | Animals, Newborn | Membrane Potentials - drug effects | Benzodiazepines - pharmacology | Chlorides - pharmacology | Rats | Logistic Models | Excitatory Amino Acid Antagonists - pharmacology | Bicuculline - pharmacology | Membrane Potentials - physiology | Serotonin Antagonists - pharmacology | GABA Antagonists - pharmacology | Cesium - pharmacology | Animals | In Vitro Techniques | Olfactory Pathways - radiation effects | Dose-Response Relationship, Radiation | Olfactory Bulb - drug effects
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 11/2001, Volume 134, Issue 5, pp. 1003 - 1012
The effects of the endocannabinoid, anandamide, and its metabolically stable analogue, methanandamide, on induced tone were examined in sheep coronary artery... 
endothelium | sheep coronary arteries | channels | arachidonic acid metabolites, K | relaxation | Anandamide | Arachidonic acid metabolites | Relaxation | Sheep coronary arteries | Endothelium | arachidonic acid metabolites | CELLS | RAT | BIOCHEMISTRY & MOLECULAR BIOLOGY | SENSORY NERVES MEDIATE | CANNABINOID RECEPTORS | ISOLATED MESENTERIC-ARTERY | HYPERPOLARIZING FACTOR | VASORELAXANT | VANILLOID RECEPTORS | K+ channels | NITRIC-OXIDE | PHARMACOLOGY & PHARMACY | anandamide | TRANSPORT INHIBITOR | Tetraethylammonium - pharmacology | Arachidonic Acid - metabolism | Cytochrome P-450 Enzyme Inhibitors | Capsaicin - pharmacology | Potassium Channels - physiology | Nitric Oxide Synthase - antagonists & inhibitors | Apamin - pharmacology | Cannabinoid Receptor Modulators | Endothelium, Vascular - physiology | Dose-Response Relationship, Drug | Polyunsaturated Alkamides | Glyburide - pharmacology | Piperidines - pharmacology | Phenylmethylsulfonyl Fluoride - pharmacology | Potassium Channel Blockers | 4-Aminopyridine - pharmacology | Endocannabinoids | Pyrazoles - pharmacology | NG-Nitroarginine Methyl Ester - pharmacology | Vasoconstrictor Agents - pharmacology | Coronary Vessels - drug effects | Coronary Vessels - physiology | Enzyme Inhibitors - pharmacology | Capsaicin - analogs & derivatives | Fatty Acids, Unsaturated - pharmacology | Barium - pharmacology | Calcium Channel Blockers - pharmacology | Potassium - pharmacology | Arachidonic Acids - pharmacology | Indomethacin - pharmacology | Cannabinoids - pharmacology | Peptides - pharmacology | Animals | Miconazole - pharmacology | 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid - pharmacology | Sheep | Vasodilation - drug effects | In Vitro Techniques | Receptors, Drug - antagonists & inhibitors | Papers | arachidonic acid metabolites, K+ channels
Journal Article
Journal of Cardiovascular Pharmacology, ISSN 0160-2446, 09/2004, Volume 44, Issue 3, pp. 302 - 309
The mechanisms involved in the cardioprotector effect of red wine have not yet been completely elucidated but probably an endothelium-dependent vasodilator... 
Antihypertensive | EDHF | Brazilian red wine | Vasodilation | Endothelium | Flavonoids - antagonists & inhibitors | Male | Nitroglycerin - pharmacology | Yohimbine - pharmacology | Glyburide - pharmacology | Charybdotoxin - pharmacology | Oxadiazoles - pharmacology | Phenols - antagonists & inhibitors | Brazil | Polyphenols | Wine - adverse effects | Muscle, Smooth, Vascular - drug effects | Phenols - pharmacology | Administration, Oral | Rats | Atropine - pharmacology | Pressure | Vasoconstriction - drug effects | Indomethacin - pharmacology | Phenols - analysis | Pyrilamine - pharmacology | Perfusion | Vasodilation - drug effects | Quinazolines - pharmacology | Bradykinin - analogs & derivatives | Norepinephrine - pharmacology | Flavonoids - analysis | Rats, Wistar | Nitric Oxide Synthase - antagonists & inhibitors | Mesenteric Arteries - drug effects | Guanylate Cyclase - antagonists & inhibitors | Apamin - pharmacology | Endothelium, Vascular - physiology | Quinoxalines - pharmacology | Hypertension - chemically induced | Potassium Chloride - pharmacology | Hypertension - prevention & control | Clonidine - pharmacology | Blood Pressure - drug effects | Flavonoids - pharmacology | Vasodilation - physiology | Drug Therapy, Combination | Oxadiazoles - chemistry | Quinazolines - chemistry | Bradykinin - pharmacology | Acetylcholine - pharmacology | NG-Nitroarginine Methyl Ester - adverse effects | Alcohol Drinking - adverse effects | Clonidine - antagonists & inhibitors | Animals | Deoxycholic Acid - pharmacology | Acetylcholine - antagonists & inhibitors
Journal Article