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index medicus (565) 565
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expression (118) 118
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angiogenesis (78) 78
blood-pressure (77) 77
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intercellular signaling peptides and proteins (76) 76
hypertension (73) 73
ligand (71) 71
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peptides (69) 69
physiology (69) 69
adult (66) 66
analysis (65) 65
carrier proteins - metabolism (65) 65
intercellular signaling peptides and proteins - pharmacology (65) 65
rats, sprague-dawley (63) 63
proteins (61) 61
heart-failure (60) 60
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carrier proteins - genetics (58) 58
heart (57) 57
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insulin (52) 52
medicine, research & experimental (52) 52
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pharmacology & pharmacy (52) 52
apoptosis (51) 51
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article (50) 50
disease models, animal (50) 50
endogenous ligand apelin (50) 50
inflammation (50) 50
diabetes (49) 49
cardiac & cardiovascular systems (48) 48
insulin resistance (48) 48
peripheral vascular disease (48) 48
messenger-rna (47) 47
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cell proliferation (42) 42
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peptide apelin (42) 42
blood pressure (41) 41
rna, messenger - genetics (41) 41
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reverse transcriptase polymerase chain reaction (40) 40
abridged index medicus (39) 39
human apj receptor (39) 39
hypoxia (39) 39
risk factors (39) 39
cells (38) 38
up-regulation (38) 38
amino acid sequence (37) 37
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PLoS ONE, ISSN 1932-6203, 12/2012, Volume 7, Issue 12, pp. e51123 - e51123
Background: Via sequencing the genes of apelin/angiotensin receptor-like 1 (apelin/APJ) pathway, we have recently identified and validated four common... 
SYSTEM | AGTRL1 GENE | MULTIDISCIPLINARY SCIENCES | HEART-FAILURE | IN-VIVO | SUSCEPTIBILITY | MULTIFACTOR DIMENSIONALITY REDUCTION | ORPHAN RECEPTOR | APJ | HAN CHINESE | GENOME-WIDE ASSOCIATION | Multifactor Dimensionality Reduction | Gene Frequency - genetics | Humans | Middle Aged | Asian Continental Ancestry Group - genetics | Genetic Loci - genetics | Male | Case-Control Studies | Haplotypes - genetics | China | Female | Hypertension - genetics | Apelin | Biomarkers - metabolism | Genetic Predisposition to Disease | Genetic Association Studies | Intercellular Signaling Peptides and Proteins - genetics | Signal Transduction - genetics | Genome, Human - genetics | Epistasis, Genetic | Apelin Receptors | Coronary Artery Disease - complications | Coronary Artery Disease - genetics | Hypertension - complications | Polymorphism, Single Nucleotide - genetics | Receptors, G-Protein-Coupled - genetics | Type 2 diabetes | Hypertension | Medical research | Analysis | Genes | Medicine, Experimental | Development and progression | Genetic aspects | Research | Coronary heart disease | Laboratories | Genomics | Cardiovascular disease | Genomes | Gender | Males | Gene sequencing | Defects | Regression models | Cardiology | Heart diseases | Genotypes | Hypothesis testing | Medical imaging | Fasting | Coronary artery | Health risks | Data processing | Regression analysis | Coronary artery disease | Patients | Cholesterol | Medicine | Studies | Hypotheses | Hospitals | Gene frequency | Coronary vessels | Angiotensin | Ligands | Females | Binding sites | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 08/2017, Volume 548, Issue 7669, pp. 537 - 542
Somatic gene mutations can alter the vulnerability of cancer cells to T-cell-based immunotherapies. Here we perturbed genes in human melanoma cells to mimic... 
