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Biochemical Journal, ISSN 0264-6021, 01/2005, Volume 385, Issue 2, pp. 595 - 603
Previously, we have reported that overexpression of IHPK2 (inositol hexakisphosphate kinase 2) sensitized NIH-OVCAR-3 ovarian carcinoma cell lines to the... 
Translocation | Inositol hexakis-phosphate kinase 2 | Interferon | Ovarian carcinoma | Apo2L/tumour-necrosis-factor-related apoptosis-inducing ligand (Apo2L/TRAIL) | Apoptosis | translocation | BIOCHEMISTRY & MOLECULAR BIOLOGY | ovarian carcinoma | apoptosis | POLYPHOSPHATES | interferon | CELL-LINES | IDENTIFICATION | COMBINATION | IFN-ALPHA-2 | INTERFERON-ALPHA | CYTOTOXIC LIGAND TRAIL | INHIBITION | GROWTH | inositol hexakisphosphate kinase 2 | BINDING | Apo2L/tumour-necrosis-factor-related apoptosis inducing ligand (Apo2L/TRAIL) | Tumor Necrosis Factor-alpha - metabolism | Cell Proliferation | Membrane Glycoproteins - metabolism | Active Transport, Cell Nucleus - physiology | Apoptosis - drug effects | Humans | Membrane Glycoproteins - biosynthesis | Ovarian Neoplasms - pathology | Protein Transport - physiology | Antibodies, Blocking - pharmacology | Interferon-beta - physiology | Phosphotransferases (Phosphate Group Acceptor) - biosynthesis | TNF-Related Apoptosis-Inducing Ligand | Tumor Necrosis Factor-alpha - immunology | Female | Ovarian Neoplasms - metabolism | Phosphotransferases (Phosphate Group Acceptor) - metabolism | Membrane Glycoproteins - immunology | Carcinoma - pathology | Antibodies, Monoclonal - pharmacology | Apoptosis Regulatory Proteins | Signal Transduction - drug effects | Cell Line, Tumor | Signal Transduction - physiology | Apoptosis - physiology | Carcinoma - metabolism | Tumor Necrosis Factor-alpha - biosynthesis | IHPK2, inositol hexakisphosphate kinase 2 | TUNEL, terminal deoxynucleotidyl transferase-mediated dUTP nick-end labelling | TRAIL, Apo2L | mAb, monoclonal antibody | eGFP, enhanced green fluorescent protein | TdT, terminal deoxynucleotidyl transferase | DR, death receptor | Apo2L | HRP, horseradish peroxidase | IP6, inositol hexaphosphate | TNF-related apoptosis-inducing ligand | TNFα, tumour necrosis factor α | IFN, interferon | TRAIL | PI, propidium iodide | tumour-necrosis-factor-related apoptosis-inducing ligand (Apo2L | FBS, fetal bovine serum | Z-VAD, benzyloxycarbonylvalyl-alanyl-aspartic acid (O-methyl)-fluoromethylketone | DcR, decoy receptor | NLS, nuclear localization sequence | Ac-DEVD-AMC, acetyl-Asp-Glu-Val-Asp-amino-4-methylcoumarin | Ac-DEVD-CHO, acetyl-Asp-Glu-Val-Asp-aldehyde | GAP3DH, glyceraldehyde-3-phosphate dehydrogenase | HEK-293T cells, human embryonic kidney 293T cells
Journal Article
Cytokine and Growth Factor Reviews, ISSN 1359-6101, 2013, Volume 25, Issue 2, pp. 185 - 193
Journal Article
International journal of molecular sciences, ISSN 1422-0067, 01/2019, Volume 20, Issue 3, p. 525
One of the main problems in oncology is the development of drugs that cause the death of cancer cells without damaging normal cells. Another key problem to be... 
tumor-penetrating peptide iRGD | sorafenib | TRAIL/Apo2L | HT-1080 human fibrosarcoma cells | multicellular TRAIL-resistance | CANCER-CELLS | APOPTOSIS | TRAIL | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, MULTIDISCIPLINARY | Apo2L | TRANSPORT | RESISTANCE | CYTOTOXICITY
Journal Article
Cell Death and Differentiation, ISSN 1350-9047, 2014, Volume 21, Issue 9, pp. 1350 - 1364
Journal Article
Journal of Cellular Physiology, ISSN 0021-9541, 08/2019, Volume 234, Issue 8, pp. 13510 - 13524
Journal Article
Science Signaling, ISSN 1945-0877, 01/2017, Volume 10, Issue 462
Major barriers to cancer therapy include the lack of selective inhibitors of regulatory T cells (T-regs) and the lack of broadly applicable ways to directly... 
