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Molecular biology of the cell, ISSN 1939-4586, 2009, Volume 20, Issue 3, pp. 870 - 881
Using a bioinformatic approach, we identified a TP53INP1-related gene encoding a protein with 30... 
GATE-16 | MOLECULAR MACHINERY | GENE | MEMBRANE-TRANSPORT MODULATOR | PANCREATITIS | INHIBITORS | EXPRESSION | CONJUGATION SYSTEM | GABARAP | SUBUNIT | CELL BIOLOGY | Gene Silencing - drug effects | Microtubule-Associated Proteins - metabolism | Humans | Molecular Sequence Data | Protein Transport - drug effects | Luminescent Measurements | Phylogeny | Autophagy - drug effects | Protein Binding - drug effects | Cloning, Molecular | Conserved Sequence | Carrier Proteins - chemistry | Membrane Proteins - metabolism | Phagosomes - drug effects | Beclin-1 | Amino Acid Sequence | Cell Line | Heat-Shock Proteins - metabolism | Phagosomes - metabolism | Nuclear Proteins - metabolism | Nuclear Proteins - chemistry | Sirolimus - pharmacology | Apoptosis Regulatory Proteins - metabolism | Animals | Carrier Proteins - metabolism | Mice | Adaptor Proteins, Signal Transducing - metabolism | Heat-Shock Proteins - chemistry | Heat-Shock Proteins: chemistry,metabolism | Membrane Proteins: metabolism | Protein Binding: drug effects | Gene Silencing: drug effects | Adaptor Proteins, Signal Transducing: metabolism | Life Sciences | Phagosomes: drug effects,metabolism | Apoptosis Regulatory Proteins: metabolism | Nuclear Proteins: chemistry,metabolism | Autophagy: drug effects | Protein Transport: drug effects | Microtubule-Associated Proteins: metabolism | Sirolimus: pharmacology | Carrier Proteins: chemistry,metabolism | Other
Journal Article
The EMBO journal, ISSN 0261-4189, 2012, Volume 31, Issue 10, pp. 2322 - 2335
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2016, Volume 291, Issue 13, pp. 6689 - 6695
Intrinsically disordered proteins (IDPs) are characterized by a lack of persistent structure... 
signaling | residual structure | electrostatics | coupled folding and binding | BIOCHEMISTRY & MOLECULAR BIOLOGY | protein electrostatics | C-MYB | TRANSITION-STATE | INDUCED FIT | protein-protein interactions | INTRINSICALLY DISORDERED PROTEINS | LINEAGE LEUKEMIA PROTEIN | IDP | MOLECULAR RECOGNITION | KIX DOMAIN | SEQUENCE | protein folding | phi-value | TRANSACTIVATION DOMAIN | kinetics | biophysics | protein dynamic | CONFORMATIONAL SELECTION | Cyclic AMP Response Element-Binding Protein - chemistry | Humans | Myeloid Cell Leukemia Sequence 1 Protein - metabolism | CREB-Binding Protein - chemistry | Proto-Oncogene Proteins - chemistry | CREB-Binding Protein - genetics | CREB-Binding Protein - metabolism | Thermodynamics | Apoptosis Regulatory Proteins - genetics | Myeloid Cell Leukemia Sequence 1 Protein - chemistry | Protein Interaction Domains and Motifs | Proto-Oncogene Proteins - metabolism | Signal Transduction | Apoptosis Regulatory Proteins - chemistry | Proto-Oncogene Proteins - genetics | Static Electricity | Intrinsically Disordered Proteins - genetics | Molecular Dynamics Simulation | Myeloid Cell Leukemia Sequence 1 Protein - genetics | Protein Folding | Apoptosis Regulatory Proteins - metabolism | Cyclic AMP Response Element-Binding Protein - genetics | Intrinsically Disordered Proteins - chemistry | Cyclic AMP Response Element-Binding Protein - metabolism | Hydrophobic and Hydrophilic Interactions | Protein Binding | Kinetics | Intrinsically Disordered Proteins - metabolism | Minireviews
Journal Article
Nature cell biology, ISSN 1476-4679, 2009, Volume 11, Issue 6, pp. 739 - 746
...). Here we show that, in the absence of its ligand, Ptc interacts with the adaptor protein DRAL... 
