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British journal of pharmacology, ISSN 0007-1188, 08/2013, Volume 169, Issue 8, pp. 1795 - 1809
Background and Purpose Atherosclerosis is associated with reduced vascular hydrogen sulfide (H2S) biosynthesis. GYY4137 is a novel slow‐releasing H2S compound... 
arteriosclerosis | hydrogen sulfide | inflammation | endothelial dysfunction | oxidative stress | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Tumor Necrosis Factor-alpha - metabolism | Humans | Male | NF-kappa B - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Aorta - metabolism | Nitric Oxide Synthase Type II | Organothiophosphorus Compounds - pharmacology | Foam Cells - drug effects | Diet, High-Fat | Superoxides - metabolism | Female | Apolipoproteins E | Phosphorylation - drug effects | Interleukin-6 - metabolism | Scavenger Receptors, Class E - drug effects | NF-KappaB Inhibitor alpha | Atherosclerosis - drug therapy | Atherosclerosis - chemically induced | Down-Regulation | Cells, Cultured | I-kappa B Proteins | Morpholines - pharmacology | Cholesterol - metabolism | Atherosclerosis - metabolism | Scavenger Receptors, Class E - metabolism | Intercellular Adhesion Molecule-1 - metabolism | Macrophages - metabolism | Animals | Endothelium, Vascular - metabolism | Macrophages - drug effects | Mice | Oxidative Stress - drug effects | Vascular Cell Adhesion Molecule-1 - metabolism | Hydrogen sulfide | RNA | Low density lipoproteins | Atherosclerosis | Lectins | Physiological aspects | Exhibitions | Acetylcholine | Superoxide | Cholesterol | Phosphorylation | Rodents | Endothelium | Research Papers
Journal Article
Arteriosclerosis, thrombosis, and vascular biology, ISSN 1524-4636, 04/2014, Volume 34, Issue 4, pp. 759 - 767
Journal Article
Journal Article
Cell metabolism, ISSN 1550-4131, 07/2014, Volume 20, Issue 1, pp. 172 - 182
Oxysterols are cholesterol metabolites that serve multiple functions in lipid metabolism, including as liver X receptor (LXR) ligands... 
Endocrinology & Metabolism | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Steroid Hydroxylases - metabolism | Apolipoproteins E - deficiency | JNK Mitogen-Activated Protein Kinases - metabolism | Male | NF-kappa B - metabolism | I-kappa B Proteins - metabolism | Apolipoproteins E - metabolism | Cytochrome P450 Family 7 | RNA Interference | Estrogen Receptor alpha - metabolism | Female | Cytokines - genetics | Steroid Hydroxylases - genetics | Macrophages - immunology | Cell Line | Atherosclerosis - pathology | NF-KappaB Inhibitor alpha | Cytokines - metabolism | Endothelial Cells - metabolism | Inflammation | Cell Adhesion - drug effects | Cholesterol - metabolism | Hydroxycholesterols - pharmacology | Atherosclerosis - metabolism | Mice, Knockout | Macrophages - metabolism | Animals | Estrogen Receptor alpha - genetics | Mitogen-Activated Protein Kinase 3 - metabolism | Endothelial Cells - cytology | Apolipoproteins E - genetics | Steroid Hydroxylases - deficiency | Hydroxycholesterols - metabolism | Macrophages - drug effects | Mice | Endothelial Cells - drug effects | Mitogen-Activated Protein Kinase 1 - metabolism | RNA, Small Interfering - metabolism | Metabolites | Atherosclerosis | Estrogen | Cytochrome P-450 | Physiological aspects | Phenols | Cholesterol | Prevention | Blood circulation disorders | Liver | Endothelium
Journal Article
Journal of molecular medicine (Berlin, Germany), ISSN 1432-1440, 06/2016, Volume 94, Issue 7, pp. 739 - 746
Apolipoprotein (apo) E was initially described as a lipid transport protein and major ligand for low density lipoprotein (LDL... 
