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Immunity, ISSN 1074-7613, 09/2017, Volume 47, Issue 3, pp. 566 - 581.e9
Microglia play a pivotal role in the maintenance of brain homeostasis but lose homeostatic function during neurodegenerative disorders. We identified a... 
Alzheimer’s disease | multiple sclerosis | transcriptional regulation | neurodegeneration | TREM2 | APOE | amyotrophic lateral sclerosis | microglia | Alzheimer's disease | GENE-EXPRESSION SIGNATURE | ACTIVATION | MULTIPLE-SCLEROSIS | ALZHEIMERS-DISEASE | MOUSE MODEL | MACROPHAGE | MICE | IMMUNOLOGY | DEFICIENCY | APOLIPOPROTEIN-E | CELL-DEATH | Microglia - metabolism | Apolipoproteins E - deficiency | Membrane Glycoproteins - metabolism | Humans | Cerebral Cortex - pathology | Transcriptome | Apoptosis - genetics | Monocytes - metabolism | Gene Expression Profiling | Monocytes - immunology | Phagocytosis - genetics | Neurodegenerative Diseases - immunology | Apolipoproteins E - metabolism | Cerebral Cortex - metabolism | Alzheimer Disease - pathology | Microglia - immunology | Superoxide Dismutase-1 - metabolism | Amyloid beta-Peptides - metabolism | Amyloid beta-Protein Precursor - metabolism | Female | Neurons - metabolism | Disease Models, Animal | Gene Targeting | Plaque, Amyloid - pathology | Signal Transduction | Gene Expression Regulation | Phagocytosis - immunology | Immune Tolerance | Mice, Transgenic | Neurodegenerative Diseases - genetics | Neurodegenerative Diseases - metabolism | Mice, Knockout | Encephalomyelitis, Autoimmune, Experimental | Phenotype | Animals | Apoptosis - immunology | Apolipoproteins E - genetics | Alzheimer Disease - metabolism | Superoxide Dismutase-1 - genetics | Plaque, Amyloid - metabolism | Mice | Alzheimer Disease - genetics | Transforming Growth Factor beta - metabolism | Receptors, Immunologic - metabolism | Cluster Analysis | Nervous system diseases | Multiple sclerosis | Neurons | Analysis | Amyotrophic lateral sclerosis | Genetic aspects | Genetic transcription | Apolipoproteins | Brain | Animal models | Disease | Transcription | Genes | Homeostasis | Sclerosis | Proteins | Restoration | Neurodegeneration | Apolipoprotein E | Rodents | Plaques | Myeloid cells | Neurodegenerative diseases | Microglia | Neurological diseases | Molecular modelling | β-Amyloid | Phagocytosis | Apoptosis | Index Medicus
Journal Article
Science, ISSN 0036-8075, 6/2010, Volume 328, Issue 5985, pp. 1570 - 1573
Cholesterol metabolism is tightly regulated at the cellular level. Here we show that miR-33, an intronic microRNA (miRNA) located within the gene encoding... 
