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Journal Article
Journal of Neuroscience, ISSN 0270-6474, 10/2012, Volume 32, Issue 43, pp. 15181 - 15192
Journal Article
Nature, ISSN 0028-0836, 09/2017, Volume 549, Issue 7673, pp. 523 - 527
APOE4 is the strongest genetic risk factor for late-onset Alzheimer disease. ApoE4 increases brain amyloid-beta pathology relative to other ApoE isoforms(1).... 
BRAIN ATROPHY | MICROGLIA | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | FRONTOTEMPORAL DEMENTIA | IN-VIVO | FRONTAL-LOBE DEMENTIA | EPSILON-4 | ASSOCIATION | APOLIPOPROTEIN-E | TRANSGENIC MICE | Tumor Necrosis Factor-alpha - metabolism | Inflammation - pathology | Microglia - metabolism | Neurons - pathology | Phosphorylation | Apolipoprotein E4 - genetics | Tauopathies - genetics | Coculture Techniques | Humans | Tauopathies - pathology | tau Proteins - metabolism | Phosphoproteins - metabolism | Inflammation - metabolism | Microglia - immunology | tau Proteins - genetics | Apolipoprotein E4 - deficiency | Phosphoproteins - analysis | Apolipoprotein E4 - toxicity | Neurons - metabolism | Neurons - drug effects | Disease Models, Animal | Cell Survival - drug effects | Apolipoprotein E4 - metabolism | Genotype | Mice, Transgenic | Phosphoproteins - genetics | Immunity, Innate | Disease Progression | Gene Knock-In Techniques | Mice, Knockout | Tauopathies - metabolism | Animals | Alleles | Inflammation - genetics | Mice | Nervous system | Development and progression | Degeneration | Models | Apolipoproteins | Health aspects | Tau proteins | Brain | Pathogenesis | Genomes | Autophagy | Neuronal-glial interactions | Risk factors | Atrophy | Neurodegeneration | Apolipoprotein E | Rodents | Aging | Alzheimer's disease | Genotypes | Recombinant | Apolipoprotein E4 | Neurodegenerative diseases | Neurons | Secretion | Health risks | Transgenic mice | Inflammation | Gene expression | Microglia | Pathology | Tau protein | Tumor necrosis factor | β-Amyloid | Alzheimers disease | Viability | Tumors | Dementia
Journal Article
Neuron, ISSN 0896-6273, 09/2017, Volume 96, Issue 1, pp. 115 - 129.e5
Diabetes and impaired brain insulin signaling are linked to the pathogenesis of Alzheimer’s disease (AD). The association between diabetes and AD-associated... 
Aggregation | Endosomal dysfunction | Alzheimer’s disease | Trafficking | Aging | APOE | Insulin signaling | Alzheimer's disease | DIABETES-MELLITUS | SKELETAL-MUSCLE | INTRANASAL INSULIN | GLUCOSE-METABOLISM | IMPROVES COGNITION | ALZHEIMERS-DISEASE | A-BETA | AMYLOID PRECURSOR PROTEIN | APOE-GENOTYPE | MILD COGNITIVE IMPAIRMENT | NEUROSCIENCES | Apolipoprotein E4 - genetics | Apolipoprotein E4 - metabolism | Insulin - physiology | Male | Mice, Transgenic | Neurons - cytology | Endosomes - metabolism | Mice, Knockout | Glycolysis - physiology | Apolipoprotein E3 - genetics | Animals | Aging - physiology | Insulin Resistance - physiology | Diet, High-Fat | Cell Respiration - physiology | Neurons - physiology | Female | Receptor, Insulin - metabolism | Mice | Neurons - metabolism | Primary Cell Culture | Mitochondria - physiology | Aging - metabolism | Insulin resistance | Apolipoproteins | Neurons | Insulin | Medical research | Medical colleges | Nervous system diseases | Neurosciences | Medicine, Experimental | Risk factors | Brain | Pathogenesis | Clinical trials | Nervous system | Glucose | Kinases | High fat diet | Signal transduction | Mitochondria | Rodents | Shinto | Amyloid | Protein transport | Age | Apolipoprotein E4 | Neurodegenerative diseases | Diabetes mellitus | Metabolism | Studies | Musculoskeletal system | Trapping | Glycolysis | Diabetes | Electron transport | Endosomes | Dementia
Journal Article
Nature, ISSN 0028-0836, 05/2012, Volume 485, Issue 7399, pp. 512 - 516
Journal Article
Journal Article
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/2012, Volume 287, Issue 8, pp. 5253 - 5266
Journal Article