Human Genetics | Biomedicine | Alzheimer’s disease | Atherosclerosis | Internal Medicine | Molecular Medicine | ApoE | Cholesterol | Small-molecule structure correctors | Genetics & Heredity | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Phosphorylation | Apolipoprotein E4 - genetics | Lipoproteins, HDL - genetics | Humans | Lipoproteins, HDL - metabolism | tau Proteins - metabolism | Cardiovascular Diseases - pathology | Lipoproteins, LDL - genetics | Cardiovascular Diseases - genetics | tau Proteins - genetics | Lipoproteins, LDL - metabolism | Protein Interaction Domains and Motifs | Receptors, LDL - genetics | Apolipoprotein E4 - metabolism | Neurodegenerative Diseases - pathology | Cardiovascular Diseases - metabolism | Signal Transduction | Apolipoprotein E2 - genetics | Gene Expression Regulation | Models, Molecular | Receptors, LDL - metabolism | Neurodegenerative Diseases - genetics | Neurodegenerative Diseases - metabolism | Apolipoprotein E3 - metabolism | Cholesterol - metabolism | Apolipoprotein E2 - metabolism | Apolipoprotein E3 - genetics | Apolipoprotein E3 - chemistry | Apolipoprotein E4 - chemistry | Physiological aspects | Development and progression | Nervous system | Genetic aspects | Degeneration | Research | Cardiovascular diseases | Apolipoproteins | Index Medicus | Molecules in Medicine
Journal Article
Neurobiology of disease, ISSN 0969-9961, 12/2014, Volume 72, pp. 3 - 12
Journal Article
Immunity (Cambridge, Mass.), ISSN 1074-7613, 09/2017, Volume 47, Issue 3, pp. 566 - 581.e9
.... We identified a specific apolipoprotein E (APOE)-dependent molecular signature in microglia from models of amyotrophic lateral sclerosis (ALS... 
Alzheimer’s disease | multiple sclerosis | transcriptional regulation | neurodegeneration | TREM2 | APOE | amyotrophic lateral sclerosis | microglia | Alzheimer's disease | Life Sciences & Biomedicine | Immunology | Science & Technology | Microglia - metabolism | Apolipoproteins E - deficiency | Membrane Glycoproteins - metabolism | Humans | Cerebral Cortex - pathology | Transcriptome | Apoptosis - genetics | Monocytes - metabolism | Gene Expression Profiling | Monocytes - immunology | Phagocytosis - genetics | Neurodegenerative Diseases - immunology | Apolipoproteins E - metabolism | Cerebral Cortex - metabolism | Alzheimer Disease - pathology | Microglia - immunology | Superoxide Dismutase-1 - metabolism | Amyloid beta-Peptides - metabolism | Amyloid beta-Protein Precursor - metabolism | Female | Neurons - metabolism | Disease Models, Animal | Gene Targeting | Plaque, Amyloid - pathology | Signal Transduction | Gene Expression Regulation | Phagocytosis - immunology | Immune Tolerance | Mice, Transgenic | Neurodegenerative Diseases - genetics | Neurodegenerative Diseases - metabolism | Mice, Knockout | Encephalomyelitis, Autoimmune, Experimental | Phenotype | Animals | Apoptosis - immunology | Apolipoproteins E - genetics | Alzheimer Disease - metabolism | Superoxide Dismutase-1 - genetics | Plaque, Amyloid - metabolism | Mice | Alzheimer Disease - genetics | Transforming Growth Factor beta - metabolism | Receptors, Immunologic - metabolism | Cluster Analysis | Nervous system diseases | Multiple sclerosis | Neurons | Analysis | Amyotrophic lateral sclerosis | Genetic aspects | Genetic transcription | Apolipoproteins | Brain | Animal models | Myeloid cells | Disease | Transcription | Neurodegenerative diseases | Genes | Homeostasis | Microglia | Neurological diseases | Proteins | Molecular modelling | Restoration | Neurodegeneration | Apolipoprotein E | Rodents | β-Amyloid | Plaques | Phagocytosis | Apoptosis
Journal Article