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Journal Article
Nature, ISSN 0028-0836, 10/2015, Volume 526, Issue 7575, pp. 666 - 671
Journal Article
Nature, ISSN 0028-0836, 2013, Volume 494, Issue 7436, pp. 201 - 206
The lysosomal degradation pathway of autophagy has a crucial role in defence against infection, neurodegenerative disorders, cancer and ageing. Accordingly,... 
PATHOGENESIS | LOCALIZES | COMPLEX | PROTEIN | BECLIN-1 | PATHWAY | MACROPHAGES | MULTIDISCIPLINARY SCIENCES | DISEASE | INFECTION | BINDING | Apoptosis Regulatory Proteins - pharmacology | Recombinant Fusion Proteins - pharmacology | Humans | Cell Membrane Permeability | Molecular Sequence Data | Peptide Fragments - pharmacology | Membrane Proteins - pharmacology | Membrane Proteins - therapeutic use | Recombinant Fusion Proteins - metabolism | Autophagy - drug effects | HIV-1 - physiology | nef Gene Products, Human Immunodeficiency Virus - metabolism | Membrane Proteins - metabolism | Beclin-1 | Amino Acid Sequence | HIV-1 - metabolism | Virus Replication - drug effects | Peptide Fragments - metabolism | HIV-1 - drug effects | tat Gene Products, Human Immunodeficiency Virus - genetics | Apoptosis Regulatory Proteins - chemistry | Cells, Cultured | West Nile virus - drug effects | Macrophages - cytology | Recombinant Fusion Proteins - chemistry | Apoptosis Regulatory Proteins - metabolism | Chikungunya virus - drug effects | Peptide Fragments - chemistry | Animals | Membrane Proteins - chemistry | Mice | HeLa Cells | Apoptosis Regulatory Proteins - therapeutic use | tat Gene Products, Human Immunodeficiency Virus - metabolism | Proteins | Peptides | Microscopy | Rodents | Mortality | Amino acids | Infections | Autophagy | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 02/2016, Volume 530, Issue 7590, pp. 354 - 357
Journal Article
Science, ISSN 0036-8075, 12/2010, Volume 330, Issue 6009, pp. 1390 - 1393
Although the proteins BAX and BAK are required for initiation of apoptosis at the mitochondria, how BAX and BAK are activated remains unsettled. We provide in... 
T lymphocytes | Mitochondria | Cytokines | Thymocytes | Neurons | Cell death | REPORTS | Cytochromes | Mice | Potassium | Apoptosis | NEURONAL APOPTOSIS | CYTOCHROME-C | MITOCHONDRIAL APOPTOSIS | MECHANISM | MULTIDISCIPLINARY SCIENCES | BH3 DOMAINS | RELEASE | JNK PATHWAY | PROTEINS | BCL-2 FAMILY-MEMBERS | MEMBRANE PERMEABILIZATION | BH3 Interacting Domain Death Agonist Protein - deficiency | T-Lymphocytes - physiology | bcl-2-Associated X Protein - chemistry | Protein Multimerization | Stress, Physiological | bcl-2 Homologous Antagonist-Killer Protein - genetics | BH3 Interacting Domain Death Agonist Protein - genetics | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Membrane Proteins - deficiency | Caspases - metabolism | Bcl-2-Like Protein 11 | Apoptosis Regulatory Proteins - deficiency | Tumor Suppressor Proteins - deficiency | Tumor Suppressor Proteins - genetics | Neurons - physiology | Apoptosis Regulatory Proteins - genetics | Membrane Proteins - metabolism | BH3 Interacting Domain Death Agonist Protein - metabolism | bcl-2-Associated X Protein - genetics | Proto-Oncogene Proteins - metabolism | Tumor Suppressor Proteins - metabolism | Membrane Proteins - genetics | Cytochromes c - metabolism | Cells, Cultured | bcl-2-Associated X Protein - metabolism | Proto-Oncogene Proteins - genetics | Mitochondria - metabolism | Permeability | Proto-Oncogene Proteins - deficiency | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Animals | Models, Biological | Cerebellum - cytology | Intracellular Membranes - metabolism | bcl-2 Homologous Antagonist-Killer Protein - chemistry | Protein research | Genetic aspects | Mitochondrial DNA | Biochemical genetics | Research | Properties | Methods | Index Medicus
Journal Article
Science, ISSN 0036-8075, 2/2007, Volume 315, Issue 5813, pp. 856 - 859
A central issue in the regulation of apoptosis by the Bcl-2 family is whether its BH3-only members initiate apoptosis by directly binding to the essential... 