CELL LUNG-CANCER | METASTATIC MELANOMA | DIFFERENTIAL GENE | CTLA-4 BLOCKADE | PD-1 BLOCKADE | MULTIDISCIPLINARY SCIENCES | ENDOTHELIAL-CELLS | RECEPTOR | T-CELLS | GENOME | LYMPHOCYTES | Neoplasms - metabolism | Humans | Genome - genetics | Adoptive Transfer | Janus Kinase 1 - metabolism | T-Lymphocytes, Cytotoxic - drug effects | Apelin - metabolism | Neoplasms - therapy | Apelin Receptors - genetics | Neoplasms - genetics | Melanoma - genetics | Immunotherapy | Female | Genes, Essential - genetics | Melanoma - metabolism | T-Lymphocytes, Cytotoxic - immunology | Knowledge Bases | Reproducibility of Results | Histocompatibility Antigens Class I - immunology | Antigen Presentation - genetics | CRISPR-Cas Systems - genetics | Apelin Receptors - metabolism | Animals | T-Lymphocytes, Cytotoxic - metabolism | Melanoma - immunology | Neoplasms - immunology | Interferon-gamma - immunology | Cell Line, Tumor | Mice | Mutation | Melanoma - therapy | Care and treatment | Genetic aspects | Nucleotide sequencing | Methods | DNA sequencing | Cancer | Cytolytic activity | Animal models | CD8 antigen | Genes | Genomics | Effector cells | Genomes | Lymphocytes T | Kinases | Cancer therapies | Lymphocytes | Janus kinase | Antigen presentation | Antigens | CRISPR | Melanoma | T cell receptors | Tumor cell lines | Signaling | Immune checkpoint | γ-Interferon | Interferon | Tumors | Index Medicus
Journal Article
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 02/2014, Volume 306, Issue 4, pp. H585 - H597
Microvascular insufficiency contributes to cardiac hypertrophy and worsens heart dysfunction in diabetic cardiomyopathy. Our recent study shows that apelin may... 
VEGF/VEGFR2 | Diabetic cardiomyopathy | Angiogenesis | Sirtuin 3 | Ang-1/Tie-2 | Apelin | NADPH OXIDASE | METABOLIC SYNDROME | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | apelin | sirtuin 3 | angiogenesis | HEART-FAILURE | diabetic cardiomyopathy | TUMOR ANGIOGENESIS | PEPTIDE APELIN | IMPAIRED ANGIOGENESIS | CARDIAC-HYPERTROPHY | PERIPHERAL VASCULAR DISEASE | ORPHAN RECEPTOR APJ | EXPRESSION | ENDOTHELIAL GROWTH-FACTOR | Diabetic Cardiomyopathies - metabolism | Reactive Oxygen Species - metabolism | Sirtuin 3 - metabolism | Male | Vascular Endothelial Growth Factor A - metabolism | Angiopoietin-1 - metabolism | Vascular Endothelial Growth Factor A - genetics | Angiopoietin-2 - metabolism | Diabetic Cardiomyopathies - physiopathology | Receptors, Vascular Endothelial Growth Factor - metabolism | Myocardium - metabolism | Neovascularization, Pathologic - physiopathology | Receptor, TIE-2 - metabolism | Diabetic Cardiomyopathies - therapy | Receptors, Vascular Endothelial Growth Factor - genetics | Neovascularization, Pathologic - therapy | Heart - physiopathology | Sirtuin 3 - genetics | Endothelium, Vascular - physiopathology | Intercellular Signaling Peptides and Proteins - genetics | Up-Regulation - genetics | Adipokines | Receptor, TIE-2 - genetics | Diabetic Cardiomyopathies - genetics | Angiopoietin-1 - genetics | Animals | Endothelium, Vascular - metabolism | Neovascularization, Pathologic - genetics | Mice | Neovascularization, Pathologic - metabolism | Apoptosis - physiology | Prevention | Cardiomyopathy | Physiological aspects | Genetic research | Genetic aspects | Research | Diabetes | Gene therapy | Heart diseases | Heart failure | Rodents | Glucose | Apoptosis | Index Medicus | VEGFR2 | Tie-2 | VEGF | Ang-1 | Integrative Cardiovascular Physiology and Pathophysiology
Journal Article
Journal of the American Society of Nephrology, ISSN 1046-6673, 09/2017, Volume 28, Issue 9, pp. 2694 - 2707
Renal ischemia-reperfusion (I/R) injury is the most common cause of AKI, which associates with high mortality and has no effective therapy. ELABELA (ELA) is a... 
