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Annual Review of Pharmacology and Toxicology, ISSN 0362-1642, 2008, Volume 48, Issue 1, pp. 199 - 225
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2012, Volume 7, Issue 1, pp. 242 - 249
Journal Article
Gastroenterology, ISSN 0016-5085, 2008, Volume 135, Issue 4, pp. 1311 - 1321
Background & Aims: Acetaminophen (APAP) overdose is the most frequent cause of drug-induced liver failure. C-jun N-terminal kinase (JNK) is thought to play a... 
Gastroenterology and Hepatology | JNK ACTIVATION | APOPTOSIS | GAMMA-RADIATION | PROTEIN-KINASE | MAP KINASES | TNF-ALPHA | STRESS | GASTROENTEROLOGY & HEPATOLOGY | ISOLATED MOUSE HEPATOCYTES | CELL-DEATH | INDUCED HEPATOTOXICITY | Drug Overdose - metabolism | Hepatocytes - pathology | JNK Mitogen-Activated Protein Kinases - metabolism | Male | Mitogen-Activated Protein Kinase 9 - genetics | Drug Overdose - pathology | Acetaminophen - poisoning | Mitogen-Activated Protein Kinase 8 - genetics | p38 Mitogen-Activated Protein Kinases - metabolism | JNK Mitogen-Activated Protein Kinases - genetics | MAP Kinase Kinase Kinase 5 - metabolism | Chemical and Drug Induced Liver Injury - pathology | Disease Models, Animal | Drug Overdose - physiopathology | MAP Kinase Kinase Kinase 5 - genetics | Mitogen-Activated Protein Kinase 9 - metabolism | Mice, Inbred C57BL | Mitogen-Activated Protein Kinase 8 - metabolism | p38 Mitogen-Activated Protein Kinases - genetics | Chemical and Drug Induced Liver Injury - physiopathology | Mice, Knockout | Gene Expression Regulation, Enzymologic | Animals | Signal Transduction - drug effects | Chemical and Drug Induced Liver Injury - metabolism | Signal Transduction - physiology | Mice | Analgesics, Non-Narcotic - poisoning | Hepatocytes - enzymology | Liver diseases | Protein kinases | Liver | Glutathione | Apoptosis | Index Medicus | Abridged Index Medicus
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 07/2015, Volume 286, Issue 1, pp. 1 - 9
Metabolic activation and oxidant stress are key events in the pathophysiology of acetaminophen (APAP) hepatotoxicity. The initial mitochondrial oxidative... 
c-Jun N-terminal kinase | Acetaminophen | Hepatotoxicity | ASK1 | Oxidant stress | C-Jun N-terminal kinase | ACTIVATION | N-TERMINAL KINASE | MOUSE HEPATOCYTES | CELL-DEATH | MITOCHONDRIAL PERMEABILITY TRANSITION | DNA FRAGMENTATION | IN-VIVO | PHARMACOLOGY & PHARMACY | MICE | TOXICOLOGY | INDUCED HEPATOTOXICITY | Liver - pathology | Acetaminophen - toxicity | Glutathione - metabolism | Liver - metabolism | Mice, Inbred C57BL | JNK Mitogen-Activated Protein Kinases - metabolism | Male | Glutathione Disulfide - metabolism | Protective Agents - therapeutic use | Animals | Liver - drug effects | Chemical and Drug Induced Liver Injury - metabolism | Protective Agents - pharmacology | Protein Kinase Inhibitors - therapeutic use | Chemical and Drug Induced Liver Injury - drug therapy | Protein Kinase Inhibitors - pharmacology | Chemical and Drug Induced Liver Injury - pathology | MAP Kinase Kinase Kinase 5 - antagonists & inhibitors | Chemical and Drug Induced Liver Injury - etiology | Acetylcysteine | Mitochondrial DNA | Analysis | Liver | Apoptosis | Index Medicus | OXIDATION | APOPTOSIS | PATIENTS | INJURIES | SAFETY | MITOCHONDRIA | SIGNALS | METABOLIC ACTIVATION | TOXICITY | 60 APPLIED LIFE SCIENCES | MOLECULES | STRESSES | INHIBITION | NECROSIS | GLUTATHIONE | OXIDIZERS | LIVER | oxidant stress | hepatotoxicity | c-jun N-terminal kinase
Journal Article
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, ISSN 0363-6135, 06/2019, Volume 316, Issue 6, pp. H1528 - H1537
Tumor necrosis factor-alpha (TNF alpha) is a proinflammatory cytokine that is closely linked to the development of cardiovascular disease. TNF alpha activates... 
CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | TYROSINE PHOSPHORYLATION | PERMEABILITY | ASK1 | TRANSDUCTION | ANGIOTENSIN-II | apoptosis signal-regulating kinase 1 | tumor necrosis factor-alpha | SMOOTH-MUSCLE | INTERNALIZATION | inflammation | endocytosis | PERIPHERAL VASCULAR DISEASE | HYDROGEN-PEROXIDE | NADPH oxidase 1 | vascular smooth muscle cells | NF-KAPPA-B | NOX1
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2005, Volume 102, Issue 27, pp. 9691 - 9696
Journal Article
Nature Medicine, ISSN 1078-8956, 01/2018, Volume 24, Issue 1, pp. 84 - 94
Journal Article
Journal Article