MicroRNA | Hepatocytes | HDL lipoproteins | Liver | Genes | REPORTS | Homeostasis | Gene expression regulation | Macrophages | Cholesterols | Endothelial cells | TANGIER-DISEASE | HDL | LIPID-METABOLISM | CASSETTE TRANSPORTER 1 | CELLULAR CHOLESTEROL | MULTIDISCIPLINARY SCIENCES | IN-VIVO | MUTATIONS | ATP Binding Cassette Transporter, Sub-Family G, Member 1 | Membrane Glycoproteins - metabolism | Cholesterol, Dietary - administration & dosage | Lipoproteins - genetics | Lipoproteins, HDL - blood | Humans | Lipoproteins, HDL - metabolism | MicroRNAs - metabolism | Transfection | ATP-Binding Cassette Transporters - genetics | Dietary Fats - administration & dosage | Lipoproteins - metabolism | ATP-Binding Cassette Transporters - metabolism | Sterol Regulatory Element Binding Protein 2 - genetics | Sterol Regulatory Element Binding Protein 2 - metabolism | ATP Binding Cassette Transporter 1 | Cell Line | Introns | Liver - metabolism | Mice, Inbred C57BL | Gene Expression Regulation | Apolipoprotein A-I - metabolism | Cholesterol - metabolism | Membrane Glycoproteins - genetics | Proteins - genetics | Carrier Proteins - genetics | Macrophages - metabolism | Animals | Carrier Proteins - metabolism | Proteins - metabolism | Mice | MicroRNAs - genetics | Hypercholesterolemia - genetics | Macrophages, Peritoneal - metabolism | Hypercholesterolemia - metabolism | Physiological aspects | Control | Research | High density lipoproteins | Cholesterol metabolism | Lipoproteins | Cellular biology | Ribonucleic acid--RNA | Gene expression | Cholesterol | Index Medicus
Journal Article
Cell Metabolism, ISSN 1550-4131, 2005, Volume 1, Issue 2, pp. 107 - 119
Fatty acid binding proteins (FABPs) are cytosolic fatty acid chaperones whose biological role and mechanisms of action are not well understood. Here, we... 
LEPTIN | TARGETED DISRUPTION | AP2 | ENDOCRINOLOGY & METABOLISM | WEIGHT-LOSS | MUSCLE | MICE | TNF-ALPHA | INDUCED INSULIN-RESISTANCE | APOLIPOPROTEIN-E | ADIPOCYTE | CELL BIOLOGY | Fatty Acid-Binding Proteins | Phosphorylation | Body Weight | Adipose Tissue - cytology | Multienzyme Complexes - metabolism | Adipocytes - cytology | Immunoblotting | RNA, Messenger - metabolism | AMP-Activated Protein Kinases | Oxygen - metabolism | Tissue Distribution | Adipose Tissue - metabolism | Time Factors | Fatty Acids - metabolism | Protein-Serine-Threonine Kinases - metabolism | Cytokines - metabolism | Liver - metabolism | Mice, Inbred C57BL | Gene Expression Regulation | Insulin Resistance | Diabetes Mellitus - metabolism | Lipid Metabolism | Mice, Transgenic | Inflammation | Macrophages - cytology | Obesity - metabolism | Triglycerides - metabolism | Insulin - metabolism | Macrophages - metabolism | Phenotype | Animals | Carrier Proteins - metabolism | Adipocytes - metabolism | Glucose - metabolism | Stearoyl-CoA Desaturase - metabolism | Receptor, Insulin - metabolism | Arteriosclerosis - metabolism | Mice | Mutation | Type 2 diabetes | Obesity | Glucose | Macrophages | Fatty acids | Dextrose | Glucose metabolism | Atherosclerosis | Physiological aspects | Insulin resistance | Binding proteins | Public health | Protein binding | Diabetes therapy | Index Medicus
Journal Article
Cell Metabolism, ISSN 1550-4131, 07/2014, Volume 20, Issue 1, pp. 172 - 182
Oxysterols are cholesterol metabolites that serve multiple functions in lipid metabolism, including as liver X receptor (LXR) ligands. 27-hydroxycholesterol... 