Research fellowships | Protein isoforms | Medical research | Myeloid cells | Antibodies | Cytochromes | Ligands | Reports | Grants | Viability | Apoptosis | RESPONSES | FAMILY-MEMBERS | X-L | MULTIDISCIPLINARY SCIENCES | BIM | HELIX | MITOCHONDRIAL-MEMBRANE | PUMA | DOMAINS | BH3-ONLY PROTEINS | CELL-DEATH | bcl-2-Associated X Protein - chemistry | Humans | BH3 Interacting Domain Death Agonist Protein - genetics | Proto-Oncogene Proteins - chemistry | Neoplasm Proteins - metabolism | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Bcl-2-Like Protein 11 | Tumor Suppressor Proteins - genetics | BH3 Interacting Domain Death Agonist Protein - chemistry | Apoptosis Regulatory Proteins - genetics | bcl-Associated Death Protein - metabolism | Membrane Proteins - metabolism | BH3 Interacting Domain Death Agonist Protein - metabolism | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | Cell Line | Tumor Suppressor Proteins - metabolism | Membrane Proteins - genetics | Apoptosis Regulatory Proteins - chemistry | Cells, Cultured | bcl-2-Associated X Protein - metabolism | Proto-Oncogene Proteins - genetics | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Animals | Proteins - metabolism | Membrane Proteins - chemistry | Models, Biological | Myeloid Cell Leukemia Sequence 1 Protein | Mice | Mutation | bcl-X Protein - metabolism | Research | Peptides | Analysis | Biochemistry | Cellular biology | Molecular biology | Binding sites | Index Medicus
Journal Article
Molecular Biology of the Cell, ISSN 1059-1524, 12/2008, Volume 19, Issue 12, pp. 5360 - 5372
Class III phosphatidylinositol 3-kinase (PI3-kinase) regulates multiple membrane trafficking. In yeast, two distinct PI3-kinase complexes are known: complex I... 
PRE-AUTOPHAGOSOMAL STRUCTURE | LATE ENDOSOMES | MOLECULAR MACHINERY | PROTEIN-KINASE | TRANS-GOLGI NETWORK | TUMOR-SUPPRESSOR | VPS34 PTDINS 3-KINASE | SACCHAROMYCES-CEREVISIAE | SELECTIVE AUTOPHAGY | SELF-DIGESTION | CELL BIOLOGY | Autophagy-Related Proteins | Adaptor Proteins, Vesicular Transport - classification | Humans | Adaptor Proteins, Vesicular Transport - genetics | Molecular Sequence Data | rab GTP-Binding Proteins - genetics | Autophagy - physiology | Phosphatidylinositol 3-Kinases - metabolism | Phylogeny | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Adaptor Proteins, Vesicular Transport - metabolism | Recombinant Fusion Proteins - metabolism | Multiprotein Complexes - metabolism | RNA Interference | Tumor Suppressor Proteins - genetics | Apoptosis Regulatory Proteins - genetics | Phagosomes - ultrastructure | Cell Membrane - metabolism | Membrane Proteins - metabolism | Androstadienes - metabolism | Beclin-1 | rab GTP-Binding Proteins - metabolism | Amino Acid Sequence | Cell Line | Tumor Suppressor Proteins - metabolism | Membrane Proteins - genetics | Phagosomes - metabolism | Apoptosis Regulatory Proteins - metabolism | Endocytosis - physiology | Phosphatidylinositol 3-Kinases - genetics | Multiprotein Complexes - chemistry | Sequence Alignment | Animals | Recombinant Fusion Proteins - genetics | Signal Transduction - physiology | Mice | Index Medicus
Journal Article
Nature Medicine, ISSN 1078-8956, 11/2013, Volume 19, Issue 11, pp. 1478 - 1488
Here we show that Mst1, a proapoptotic kinase, impairs protein quality control mechanisms in the heart through inhibition of autophagy. Stress-induced... 
MEDICINE, RESEARCH & EXPERIMENTAL | APOPTOSIS | PROTEIN AGGREGATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | PHOSPHATIDYLINOSITOL 3-KINASE COMPLEXES | KINASE | STARVATION-INDUCED AUTOPHAGY | CELL BIOLOGY | HEMODYNAMIC STRESS | PATHWAY | X-L | CARDIAC-HYPERTROPHY | TUMOR-SUPPRESSOR | Cardiomyopathy, Dilated - pathology | Phosphorylation | Humans | Middle Aged | Protein Multimerization | Molecular Sequence Data | Male | Autophagy - physiology | Young Adult | Proto-Oncogene Proteins c-bcl-2 - metabolism | Myocardial Infarction - pathology | Apoptosis Regulatory Proteins - genetics | Hepatocyte Growth Factor - genetics | Adult | Female | Membrane Proteins - metabolism | Beclin-1 | Proto-Oncogene Proteins - metabolism | Amino Acid Sequence | Myocytes, Cardiac - cytology | Membrane Proteins - genetics | Apoptosis Regulatory Proteins - chemistry | Mice, Inbred C57BL | bcl-2-Associated X Protein - metabolism | Class III Phosphatidylinositol 3-Kinases - metabolism | Models, Molecular | Rats | Mice, Transgenic | Proto-Oncogene Proteins - genetics | Myocardial Infarction - metabolism | Proto-Oncogene Proteins - deficiency | Cardiomyopathy, Dilated - metabolism | Apoptosis Regulatory Proteins - metabolism | Hepatocyte Growth Factor - metabolism | Mice, Knockout | Hepatocyte Growth Factor - deficiency | Animals | Membrane Proteins - chemistry | Myocytes, Cardiac - metabolism | Class III Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Mice | Apoptosis - physiology | Autophagy (Cytology) | Heart cells | Physiological aspects | Research | Properties | Phosphotransferases | Apoptosis | Cardiomyocytes | Kinases | Cardiomyopathy | Autophagy | Index Medicus
Journal Article
Journal Article