PROTEIN | INHIBITION | GENE | MECHANISM | SONIC HEDGEHOG | NEURONAL DEATH | PRODUCT INDUCES APOPTOSIS | KAPPA-B | CASPASE ACTIVATION | CELL-DEATH | CELL BIOLOGY | RNA, Small Interfering - genetics | Caspase 9 - metabolism | Homeodomain Proteins - metabolism | Humans | Hedgehog Proteins - metabolism | Neoplasm Proteins - metabolism | CARD Signaling Adaptor Proteins - genetics | Multiprotein Complexes - metabolism | CARD Signaling Adaptor Proteins - metabolism | Hedgehog Proteins - genetics | Muscle Proteins - metabolism | Apoptosis Regulatory Proteins - genetics | Patched Receptors | Neoplasm Proteins - genetics | Cell Line | Receptors, Cell Surface - metabolism | Transcription Factors - genetics | Chick Embryo | Homeodomain Proteins - genetics | Apoptosis Regulatory Proteins - metabolism | Muscle Proteins - genetics | Transcription Factors - metabolism | Two-Hybrid System Techniques | Animals | Adaptor Proteins, Signal Transducing - genetics | LIM-Homeodomain Proteins | Signal Transduction - physiology | Apoptosis - physiology | Adaptor Proteins, Signal Transducing - metabolism | RNA, Small Interfering - metabolism | Receptors, Cell Surface - genetics | Causes of | Physiological aspects | Cell receptors | Research | Proteases | Apoptosis | Caspase 9 | Signal Transduction | Multiprotein Complexes | Receptors, Cell Surface | Cellular Biology | Hedgehog Proteins | Life Sciences | Muscle Proteins | Adaptor Proteins, Signal Transducing | Apoptosis Regulatory Proteins | Homeodomain Proteins | Neoplasm Proteins | CARD Signaling Adaptor Proteins | RNA, Small Interfering | Transcription Factors | Development Biology | physiology | genetics | metabolism
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2010, Volume 330, Issue 6009, pp. 1390 - 1393
Although the proteins BAX and BAK are required for initiation of apoptosis at the mitochondria, how BAX and BAK are activated remains unsettled... 
T lymphocytes | Mitochondria | Cytokines | Thymocytes | Neurons | Cell death | REPORTS | Cytochromes | Mice | Potassium | Apoptosis | NEURONAL APOPTOSIS | CYTOCHROME-C | MITOCHONDRIAL APOPTOSIS | MECHANISM | MULTIDISCIPLINARY SCIENCES | BH3 DOMAINS | RELEASE | JNK PATHWAY | PROTEINS | BCL-2 FAMILY-MEMBERS | MEMBRANE PERMEABILIZATION | BH3 Interacting Domain Death Agonist Protein - deficiency | T-Lymphocytes - physiology | bcl-2-Associated X Protein - chemistry | Protein Multimerization | Stress, Physiological | bcl-2 Homologous Antagonist-Killer Protein - genetics | BH3 Interacting Domain Death Agonist Protein - genetics | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Membrane Proteins - deficiency | Caspases - metabolism | Bcl-2-Like Protein 11 | Apoptosis Regulatory Proteins - deficiency | Tumor Suppressor Proteins - deficiency | Tumor Suppressor Proteins - genetics | Neurons - physiology | Apoptosis Regulatory Proteins - genetics | Membrane Proteins - metabolism | BH3 Interacting Domain Death Agonist Protein - metabolism | bcl-2-Associated X Protein - genetics | Proto-Oncogene Proteins - metabolism | Tumor Suppressor Proteins - metabolism | Membrane Proteins - genetics | Cytochromes c - metabolism | Cells, Cultured | bcl-2-Associated X Protein - metabolism | Proto-Oncogene Proteins - genetics | Mitochondria - metabolism | Permeability | Proto-Oncogene Proteins - deficiency | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Animals | Models, Biological | Cerebellum - cytology | Intracellular Membranes - metabolism | bcl-2 Homologous Antagonist-Killer Protein - chemistry | Protein research | Genetic aspects | Mitochondrial DNA | Biochemical genetics | Research | Properties | Methods
Journal Article
Cell Death and Differentiation, ISSN 1350-9047, 01/2007, Volume 14, Issue 1, pp. 128 - 136
All BH3-only proteins, key initiators of programmed cell death, interact tightly with multiple binding partners and have sequences of low complexity, properties that are the hallmark of intrinsically... 
