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Journal of Endocrinology, ISSN 0022-0795, 2013, Volume 219, Issue 1, pp. R13 - R35
The apelin receptor (APJ; gene symbol APLNR) is a member of the G protein-coupled receptor gene family. Neural gene expression patterns of APJ, and its cognate... 
G protein-coupled receptor | Homeostasis | APJ | Apelin | ENDOGENOUS LIGAND APELIN | apelin | MESSENGER-RNA EXPRESSION | RIBONUCLEIC-ACID EXPRESSION | ANGIOTENSIN-CONVERTING ENZYME | VASCULAR SMOOTH-MUSCLE | HYPOTHALAMIC PARAVENTRICULAR NUCLEUS | INSULIN-RESISTANT MICE | homeostasis | PROTEIN-COUPLED RECEPTOR | CENTRALLY-ADMINISTERED APELIN-13 | ENDOCRINOLOGY & METABOLISM | IMMUNODEFICIENCY-VIRUS TYPE-1 | Central Nervous System - metabolism | Reactive Oxygen Species - metabolism | Humans | Protein Multimerization | Neovascularization, Pathologic | Intercellular Signaling Peptides and Proteins - biosynthesis | Intercellular Signaling Peptides and Proteins - physiology | Tissue Distribution | Homeostasis - drug effects | Extracellular Signal-Regulated MAP Kinases - physiology | Receptors, G-Protein-Coupled - physiology | Amino Acid Sequence | Obesity | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Pituitary-Adrenal System - metabolism | Intercellular Signaling Peptides and Proteins - genetics | Rats | Receptors, G-Protein-Coupled - biosynthesis | Cardiovascular System - drug effects | Proto-Oncogene Proteins c-akt - physiology | Hypothalamo-Hypophyseal System - metabolism | Intercellular Signaling Peptides and Proteins - agonists | Animals | Apelin Receptors | Homeostasis - physiology | Phosphatidylinositol 3-Kinases - physiology | Signal Transduction - physiology | Mice | Nitric Oxide Synthase - metabolism | Receptors, G-Protein-Coupled - genetics | Receptors, G-Protein-Coupled - chemistry
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 09/2012, Volume 303, Issue 5, pp. 605 - 618
Apelin is an endogenous ligand for the angiotensin-like 1 receptor (APJ) and has beneficial effects against myocardial ischemia-reperfusion injury. Little is... 
Stromal cell-derived factor-1α/C-X-C chemokine receptor-4 | Vascular progenitor cell | Myocardial repair | c-kit | Jagged1/notch3 | ISCHEMIA/REPERFUSION INJURY | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | c-Kit | ANGIOGENESIS | HEART-FAILURE | myocardial repair | vascular progenitor cell | APJ RECEPTOR | PROTEIN-COUPLED RECEPTOR | EMBRYONIC STEM-CELLS | PERIPHERAL VASCULAR DISEASE | LIGAND | stromal cell-derived factor-1 alpha/C-X-C chemokine receptor-4 | jagged1/notch3 | TOPCARE-AMI | ISCHEMIC-STROKE | PARACRINE | Apoptosis - drug effects | Receptors, Notch - metabolism | Cardiomegaly - pathology | Vascular Endothelial Growth Factor A - metabolism | Antigens, CD - metabolism | Peptides - metabolism | Time Factors | Serrate-Jagged Proteins | Antigens, Ly - metabolism | Myocardial Infarction - physiopathology | Proto-Oncogene Proteins c-akt - metabolism | Apelin | Disease Models, Animal | Jagged-1 Protein | Biomarkers - metabolism | Ventricular Function, Left - drug effects | Cardiomegaly - physiopathology | Cardiotonic Agents - pharmacology | Myocardial Infarction - metabolism | Receptors, CXCR4 - metabolism | Cell Movement - drug effects | Myocytes, Cardiac - pathology | Regeneration - drug effects | Cardiomegaly - prevention & control | Chemokine CXCL12 - metabolism | Myocytes, Cardiac - drug effects | Intercellular Signaling Peptides and Proteins - pharmacology | Fibrosis | Myocytes, Cardiac - metabolism | Stem Cells - pathology | Mice | Myocardial Infarction - genetics | Neovascularization, Physiologic - drug effects | Glycoproteins - metabolism | Proto-Oncogene Proteins c-kit - metabolism | Stem Cells - metabolism | Recovery of Function | Intercellular Signaling Peptides and Proteins - metabolism | Myocardial Infarction - pathology | Membrane Proteins - metabolism | Nitric Oxide Synthase Type III - metabolism | Calcium-Binding Proteins - metabolism | Mice, Inbred C57BL | Cells, Cultured | Adipokines | AC133 Antigen | Animals | Myocardial Infarction - drug therapy | Stem Cells - drug effects | Receptor, Notch3 | Physiological aspects | Care and treatment | Health aspects | Ligands (Biochemistry) | Heart attack | stromal cell-derived factor-1α | notch3 | Integrative Cardiovascular Physiology and Pathophysiology | jagged1 | C-X-C chemokine receptor-4
Journal Article
Journal Article
Blood, ISSN 0006-4971, 11/2010, Volume 116, Issue 19, pp. 4025 - 4033
Sprouting of developing blood vessels is mediated by specialized motile endothelial cells localized at the tips of growing capillaries. Following behind the... 
