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Nature structural & molecular biology, ISSN 1545-9985, 2010, Volume 17, Issue 6, pp. 688 - 695
.... Here we identify p53-binding protein 1 (53BP1) as an essential factor for sustaining the growth arrest induced by Brca1 deletion... 
STEM-CELLS | GENE BRCA1 | DNA-DAMAGE RESPONSE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CONDITIONAL MOUSE MODEL | DOUBLE-STRAND BREAKS | OVARIAN-CANCER | CELL BIOLOGY | GENOMIC INSTABILITY | MAMMARY-TUMORS | BIOPHYSICS | TUMOR-SUPPRESSOR | CELL-CYCLE | Embryonic Stem Cells - metabolism | Cell Proliferation | Embryonic Stem Cells - cytology | Humans | Breast Neoplasms - metabolism | Intracellular Signaling Peptides and Proteins - deficiency | Gene Deletion | Genes, BRCA2 | Female | Genes, BRCA1 | Tumor Cells, Cultured | BRCA1 Protein - deficiency | Intracellular Signaling Peptides and Proteins - genetics | DNA-Binding Proteins | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Chromosomal Proteins, Non-Histone | Breast Neoplasms - drug therapy | Mice, Knockout | BRCA1 Protein - genetics | Drug Resistance, Neoplasm - genetics | Animals | Apoptosis Regulatory Proteins | Breast Neoplasms - genetics | Cell Cycle | Breast Neoplasms - pathology | DNA Repair | BRCA2 Protein - deficiency | Mice | Mutagenesis, Insertional | DNA Damage | Mutation | Tumor Suppressor p53-Binding Protein 1 | Drug Resistance, Neoplasm - physiology | BRCA2 Protein - genetics | BRCA mutations | DNA damage | Physiological aspects | Breast cancer | Genetic aspects | Research | Health aspects | DNA repair | Risk factors | Molecular biology | Ovarian cancer
Journal Article
Nature (London), ISSN 1476-4687, 2012, Volume 490, Issue 7418, pp. 107 - 111
... (NLR family, apoptosis inhibitory protein 5)/NLRC4 (NLR family, CARD-domain-containing 4) inflammasome(2-4... 
CYTOSOLIC PHOSPHOLIPASE A | FLAGELLIN | III SECRETION APPARATUS | MECHANISM | MICE DEFICIENT | MULTIDISCIPLINARY SCIENCES | NLRC4 INFLAMMASOME | INFECTION | PYROPTOSIS | CASPASE-1 ACTIVATION | IMMUNE RECOGNITION | Inflammation - pathology | Inflammasomes - metabolism | Hematocrit | Salmonella Infections - immunology | Eicosanoids - biosynthesis | Caspase 1 - metabolism | Male | Inflammation - metabolism | Time Factors | Flagellin - metabolism | Bacterial Toxins - genetics | Antigens, Bacterial - chemistry | Neuronal Apoptosis-Inhibitory Protein - deficiency | Macrophages, Peritoneal - immunology | Calcium-Binding Proteins - deficiency | Interleukin-1beta | Bacterial Toxins - chemistry | Apoptosis Regulatory Proteins - metabolism | Cyclooxygenase 1 - deficiency | Body Fluids - metabolism | Caspase 1 - deficiency | Recombinant Fusion Proteins - genetics | Cytosol - metabolism | Death | Mice | Antigens, Bacterial - metabolism | Capillary Permeability | Peritoneal Cavity | Legionella pneumophila | Intestines - metabolism | Antigens, Bacterial - genetics | Recombinant Fusion Proteins - metabolism | Peritoneal Lavage | Apoptosis Regulatory Proteins - deficiency | Flagellin - genetics | Female | Interleukin-18 | Calcium Signaling | Calcium-Binding Proteins - metabolism | Flagellin - immunology | Salmonella typhimurium - immunology | Mice, Inbred C57BL | Inflammation - immunology | Body Temperature | Neuronal Apoptosis-Inhibitory Protein - metabolism | Immunity, Innate - immunology | Bacterial Toxins - metabolism | Animals | Eicosanoids - metabolism | Fluid Shifts | Cellular signal transduction | Research | Properties | Bacterial proteins | Flagella (Microbiology) | Immune system | Proteins | Bone marrow | Pathology | Infections | Biosynthesis | Rodents
Journal Article
Nature (London), ISSN 1476-4687, 2012, Volume 482, Issue 7384, pp. 179 - 185
Journal Article
Nature medicine, ISSN 1546-170X, 2013, Volume 19, Issue 11, pp. 1478 - 1488
Here we show that Mst1, a proapoptotic kinase, impairs protein quality control mechanisms in the heart through inhibition of autophagy... 
