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Cancer Research, ISSN 0008-5472, 04/2011, Volume 71, Issue 7, pp. 2750 - 2760
This study addresses the role of PTEN loss in intrinsic resistance to the BRAF inhibitor PLX4720. Immunohistochemical staining of a tissue array covering all... 
METASTATIC MELANOMA | APOPTOSIS | PROTEIN | ONCOLOGY | PHOSPHORYLATION | CUTANEOUS MELANOMA | RAF KINASE | CANCER | MEDIATES RESISTANCE | LINES | ERK | RNA, Small Interfering - genetics | Up-Regulation | Humans | Drug Resistance, Neoplasm | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Proto-Oncogene Proteins - biosynthesis | Bcl-2-Like Protein 11 | Melanoma - genetics | Apoptosis Regulatory Proteins - genetics | Indoles - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | Proto-Oncogene Proteins B-raf - metabolism | Apoptosis Regulatory Proteins - biosynthesis | Melanoma - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | PTEN Phosphohydrolase - deficiency | Membrane Proteins - genetics | PTEN Phosphohydrolase - biosynthesis | Proto-Oncogene Proteins - genetics | Melanoma - pathology | Sulfonamides - pharmacology | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Membrane Proteins - biosynthesis | Membrane Proteins - antagonists & inhibitors | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Apoptosis Regulatory Proteins - antagonists & inhibitors | Cell Line, Tumor | Protein Kinase Inhibitors - pharmacology | Apoptosis - physiology | Mutation | RNA, Small Interfering - administration & dosage | Index Medicus | PTEN | melanoma | BRAF | PLX4032 | therapy | resistance
Journal Article
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 05/2012, Volume 18, Issue 9, pp. 2502 - 2514
Purpose: The clinical use of BRAF inhibitors is being hampered by the acquisition of drug resistance. This study shows the potential therapeutic use of the... 
BREAST-CANCER | MULTIPLE-MYELOMA | APOPTOSIS | PHASE-II TRIAL | TANESPIMYCIN 17-AAG | TRASTUZUMAB | ONCOLOGY | BIM | ACQUIRED-RESISTANCE | MELANOMA-CELLS | POTENTIAL MECHANISM | Prospective Studies | Apoptosis - drug effects | Humans | Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Immunoenzyme Techniques | Forkhead Transcription Factors - metabolism | Colony-Forming Units Assay | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | Phthalic Acids - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | Real-Time Polymerase Chain Reaction | Proto-Oncogene Proteins B-raf - metabolism | Membrane Proteins - genetics | Melanoma - pathology | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Apoptosis Regulatory Proteins - metabolism | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Indoles - adverse effects | Membrane Proteins - antagonists & inhibitors | Signal Transduction - drug effects | HSP90 Heat-Shock Proteins - antagonists & inhibitors | Cell Line, Tumor | HSP90 Heat-Shock Proteins - metabolism | Mice | Mice, Inbred BALB C | Forkhead Box Protein O3 | Azabicyclo Compounds - pharmacology | Phosphatidylinositol 3-Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - genetics | Proto-Oncogene Proteins c-akt - genetics | Proto-Oncogene Proteins c-bcl-2 - metabolism | Flow Cytometry | Bcl-2-Like Protein 11 | Apoptosis Regulatory Proteins - genetics | Membrane Proteins - metabolism | Forkhead Transcription Factors - antagonists & inhibitors | Melanoma - metabolism | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | RNA, Messenger - genetics | Proto-Oncogene Proteins - genetics | Forkhead Transcription Factors - genetics | Phosphatidylinositol 3-Kinases - genetics | Animals | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Myeloid Cell Leukemia Sequence 1 Protein | Apoptosis Regulatory Proteins - antagonists & inhibitors | Fluorescent Antibody Technique | Sulfonamides - adverse effects | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Proto-Oncogene Proteins c-bcl-2 - genetics | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Drug Resistance, Neoplasm - drug effects | Index Medicus
Journal Article
Immunity, ISSN 1074-7613, 11/2013, Volume 39, Issue 5, pp. 833 - 845
Upon infection, CD8 T cells undergo a stepwise process of early activation, expansion, and differentiation into effector cells. How these phases are... 