VASCULAR DEVELOPMENT | ANGIOGENIC FACTOR | FACTOR-BETA | BASEMENT-MEMBRANE FORMATION | IN-VIVO | NETWORK FORMATION | UROKINASE RECEPTOR | APELIN | DEFICIENT MICE | HEMATOLOGY | INHIBITS TUMOR-GROWTH | Multigene Family | Oligonucleotide Array Sequence Analysis | Receptors, G-Protein-Coupled - metabolism | TOR Serine-Threonine Kinases - metabolism | Extracellular Matrix - metabolism | Gene Expression Profiling | Intracellular Signaling Peptides and Proteins - metabolism | Intracellular Signaling Peptides and Proteins - deficiency | Membrane Proteins - deficiency | Retinal Vessels - cytology | Membrane Proteins - metabolism | Capillaries - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Vascular Endothelial Growth Factor A - pharmacology | Apelin | Retinal Vessels - metabolism | Signal Transduction | Endothelial Cells - metabolism | Membrane Proteins - genetics | Neovascularization, Physiologic - genetics | Intercellular Signaling Peptides and Proteins | Mice, Inbred C57BL | Zebrafish | Adipokines | Capillaries - growth & development | Haploinsufficiency | Mice, Knockout | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Receptors, G-Protein-Coupled - deficiency | Capillaries - cytology | Endothelial Cells - cytology | Retinal Vessels - growth & development | Apelin Receptors | Mice | Receptors, G-Protein-Coupled - genetics | Endothelial Cells - drug effects | Vascular Biology
Journal Article
Nature, ISSN 0028-0836, 08/2012, Volume 488, Issue 7411, pp. 394 - 398
Cardiac hypertrophy is initiated as an adaptive response to sustained overload but progresses pathologically as heart failure ensues(1). Here we report that... 
PROTEIN | CONTRACTILITY | MYOCYTES | STRETCH | MULTIDISCIPLINARY SCIENCES | IN-VIVO | INVOLVEMENT | GENE-EXPRESSION | APELIN | ANGIOTENSIN-II | CARDIOMYOCYTES | Blood Pressure | Mechanotransduction, Cellular - drug effects | Receptors, G-Protein-Coupled - metabolism | Arrestins - genetics | Cardiomegaly - pathology | Male | Receptors, G-Protein-Coupled - agonists | Mechanotransduction, Cellular - physiology | Arrestins - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Female | Intercellular Signaling Peptides and Proteins - deficiency | Mechanoreceptors - metabolism | Apelin | Mice, Inbred C57BL | Intercellular Signaling Peptides and Proteins - genetics | Cardiomegaly - physiopathology | Adipokines | Mice, Knockout | Aorta - pathology | Myocytes, Cardiac - pathology | Animals | Cardiomegaly - prevention & control | Myocytes, Cardiac - drug effects | Receptors, G-Protein-Coupled - deficiency | Signal Transduction - drug effects | Intercellular Signaling Peptides and Proteins - pharmacology | beta-Arrestins | Apelin Receptors | Mice | Receptors, G-Protein-Coupled - genetics | Arrestins - deficiency | GTP-Binding Protein alpha Subunits, Gi-Go - metabolism | Cardiomegaly - metabolism | Genetically modified mice | Physiological aspects | Development and progression | Research | Heart enlargement | Proteins | Heart failure | Cardiomyocytes | Kinases | Laboratory animals | Rodents
Journal Article
Nature, ISSN 0028-0836, 08/2017, Volume 548, Issue 7669, pp. 537 - 542
Somatic gene mutations can alter the vulnerability of cancer cells to T-cell-based immunotherapies. Here we perturbed genes in human melanoma cells to mimic... 
CELL LUNG-CANCER | METASTATIC MELANOMA | DIFFERENTIAL GENE | CTLA-4 BLOCKADE | PD-1 BLOCKADE | MULTIDISCIPLINARY SCIENCES | ENDOTHELIAL-CELLS | RECEPTOR | T-CELLS | GENOME | LYMPHOCYTES | Neoplasms - metabolism | Humans | Genome - genetics | Adoptive Transfer | Janus Kinase 1 - metabolism | T-Lymphocytes, Cytotoxic - drug effects | Apelin - metabolism | Neoplasms - therapy | Apelin Receptors - genetics | Neoplasms - genetics | Melanoma - genetics | Immunotherapy | Female | Genes, Essential - genetics | Melanoma - metabolism | T-Lymphocytes, Cytotoxic - immunology | Knowledge Bases | Reproducibility of Results | Histocompatibility Antigens Class I - immunology | Antigen Presentation - genetics | CRISPR-Cas Systems - genetics | Apelin Receptors - metabolism | Animals | T-Lymphocytes, Cytotoxic - metabolism | Melanoma - immunology | Neoplasms - immunology | Interferon-gamma - immunology | Cell Line, Tumor | Mice | Mutation | Melanoma - therapy | Care and treatment | Genetic aspects | Nucleotide sequencing | Methods | DNA sequencing | Cancer | Cytolytic activity | Animal models | CD8 antigen | Genes | Genomics | Effector cells | Genomes | Lymphocytes T | Kinases | Cancer therapies | Lymphocytes | Janus kinase | Antigen presentation | Antigens | CRISPR | Melanoma | T cell receptors | Tumor cell lines | Signaling | Immune checkpoint | γ-Interferon | Interferon | Tumors
Journal Article
Journal Article