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Nature structural & molecular biology, ISSN 1545-9985, 2010, Volume 17, Issue 10, pp. 1247 - 1254
... of genome stability after mutations in proteins that carry out repair through homologous recombination, such as BRCA2 (refs. 2,3). In mammalian cells, homologous... 
POLY(ADP-RIBOSE) POLYMERASE | COMPLEX | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOUBLE-STRAND BREAKS | HISTONE H2AX | FANCONI-ANEMIA | CELL BIOLOGY | RAD51 | BIOPHYSICS | IN-VIVO | SUSCEPTIBILITY GENE | D-LOOP FORMATION | DNA-REPAIR | Recombination, Genetic - physiology | DNA, Neoplasm - metabolism | Humans | Neoplasm Proteins - physiology | DNA Repair - physiology | Molecular Sequence Data | Structure-Activity Relationship | DNA Breaks, Double-Stranded | BRCA2 Protein - physiology | Breast Neoplasms - metabolism | Base Sequence | Tumor Suppressor Proteins - chemistry | Tumor Suppressor Proteins - genetics | Female | Protein Interaction Domains and Motifs | Nuclear Proteins - genetics | Nucleic Acid Conformation | Fanconi Anemia Complementation Group N Protein | Peptide Fragments - metabolism | Neoplasm Proteins - chemistry | Nuclear Proteins - chemistry | Poly(ADP-ribose) Polymerase Inhibitors | Protein Interaction Mapping | Tumor Suppressor Proteins - physiology | Peptide Fragments - chemistry | Apoptosis Regulatory Proteins | Models, Biological | Rad51 Recombinase - chemistry | Rad51 Recombinase - physiology | BRCA2 Protein - chemistry | Nuclear Proteins - physiology | Poly (ADP-Ribose) Polymerase-1 | Breast cancer | Genetic aspects | Research | BRCA mutations | Ovarian cancer | Proteins | Mutation | Molecular biology | Prostate cancer | homologous recombination | BRCA2 | PALB2
Journal Article
Nature reviews. Cancer, ISSN 1474-1768, 2002, Volume 2, Issue 1, pp. 38 - 47
Cells undergo a variety of biological responses when placed in hypoxic conditions, including activation of signalling pathways that regulate proliferation,... 
TARGET GENES | ACTIVATED PROTEIN-KINASE | P53-DEPENDENT APOPTOSIS | ONCOLOGY | INDUCIBLE FACTOR 1-ALPHA | GENE-EXPRESSION | BINDING-PROTEIN | FACTOR-I | FACTORS HIF-1-ALPHA | FACTOR (HIF)-1-ALPHA | UP-REGULATION | Oxidative Stress | Vascular Endothelial Growth Factors | Humans | Hypoxia-Inducible Factor 1, alpha Subunit | Trans-Activators - physiology | Aryl Hydrocarbon Receptor Nuclear Translocator | Antineoplastic Agents - pharmacokinetics | Dimerization | Basic Helix-Loop-Helix Transcription Factors | Endothelial Growth Factors - physiology | DNA-Binding Proteins - physiology | Hypoxia-Inducible Factor 1 | Oxidation-Reduction | Signal Transduction | Lymphokines - physiology | Neoplasms - blood supply | Forecasting | Trans-Activators - deficiency | Mice | Neovascularization, Pathologic - metabolism | DNA Damage | Hydrogen-Ion Concentration | Neoplasms - metabolism | Vascular Endothelial Growth Factor A | Erythropoietin - therapeutic use | Receptor Protein-Tyrosine Kinases - physiology | Transcription Factors - deficiency | Embryonic and Fetal Development | Oxygen - metabolism | Vascular Endothelial Growth Factor Receptor-1 | Cell Hypoxia | Neoplasms - genetics | Cell Division | Trans-Activators - genetics | Transcription Factors - physiology | Cell Survival | Gene Expression Regulation | Transcription Factors - genetics | Cyclic AMP Response Element-Binding Protein - physiology | Xenograft Model Antitumor Assays | Animals | Prodrugs - pharmacokinetics | NF-kappa B - physiology | Proto-Oncogene Proteins - physiology | Glycolysis | Neovascularization, Pathologic - genetics | Nuclear Proteins - physiology | Neoplasms - pathology | Receptors, Aryl Hydrocarbon | Apoptosis | Complications and side effects | Care and treatment | Prognosis | Growth | Physiological aspects | Hypoxia | Research | Tumors
Journal Article
Developmental cell, ISSN 1534-5807, 2008, Volume 14, Issue 3, pp. 388 - 398
.... Here we identify the TEAD/TEF family protein Scalloped (Sd) as a DNA-binding transcription factor that partners with Yki to mediate the transcriptional output of the Hpo growth-regulatory pathway. The diap1 ( th... 