ADHESION | SIGNALING PATHWAYS | HEART-DISEASE | DNA-BINDING | LIVER X RECEPTORS | INFLAMMATION | TRANSCRIPTION | ENDOCRINOLOGY & METABOLISM | NF-KAPPA-B | INTERLEUKIN-6 GENE-EXPRESSION | STEROL 27-HYDROXYLASE | CELL BIOLOGY | Steroid Hydroxylases - metabolism | Apolipoproteins E - deficiency | JNK Mitogen-Activated Protein Kinases - metabolism | Male | NF-kappa B - metabolism | I-kappa B Proteins - metabolism | Apolipoproteins E - metabolism | Cytochrome P450 Family 7 | RNA Interference | Estrogen Receptor alpha - metabolism | Female | Cytokines - genetics | Steroid Hydroxylases - genetics | Macrophages - immunology | Cell Line | Atherosclerosis - pathology | NF-KappaB Inhibitor alpha | Cytokines - metabolism | Endothelial Cells - metabolism | Inflammation | Cell Adhesion - drug effects | Cholesterol - metabolism | Hydroxycholesterols - pharmacology | Atherosclerosis - metabolism | Mice, Knockout | Macrophages - metabolism | Animals | Estrogen Receptor alpha - genetics | Mitogen-Activated Protein Kinase 3 - metabolism | Endothelial Cells - cytology | Apolipoproteins E - genetics | Steroid Hydroxylases - deficiency | Hydroxycholesterols - metabolism | Macrophages - drug effects | Mice | Endothelial Cells - drug effects | Mitogen-Activated Protein Kinase 1 - metabolism | RNA, Small Interfering - metabolism | Metabolites | Atherosclerosis | Estrogen | Cytochrome P-450 | Physiological aspects | Phenols | Cholesterol | Prevention | Blood circulation disorders | Liver | Endothelium | Index Medicus
Journal Article
Gastroenterology, ISSN 0016-5085, 2017, Volume 152, Issue 7, pp. 1707 - 1717.e2
The gastrointestinal tract, the key interface between ingested nutrients and the body, plays a critical role in regulating energy homeostasis. Gut-derived... 
Gastroenterology and Hepatology | Enteroendocrine Cells | Obesity | Gastrointestinal Peptides | L-CELLS | INTESTINAL GUANYLATE-CYCLASE | PLASMA GHRELIN LEVELS | PERIPHERAL NEUROTENSIN | APOLIPOPROTEIN-A-IV | BODY-WEIGHT | GASTRIC BYPASS-SURGERY | GLUCOSE-HOMEOSTASIS | GLUCAGON-LIKE PEPTIDE-1 | GASTROENTEROLOGY & HEPATOLOGY | PRADER-WILLI-SYNDROME | Apolipoproteins A - metabolism | Obesity - drug therapy | Peptide YY - metabolism | Receptors, G-Protein-Coupled - metabolism | Humans | Leptin - metabolism | Homeostasis | Enteroendocrine Cells - secretion | Neurotensin - metabolism | DNA-Binding Proteins - metabolism | Cholecystokinin - metabolism | Neurons, Afferent | Gastrointestinal Tract - physiology | Gastrointestinal Hormones - metabolism | Oxyntomodulin - metabolism | Calcium-Binding Proteins - metabolism | Eating | Glucagon-Like Peptide 1 - metabolism | Natriuretic Peptides - metabolism | Obesity - physiopathology | Gastrointestinal Tract - metabolism | Obesity - metabolism | Ghrelin - metabolism | Nerve Tissue Proteins - metabolism | Animals | Energy Metabolism | Medical research | Glucagon | Food habits | Body weight | Weight loss maintenance | Homeopathy | Materia medica and therapeutics | Hospitals | Gastrointestinal system | Therapeutics | Medicine, Experimental | Genetic engineering | Research institutes | Health aspects | Type 2 diabetes | Bile acids | Goats | Apolipoproteins | Fatty acids | Membrane proteins | G proteins | Cholecystokinin | Index Medicus | Abridged Index Medicus
Journal Article
Cell, ISSN 0092-8674, 08/2017, Volume 170, Issue 4, pp. 649 - 663.e13
Journal Article
Thrombosis and Haemostasis, ISSN 0340-6245, 2014, Volume 111, Issue 3, pp. 518 - 530
Apart from transporting lipids through the body, the human plasma lipoproteins very low-density lipoprotein (VLDL) and low-density lipoprotein (LDL) are also... 