RESPONSES | ACTIVATION | VIRUS | IRF4 | TRANSCRIPTION | INFECTION | IMMUNOLOGY | NF-KAPPA-B | EXPRESSION | MTOR | ANTIGEN | CD8-Positive T-Lymphocytes - cytology | Cells, Cultured - cytology | Coculture Techniques | Dendritic Cells - immunology | T-Box Domain Proteins - biosynthesis | Interferon Regulatory Factors - deficiency | Bcl-2-Like Protein 11 | Interferon Regulatory Factors - physiology | Receptors, Antigen, T-Cell - immunology | TOR Serine-Threonine Kinases - physiology | Cell Differentiation | Proto-Oncogene Proteins - antagonists & inhibitors | Specific Pathogen-Free Organisms | Lymphocyte Activation | Mice, Inbred C57BL | Gene Expression Regulation | Interferon Regulatory Factors - genetics | Viral Plaque Assay | Mice, Transgenic | Transcription Factors - biosynthesis | Transcription Factors - genetics | T-Box Domain Proteins - genetics | Interferon Regulatory Factors - immunology | Animals | Membrane Proteins - antagonists & inhibitors | Apoptosis Regulatory Proteins - antagonists & inhibitors | Mice | Orthomyxoviridae Infections - virology | Orthomyxoviridae Infections - immunology | Apoptosis | Cyclin-Dependent Kinase Inhibitor Proteins - antagonists & inhibitors | Positive Regulatory Domain I-Binding Factor 1 | Transcription factors | Peptides | Lymphocytes | Rodents | T cell receptors | Infections | Expansion | Immune system | Index Medicus
Journal Article
Molecular Cell, ISSN 1097-2765, 2011, Volume 42, Issue 1, pp. 23 - 35
Journal Article
Gastroenterology, ISSN 0016-5085, 2014, Volume 146, Issue 1, pp. 268 - 277.e18
Background & Aims There has not been a broad analysis of the combined effects of altered activities of microRNAs (miRNAs) in pancreatic ductal adenocarcinoma... 
Gastroenterology and Hepatology | miRNA−mRNA Interaction | Tumorigenesis | Pancreatic Cancer | Oncogene | miRNA-mRNA Interaction | SURVIVAL | TRANSFORMATION | POSTTRANSCRIPTIONAL REGULATION | CANCER CELLS | DUCTAL ADENOCARCINOMA | NEDD4L | IN-VITRO | TARGETS | GASTROENTEROLOGY & HEPATOLOGY | EXPRESSION | LASER MICRODISSECTION | Cell Proliferation | Prognosis | Tumor Suppressor Proteins - antagonists & inhibitors | Humans | Ubiquitin-Protein Ligases - antagonists & inhibitors | Gene Expression Profiling | Ubiquitin-Protein Ligases - physiology | Carcinoma, Pancreatic Ductal - genetics | Endosomal Sorting Complexes Required for Transport - antagonists & inhibitors | Genes, Tumor Suppressor - physiology | Nedd4 Ubiquitin Protein Ligases | Gene Expression Regulation, Neoplastic - genetics | RNA-Binding Proteins - antagonists & inhibitors | Immediate-Early Proteins - physiology | RNA-Binding Proteins - physiology | RNA, Messenger - genetics | Pancreatic Neoplasms - genetics | Disease Progression | Tumor Suppressor Proteins - physiology | Animals | Apoptosis Regulatory Proteins - antagonists & inhibitors | Cell Line, Tumor | Apoptosis Regulatory Proteins - physiology | Mice | MicroRNAs - genetics | MicroRNAs - physiology | Endosomal Sorting Complexes Required for Transport - physiology | Immediate-Early Proteins - antagonists & inhibitors | Care and treatment | MicroRNA | Pancreatic cancer | Analysis | Genes | Development and progression | Cancer | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article
Nature Communications, ISSN 2041-1723, 07/2017, Volume 8, Issue 1, pp. 16078 - 16078
BCL-2 family proteins are central regulators of mitochondrial apoptosis and validated anticancer targets. Using small cell lung cancer (SCLC) as a model, we... 
