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Nature, ISSN 0028-0836, 10/2015, Volume 526, Issue 7575, pp. 666 - 671
Journal Article
Nature, ISSN 0028-0836, 10/2012, Volume 490, Issue 7418, pp. 49 - 54
Journal Article
Immunity, ISSN 1074-7613, 06/2013, Volume 38, Issue 6, pp. 1116 - 1128
Immune tolerance requires regulatory T (Treg) cells to prevent autoimmune disease, with the transcription factor Foxp3 functioning as the critical regulator of... 
APOPTOSIS | THYMUS | GENE | SPECIFICITY | AUTOIMMUNITY | BIM | NEGATIVE SELECTION | SELF | DIFFERENTIATION | IMMUNOLOGY | LINEAGE FATE | Dual Specificity Phosphatase 6 - genetics | Lymphopoiesis - genetics | Apoptosis - genetics | Male | Interleukin Receptor Common gamma Subunit - immunology | Proto-Oncogene Proteins c-bcl-2 - metabolism | MAP Kinase Kinase 4 - metabolism | Bcl-2-Like Protein 11 | Forkhead Transcription Factors - metabolism | Gene Expression Regulation, Developmental | Tumor Suppressor Proteins - genetics | Apoptosis Regulatory Proteins - genetics | Membrane Proteins - metabolism | Cytokines - immunology | T-Lymphocytes, Regulatory - physiology | Proto-Oncogene Proteins - metabolism | Tumor Suppressor Proteins - metabolism | Cell Survival | Membrane Proteins - genetics | Cells, Cultured | Mice, Transgenic | Proto-Oncogene Proteins - genetics | Forkhead Transcription Factors - genetics | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Dual Specificity Phosphatase 6 - metabolism | Animals | MAP Kinase Kinase 4 - genetics | Mice | Proto-Oncogene Proteins c-bcl-2 - genetics | Cytokines | T cells | Singers | Apoptosis | Proteins | Medical research | Transcription factors | Lymphocytes | Rodents | Bone marrow | Protein expression | T cell receptors | Gene expression | Chromosomes | Index Medicus
Journal Article
Science, ISSN 0036-8075, 12/2010, Volume 330, Issue 6009, pp. 1390 - 1393
Although the proteins BAX and BAK are required for initiation of apoptosis at the mitochondria, how BAX and BAK are activated remains unsettled. We provide in... 
T lymphocytes | Mitochondria | Cytokines | Thymocytes | Neurons | Cell death | REPORTS | Cytochromes | Mice | Potassium | Apoptosis | NEURONAL APOPTOSIS | CYTOCHROME-C | MITOCHONDRIAL APOPTOSIS | MECHANISM | MULTIDISCIPLINARY SCIENCES | BH3 DOMAINS | RELEASE | JNK PATHWAY | PROTEINS | BCL-2 FAMILY-MEMBERS | MEMBRANE PERMEABILIZATION | BH3 Interacting Domain Death Agonist Protein - deficiency | T-Lymphocytes - physiology | bcl-2-Associated X Protein - chemistry | Protein Multimerization | Stress, Physiological | bcl-2 Homologous Antagonist-Killer Protein - genetics | BH3 Interacting Domain Death Agonist Protein - genetics | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Membrane Proteins - deficiency | Caspases - metabolism | Bcl-2-Like Protein 11 | Apoptosis Regulatory Proteins - deficiency | Tumor Suppressor Proteins - deficiency | Tumor Suppressor Proteins - genetics | Neurons - physiology | Apoptosis Regulatory Proteins - genetics | Membrane Proteins - metabolism | BH3 Interacting Domain Death Agonist Protein - metabolism | bcl-2-Associated X Protein - genetics | Proto-Oncogene Proteins - metabolism | Tumor Suppressor Proteins - metabolism | Membrane Proteins - genetics | Cytochromes c - metabolism | Cells, Cultured | bcl-2-Associated X Protein - metabolism | Proto-Oncogene Proteins - genetics | Mitochondria - metabolism | Permeability | Proto-Oncogene Proteins - deficiency | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Animals | Models, Biological | Cerebellum - cytology | Intracellular Membranes - metabolism | bcl-2 Homologous Antagonist-Killer Protein - chemistry | Protein research | Genetic aspects | Mitochondrial DNA | Biochemical genetics | Research | Properties | Methods | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 02/2016, Volume 530, Issue 7590, pp. 354 - 357
Journal Article
Cancer Research, ISSN 0008-5472, 04/2011, Volume 71, Issue 7, pp. 2750 - 2760
This study addresses the role of PTEN loss in intrinsic resistance to the BRAF inhibitor PLX4720. Immunohistochemical staining of a tissue array covering all... 