MEDICINE, RESEARCH & EXPERIMENTAL | APOPTOSIS | PROTEIN AGGREGATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | PHOSPHATIDYLINOSITOL 3-KINASE COMPLEXES | KINASE | STARVATION-INDUCED AUTOPHAGY | CELL BIOLOGY | HEMODYNAMIC STRESS | PATHWAY | X-L | CARDIAC-HYPERTROPHY | TUMOR-SUPPRESSOR | Cardiomyopathy, Dilated - pathology | Phosphorylation | Humans | Middle Aged | Protein Multimerization | Molecular Sequence Data | Male | Autophagy - physiology | Young Adult | Proto-Oncogene Proteins c-bcl-2 - metabolism | Myocardial Infarction - pathology | Apoptosis Regulatory Proteins - genetics | Hepatocyte Growth Factor - genetics | Adult | Female | Membrane Proteins - metabolism | Beclin-1 | Proto-Oncogene Proteins - metabolism | Amino Acid Sequence | Myocytes, Cardiac - cytology | Membrane Proteins - genetics | Apoptosis Regulatory Proteins - chemistry | Mice, Inbred C57BL | bcl-2-Associated X Protein - metabolism | Class III Phosphatidylinositol 3-Kinases - metabolism | Models, Molecular | Rats | Mice, Transgenic | Proto-Oncogene Proteins - genetics | Myocardial Infarction - metabolism | Proto-Oncogene Proteins - deficiency | Cardiomyopathy, Dilated - metabolism | Apoptosis Regulatory Proteins - metabolism | Hepatocyte Growth Factor - metabolism | Mice, Knockout | Hepatocyte Growth Factor - deficiency | Animals | Membrane Proteins - chemistry | Myocytes, Cardiac - metabolism | Class III Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Mice | Apoptosis - physiology | Autophagy (Cytology) | Heart cells | Physiological aspects | Research | Properties | Phosphotransferases | Apoptosis | Cardiomyocytes | Kinases | Cardiomyopathy | Autophagy
Journal Article
Nature reviews. Cancer, ISSN 1474-1768, 2002, Volume 2, Issue 1, pp. 38 - 47
Cells undergo a variety of biological responses when placed in hypoxic conditions, including activation of signalling pathways that regulate proliferation,... 
TARGET GENES | ACTIVATED PROTEIN-KINASE | P53-DEPENDENT APOPTOSIS | ONCOLOGY | INDUCIBLE FACTOR 1-ALPHA | GENE-EXPRESSION | BINDING-PROTEIN | FACTOR-I | FACTORS HIF-1-ALPHA | FACTOR (HIF)-1-ALPHA | UP-REGULATION | Oxidative Stress | Vascular Endothelial Growth Factors | Humans | Hypoxia-Inducible Factor 1, alpha Subunit | Trans-Activators - physiology | Aryl Hydrocarbon Receptor Nuclear Translocator | Antineoplastic Agents - pharmacokinetics | Dimerization | Basic Helix-Loop-Helix Transcription Factors | Endothelial Growth Factors - physiology | DNA-Binding Proteins - physiology | Hypoxia-Inducible Factor 1 | Oxidation-Reduction | Signal Transduction | Lymphokines - physiology | Neoplasms - blood supply | Forecasting | Trans-Activators - deficiency | Mice | Neovascularization, Pathologic - metabolism | DNA Damage | Hydrogen-Ion Concentration | Neoplasms - metabolism | Vascular Endothelial Growth Factor A | Erythropoietin - therapeutic use | Receptor Protein-Tyrosine Kinases - physiology | Transcription Factors - deficiency | Embryonic and Fetal Development | Oxygen - metabolism | Vascular Endothelial Growth Factor Receptor-1 | Cell Hypoxia | Neoplasms - genetics | Cell Division | Trans-Activators - genetics | Transcription Factors - physiology | Cell Survival | Gene Expression Regulation | Transcription Factors - genetics | Cyclic AMP Response Element-Binding Protein - physiology | Xenograft Model Antitumor Assays | Animals | Prodrugs - pharmacokinetics | NF-kappa B - physiology | Proto-Oncogene Proteins - physiology | Glycolysis | Neovascularization, Pathologic - genetics | Nuclear Proteins - physiology | Neoplasms - pathology | Receptors, Aryl Hydrocarbon | Apoptosis | Complications and side effects | Care and treatment | Prognosis | Growth | Physiological aspects | Hypoxia | Research | Tumors
Journal Article
Nature (London), ISSN 1476-4687, 2006, Volume 441, Issue 7089, pp. 106 - 110
Journal Article
Journal Article
Immunity (Cambridge, Mass.), ISSN 1074-7613, 2013, Volume 39, Issue 5, pp. 833 - 845
.... How these phases are transcriptionally regulated is incompletely defined. Here, we report that interferon regulatory factor 4 (IRF4... 
RESPONSES | ACTIVATION | VIRUS | IRF4 | TRANSCRIPTION | INFECTION | IMMUNOLOGY | NF-KAPPA-B | EXPRESSION | MTOR | ANTIGEN | CD8-Positive T-Lymphocytes - cytology | Cells, Cultured - cytology | Coculture Techniques | Dendritic Cells - immunology | T-Box Domain Proteins - biosynthesis | Interferon Regulatory Factors - deficiency | Bcl-2-Like Protein 11 | Interferon Regulatory Factors - physiology | Receptors, Antigen, T-Cell - immunology | TOR Serine-Threonine Kinases - physiology | Cell Differentiation | Proto-Oncogene Proteins - antagonists & inhibitors | Specific Pathogen-Free Organisms | Lymphocyte Activation | Mice, Inbred C57BL | Gene Expression Regulation | Interferon Regulatory Factors - genetics | Viral Plaque Assay | Mice, Transgenic | Transcription Factors - biosynthesis | Transcription Factors - genetics | T-Box Domain Proteins - genetics | Interferon Regulatory Factors - immunology | Animals | Membrane Proteins - antagonists & inhibitors | Apoptosis Regulatory Proteins - antagonists & inhibitors | Mice | Orthomyxoviridae Infections - virology | Orthomyxoviridae Infections - immunology | Apoptosis | Cyclin-Dependent Kinase Inhibitor Proteins - antagonists & inhibitors | Positive Regulatory Domain I-Binding Factor 1 | Transcription factors | Peptides | Lymphocytes | Rodents | T cell receptors | Infections | Expansion | Immune system
Journal Article