CELL CYCLE | SIGNALING | ORGAN SIZE | APOPTOSIS | GENE | WING FORMATION | FAT | TUMOR-SUPPRESSOR | EXPANDED ACT | CELL-PROLIFERATION | DEVELOPMENTAL BIOLOGY | BANTAM MICRORNA | DROSOPHILA | CELL BIOLOGY | Inhibitor of Apoptosis Proteins - genetics | Molecular Sequence Data | Drosophila - physiology | Trans-Activators - physiology | Drosophila Proteins - physiology | Wings, Animal - growth & development | Gene Expression Regulation, Developmental | Base Sequence | Trans-Activators - genetics | Transcription, Genetic | Nuclear Proteins - genetics | Intracellular Signaling Peptides and Proteins - genetics | Drosophila - genetics | Genes, Insect | Amino Acid Sequence | Transcription Factors - physiology | Signal Transduction | Animals, Genetically Modified | Protein-Serine-Threonine Kinases - physiology | Protein-Serine-Threonine Kinases - genetics | Organ Size - physiology | Gene Dosage | Binding Sites - genetics | DNA - metabolism | Transcription Factors - genetics | DNA - genetics | Sequence Homology, Amino Acid | Animals | Epistasis, Genetic | Models, Biological | Drosophila - growth & development | Nuclear Proteins - physiology | Drosophila Proteins - genetics | Mutation | Intracellular Signaling Peptides and Proteins - physiology | Growth | Genetic aspects | Genetic transcription
Journal Article
Oncogene, ISSN 1476-5594, 2009, Volume 27, Issue S1, pp. S137 - S148
.... Beclin 1 contains a BH3 domain, similar to that of Bcl-2 proteins, which is necessary and sufficient for binding to antiapoptotic Bcl- 2 homologs and required for Bcl-2-mediated inhibition of autophagy... 
Bcl-2 | Autophagy | Tumor suppressor | Beclin 1 | Apoptosis | BH3-only | autophagy | 1-DEPENDENT AUTOPHAGY | BIOCHEMISTRY & MOLECULAR BIOLOGY | REGULATES AUTOPHAGY | BCL-2 FAMILY PROTEINS | apoptosis | tumor suppressor | 3-KINASE COMPLEX | JNK1-MEDIATED PHOSPHORYLATION | CELL BIOLOGY | PROGRAMMED CELL-DEATH | LIFE-SPAN EXTENSION | ONCOLOGY | GENETICS & HEREDITY | TUMOR-SUPPRESSOR | PEPTIDE COMPLEX | C-ELEGANS | Humans | Molecular Sequence Data | Eukaryotic Cells - metabolism | Autophagy - physiology | Structure-Activity Relationship | Vesicular Transport Proteins - physiology | Proto-Oncogene Proteins c-bcl-2 - metabolism | Membrane Proteins - physiology | Tumor Suppressor Proteins - chemistry | Apoptosis Regulatory Proteins - genetics | Conserved Sequence | Beclin-1 | Protein Structure, Tertiary | Amino Acid Sequence | Arabidopsis Proteins - physiology | Adaptor Proteins, Vesicular Transport - physiology | Apoptosis Regulatory Proteins - chemistry | Models, Molecular | Protein Interaction Mapping | Sequence Homology, Amino Acid | Tumor Suppressor Proteins - physiology | Sequence Alignment | Animals | Membrane Proteins - chemistry | Apoptosis Regulatory Proteins - physiology | Protein Conformation | Signal Transduction - physiology | Eukaryotic Cells - cytology | Mice | Saccharomyces cerevisiae Proteins - physiology | Proteins | Oncology | Cellular biology | Molecular biology | Cancer
Journal Article
Biochemical pharmacology, ISSN 0006-2952, 2009, Volume 78, Issue 2, pp. 105 - 114
Journal Article
Cellular and molecular life sciences : CMLS, ISSN 1420-9071, 2010, Volume 68, Issue 5, pp. 765 - 783
.... The nucleotide-binding domain leucine-rich repeat (NLR)-containing family of pattern recognition receptors includes several proteins that drive inflammation in response to a wide variety of molecular patterns... 