Bcl-2 | intrinsically unstructured | APOPTOSIS | EGL-1 | RECOGNITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | UNFOLDED PROTEINS | DISORDERED PROTEINS | BH3-only | FAMILY | MEMBER | CELL BIOLOGY | STRUCTURAL BASIS | ROLES | molecular recognition | PEPTIDE COMPLEX | Adaptor Proteins, Signal Transducing - chemistry | Recombinant Fusion Proteins - isolation & purification | Adaptor Proteins, Signal Transducing - isolation & purification | Apoptosis Regulatory Proteins - isolation & purification | Proto-Oncogene Proteins - chemistry | Recombinant Fusion Proteins - metabolism | Bcl-2-Like Protein 11 | Apoptosis Regulatory Proteins - genetics | Nuclear Magnetic Resonance, Biomolecular | bcl-Associated Death Protein - metabolism | Membrane Proteins - metabolism | Circular Dichroism | Proto-Oncogene Proteins - isolation & purification | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | bcl-Associated Death Protein - genetics | Membrane Proteins - isolation & purification | Protein Structure, Secondary | bcl-Associated Death Protein - chemistry | Membrane Proteins - genetics | bcl-Associated Death Protein - isolation & purification | Apoptosis Regulatory Proteins - chemistry | Proto-Oncogene Proteins - genetics | Recombinant Fusion Proteins - chemistry | Protein Folding | Apoptosis Regulatory Proteins - metabolism | Animals | Membrane Proteins - chemistry | Adaptor Proteins, Signal Transducing - genetics | Recombinant Fusion Proteins - genetics | Mice | Adaptor Proteins, Signal Transducing - metabolism
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2014, Volume 111, Issue 11, pp. 4097 - 4102
The serine/threonine protein phosphatase 1 (PP1) dephosphorylates hundreds of key biological targets by associating with nearly 200 regulatory proteins to form highly specific holoenzymes... 
Proteins | Phosphorylation | Phosphatases | Active sites | Drug regulation | Substrate specificity | Amino acids | Gene expression regulation | Physiological regulation | Regulator genes | Enzyme regulation | X-ray crystal structure | Nuclear magnetic resonance | Enzyme specificity | Nuclear phosphatases | CATALYTIC SUBUNIT | APOPTOSIS | enzyme specificity | CLASS-I REGION | SPECIFICITY | enzyme regulation | MULTIDISCIPLINARY SCIENCES | nuclear phosphatases | nuclear magnetic resonance | NUCLEAR TARGETING SUBUNIT | PHOSPHATASE 1 | GENE | STRUCTURAL BASIS | RNA-Binding Proteins - genetics | Protein Phosphatase 1 - chemistry | Humans | Molecular Sequence Data | Substrate Specificity | DNA-Binding Proteins - metabolism | Protein Interaction Domains and Motifs - genetics | Cloning, Molecular | Protein Phosphatase 1 - genetics | Nuclear Proteins - genetics | Proto-Oncogene Proteins c-mdm2 - metabolism | Amino Acid Sequence | Magnetic Resonance Spectroscopy | RNA-Binding Proteins - chemistry | Retinoblastoma Protein - metabolism | Computational Biology | Crystallization | Models, Molecular | Nuclear Proteins - metabolism | DNA-Binding Proteins - genetics | Nuclear Proteins - chemistry | DNA-Binding Proteins - chemistry | Protein Phosphatase 1 - metabolism | Sequence Alignment | Gene Expression Regulation, Enzymologic - genetics | Calorimetry | Protein Conformation | RNA-Binding Proteins - metabolism | Chromatin Assembly and Disassembly - physiology | Enzymes | Usage | Analysis | Regulation | Diagnosis | Retinoblastoma | Biological Sciences
Journal Article
Immunity (Cambridge, Mass.), ISSN 1074-7613, 2013, Volume 39, Issue 5, pp. 833 - 845
.... How these phases are transcriptionally regulated is incompletely defined. Here, we report that interferon regulatory factor 4 (IRF4... 