CETP | proteomics | atherothrombosis | LCAT | protein S | Apolipoproteins | prenylcysteine oxidase | coagulation | prothrombin | anti-microbial peptides | cathepcin D | nLC-MS/MS | dermicidin | TFPI-1 | lysozyme C | CD14 | lipopolysaccharide binding protein | PLTP | apoAV | Cardiovascular Biology and Cell Signalling | Prenylcysteine oxidase | Coagulation | Atherothrombosis | Cathepcin D | Lysozyme C | Lipopolysaccharide binding protein | Dermicidin | Antimicrobial peptides | Proteomics | Prothrombin | Protein S | ApoAV | PATTERNS | MASS-SPECTROMETRY | PARAOXONASE-1 | PERIPHERAL VASCULAR DISEASE | DYSLIPIDEMIA | HEMATOLOGY | OXIDATION | apolipoproteins | PROTHROMBINASE | 2-DIMENSIONAL GEL-ELECTROPHORESIS | REVERSE CHOLESTEROL TRANSPORT | ENHANCEMENT | CHYLOMICRONS | Apolipoproteins A - metabolism | Humans | Antimicrobial Cationic Peptides - metabolism | Lipopolysaccharide Receptors - metabolism | Phospholipid Transfer Proteins - metabolism | Protein S - metabolism | Dyslipidemias - blood | Plasma - metabolism | Mass Spectrometry | Blood Coagulation | Lipoproteins - metabolism | Lipoproteins, LDL - metabolism | Prothrombin - metabolism | Apolipoprotein A-V | Computational Biology | Lipid Metabolism | Muramidase - metabolism | Cathepsin D - metabolism | Carbon-Sulfur Lyases - metabolism | Atherosclerosis - blood | Lipoproteins, VLDL - metabolism | Blood Coagulation Disorders - blood | Cholesterol Ester Transfer Proteins - metabolism | Proteome - metabolism | Phosphatidylcholine-Sterol O-Acyltransferase - metabolism
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 05/2011, Volume 286, Issue 20, pp. 17536 - 17542
Apolipoprotein E (apoE) is a major apolipoprotein in the brain. The epsilon 4 allele of apoE is a major risk factor for Alzheimer disease, and apoE deficiency... 
CHOLESTEROL-METABOLISM | PROTEIN-KINASE-C | RECEPTOR-RELATED PROTEIN | LIPOPROTEIN RECEPTORS | LDL-RECEPTOR | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE MODEL | ENDOTHELIAL-CELLS | A-BETA | PLAQUE-FORMATION | Protein Kinase C - genetics | Apolipoprotein E4 - genetics | Humans | Astrocytes - pathology | Low Density Lipoprotein Receptor-Related Protein-1 - genetics | Antigens, CD - genetics | Alzheimer Disease - pathology | Antigens, CD - metabolism | Occludin | Phosphorylation - genetics | Protein Isoforms - metabolism | Pericytes - pathology | Protein Kinase C - metabolism | Tumor Suppressor Proteins - genetics | Membrane Proteins - metabolism | Tight Junctions - metabolism | Receptors, LDL - genetics | Tumor Suppressor Proteins - metabolism | Apolipoprotein E4 - metabolism | Endothelial Cells - metabolism | Membrane Proteins - genetics | Pericytes - metabolism | Cells, Cultured | Low Density Lipoprotein Receptor-Related Protein-1 - metabolism | Receptors, LDL - metabolism | Permeability | Apolipoprotein E3 - metabolism | Blood-Brain Barrier - metabolism | Gene Knock-In Techniques | Mice, Knockout | Blood-Brain Barrier - pathology | Apolipoprotein E3 - genetics | Animals | Models, Biological | Alzheimer Disease - metabolism | Mice | Alzheimer Disease - genetics | Endothelial Cells - pathology | Enzyme Activation - genetics | Tight Junctions - pathology | Astrocytes - metabolism | Protein Isoforms - genetics | Index Medicus | HDL | Neurobiology | PKC | Alzheimer Disease | Apolipoproteins | Endothelium | Tight Junction | Blood-Brain Barrier
Journal Article
Science, ISSN 0036-8075, 03/2012, Volume 335, Issue 6075, pp. 1503 - 1506
Journal Article
Nature, ISSN 0028-0836, 05/2012, Volume 485, Issue 7399, pp. 512 - 516
Human apolipoprotein E has three isoforms: APOE2, APOE3 and APOE4(1). APOE4 is a major genetic risk factor for Alzheimer's disease(2,3) and is associated with... 