METASTATIC MELANOMA | APOPTOSIS | PROTEIN | ONCOLOGY | PHOSPHORYLATION | CUTANEOUS MELANOMA | RAF KINASE | CANCER | MEDIATES RESISTANCE | LINES | ERK | RNA, Small Interfering - genetics | Up-Regulation | Humans | Drug Resistance, Neoplasm | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Proto-Oncogene Proteins - biosynthesis | Bcl-2-Like Protein 11 | Melanoma - genetics | Apoptosis Regulatory Proteins - genetics | Indoles - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | Proto-Oncogene Proteins B-raf - metabolism | Apoptosis Regulatory Proteins - biosynthesis | Melanoma - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | PTEN Phosphohydrolase - deficiency | Membrane Proteins - genetics | PTEN Phosphohydrolase - biosynthesis | Proto-Oncogene Proteins - genetics | Melanoma - pathology | Sulfonamides - pharmacology | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Membrane Proteins - biosynthesis | Membrane Proteins - antagonists & inhibitors | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Apoptosis Regulatory Proteins - antagonists & inhibitors | Cell Line, Tumor | Protein Kinase Inhibitors - pharmacology | Apoptosis - physiology | Mutation | RNA, Small Interfering - administration & dosage | Index Medicus | PTEN | melanoma | BRAF | PLX4032 | therapy | resistance
Journal Article
Nature Medicine, ISSN 1078-8956, 04/2012, Volume 18, Issue 4, pp. 521 - 528
Tyrosine kinase inhibitors (TKIs) elicit high response rates among individuals with kinase-driven malignancies, including chronic myeloid leukemia (CML) and... 
CHRONIC MYELOGENOUS LEUKEMIA | MEDICINE, RESEARCH & EXPERIMENTAL | APOPTOSIS | GEFITINIB | BIOCHEMISTRY & MOLECULAR BIOLOGY | EYE DISEASES | CHRONIC MYELOID-LEUKEMIA | CELL BIOLOGY | CELL LUNG-CANCER | FACTOR RECEPTOR EGFR | GROWTH | ACTIVATING MUTATIONS | MUTANT EGFR | Enzyme-Linked Immunosorbent Assay - methods | Lung Neoplasms - drug therapy | Receptor, Epidermal Growth Factor - genetics | Follow-Up Studies | Apoptosis - drug effects | Humans | Middle Aged | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics | Male | BH3 Interacting Domain Death Agonist Protein - genetics | Dose-Response Relationship, Drug | Protein Isoforms - metabolism | Transfection | Bcl-2-Like Protein 11 | Statistics, Nonparametric | Aged, 80 and over | Apoptosis Regulatory Proteins - genetics | Adult | Female | Gene Expression Regulation, Neoplastic - drug effects | Lung Neoplasms - genetics | Annexins - metabolism | Carcinoma, Non-Small-Cell Lung - genetics | Membrane Proteins - genetics | Gene Frequency | Exons - genetics | Genotype | Proto-Oncogene Proteins - genetics | International Cooperation | Drug Resistance, Neoplasm - genetics | Cell Line, Tumor | Polymorphism, Genetic - genetics | Aged | Protein Kinase Inhibitors - pharmacology | Carcinoma, Non-Small-Cell Lung - drug therapy | Cohort Studies | Drug Resistance, Neoplasm - drug effects | Protein Isoforms - genetics | RNA, Small Interfering - metabolism | Sequence Deletion - genetics | Antimitotic agents | Physiological aspects | Protein tyrosine kinase | Dosage and administration | Genetic aspects | Research | Antineoplastic agents | Tumor proteins | Genetic polymorphisms | Inhibitor drugs | Mutation | Kinases | Gene expression | Apoptosis | Polymorphism | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 01/2013, Volume 110, Issue 5, pp. 1851 - 1856
A flagellin-independent caspase-1 activation pathway that does not require NAIP5 or NRLC4 is induced by the intracellular pathogen Legionella pneumophila .... 
Cell death | Innate immunity | Inflammasome | PATTERN-RECOGNITION | innate immunity | cell death | inflammasome | MULTIDISCIPLINARY SCIENCES | NLRP3 INFLAMMASOME ACTIVATION | INFECTION | RECEPTORS | Cytoskeletal Proteins - genetics | NLR Family, Pyrin Domain-Containing 3 Protein | Adaptor Proteins, Vesicular Transport - genetics | Caspase 1 - metabolism | Immunoblotting | Legionella pneumophila - genetics | Adaptor Proteins, Vesicular Transport - metabolism | Necrosis | Caspases - metabolism | Flagellin - genetics | Flagellin - metabolism | Apoptosis Regulatory Proteins - genetics | Cytoskeletal Proteins - metabolism | Receptor, Interferon alpha-beta - genetics | Macrophages - microbiology | Receptor, Interferon alpha-beta - metabolism | Calcium-Binding Proteins - metabolism | Cytokines - metabolism | Caspases - genetics | Mice, Inbred C57BL | Cells, Cultured | Myeloid Differentiation Factor 88 - genetics | Macrophages - cytology | Legionella pneumophila - metabolism | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Host-Pathogen Interactions | Carrier Proteins - genetics | Macrophages - metabolism | Animals | Carrier Proteins - metabolism | Caspase 1 - genetics | CARD Signaling Adaptor Proteins | Bone Marrow Cells - microbiology | Legionella pneumophila - physiology | Mice | Enzyme Activation | Mutation | Myeloid Differentiation Factor 88 - metabolism | Bone Marrow Cells - metabolism | Apoptosis | Calcium-Binding Proteins - genetics | Legionella pneumophila | Genetic aspects | Research | Macrophages | Properties | Immunological research | Proteins | Bacteria | Medical treatment | Cells | Index Medicus | Biological Sciences
Journal Article
Journal Article
PLoS Genetics, ISSN 1553-7390, 05/2013, Volume 9, Issue 5, pp. e1003532 - e1003532