ISCHEMIA-REPERFUSION INJURY | ACUTE KIDNEY INJURY | APOPTOSIS | DNA-DAMAGE RESPONSE | INFLAMMATION | UROLOGY & NEPHROLOGY | ACUTE-RENAL-FAILURE | ENDOPLASMIC-RETICULUM STRESS | RETINAL INJURY | APELIN RECEPTOR | PROXIMAL TUBULE | Cell Adhesion Molecules - genetics | Peptide Hormones - pharmacology | Phosphorylation | Ataxia Telangiectasia Mutated Proteins - metabolism | Gene Expression - drug effects | Apoptosis - drug effects | Humans | Tumor Necrosis Factor-alpha - genetics | Peptide Fragments - pharmacology | Acute Kidney Injury - genetics | Hepatitis A Virus Cellular Receptor 1 - genetics | Phosphoproteins - metabolism | RNA, Messenger - metabolism | Autophagy - drug effects | Cell Hypoxia | Carrier Proteins - pharmacology | Carrier Proteins - therapeutic use | Peptide Fragments - genetics | Reperfusion Injury - genetics | Reperfusion Injury - metabolism | Cell Line | Cell Survival - drug effects | DNA Repair - drug effects | Interleukin-6 - genetics | Rats | Transforming Growth Factor beta1 - genetics | Acute Kidney Injury - physiopathology | Acute Kidney Injury - prevention & control | Kidney Tubules - cytology | Carrier Proteins - genetics | Checkpoint Kinase 1 - metabolism | Animals | Reperfusion Injury - prevention & control | Intercellular Adhesion Molecule-1 - genetics | Reperfusion Injury - physiopathology | Inflammation - genetics | Peptide Hormones - therapeutic use | Inflammation - prevention & control | Mice | Peptide Fragments - therapeutic use | Histones - metabolism | Acute Kidney Injury - metabolism | Index Medicus | acute kidney injury | ELABELA | DNA damage response | inflammation | Basic Research
Journal Article
Molecular Therapy, ISSN 1525-0016, 03/2018, Volume 26, Issue 3, pp. 902 - 916
Despite considerable advances in cardiovascular disease treatment, heart failure remains a public health challenge. In this context, gene therapy appears as an... 
combined therapy | SERCA2 | lentivector | gene transfer | apelin | IRES | angiogenesis | ischemic heart disease | fibrosis | FGF2 | SYSTEM | MEDICINE, RESEARCH & EXPERIMENTAL | FAILURE | TRIAL | INFARCTION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | DISEASE | GROWTH | GENETICS & HEREDITY | UP-REGULATION | EXPRESSION | VECTORS | Myocardial Ischemia - genetics | Gene Transfer Techniques | Genetic Therapy | Gene Expression | Transduction, Genetic | Endothelial Cells - metabolism | Transcriptome | Gene Regulatory Networks | Genetic Vectors - genetics | Apelin - genetics | Myocardial Ischemia - pathology | Cardiomegaly | Animals | Fibroblast Growth Factor 2 - genetics | Fibrosis | Myocardial Ischemia - therapy | Lentivirus - genetics | Neovascularization, Pathologic - genetics | Mice | Neovascularization, Pathologic - metabolism | Sarcoplasmic Reticulum Calcium-Transporting ATPases - genetics | Gene Order | Disease Models, Animal | Myocardial infarction | Fibroblast growth factor | Clinical trials | Recovery of function | Cancer therapies | Experiments | Ca2+-transporting ATPase | Design | Angiogenesis | Scholarships & fellowships | Ischemia | Heart diseases | Growth factors | Public health | Heart failure | Fibroblast growth factor 2 | Contractility | Gene expression | Muscle contraction | Vectors (Biology) | Coronary artery disease | Coronary vessels | Software | Gene therapy | Cardiovascular diseases | Hypertrophy | Index Medicus | Biotechnology | Endothelial Cells | Biochemistry, Molecular Biology | Neovascularization, Pathologic | Myocardial Ischemia | Sarcoplasmic Reticulum Calcium-Transporting ATPases | Lentivirus | Life Sciences | Fibroblast Growth Factor 2 | Genetic Vectors | Apelin | Original
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/2012, Volume 287, Issue 6, pp. 4188 - 4197
In obesity, rapidly expanding adipose tissue becomes hypoxic, precipitating inflammation, fibrosis, and insulin resistance. Compensatory angiogenesis may... 