OXIDATIVE STRESS | DEMENTIA | PROTEIN | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | COGNITIVE IMPAIRMENT | NEURODEGENERATION | MICE | APOE | BLOOD-BRAIN-BARRIER | EXPRESSION | Neurons - pathology | Apolipoprotein E4 - genetics | Apolipoproteins E - deficiency | Cerebrovascular Circulation - physiology | Humans | Blood-Brain Barrier - physiopathology | NF-kappa B - metabolism | Apolipoproteins E - metabolism | Microcirculation | Matrix Metalloproteinase 9 - metabolism | Apolipoprotein E2 - deficiency | Apolipoprotein E4 - deficiency | Apolipoprotein E3 - deficiency | Blood-Brain Barrier - physiology | Neurons - metabolism | Cyclophilin A - metabolism | Apolipoprotein E4 - metabolism | Neurodegenerative Diseases - pathology | Apolipoprotein E2 - genetics | Pericytes - metabolism | Mice, Transgenic | Hippocampus - pathology | Neurodegenerative Diseases - metabolism | Apolipoprotein E3 - metabolism | Apolipoprotein E2 - metabolism | Blood-Brain Barrier - drug effects | Cyclophilin A - antagonists & inhibitors | Hippocampus - metabolism | Apolipoprotein E3 - genetics | Animals | Apolipoproteins E - genetics | Mice | Cyclophilin A - deficiency | Cyclophilin | Brain cells | Physiological aspects | Development and progression | Apolipoproteins | Properties | Alzheimer's disease | Proteins | Studies | Rodents | Index Medicus
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 12/2007, Volume 27, Issue 12, pp. 2684 - 2690
OBJECTIVE—Whereas growth factors, via their ability to stimulate vascular smooth muscle cell (VSMC) proliferation and migration, have been thought to play a... 
Oxidative stress | Inflammatory response | Insulin-like growth factor | Apolipoprotein E | Atherosclerosis | atherosclerosis | PROGENITOR CELLS | SEVERELY BURNED CHILDREN | inflammatory response | LOW-DENSITY-LIPOPROTEIN | DOWN-REGULATION | ENDOTHELIAL NITRIC-OXIDE | INSULIN | MESSENGER-RNA | apolipoprotein E | PERIPHERAL VASCULAR DISEASE | insulin-like growth factor | SMOOTH-MUSCLE-CELLS | HEMATOLOGY | EXPRESSION | oxidative stress | GROWTH-FACTOR-I | Tumor Necrosis Factor-alpha - metabolism | Inflammation - pathology | Phosphorylation | Apolipoproteins E - deficiency | Antioxidants - metabolism | Atherosclerosis - genetics | Humans | Aorta - metabolism | RNA, Messenger - metabolism | Stem Cells - metabolism | Anti-Inflammatory Agents - metabolism | Apolipoproteins E - metabolism | Inflammation - metabolism | Dietary Fats - administration & dosage | Insulin-Like Growth Factor I - administration & dosage | Superoxides - metabolism | Anti-Inflammatory Agents - administration & dosage | Dinoprost - analogs & derivatives | Proto-Oncogene Proteins c-akt - metabolism | Interleukin-6 - metabolism | Disease Models, Animal | Recombinant Proteins - metabolism | Atherosclerosis - pathology | Dinoprost - urine | Macrophages - pathology | Endothelial Cells - metabolism | Mice, Inbred C57BL | Cells, Cultured | Nitric Oxide Synthase Type III | Atherosclerosis - metabolism | Disease Progression | Mice, Knockout | Aorta - pathology | Macrophages - metabolism | Animals | Apolipoproteins E - genetics | Antioxidants - administration & dosage | Inflammation - genetics | Stem Cells - pathology | Inflammation - prevention & control | Mice | Oxidative Stress - drug effects | Endothelial Cells - pathology | Atherosclerosis - prevention & control | Insulin-Like Growth Factor I - metabolism | Nitric Oxide Synthase Type II - metabolism | Index Medicus
Journal Article
Journal Article