Life Sciences | Biochemistry, general | AIM2 | Life Sciences, general | NLR | NLRP3 | IL-1β | Biomedicine general | Cell Biology | Caspase-1 | ANTHRAX LETHAL TOXIN | CONTAINING APAF1-LIKE PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | INNATE IMMUNE-RESPONSE | MEDIATED IL-1-BETA SECRETION | IL-1 beta | NLRP3 INFLAMMASOME | BLOOD MONONUCLEAR-CELLS | NALP3 INFLAMMASOME | CUTTING EDGE | CELL BIOLOGY | NF-KAPPA-B | CASPASE-1 ACTIVATION | Adaptor Proteins, Signal Transducing - chemistry | Calcium-Binding Proteins - chemistry | Carrier Proteins - physiology | Interleukin-1beta - physiology | CARD Signaling Adaptor Proteins - physiology | Signal Transduction | NLR Family, Pyrin Domain-Containing 3 Protein | Apoptosis Regulatory Proteins - chemistry | Humans | Caspase 1 - metabolism | Immunity, Innate | Nuclear Proteins - chemistry | Inflammasomes - physiology | Adaptor Proteins, Signal Transducing - physiology | Models, Immunological | Interleukin-1beta - metabolism | Calcium-Binding Proteins - physiology | CARD Signaling Adaptor Proteins - chemistry | Apoptosis Regulatory Proteins - physiology | Carrier Proteins - chemistry | Nuclear Proteins - physiology | DNA-Binding Proteins | Proteins | Signal transduction | Cellular biology | Rodents | Molecular biology | Gene expression | Immune system
Journal Article
Oncogene, ISSN 1476-5594, 2009, Volume 27, Issue S1, pp. S2 - S19
BH3-only BCL-2 family proteins are effectors of canonical mitochondrial apoptosis... 
Non-apoptotic functions | Autophagy | Apoptosis | BH3-only | Cancer | BCL-2 FAMILY-MEMBER | autophagy | BECLIN 1-DEPENDENT AUTOPHAGY | DNA-DAMAGE RESPONSE | BIOCHEMISTRY & MOLECULAR BIOLOGY | apoptosis | CELL BIOLOGY | PROGRAMMED CELL-DEATH | BREAST-CANCER CELLS | MITOCHONDRIAL-MEMBRANE PERMEABILIZATION | SURVIVAL-PROMOTING PROTEINS | ONCOLOGY | SMALL-MOLECULE INHIBITORS | GENETICS & HEREDITY | CHRONIC LYMPHOCYTIC-LEUKEMIA | cancer | non-apoptotic functions | CYTOCHROME-C RELEASE | Multigene Family | Proto-Oncogene Proteins c-bcl-2 - physiology | Apoptosis - drug effects | Humans | Molecular Sequence Data | Antineoplastic Agents - therapeutic use | Autophagy - physiology | Proto-Oncogene Proteins - chemistry | Peptide Fragments - physiology | Arthritis, Rheumatoid - metabolism | Apoptosis Regulatory Proteins - genetics | Proto-Oncogene Proteins c-bcl-2 - chemistry | Antineoplastic Agents - pharmacology | Protein Structure, Tertiary | Amino Acid Sequence | Mammals - metabolism | Apoptosis Regulatory Proteins - chemistry | Gene Expression Regulation | Heart Failure - metabolism | Heart Failure - pathology | Mitochondrial Membranes - metabolism | Protein Interaction Mapping | Peptide Fragments - chemistry | Animals | Cell Transformation, Neoplastic | Consensus Sequence - physiology | Proto-Oncogene Proteins - physiology | Cell Cycle - physiology | Apoptosis Regulatory Proteins - physiology | Protein Conformation | Caenorhabditis elegans Proteins - physiology | Mice | Apoptosis - physiology | Proteins | Oncology | Cellular biology | Molecular biology
Journal Article