INSULIN | CELLS | GLUCOCORTICOID-RECEPTOR | INDUCIBLE FACTOR 1-ALPHA | PATHWAY | INFLAMMATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | INDUCED VISCERAL OBESITY | GENE-EXPRESSION | HIF-1-ALPHA | TISSUE HYPOXIA | Actins - metabolism | Male | Smad3 Protein - metabolism | Vascular Endothelial Growth Factor A - metabolism | PPAR gamma - metabolism | Vascular Endothelial Growth Factor A - genetics | Actins - genetics | Intercellular Signaling Peptides and Proteins - metabolism | Smad3 Protein - genetics | Angiopoietin-like 4 Protein | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Apelin | PPAR gamma - genetics | Angiopoietins - metabolism | Fibrosis - genetics | Hypoxia - enzymology | Fibrosis - enzymology | Fibrosis - physiopathology | Signal Transduction | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Adipose Tissue - pathology | Intercellular Signaling Peptides and Proteins - genetics | Obesity - physiopathology | Adipokines | Mice, Knockout | Obesity - pathology | 11-beta-Hydroxysteroid Dehydrogenase Type 1 - metabolism | Animals | Transforming Growth Factor beta - genetics | Adipose Tissue - blood supply | Hypoxia - pathology | Insulin Resistance - genetics | Weight Gain - genetics | Hypoxia - physiopathology | Adipose Tissue - enzymology | Mice | Obesity - enzymology | Angiopoietins - genetics | Transforming Growth Factor beta - metabolism | Neovascularization, Physiologic | Index Medicus | Molecular Bases of Disease | Angiogenesis | Glucocorticoids | Extracellular Matrix Proteins | Collagen | Fibrosis | Hypoxia | Adipose Tissue | Fibroblast
Journal Article
Developmental Cell, ISSN 1534-5807, 2007, Volume 12, Issue 3, pp. 403 - 413
While many factors that modulate the morphogenesis and patterning of the embryonic heart have been identified, relatively little is known about the molecular... 
HUMDISEASE | DEVBIO | VASCULAR DEVELOPMENT | MIGRATION | HEART PRECURSOR CELLS | XENOPUS-LAEVIS | CARDIOVASCULAR DEVELOPMENT | TRANSGENIC ZEBRAFISH | APJ RECEPTOR | GENE | IN-VIVO | APELIN | DEVELOPMENTAL BIOLOGY | CELL BIOLOGY | Receptors, G-Protein-Coupled - metabolism | Xenopus Proteins - genetics | Heart - embryology | Gene Expression Regulation, Developmental - genetics | Mesoderm - cytology | Cell Movement - genetics | Cell Differentiation - genetics | Intercellular Signaling Peptides and Proteins - metabolism | Myocardium - metabolism | Receptors, G-Protein-Coupled - physiology | Myoblasts, Cardiac - cytology | Intercellular Signaling Peptides and Proteins - genetics | Zebrafish | Gastrula - cytology | Mutation - genetics | Zebrafish Proteins - physiology | Myoblasts, Cardiac - metabolism | Myocardium - cytology | Animals | Animals, Genetically Modified - embryology | Animals, Genetically Modified - genetics | Organogenesis - genetics | Apelin Receptors | Gastrula - metabolism | Xenopus Proteins - metabolism | Mesoderm - metabolism | Receptors, G-Protein-Coupled - genetics | Zebrafish Proteins - genetics | Index Medicus | Heart | Animals, Genetically Modified | Intercellular Signaling Peptides and Proteins | Receptors, G-Protein-Coupled | Zebrafish Proteins | Mesoderm | Xenopus Proteins | Organogenesis | Gene Expression Regulation, Developmental | Gastrula | Myoblasts, Cardiac | Myocardium | Cell Differentiation | Mutation | Cell Movement
Journal Article
Science, ISSN 0036-8075, 2017, Volume 357, Issue 6352, pp. 707 - +
Journal Article
Journal Article