CELL LUNG-CANCER | SELECTIVE-INHIBITION | BAK ACTIVATION | POTENT | MULTIDISCIPLINARY SCIENCES | BIM | TRANSCRIPTION | DEATH | CDK INHIBITOR | ABT-263 | BH3 DOMAIN | Lung Neoplasms - drug therapy | Apoptosis - drug effects | Humans | Lung Neoplasms - metabolism | Myeloid Cell Leukemia Sequence 1 Protein - metabolism | Drug Resistance, Neoplasm | Molecular Targeted Therapy | Apoptosis Regulatory Proteins - drug effects | Myeloid Cell Leukemia Sequence 1 Protein - drug effects | Small Cell Lung Carcinoma - drug therapy | Small Cell Lung Carcinoma - metabolism | bcl-X Protein - drug effects | Proto-Oncogene Proteins c-bcl-2 - metabolism | bcl-X Protein - antagonists & inhibitors | Antineoplastic Agents - pharmacology | Myeloid Cell Leukemia Sequence 1 Protein - antagonists & inhibitors | Aniline Compounds - pharmacology | Cyclin-Dependent Kinase 9 - antagonists & inhibitors | Sulfonamides - pharmacology | Apoptosis Regulatory Proteins - metabolism | Drug Synergism | Pyridinium Compounds - pharmacology | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | High-Throughput Screening Assays | Apoptosis Regulatory Proteins - antagonists & inhibitors | Proto-Oncogene Proteins c-bcl-2 - drug effects | Cell Line, Tumor | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Protein Kinase Inhibitors - pharmacology | bcl-X Protein - metabolism | Doxorubicin - pharmacology | Regulators | Bax protein | Bcl-2 protein | Lung cancer | High-throughput screening | Doxorubicin | BAK protein | Mcl-1 protein | Proteins | Mitochondria | Inhibitors | Bcl-x protein | Anthracycline | Addiction | Cell death | Sequestering | Cancer | Apoptosis | Index Medicus
Journal Article
Cancer Cell, ISSN 1535-6108, 2007, Volume 12, Issue 2, pp. 171 - 185
Cancer cells exhibit many abnormal phenotypes that induce apoptotic signaling via the intrinsic, or mitochondrial, pathway. That cancer cells nonetheless... 
CELLCYCLE | MITOCHONDRIAL-MEMBRANE PERMEABILIZATION | B-CELL LYMPHOMA | ONCOLOGY | PROTOTYPE CANCER THERAPEUTICS | CHROMOSOMAL BREAKPOINT | FOLLICULAR LYMPHOMA | INDUCE APOPTOSIS | CYTOCHROME-C RELEASE | BCL-2 FAMILY-MEMBERS | BH3-ONLY PROTEINS | ANTIAPOPTOTIC BCL-2 | Vincristine - pharmacology | Immunoprecipitation | Proto-Oncogene Proteins c-bcl-2 - physiology | Antibiotics, Antineoplastic - pharmacology | Apoptosis - drug effects | Humans | Immunoblotting | Lymphoma, B-Cell - genetics | Bcl-2-Like Protein 11 | Biphenyl Compounds - pharmacology | Nitrophenols - pharmacology | Apoptosis Regulatory Proteins - genetics | Membrane Proteins - metabolism | BH3 Interacting Domain Death Agonist Protein - metabolism | Lymphoma, B-Cell - drug therapy | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Lymphoma, Large B-Cell, Diffuse - drug therapy | Lymphoma, Large B-Cell, Diffuse - pathology | Membrane Proteins - genetics | Tumor Cells, Cultured - drug effects | Etoposide - pharmacology | Proto-Oncogene Proteins - genetics | Sulfonamides - pharmacology | Piperazines - pharmacology | Blotting, Western | Apoptosis Regulatory Proteins - metabolism | Membrane Proteins - antagonists & inhibitors | Apoptosis Regulatory Proteins - antagonists & inhibitors | Lymphoma, B-Cell - pathology | Apoptosis Regulatory Proteins - physiology | Antineoplastic Agents, Phytogenic - pharmacology | Lymphoma, Large B-Cell, Diffuse - genetics | Doxorubicin - pharmacology | Index Medicus
Journal Article
Journal of Immunology, ISSN 0022-1767, 12/2012, Volume 189, Issue 11, pp. 5113 - 5117
Although the NLRP3 inflammasome plays a pivotal role in host defense, its uncontrolled activation is associated with inflammatory disorders, suggesting that... 