RESPONSES | ACTIVATION | VIRUS | IRF4 | TRANSCRIPTION | INFECTION | IMMUNOLOGY | NF-KAPPA-B | EXPRESSION | MTOR | ANTIGEN | CD8-Positive T-Lymphocytes - cytology | Cells, Cultured - cytology | Coculture Techniques | Dendritic Cells - immunology | T-Box Domain Proteins - biosynthesis | Interferon Regulatory Factors - deficiency | Bcl-2-Like Protein 11 | Interferon Regulatory Factors - physiology | Receptors, Antigen, T-Cell - immunology | TOR Serine-Threonine Kinases - physiology | Cell Differentiation | Proto-Oncogene Proteins - antagonists & inhibitors | Specific Pathogen-Free Organisms | Lymphocyte Activation | Mice, Inbred C57BL | Gene Expression Regulation | Interferon Regulatory Factors - genetics | Viral Plaque Assay | Mice, Transgenic | Transcription Factors - biosynthesis | Transcription Factors - genetics | T-Box Domain Proteins - genetics | Interferon Regulatory Factors - immunology | Animals | Membrane Proteins - antagonists & inhibitors | Apoptosis Regulatory Proteins - antagonists & inhibitors | Mice | Orthomyxoviridae Infections - virology | Orthomyxoviridae Infections - immunology | Apoptosis | Cyclin-Dependent Kinase Inhibitor Proteins - antagonists & inhibitors | Positive Regulatory Domain I-Binding Factor 1 | Transcription factors | Peptides | Lymphocytes | Rodents | T cell receptors | Infections | Expansion | Immune system
Journal Article
Nature (London), ISSN 1476-4687, 2016, Volume 530, Issue 7590, pp. 354 - 357
Journal Article
The Journal of experimental medicine, ISSN 1540-9538, 2013, Volume 210, Issue 2, pp. 269 - 285
.... Helios and the proapoptotic protein Bim were coinduced in 55% of nascent CCR7− CD4+ CD69+ thymocytes. These were short-lived cells that up-regulated PD-1 and down-regulated CD4 and CD8 during Bim-dependent apoptosis... 
DEVELOPING THYMOCYTES | MEDICINE, RESEARCH & EXPERIMENTAL | TISSUE-RESTRICTED ANTIGENS | SELF-PEPTIDE | RECEPTOR TRANSGENIC MICE | IN-VIVO | BIM | NEGATIVE SELECTION | C-MYC | CLONAL DELETION | IMMUNOLOGY | EXPRESSION | Autoimmunity | Cell Proliferation | NF-kappa B - immunology | Proto-Oncogene Proteins c-rel - metabolism | Proto-Oncogene Proteins - biosynthesis | Proto-Oncogene Proteins c-rel - immunology | CARD Signaling Adaptor Proteins - genetics | CD4-Positive T-Lymphocytes - immunology | Membrane Proteins - deficiency | CARD Signaling Adaptor Proteins - metabolism | Bcl-2-Like Protein 11 | Receptors, CCR7 - metabolism | Apoptosis Regulatory Proteins - deficiency | Programmed Cell Death 1 Receptor - biosynthesis | Proto-Oncogene Proteins - immunology | Apoptosis Regulatory Proteins - genetics | Transcription Factors - immunology | Apoptosis Regulatory Proteins - biosynthesis | CARD Signaling Adaptor Proteins - immunology | Apoptosis Regulatory Proteins - immunology | DNA-Binding Proteins - immunology | Lymphocyte Activation | Membrane Proteins - genetics | CD4-Positive T-Lymphocytes - cytology | Mice, Inbred C57BL | CD4-Positive T-Lymphocytes - metabolism | Self Tolerance | Membrane Proteins - immunology | Mice, Transgenic | Proto-Oncogene Proteins - genetics | Transcription Factors - biosynthesis | Proto-Oncogene Proteins - deficiency | Clonal Deletion - immunology | Mice, Knockout | Membrane Proteins - biosynthesis | Animals | Apoptosis - immunology | Proto-Oncogene Proteins c-rel - genetics | NF-kappa B - biosynthesis | Mice | Mutation | Programmed Cell Death 1 Receptor - immunology | DNA-Binding Proteins - biosynthesis | 309
Journal Article
EMBO reports, ISSN 1469-3178, 2012, Volume 13, Issue 4, pp. 322 - 330
Journal Article