REGULATORY-CELLS | APO2L/TRAIL | NECROSIS-FACTOR RECEPTOR | COMPLEX | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMORADIOTHERAPY | PERIPHERAL-BLOOD | INDUCTION | EXPRESSION | FACTOR-ALPHA | CELL BIOLOGY
Journal Article
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 03/2010, Volume 16, Issue 6, pp. 1701 - 1708
Apoptosis is integral to normal, physiologic processes that regulate cell number and results in the removal of unnecessary or damaged cells. Apoptosis is... 
APO2L/TRAIL | APOPTOSIS | TRAIL | ONCOLOGY | HUMAN MONOCLONAL-ANTIBODY | MAPATUMUMAB | LIGAND | ANTITUMOR-ACTIVITY | COMBINATION | PHASE-I | TUMOR-CELL | Antineoplastic Agents - therapeutic use | Clinical Trials as Topic | Animals | Humans | Receptors, Death Domain - agonists | Neoplasms - drug therapy
Journal Article
Journal of Controlled Release, ISSN 0168-3659, 11/2015, Volume 217, pp. 160 - 169
Interstitial fluid pressure (IFP) is elevated in tumors and high IFP, a negative cancer prognosticator, is known to limit the uptake and efficacy of anti-tumor... 
Patient tumor xenograft | Drug uptake | Interstitial fluid pressure | Liposomes | Gemcitabine | Apo2L/TRAIL | CANCER-CELLS | SOLID TUMORS | PANCREATIC-CANCER | CHEMISTRY, MULTIDISCIPLINARY | APOPTOSIS-INDUCING LIGAND | DRUG PENETRATION | THERAPY | CLINICAL-IMPLICATIONS | BLOOD-VESSELS | PHARMACOLOGY & PHARMACY | TRAIL-INDUCED APOPTOSIS | HUMAN HEAD | Extracellular Fluid - physiology | Neoplasms - metabolism | Tumor Microenvironment - drug effects | Antimetabolites, Antineoplastic - pharmacokinetics | Apoptosis - drug effects | Deoxycytidine - administration & dosage | Humans | Mice, SCID | Deoxycytidine - blood | Extracellular Fluid - drug effects | Antimetabolites, Antineoplastic - administration & dosage | Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Antimetabolites, Antineoplastic - therapeutic use | Deoxycytidine - pharmacokinetics | Deoxycytidine - therapeutic use | Animals | Antimetabolites, Antineoplastic - blood | TNF-Related Apoptosis-Inducing Ligand - pharmacology | Tumor Burden - drug effects | Neoplasms - pathology | Deoxycytidine - analogs & derivatives | Antimitotic agents | Analysis | Therapeutics | Antineoplastic agents | Tumors | Homeopathy | Materia medica and therapeutics | Cancer | Apo2L | TRAIL | liposomes | patient tumor xenograft | interstitial fluid pressure | gemcitabine | drug uptake
Journal Article
Anticancer research, ISSN 0250-7005, 12/2017, Volume 37, Issue 12, pp. 6655 - 6665
Background/Aim: Targeting the extrinsic apoptotic pathway is an interesting option for anticancer therapy. A protein which such ability is Apo2 ligand, also... 
apoptosis | TRAIL | canine lymphoma cells | flavopiridol | APO2L/TRAIL | PROTEIN | DEATH | MECHANISMS | INDUCTION | IDENTIFICATION | CANCER | MEMBER | ONCOLOGY | RESISTANCE |