ACTIVATION | PATTERN-RECOGNITION | MACROPHAGES | THIOREDOXIN | IMMUNOLOGY | RECEPTORS | EXPRESSION | Interferon-beta - immunology | Reactive Oxygen Species - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Calcium-Binding Proteins - antagonists & inhibitors | Mitochondria - immunology | Adenosine Triphosphate - pharmacology | Signal Transduction - immunology | Inflammasomes - drug effects | Calcium-Binding Proteins - immunology | Apoptosis Regulatory Proteins - genetics | Female | Nuclear Proteins - genetics | Macrophages, Peritoneal - drug effects | Carrier Proteins - immunology | DNA-Binding Proteins | Apoptosis Regulatory Proteins - immunology | S-Nitroso-N-Acetylpenicillamine - metabolism | Mice, Inbred C57BL | Carrier Proteins - antagonists & inhibitors | Cells, Cultured | Macrophages, Peritoneal - immunology | Mitochondria - metabolism | Mitochondria - drug effects | Nuclear Proteins - immunology | Gene Expression Regulation - drug effects | Carrier Proteins - genetics | Animals | Interferon-beta - pharmacology | Signal Transduction - drug effects | Inflammasomes - immunology | Nuclear Proteins - antagonists & inhibitors | Apoptosis Regulatory Proteins - antagonists & inhibitors | Lipopolysaccharides - pharmacology | Mice | Macrophages, Peritoneal - metabolism | Nitric Oxide - metabolism | S-Nitroso-N-Acetylpenicillamine - pharmacology | Calcium-Binding Proteins - genetics | Index Medicus | Abridged Index Medicus
Journal Article
Cancer Research, ISSN 0008-5472, 12/2009, Volume 69, Issue 23, pp. 8844 - 8852
Transforming growth factor-beta (TGF-beta) is a multifunctional cytokine that regulates cell growth, differentiation, and apoptosis of various types of cells.... 
SURVIVAL | THERAPY | BECLIN-1 | ONCOLOGY | INDUCED APOPTOSIS | MESANGIAL CELLS | PAI-1 GENE-EXPRESSION | INDUCTION | TUMORIGENESIS | CANCER | LC3 | Microtubule-Associated Proteins - genetics | Humans | Ubiquitin-Activating Enzymes - biosynthesis | Cell Growth Processes - physiology | JNK Mitogen-Activated Protein Kinases - metabolism | Autophagy - physiology | Proto-Oncogene Proteins - biosynthesis | Transforming Growth Factor beta - biosynthesis | Breast Neoplasms - metabolism | Transfection | Bcl-2-Like Protein 11 | Carcinoma, Hepatocellular - genetics | Apoptosis Regulatory Proteins - genetics | Liver Neoplasms - pathology | Apoptosis Regulatory Proteins - biosynthesis | Beclin-1 | Ubiquitin-Activating Enzymes - genetics | Liver Neoplasms - genetics | Membrane Proteins - genetics | Transforming Growth Factor beta - physiology | Proto-Oncogene Proteins - genetics | Microtubule-Associated Proteins - antagonists & inhibitors | Microtubule-Associated Proteins - biosynthesis | Autophagy-Related Protein 7 | Membrane Proteins - biosynthesis | Breast Neoplasms - genetics | Transforming Growth Factor beta - genetics | Autophagy-Related Protein 5 | Membrane Proteins - antagonists & inhibitors | Receptors, Transforming Growth Factor beta - metabolism | Breast Neoplasms - pathology | Ubiquitin-Activating Enzymes - antagonists & inhibitors | Adaptor Proteins, Signal Transducing - genetics | Apoptosis Regulatory Proteins - antagonists & inhibitors | Carcinoma, Hepatocellular - pathology | Liver Neoplasms - metabolism | Cell Line, Tumor | Adaptor Proteins, Signal Transducing - biosynthesis | Smad Proteins - metabolism | Carcinoma, Hepatocellular - metabolism | Index Medicus
Journal Article